Article
Environmental Sciences
Wenjie Zhang, Xiaoming Xia, Jinhua Wang, Lusheng Zhu, Jun Wang, Guangchi Wang, Yangyang Chen, Young Mo Kim
Summary: The study utilized artificial soil poisoning method to investigate the antioxidative stress mechanism and gene changes of earthworms (Eisenia foetida) after exposure to nitenpyram. The toxic effects were analyzed comprehensively using the IBRv2 method, showing significant impact on the physiological and genetic levels of earthworms.
Article
Environmental Sciences
Andrea C. Crupkin, Ariana B. Fulvi, Fernando G. Iturburu, Sandra Medici, Julieta Mendieta, Ana M. Panzeri, Mirta L. Menone
Summary: Azoxystrobin is a widely used systemic fungicide that inhibits mitochondrial respiration in target fungi, but its effects on non-target organisms are not well studied. This research evaluated biomarkers of oxidative stress, hematological, physiological, and genotoxicity in cichlid fish exposed to environmentally relevant concentrations of AZX, showing negative effects at realistic concentrations and highlighting the importance of considering developmental stage on biomarker evaluation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Galina N. Chelomina, Sergey P. Kukla, Viktor P. Chelomin, Pham N. Doanh
Summary: Parasite infection can lead to DNA damage, potentially involving oxidative stress and cancer development; these research findings are important for understanding the pathogenesis mechanisms of parasitic diseases.
Article
Public, Environmental & Occupational Health
Martin Roursgaard, Monika Hezareh Rothmann, Juliane Schulte, Ioanna Karadimou, Elena Marinelli, Peter Moller
Summary: This study investigated the extraction of nanoplastic particles from food containers and found that these nanoparticles can cause genotoxicity in cell cultures, while their cytotoxic effects were limited.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Pharmacology & Pharmacy
Wei Liu, Zechang Li, Xiaoyu Cui, Fang Luo, Chunyan Zhou, Jiangyu Zhang, Liguo Xing
Summary: The genotoxicity of nitenpyram (NIT) has been evaluated using human bone marrow mesenchymal stem cells (hBMSCs), showing potential genotoxic effects through oxidative stress and dysregulation of various signaling pathways. Although the risk of NIT alone to human health is low, the synergistic or additive effects with other pesticides should be considered.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Environmental Sciences
Jelena Radovanovic, Biljana Antonijevic, Marijana Curcic, Katarina Baralic, Stoimir Kolarevic, Zorica Bulat, Danijela Dukic-cosic, Aleksandra Buha Djordjevic, Branka Vukovic-Gacic, Dragana Javorac, Evica Antonijevic Miljakovic, Momir Carevic, Zoran Mandinic
Summary: Excessive fluoride exposure can lead to pathological changes in testicular tissues, affecting oxidative stress, essential elements levels, and DNA damage. SOD1 activity and DNA damage are the most sensitive indicators, with the lowest BMDLs at 0.1 µg F-/kg b.w. This study provides valuable insights for further research on the health risks associated with fluoride exposure in both human and animal populations.
ENVIRONMENTAL POLLUTION
(2022)
Article
Multidisciplinary Sciences
Omar A. Ahmed-Farid, Mohamed Taha, Rofanda M. Bakeer, Omyma K. Radwan, Hassan A. M. Hendawy, Ayman S. Soliman, Einas Yousef
Summary: Parkinson's disease is a progressive chronic neurodegenerative condition characterized by the loss of dopaminergic neurons within the substantia nigra. The current therapeutic strategies mainly focus on symptomatic relief, and alternative medicine such as Bee Venom and dopamine-loaded nanoparticles could be effective adjunct treatments for PD.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Roberta Nugnes, Chiara Russo, Elena Orlo, Margherita Lavorgna, Marina Isidori
Summary: This study aimed to determine the acute, sub-chronic, and chronic toxicity of imidacloprid in freshwater producers and primary consumers, as well as its potential eco-genotoxic effects on non-target organisms. The results showed that the genotoxicological risk quotient values of imidacloprid were higher than the threshold value in all continents, while chronic toxicity risk quotient values were generally below the threshold value.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Haiyang Luan, Jing Zhao, Jing Yang, Xin Gao, Jingyang Song, Xiaofeng Chen, Qinyu Cai, Chen Yang, Liqian Zhao, Min Ji, Hongyan Zhai, Zhiqiang Chen, Xuehua Li, Wei Liu
Summary: The genotoxic effects of effluents from wastewater treatment plants on Chinese rare minnows were evaluated, and the efficiency of various treatment processes in reducing genotoxicity was compared. The results showed that the effluents caused disturbances in antioxidant systems and increased DNA damage in the fish. The tertiary treatment plant had higher genotoxicity removal, but the ozone disinfection process needs improvement.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Pharmacology & Pharmacy
Kemal Ertilav, Mustafa Naziroglu
Summary: The study found that melittin (MLT) treatment can enhance the cytotoxic effects of cisplatin (CSP) on tumor cells by modulating Ca2+ channels. This enhancement is achieved through the activation of TRPM2 channels, which leads to the accumulation of mitochondrial reactive oxygen species (MitSOX) induced by mitochondrial Ca2+ and Zn2+. The study aimed to investigate the effects of CSP and MLT combination on DBTRG-05MG cells, including cell viability, cell death, apoptosis, and MitSOX levels.
