期刊
JOURNAL OF CLINICAL MICROBIOLOGY
卷 49, 期 10, 页码 3504-3513出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.01131-11
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资金
- Surveillance and Investigation of Epidemic Situations in Southeast Asia (SISEA) project
- French Agency for Development
- Office of the Assistant Secretary for Preparedness and Response within the U.S. Department of Health and Human Services
- U.S. CDC
- WHO Cambodia
Human respiratory syncytial virus (HRSV) is the leading cause of hospitalization of children aged < 5 years due to respiratory illness in industrialized countries, and pneumonia is the leading cause of mortality among children aged < 5 years worldwide. Although HRSV was first identified in 1956, a preventative vaccine has yet to be developed. Here we report the results of the first study to investigate the circulation and genetic diversity of HRSV in Cambodia among an all-ages population over 5 consecutive years. The incidences of HRSV infection among all-ages outpatient and hospitalized populations were equivalent, at 9.5% and 8.2%, respectively. Infection was most prevalent among children aged < 5 years, with bronchiolitis being the most frequently observed clinical syndrome in the same age group. Circulation of HRSV was seasonal, typically coinciding with the rainy season between July and November annually. Strains belonging to HRSV groups A and B were detected with equivalent frequencies; however, we observed a potentially biennial shift in the predominant circulating HRSV genotype. The majority of HRSV group B strains belonged to the recently described BA genotype, with the exception of 10 strains classified as belonging to a novel HRSV group B genotype, SAB4, first reported here.
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