Article
Infectious Diseases
Ziding Yu, Hang Ren, Mengxu Sun, Wanying Xie, Songsong Sun, Ning Liang, Haijian Wang, Xiaoqiang Ying, Yuxi Sun, Yuling Wang, Yunping Zheng, Xueying Hu, Jingliang Su
Summary: Research revealed the occurrence of cluster 3 TMUV infection in laying chickens in southern China, with the isolation of a TMUV strain belonging to cluster 3 with closest relation to mosquito-origin TMUV YN12193. Experimental infection confirmed the ability of the virus to replicate in multiple tissues and cause ovary damage, and high seroconversion rates were detected in three flocks following retrospective investigation.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Virology
Guiru Qiu, Yongqiu Cui, Yeqiu Li, Yongdong Li, Yong Wang
Summary: The study revealed that the origin of Tembusu virus (TMUV) may be linked to a mosquito TMUV ancestor, with the TMUV genome experiencing stronger mutation pressure than natural selection pressure. Different clades of TMUV were identified through phylogenetic analysis methods. These findings provide important insights into the ongoing spread of TMUV in China and can be valuable for future prevention and control efforts.
Article
Microbiology
Danhe Hu, Chao Wu, Ruichen Wang, Xiaohui Yao, Kai Nie, Quan Lv, Shihong Fu, Qikai Yin, Wenzhe Su, Fan Li, Songtao Xu, Ying He, Guodong Liang, Xiangdong Li, Huanyu Wang
Summary: In 2020, a strain of Tembusu virus (TMUV) was isolated from mosquito samples collected in Yunnan province, China. The virus showed significant cytopathic effect in certain cells, indicating its potential pathogenicity. Phylogenetic analysis revealed its close relationship with previous isolates from mosquitoes and avian sources in China. The study highlights the need for surveillance in the continuous circulation and unique evolution of TMUV.
Article
Microbiology
Dawei Yan, Xuesong Li, Zhanxin Wang, Xingpo Liu, Xuan Dong, Rui Fu, Xin Su, Bangfeng Xu, Qiaoyang Teng, Chunxiu Yuan, Zhifei Zhang, Qinfang Liu, Zejun Li
Summary: In 2021, outbreaks of a disease characterized by retarded growth and egg production decline in chickens in China were caused by a chicken Tembusu virus (TMUV). The TMUV strains SD2021 and GX2021 isolated from the diseased chickens were closely related to mosquito-origin TMUV in Cluster 3.2, and they caused growth retardation and neurological symptoms in chickens through both intranasal and intramuscular infection routes.
VETERINARY MICROBIOLOGY
(2022)
Article
Infectious Diseases
Yuan Fang, Tian Hang, Li-Min Yang, Jing-Bo Xue, Ryosuke Fujita, Xue-Song Feng, Tian-Ge Jiang, Yi Zhang, Shi-Zhu Li, Xiao-Nong Zhou
Summary: This study aims to explore the role of migratory birds in the spread of mosquito-borne pathogens and their prevalence on Chongming Island. The results indicate that migratory birds may introduce mosquito-borne viruses to the island through migration, posing a threat to the local poultry industry. The expansion and prevalence of insect-specific flaviviruses and their simultaneous circulation with mosquito-borne viruses deserve attention and further study.
INFECTIOUS DISEASES OF POVERTY
(2023)
Article
Veterinary Sciences
Yunzhen Huang, Ziqiang Hu, Jiawen Dong, Linlin Li, Junqin Zhang, Ruihuan Kuang, Shimin Gao, Minhua Sun, Ming Liao
Summary: In this study, a chicken-origin TMUV strain was isolated from laying hens with egg drop syndrome in south China. The results showed that this strain exhibited high infectivity and pathogenicity in both chicks and ducklings, suggesting its potential for widespread infection of chickens and ducks.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Min Li, Peikun Wang, Qiuhong Li, Qiaomu Deng, Mengya Shi, Meilan Mo, Tianchao Wei, Teng Huang, Ping Wei
Summary: Our laboratory found that from 2010 to 2017, the prevalence of co-infection of reticuloendotheliosis virus (REV) and Marek's disease virus (MDV) in poultry remained at low levels. However, from October 2018 to July 2020, we diagnosed and analyzed four clinical cases of high morbidity and mortality caused by the co-infection of REV and vv+MDV-like strains, indicating a potential threat to the poultry industry in southern China.
