Article
Cell Biology
Drew J. Schwartz, Nitan Shalon, Kate Wardenburg, Anna DeVeaux, Meghan A. Wallace, Carla Hall-Moore, I. Malick Ndao, Janice E. Sullivan, Paula Radmacher, Marilyn Escobedo, Carey-Ann D. Burnham, Barbara B. Warner, Phillip I. Tarr, Gautam Dantas
Summary: BSI in preterm infants is commonly transmitted through the gut microbiome and is associated with antibiotic exposure. Ampicillin, gentamicin, or vancomycin can increase the abundance of Enterobacteriaceae and Enterococcaceae in the gut of preterm infants. This study suggests that the microbial composition of the gut can be utilized to predict the risk of BSI in hospitalized preterm infants.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Microbiology
Yuan Jiang, Yinhuan Ding, Yueshuai Wei, Chunxia Jian, Jinbo Liu, Zhangrui Zeng
Summary: Carbapenem-resistant Acinetobacter baumannii (CRAB) has become a leading cause of healthcare-associated infections globally, particularly in intensive care units (ICUs). Cross-transmission between patients and the hospital environment may play a crucial role in ICU-acquired CRAB colonization and infection. The control and treatment of CRAB infection in ICUs are challenging due to its multiple-drug resistance. Therefore, it is important to systematically study the colonization, infection, transmission, and resistance mechanisms of CRAB in ICUs.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Julien Demiselle, Pierre Meyer, Thierry Lavigne, Julian Kaurin, Hamid Merdji, Maleka Schenck, Antoine Studer, Ralf Janssen-Langenstein, Julie Helms, Baptiste Hoellinger, Vincent Castelain, Antoine Grillon, Francis Schneider, Ferhat Meziani, Raphael Clere-Jehl
Summary: This study highlights SE-BSIs as a cause of septic shock, mostly occurring in immunocompromised ICU patients, with increasing concerns about antibiotic resistance and central line management.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Microbiology
Karolina Dobrovic, Tea Skrobo, Katarina Selec, Marko Jelic, Rok Civljak, Jasminka Persec, Sanja Sakan, Nikolina Busic, Antonija Mihelcic, Sonja Hleb, Arjana Tambic Andrasevic
Summary: Healthcare-associated infections, especially those caused by multidrug-resistant pathogens, are a growing cause of morbidity and mortality in COVID-19 ICUs worldwide. This study aimed to assess the incidence of bloodstream infections among critically ill COVID-19 patients and analyze the characteristics of healthcare-associated BSIs due to MDR Acinetobacter baumannii in a COVID-19 ICU.
Article
Public, Environmental & Occupational Health
Viraj Ambalam, Anna C. Sick-Samuels, Julia Johnson, Elizabeth Colantuoni, Avinash Gadala, Clare Rock, Aaron M. Milstone
Summary: Bloodstream infections in the NICU have both short-term and long-term impacts on patients, and are closely monitored as a quality measure. While NICU infection rates are currently adjusted for birth weight, considering postnatal age in addition to birth weight may lead to improved comparisons between units.
AMERICAN JOURNAL OF INFECTION CONTROL
(2021)
Article
Multidisciplinary Sciences
Maskit Bar-Meir, Shoshana Bendelac, Irina Shchors
Summary: The aim of this study was to assess the safety of 2% chlorhexidine gluconate (CHG) bathing in NICU patients. The results showed that after 661 days of treatment on 810 newborns, no skin reactions were observed and the bloodstream infection rate was similar to the control group. It was concluded that 2% CHG bathing is safe for infants >30 weeks and >3 days old.
Article
Public, Environmental & Occupational Health
I Gajic, M. Jovicevic, M. Milic, D. Kekic, N. Opavski, Z. Zrnic, S. Dacic, Lj Pavlovic, V Mijac
Summary: This study describes an outbreak of Acinetobacter baumannii among preterm neonates in a NICU in Serbia. By conducting a case-control study, the researchers identified risk factors and molecular characteristics of the infection. Strengthening infection control measures effectively brought the outbreak under control.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Infectious Diseases
Giacomo Pozza, Giacomo Casalini, Cosmin Lucian Ciubotariu, Andrea Giacomelli, Miriam Galimberti, Martina Zacheo, Andrea Rabbione, Margherita Pieruzzi, Letizia Oreni, Laura Galimberti, Riccardo Colombo, Giuliano Rizzardini, Cristina Pagani, Sara Giordana Rimoldi, Cecilia Bonazzetti, Anna Lisa Ridolfo, Spinello Antinori
Summary: A retrospective observational study was conducted to assess the incidence of bloodstream infections (BSIs) in critically ill COVID-19 patients admitted to the ICU. The study found that the incidence of BSIs remained stable during different epidemic periods, and gram-positive bacteria were the most common pathogens. There was a decrease in the incidence of BSIs caused by Enterococcus spp.
