期刊
JOURNAL OF CLINICAL MICROBIOLOGY
卷 50, 期 5, 页码 1777-1778出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.05478-11
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资金
- Instituto de Salud Carlos III-FIS [CB05/137]
- European Project TROCAR [HEALTH-F3-2008-223031]
- Microbial Sciences Foundation (Madrid, Spain)
A multilocus sequence type (MLST) shift (from ST242 to ST996) was detected in Pseudomonas aeruginosa isolates with a uniform pulsed-field gel electrophoresis (PFGE) pattern obtained from a chronically colonized patient. MLST mutational change involved the mutL gene with the consequent emergence of a hypermutable phenotype. This observation challenges the required neutrality of mutL as an appropriate marker in MLST and alerts researchers to the limitations of MLST-only-based population studies in chronic infections under constant antibiotic selective pressure.
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