Article
Pharmacology & Pharmacy
Hossam El Din H. Abdelhafez, Amr A. Abdallah, Asmaa A. El-Dahshan, Yasser A. Abd El-Baset, Osama M. Morsy, Mohamed Bedair M. Ahmed
Summary: The study found that fipronil induces various health risks in vivo, while date extract can alleviate the toxic effects of fipronil but failed to reduce genotoxicity.
Article
Biochemistry & Molecular Biology
Hanan A. Alfawaz, Afaf El-Ansary, Laila Al-Ayadhi, Ramesa Shafi Bhat, Wail M. Hassan
Summary: Bee pollen supplementation demonstrates protective potency against autism by alleviating oxidative stress, neuroinflammation, and glutamate excitotoxicity, and improving neurochemical markers.
Article
Biochemistry & Molecular Biology
Mona Alonazi, Abir Ben Bacha, Mona G. Alharbi, Arwa Ishaq A. Khayyat, Laila AL-Ayadhi, Afaf El-Ansary
Summary: Rodent models are useful for studying the potential connection between autism spectrum disorder (ASD) and gut microbiota, as autistic patients often experience gastrointestinal problems. In this study, 30 young male rats were divided into different groups and treated with bee pollen and probiotics to investigate the effects on gut health and oxidative stress markers. The results showed that the combination treatment significantly improved leaky gut biomarkers and reduced oxidative stress levels in rats exposed to propionic acid, which is associated with the pathogenesis of autism. These findings suggest that bee pollen and probiotics could be a beneficial therapeutic intervention for relieving the neurotoxic effects of propionic acid.
Article
Nanoscience & Nanotechnology
Regitze Solling Wils, Nicklas Raun Jacobsen, Emilio Di Ianni, Martin Roursgaard, Peter Moller
Summary: This study evaluated the genotoxicity of different types of carbon nanotubes on mouse lung epithelial cells, showing that CNTs can cause DNA damage, reactive oxygen species production, and impact telomere length in long-term exposure.
Article
Medicine, Research & Experimental
Faten Zahran, Alaa Mohamad, Nabila Zein
Summary: Bee venom has hypoglycemic, hypolipidemic, anti-inflammatory, and antioxidant effects, improving cardiac dysfunction in diabetic hyperlipidemic rats. Administration of bee venom and combined therapy with metformin and atorvastatin significantly reduced concentrations of various markers in blood.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Fisheries
Walaa El-Houseiny, Yasmina M. Abd El-Hakim, Mohamed M. M. Metwally, Sayed S. Abdel Ghfar, AlShimaa A. Khalil
Summary: The study highlighted the negative impacts of high fluoride exposure on the growth, hematological, liver and kidney function, oxidative status, and disease resistance of Clarias gariepinus. However, the addition of Silybum marianum and/or coenzyme Q10 significantly alleviated most of the fluoride-associated detrimental effects.
Article
Medicine, Legal
Yasmina M. Abd-Elhakim, Bothina H. F. Omran, Shimaa A. Ezzeldein, Amany Ahmed, Nabela El-Sharkawy, Amany Abdel-Rahman Mohamed
Summary: The relative expression levels of HMGB1, TLR2, and TLR4 in rat skin wounds showed a time-dependent relationship with wound age, making them reliable indicators for wound age determination in living subjects.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2022)
Article
Food Science & Technology
Naief Dahran, Yasmina M. Abd-Elhakim, Amany Abdel-Rahman Mohamed, Marwa M. Abd-Elsalam, Enas N. Said, Mohamed M. M. Metwally, Ahmed E. Abdelhamid, Bayan A. Hassan, Mohammed Alsieni, Manal E. Alosaimi, Maram H. Abduljabbar, Eman S. El-Shetry
Summary: Green synthesized zinc oxide nanoparticles (MO-ZnONP) can effectively mitigate the neurobehavioral and neurotoxic effects induced by acrylamide (ACR).