Article
Medicine, General & Internal
Xiangyuan Sun, Xiaocui Zou, Boting Zhou, Tao Yin, Ping Wang
Summary: The proportion of CRKP BSI has been gradually increasing over the past nine years, with prior use of carbapenems identified as an independent risk factor. The CRKP BSI group had more non-susceptibility to tested carbapenems and a higher mortality rate.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
He-Ning Wu, Er-Yan Yuan, Wen-Bin Li, Min Peng, Qing-Yu Zhang, Ke-liang Xie
Summary: This study retrospectively analyzed the microbiological and clinical data of bloodstream infection (BSI) patients in an ICU in Tianjin, China. The results showed that Gram-negative bacteria had the highest drug resistance rate and resulted in more severe brain damage, renal function damage, and thrombocytopenia. The test index of procalcitonin (PCT) could be used to distinguish Gram-negative bacteremia from Gram-positive and differentiate bacteremia from fungemia, but further research is needed.
FRONTIERS IN MEDICINE
(2022)
Article
Infectious Diseases
Hyeri Seok, Ji Hoon Jeon, Ji Hye Jung, Sang Hee Ahn, Minji Seo, Hyun Kyung Cho, Sul A. Sung, Su-Hyun Kim, Hee Kyoung Choi, Won Suk Choi, Dae Won Park
Summary: Increasing the frequency of environmental cleaning did not reduce the acquisition of CRAB in ICU, with ventilator utilization ratio potentially playing a more significant role than environmental cleaning. Inexperienced nurses may contribute to the increased incidence of CRAB acquisition.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Cecilia Herbozo, Irene Julca, Fiorella Flores, Roger Hernandez, Jaime Zegarra
Summary: This study aimed to determine the incidence of late onset sepsis and the most frequent causative microorganisms in the neonatal unit at Hospital Cayetano Heredia in Lima, Peru. The results showed that late onset sepsis was more prevalent in low birth weight infants, with gram-negative bacteria being the main causative microorganism in very low birth weight infants.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Alexis Tabah, Jeffrey Lipman, Francois Barbier, Niccolo Buetti, Jean-Francois Timsit
Summary: Bloodstream infections in critically ill patients have a high mortality rate. Patients with septic shock should be treated with antibiotics within one hour, taking into consideration local epidemiology and risk factors for bacterial resistance. It is crucial to perform blood cultures and other tests before antibiotic administration to enable microbiological diagnosis and antimicrobial stewardship. Rapid diagnostic testing can provide faster identification of pathogens and resistance patterns, allowing for optimized antibiotic treatment.
Article
Public, Environmental & Occupational Health
Paula Eckardt, Kelsi Canavan, Rachel Guran, Elizabeth George, Nancimae Miller, Dianeysis H. Avendano, Myeongji Kim, Khaled Himed, Karen Heidi Gonzalez Ramirez
Summary: This study reports on an outbreak investigation and containment strategy for a carbapenem-resistant Acinetobacter baumannii outbreak in a community hospital's COVID intensive care unit. The study emphasizes the importance of prevention strategies and maintaining infection control best practices to reduce the spread of multidrug resistant organisms.
AMERICAN JOURNAL OF INFECTION CONTROL
(2022)
Article
Health Care Sciences & Services
Emma L. Doughty, Haiyang Liu, Robert A. Moran, Xiaoting Hua, Xiaoliang Ba, Feng Guo, Xiangping Chen, Linghong Zhang, Mark Holmes, Willem van Schaik, Alan Mcnally, Yunsong Yu
Summary: This study conducted a three-month observational study in a 28-bed intensive care unit (ICU) in Hangzhou, China, to explore the persistence and evolutionary dynamics of carbapenem-resistant Acinetobacter baumannii (CRAB). The study found that the ICU population of CRAB was dominated by OXA-23-producing global clone 2 isolates, which could be divided into 20 distinct clusters through genome sequencing. The study emphasized the importance of environmental CRAB reservoirs in the epidemiology of ICUs and the unique challenges in containing the spread of CRAB.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Mycology
