NMDA Receptors and Oxidative Stress Induced by the Major Metabolites Accumulating in HMG Lyase Deficiency Mediate Hypophosphorylation of Cytoskeletal Proteins in Brain From Adolescent Rats: Potential Mechanisms Contributing to the Neuropathology of This Disease

Acute intrastriatal injection of quinolinic acid provokes long-lasting misregulation of the cytoskeleton in the striatum, cerebral cortex and hippocampus of young rats

(2014) Paula Pierozan et al.   BRAIN RESEARCH

Dynorphin up-regulation in the dentate granule cell mossy fiber pathway following chronic inhibition of GluN2B-containing NMDAR is associated with increased CREB (Ser 133) phosphorylation, but is independent of BDNF/TrkB signaling pathways

(2014) W. Bradley Rittase et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mechanisms of NOS1AP action on NMDA receptor-nNOS signaling

(2014) Michael J. Courtney et al.   Frontiers in Cellular Neuroscience

Redox homeostasis is compromised in vivo by the metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency in rat cerebral cortex and liver

(2013) M. S. da Rosa et al.   FREE RADICAL RESEARCH

Involvement of the GluN2A and GluN2B Subunits in Synaptic and Extrasynaptic N -methyl-d-aspartate Receptor Function and Neuronal Excitotoxicity

(2013) Xianju Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extinction of Remotely Acquired Fear Depends on an Inhibitory NR2B/PKA Pathway in the Retrosplenial Cortex

(2013) K. A. Corcoran et al.   JOURNAL OF NEUROSCIENCE

Methylglyoxal-induced cytotoxicity in neonatal rat brain: a role for oxidative stress and MAP kinases

(2013) Luana Heimfarth et al.   METABOLIC BRAIN DISEASE

Congenital hypothyroidism alters the oxidative status, enzyme activities and morphological parameters in the hippocampus of developing rats

(2013) Daiane Cattani et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

In vivo experimental evidence that the major metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency induce oxidative stress in striatum of developing rats: A potential pathophysiological mechanism of striatal damage in this disorder

(2013) Carolina Gonçalves Fernandes et al.   MOLECULAR GENETICS AND METABOLISM

NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors

(2013) X Zhou et al.   Cell Death & Disease

Amyloid-Beta Peptide 1-42 Causes Microtubule Deregulation through N-methyl-D-aspartate Receptors in Mature Hippocampal Cultures

(2012) Sandra I. Mota et al.   Current Alzheimer Research

Cytoskeleton of cortical astrocytes as a target to proline through oxidative stress mechanisms

(2012) Samanta Oliveira Loureiro et al.   EXPERIMENTAL CELL RESEARCH

Disrupted cytoskeletal homeostasis, astrogliosis and apoptotic cell death in the cerebellum of preweaning rats injected with diphenyl ditelluride

(2012) Luana Heimfarth et al.   NEUROTOXICOLOGY

In vivo treatment with diphenyl ditelluride induces neurodegeneration in striatum of young rats: Implications of MAPK and Akt pathways

(2012) Luana Heimfarth et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Diphenyl ditelluride induces hypophosphorylation of intermediate filaments through modulation of DARPP-32-dependent pathways in cerebral cortex of young rats

(2011) Luana Heimfarth et al.   ARCHIVES OF TOXICOLOGY

Signaling mechanisms downstream of quinolinic acid targeting the cytoskeleton of rat striatal neurons and astrocytes

(2011) Paula Pierozan et al.   EXPERIMENTAL NEUROLOGY

GFAP in health and disease

(2011) J. Middeldorp et al.   PROGRESS IN NEUROBIOLOGY

Homocysteine induces cytoskeletal remodeling and production of reactive oxygen species in cultured cortical astrocytes

(2010) Samanta Oliveira Loureiro et al.   BRAIN RESEARCH

Acute intrastriatal administration of quinolinic acid provokes hyperphosphorylation of cytoskeletal intermediate filament proteins in astrocytes and neurons of rats

(2010) Paula Pierozan et al.   EXPERIMENTAL NEUROLOGY

Neurochemical evidence that 3-methylglutaric acid inhibits synaptic Na+,K+-ATPase activity probably through oxidative damage in brain cortex of young rats

(2010) César Augusto João Ribeiro et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Clinical Physiology and Mechanism of Dizocilpine (MK-801): Electron Transfer, Radicals, Redox Metabolites and Bioactivity

(2010) Peter Kovacic et al.   Oxidative Medicine and Cellular Longevity

Experimental evidence that ornithine and homocitrulline disrupt energy metabolism in brain of young rats

(2009) Carolina Maso Viegas et al.   BRAIN RESEARCH

Neuronal intermediate filaments and neurodegenerative disorders

(2009) Rodolphe Perrot et al.   BRAIN RESEARCH BULLETIN

Homocysteine Induces Hypophosphorylation of Intermediate Filaments and Reorganization of Actin Cytoskeleton in C6 Glioma Cells

(2009) Samanta Oliveira Loureiro et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Striatum is more vulnerable to oxidative damage induced by the metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency as compared to liver

(2009) Guilhian Leipnitz et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

3-Hydroxy-3-methylglutaryl-coenzyme A lyase deficiency: Initial presentation in a young adult

(2009) S. Reimão et al.   JOURNAL OF INHERITED METABOLIC DISEASE

NMDA Receptor GluN2B (GluR 2/NR2B) Subunit Is Crucial for Channel Function, Postsynaptic Macromolecular Organization, and Actin Cytoskeleton at Hippocampal CA3 Synapses

(2009) K. Akashi et al.   JOURNAL OF NEUROSCIENCE

Methylmalonate inhibits succinate-supported oxygen consumption by interfering with mitochondrial succinate uptake

(2008) S. R. Mirandola et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Propylthiouracil-induced congenital hypothyroidism upregulates vimentin phosphorylation and depletes antioxidant defenses in immature rat testis

(2008) Ariane Zamoner et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats

(2008) Guilhian Leipnitz et al.   LIFE SCIENCES

Vimentin phosphorylation as a target of cell signaling mechanisms induced by 1α,25-dihydroxyvitamin D3 in immature rat testes

(2008) Ariane Zamoner et al.   STEROIDS

Evidence that 3-hydroxy-3-methylglutaric acid promotes lipid and protein oxidative damage and reduces the nonenzymatic antioxidant defenses in rat cerebral cortex

(2007) Guilhian Leipnitz et al.   JOURNAL OF NEUROSCIENCE RESEARCH