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Khaled Abo-EL-Sooud, Yasmina M. M. Abd-Elhakim, Mohamed M. M. Hashem, Abeer E. E. El-Metwally, Bayan A. A. Hassan, Hayat H. M. El-Nour
Summary: The study aimed to evaluate the potential protective role of quercetin against oxidative hepatotoxicity induced by aluminum oxide nanoparticles and lead acetate co-exposure. The results showed that quercetin significantly reduced hepatic enzymes, improved liver tissue damage, and protected the liver from the harmful effects of aluminum oxide nanoparticles and lead toxicity.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Correction
Pharmacology & Pharmacy
Khaled Abo-EL-Sooud, Yasmina M. Abd-Elhakim, Mohamed M. M. Hashem, Abeer E. El-Metwally, Bayan A. Hassan, Hayat H. M. El-Nour
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gomaa Mostafa-Hedeab, Amany Behairy, Yasmina M. Abd-Elhakim, Amany Abdel-Rahman Mohamed, Ahmed E. Noreldin, Naief Dahran, Rasha A. Gaber, Leena S. Alqahtani, Walaa M. Essawi, Areej A. Eskandrani, Eman S. El-Shetry
Summary: This study investigated the protective role of green synthesized zinc oxide nanoparticles (MO-ZNPs) in acrylamide (ACR)-induced reproductive dysfunctions in male rats. The findings indicated that MO-ZNPs effectively ameliorated the ACR-induced decline in reproductive parameters and hormonal imbalance, as well as sperm analysis disruption. Additionally, MO-ZNPs showed potential in reducing oxidative stress and apoptosis, while enhancing steroidogenesis and sex hormone levels, thereby protecting male rats from ACR-induced reproductive toxicity.
Article
Food Science & Technology
Hala Mahfouz, Naief Dahran, Amany Abdel-Rahman Mohamed, Yasmina M. Abd El-Hakim, Mohamed M. M. Metwally, Leena S. Alqahtani, Hassan Abdelraheem Abdelmawlla, Hazim A. Wahab, Ghalia Shamlan, Mohamed A. Nassan, Rasha A. Gaber
Summary: This study develops a more reliable method for the bio-fabrication of zinc oxide nanoparticles (ZNPs) using Moringa Oleifera extract as a chelating agent to remove acrylamide contamination. The effects of acrylamide on glutathione redox dynamics, liver function, lipid profile, and zinc residues in rats are investigated.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Yasmina M. Abd-Elhakim, Nabela I. El Sharkawy, Heba S. A. Gharib, Mona A. Hassan, Mohamed M. M. Metwally, Khlood M. Elbohi, Bayan A. Hassan, Amany Tharwat Mohammed
Summary: The study found that exposure to chlorpyrifos and iprodione had effects on the behavior and nervous system of male juvenile rats, such as reducing locomotion and exploration and increasing the severity of depression and anxiety. Additionally, significant biochemical and histological abnormalities were observed in their brain tissues, with the abnormalities being relatively less severe in the co-exposure group.
Article
Multidisciplinary Sciences
Khaled Abo-EL-Sooud, Yasmina M. Abd-El Hakim, Mohamed M. M. Hashem, Abeer E. El-Metwally, Bayan A. Hassan, Hayat H. M. El-Nour
Summary: This study investigated the effects of zinc oxide nanoparticles (ZNPs) and/or arsenic trioxide (ATO) exposure on the liver of adult male Sprague Dawley rats. Gallic acid (GA) was found to have a potential protective effect against ZNPs and ATO-induced liver toxicity. The results showed that ZNPs, ATO, and ZNPs+ATO exposure led to liver damage and alterations in oxidative stress markers, apoptotic proteins, and lipid metabolism.