Isabella Barbosa Cleinman, Sarah Santos Goncalves, Marcio Nucci, Danielle Carvalho Quintella, Marcia Halpern, Tiyomi Akiti, Gloria Barreiros, Arnaldo Lopes Colombo, Guilherme Santoro-Lopes
Article
Infectious Diseases
Luciana Gomes Pedro Brandao, Pedro Emmanuel Aluarenga Americano do Brasil, Silas de Souza Oliveira, Edson Elias da Silva, Guilherme Santoro Lopes
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Infectious Diseases
Ana Paula Ramalho da Costa-Lourenco, A. Jeanine Abrams, Kesia Thais Barros dos Santos, Isabella Campelo Vilardi Argentino, Talita Coelho-Souza, Maria Cristina Albuquerque Canine, Adriana Lucia Pires Ferreira, Beatriz Meurer Moreira, Sergio Eduardo Longo Fracalanzza, David L. Trees, Raquel Regina Bonelli
INFECTION GENETICS AND EVOLUTION
(2018)
Review
Immunology
Guilherme Santoro-Lopes, Aruna K. Subramanian, Israel Molina, Jose Maria Aguado, Ricardo Rabagliatti, Oscar Len
Review
Immunology
Wanessa Trindade Clemente, Ligia Camera Pierrotti, Edson Abdala, Michele I. Morris, Luiz S. Azevedo, Rogelio Lopez-Velez, Manuel Cuenca-Estrella, Julian Torre-Cisneros, Eskild Petersen, Luis Fernando A. Camargo, Alissa Jade Wright, Nicholas J. Beeching, Eduardo Garcia Vilela, Guilherme Santoro-Lopes, Oscar Len, Raquel S. B. Stucchi, Oriol Manuel, Luciana Costa Faria, Hakan Leblebicioglu, Shirish Huprikar, Israel Molina, Paulo Henrique Orlandi Mourao, Camille N. Kotton, Jose Maria Aguado
Article
Immunology
Luciana Gomes Pedro Brandao, Guilherme Santoro-Lopes, Silas de Souza Oliveira, Edson Elias da Silva, Pedro Emmanuel Alvarenga Americano do Brasil
Article
Virology
Rafael B. Varella, Ana Carolina J. Zalona, Nuria C. Diaz, Mariano G. Zalis, Guilherme Santoro-Lopes
Article
Virology
Luis Filipe da Costa Marques Borges, Mariano Gustavo Zalis, Guilherme Santoro-Lopes, Rafael Brandao Varella
JOURNAL OF MEDICAL VIROLOGY
(2019)
Article
Microbiology
Livia Helena Justo-da-Silva, Andrea Nunes De-Azeredo, Arnaldo Costa Bueno, Lara Feital Montezzi, Maria Beatriz Gerardin Poirot Leobons, Maria Silvana Alves, Patricia de Souza Inhaquite, Rosana Rangel Santos, Valeria Brigido Carvalho Girao, Antonio Jose Ledo Alves da Cunha, Carmem Lucia Pessoa-Silva, Renata Cristina Picao, Cristina Barroso Hofer, Guilherme Santoro-Lopes, Lee Woodland Riley, Beatriz Meurer Moreira
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2019)
Article
Infectious Diseases
Stephanie Gomes Santos de Almeida, Guilherme Santoro-Lopes, Flavia Savassi-Ribas, Tereza Cristina Simao Wagner, Tereza Azevedo Matuck, Deise de Boni Monteiro de Carvalho, Ana Carolina Jonard Zalona, Mariano Gustavo Zalis, Rafael Brandao Varella
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2020)
Article
Infectious Diseases
Lisia Miglioli-Galvao, Jose Osmar Medina Pestana, Guilherme Lopes-Santoro, Renato Torres Goncalves, Lucio R. Requiao Moura, Alvaro Pacheco Silva, Ligia Camera Pierrotti, Elias David Neto, Evelyne Santana Girao, Claudia Maria Costa de Oliveira, Cely Saad Abboud, Joao Italo Dias Franca, Carolina Devite Bittante, Luci Correa, Luis Fernando Aranha Camargo
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Immunology
Eduardo Scarlatelli Pimenta, Marta Guimaraes Cavalcanti, Mauro Jorge Cabral-Castro, Marco Antonio Lima, Jose Mauro Peralta, Guilherme Santoro-Lopes
Summary: This case report highlights the importance of considering chikungunya virus infection in the differential diagnosis of acute neurologic disease in solid organ transplant recipients who live in or have recently traveled to endemic areas.
TRANSPLANT INFECTIOUS DISEASE
(2021)
Article
Infectious Diseases
Ana Paula de Souza da-Silva, Viviane Santos de Sousa, Luis Guilherme de Araujo Longo, Saharai Caldera, Isabel Cristina Lemos Baltazar, Raquel Regina Bonelli, Guilherme Santoro-Lopes, Lee Woodland Riley, Beatriz Meurer Moreira
INFECTION GENETICS AND EVOLUTION
(2020)
Article
Immunology
Juliana de Souza Lapa, Marcia Halpem, Erika Ferraz de Gouvea, Alberto dos Santos de Lemos, Renato Torres Goncalves, Guilherme Santoro-Lopes
TRANSPLANTATION PROCEEDINGS
(2020)
Article
Parasitology
Karis Maria de Pinho Rodrigues, Andre Bon Fernandes da Costa, Guilherme Santoro-Lopes
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
(2019)