Article
Immunology
Pengju Zhang, Tiantian Yang, Yixue Sun, Haiying Qiao, Nianzhi Hu, Xintao Li, Weixia Wang, Lichun Zhang, Yanlong Cong
Summary: Infectious bronchitis (IB) is a significant challenge for the poultry industry globally. Despite the existence of commercial vaccines, effective control of IB epidemics has not been achieved. The development of novel IBV vaccines may offer a new approach for preventing and controlling IB.
Article
Reproductive Biology
Yufei Huang, Xiaoya Chu, Yafei Zhang, Sheng Yang, Yonghong Shi, Jingxian Wu, Qiusheng Chen
Summary: This study investigated the morphological changes in the testis of adult Shaoxing ducks infected with DTMUV. The results showed that DTMUV infection caused significant atrophy in the testis, cytoplasmic vacuolation and exfoliation in the seminiferous epithelium, decrease in the diameter of seminiferous tubule, and interstitial inflammation. Immunohistochemistry confirmed that spermatogenic cells, especially spermatocytes, were the target cells of DTMUV infection in the testis. Single and clustered virus particles were observed in the spermatogenic cells of infected ducks.
Article
Immunology
Jing Guo, Yanwen Wang, Conghui Zhao, Xinxin Gao, Yaping Zhang, Jiqing Li, Mengjing Wang, Hong Zhang, Wenqiang Liu, Chao Wang, Yingju Xia, Lu Xu, Guimei He, Jinyan Shen, Xiaohong Sun, Wenting Wang, Xinyu Han, Xiaoxuan Zhang, Zhengyang Hou, Xinlin Jin, Na Peng, Yubao Li, Guohua Deng, Pengfei Cui, Qianyi Zhang, Xuyong Li, Hualan Chen
Summary: The study shows that H9N2 avian influenza viruses exhibit different genetic evolution, receptor binding specificity, and transmission efficiency in different hosts, with viruses from chickens, green peafowls, and swans preferentially binding to human-like receptors.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Infectious Diseases
Nichapat Yurayart, Patchareeporn Ninvilai, Theeraphap Chareonviriyaphap, Theerayuth Kaewamatawong, Aunyaratana Thontiravong, Sonthaya Tiawsirisup
Summary: The study found that Thai DTMUV caused disease in BALB/c mice through intracerebral inoculation, resulting in systemic and neurological symptoms, with pathological changes and virus distribution observed in all tested organs. The viral load was significantly higher in the brain than in other organs, and the virus caused acute death in the mice. Virus shedding was not found in saliva and feces, indicating the potential for Thai DTMUV to transmit disease in mammalian hosts.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Infectious Diseases
Aunyaratana Thontiravong, Teerawut Nedumpun, Patchareeporn Ninvilai, Wikanda Tunterak, Navapon Techakriengkrai, Wijit Banlunara, Sanipa Suradhat
Summary: DTMUV infection significantly impacts the immune components and functions of ducks, leading to the loss of non-T and B lymphocyte/myeloid cell subpopulations and reduced phagocytic activity. However, T and B cell numbers increase during the early phase of infection. There is a negative correlation between CD4(+) and CD8(+) T, B and non-T and B lymphocyte levels and viral loads. Furthermore, DTMUV infection induces an early and robust neutralizing antibody response.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Agriculture, Dairy & Animal Science
Sheng Yang, Jingxian Wu, Yufei Huang, Yafei Zhang, Yonghong Shi, Ping Yang, Qiusheng Chen
Summary: This study constructed a DTMUV-infected duckling model to investigate apoptosis in the duckling brains. It was found that DTMUV infection could induce apoptosis in the brains of ducklings, and the occurrence of apoptosis was accompanied by the virus infection process with certain regularity.
Article
Agriculture, Dairy & Animal Science
Shuqi Xu, Xinhao Mu, Xin Xu, Congying Bi, Jun Ji, Yunchao Kan, Lunguang Yao, Yingzuo Bi, Qingmei Xie
Summary: This study analyzed 23 complete genomes of Chinese strains of duck hepatitis B virus (DHBV) and predicted and analyzed their recombinant events. These data aid in understanding the intergenotypic recombination of HBV and are expected to promote further research on the epidemiology and evolution of DHBV.
Article
Veterinary Sciences
Han Kaikai, Dongmin Zhao, Yuzhuo Liu, Qingtao Liu, Xinmei Huang, Jing Yang, Lijiao Zhang, Yin Li
Summary: Duck Tembusu virus (DTMUV) is a newly emerging pathogenic flavivirus that has caused significant economic losses to the duck industry in China. Research shows that TRIM25 plays an antiviral role against DTMUV and may provide insights into the molecular mechanisms underlying host response to DTMUV infection, suggesting potential control measures for DTMUV outbreaks.
FRONTIERS IN VETERINARY SCIENCE
(2021)