Article
Biochemistry & Molecular Biology
Manal Alosaimi, Yasmina M. Abd-Elhakim, Amany Abdel-Rahman Mohamed, Mohamed M. M. Metwally, Tarek Khamis, Wafa S. Alansari, Areej A. Eskandrani, Walaa M. Essawi, Marwa M. Awad, Rehab A. A. El-Shaer, Sarah Ibrahim, Mohamed A. Nassan, Aya Sh. Metwally
Summary: This study assessed the cardioprotective properties of eco-friendly metal oxide nanoparticles against acrylamide-induced cardiac damage. The results showed that these nanoparticles could alleviate cardiac damage indicators, restore antioxidant levels, and reverse the abnormal gene expression related to cardiac damage. Green synthesized zinc oxide nanoparticles may be a biologically potent compound to alleviate acrylamide's cardiotoxic effects.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yasmina M. Abd-Elhakim, Taghred M. Saber, Mohamed M. M. Metwally, Noura A. Abd-Allah, Rasha M. S. M. Mohamed, Gehan A. Ahmed
Summary: Thymol has a potential protective effect against the harmful effects of IMID on the brain, which is achieved through its antioxidant, anti-inflammatory, and anti-apoptotic activities.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Food Science & Technology
Amany Abdel-Rahman Mohamed, Amany Behairy, Yasmina M. Abd El-Hakim, Mohamed M. M. Metwally, Tarek Khamis, Samah S. Abuzahrah, Ahmed E. Abdelhamid, Leena S. Alqahtani, Walaa M. Essawi, Badriyah S. Alotaibi, Manal Alosaimi, Rehab Ahmed Ahmed El-Shaer, Marwa Mahmoud Awad, Eman S. El-Shetry
Summary: This study explores the potential toxic effects of subchronic exposure to fenpropathrin (FNP) on the reproductive system of male SD rats, and compares the effects of curcumin (CUR) and curcumin-encapsulated chitosan nanoparticles (Cs.CUR.NPs) on these toxic effects. The study involved a cohort of sixty male SD rats, and the findings showed that FNP caused oxidative stress, sperm abnormalities, reduced motility and sperm count, as well as decreased levels of sex hormones. However, treatment with CUR and Cs.CUR.NPs exhibited remarkable restorative effects on semen quality, sex hormone levels, and antioxidant capacity.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Walaa El-Houseiny, Ahmed H. Arisha, Mohamed M. M. Metwally, Abdel-Wahab A. Abdel-Warith, Elsayed M. Younis, Simon J. Davies, Bayan A. Hassan, Yasmina M. Abd-Elhakim
Summary: This study investigates the protective effects of alpha lipoic acid (ALA) against the toxic effects of gibberellic acid (GA) in Nile tilapia fish. The results show that GA exposure leads to hematotoxicity, oxidative damage, and nephrotoxic effects in fish, including abnormal hematological parameters, increased oxidative stress, and kidney dysfunction. However, supplementing the diet with ALA can protect against these effects and restore normal kidney function. The study also reveals that GA exposure upregulates pro-inflammatory and apoptotic genes while downregulating antioxidant genes, and ALA supplementation can reverse these gene expression changes.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Environmental Sciences
Naglaa Z. H. Eleiwa, Mahmoud Abo-Alkasem Ali, Enas N. Said, Mohamed M. M. Metwally, Yasmina M. Abd-ElHakim
Summary: This study investigated the beneficial role of bee venom (BV) against neurobehavioral and neurotoxic effects induced by zinc oxide nanoparticles (ZNPs) in rats. The results showed that BV significantly reduced ZNPs-induced depression, anxiety, memory impairment, and spatial learning disorders. BV also suppressed the increased serotonin and dopamine levels and zinc content caused by ZNPs exposure. Moreover, BV restored the depleted antioxidant capacity and minimized the elevated malondialdehyde (MDA) content associated with ZNPs exposure. Additionally, BV alleviated the neurodegenerative changes and decreased the expression of neurofilament and GAP-43 protein induced by ZNPs. These findings suggest that BV could be an effective therapy for mitigating the neurotoxic and neurobehavioral effects of ZNPs.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Hosny Abd El Fadil, Amany Behairy, Lamiaa L. M. Ebraheim, Yasmina M. Abd-Elhakim, Heba Hussein Fathy
Summary: This study investigated the protective effects of mulberry leaf and olive leaf ethanolic extracts against paracetamol-induced liver injury in rats. The results showed that olive leaf extract had superior antioxidant and antiapoptotic capabilities compared to mulberry leaf extract in protecting against paracetamol-induced liver injury.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)