Article
Infectious Diseases
Maria A. Gomis-Font, Gabriel Cabot, Silvia Lopez-Arguello, Laura Zamorano, Carlos Juan, Bartolome Moya, Antonio Oliver
Summary: The study found that resistance development to imipenem/relebactam was slower and reached a lower level compared to ceftolozane/tazobactam in all tested XDR strains. Additionally, imipenem/relebactam resistance remained low even in ST175 isolates that had developed resistance to ceftolozane/tazobactam. Lineages evolved in the presence of ceftolozane/tazobactam exhibited high-level resistance, hypersusceptibility to imipenem/relebactam, and low fitness cost, while lineages evolved in the presence of imipenem/relebactam showed moderate resistance, no cross-resistance to ceftolozane/tazobactam, and high fitness cost.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Jesus Sojo-Dorado, Inmaculada Lopez-Hernandez, Clara Rosso-Fernandez, Isabel M. Morales, Zaira R. Palacios-Baena, Alicia Hernandez-Torres, Esperanza Merino de Lucas, Laura Escola-Verge, Elena Bereciartua, Elisa Garcia-Vazquez, Vicente Pintado, Lucia Boix-Palop, Clara Natera-Kindelan, Luisa Sorli, Nuria Borrell, Livia Giner-Oncina, Concha Amador-Prous, Evelyn Shaw, Alfredo Jover-Saenz, Jose Molina, Rosa M. Martinez-Alvarez, Carlos J. Duenas, Jorge Calvo-Montes, Jose T. Silva, Miguel A. Cardenes, Maria Lecuona, Virginia Pomar, Lucia Valiente de Santis, Genoveva Yague-Guirao, Maria Angeles Lobo-Acosta, Vicente Merino-Bohorquez, Alvaro Pascual, Jesus Rodriguez-Bano
Summary: This study aimed to compare the noninferiority of fosfomycin to ceftriaxone or meropenem in the treatment of bacteremic urinary tract infections caused by multidrug-resistant Escherichia coli. The results showed that there was no significant difference in clinical and microbiological cure rates between the fosfomycin group and the comparator group, but the rate of adverse event-related discontinuations was higher in the fosfomycin group.
Article
Infectious Diseases
Sara Grillo, Guillermo Cuervo, Julia Laporte-Amargos, Manel Tuells, Immaculada Grau, Damaris Berbel, Carlota Gudiol, Miquel Pujol, Jordi Carratala
Summary: Among patients with Staphylococcus aureus bloodstream infection, those with active cancer were less likely to develop infective endocarditis compared to those without cancer. Active cancer patients were typically younger, had fewer comorbidities, and had less community-acquired SABSI.
INFECTIOUS DISEASES AND THERAPY
(2022)
Review
Infectious Diseases
Andrea Aira, Claudia Arajol, Climent Casals-Pascual, Begona Gonzalez-Suarez, Silvia Marti, M. Angeles Dominguez, Jordi Guardiola, Alex Soriano
Summary: Fecal microbiota transplantation (FMT) is an effective and safe treatment for recurrent Clostridioides difficile infection, with the selection of an appropriate fecal microbiota donor being crucial for recipient safety. To minimize risks and ensure maximum guarantees, a multidisciplinary working group has been established in Cataluna to provide recommendations for donor selection.
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2022)
Article
Infectious Diseases
Laia Badia-Cebada, Judit Penafiel, Patrick Saliba, Marta Andres, Jordi Camara, Dolors Domenech, Emili Jimenez-Martinez, Anna Marron, Encarna Moreno, Virginia Pomar, Montserrat Vaque, Enric Limon, Ursula Masats, Miquel Pujol, Oriol Gasch
Summary: A study conducted in Catalonia, Spain, analyzed the changes in catheter-related bloodstream infections (CRBSI) over a 12-year period. The study found a decrease in CRBSI associated with central venous catheters (CVC) and diagnosed in intensive care units (ICU), while the incidence of CRBSI related to peripheral venous catheters (PVC) and peripherally-inserted central venous catheters (PICVC) increased, especially in medical wards. The findings suggest the importance of implementing preventive measures in conventional wards to reduce CRBSI.
Article
Public, Environmental & Occupational Health
Gabriela Abelenda-Alonso, Mireia Puig-Asensio, Emilio Jimenez-Martinez, Esther Garcia-Lerma, Ana Hornero, Carmen Gutierrez, Miriam Torrecillas, Cristian Tebe, Miquel Pujol, Jordi Carratala
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Surgery
Nares Arroyo-Garcia, Josep M. Badia, Ana Vazquez, Miguel Pera, David Pares, Enric Limon, Alexander Almendral, Marta Piriz, Cecilia Diez, Domenico Fraccalvieri, Joaquin Lopez- Contreras, Miquel Pujol
Summary: This study investigated the effectiveness of an interventional surveillance program on surgical site infection (SSI) rates after elective colorectal surgery. The analysis of risk factors and postoperative infection in colorectal surgery allowed strategies for reducing SSI incidence to be designed, and the interventional surveillance program was proven effective in decreasing SIR and SSI rates.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Microbiology
Miquel Pujol, Enric Limon, Nieves Sopena, Joaquin Lopez-Contreras, Laia Castella, Jordi Cuquet, Maria Lopez-Sanchez, Rafel Perez, Carlota Gudiol, Ana Coloma, Marilo Marimon, Joan Espinach, Marta Andres, Purificacion Martos, Sergi Hernandez, Alexander Almendral, Patrick Saliba, Goncalo Carvalho Rodrigues, Esther Calbo
Summary: This multicenter observational cohort study examined the risk factors determining 90-day CDI recurrence in Catalonia, Spain. It found that receiving multiple courses of antibiotics in the 30 days prior to CDI diagnosis and undergoing active chemotherapy were significant predictors of 90-day CDI recurrence.
FUTURE MICROBIOLOGY
(2022)
Article
Microbiology
Maria Montaner, Silvia Lopez-Arguello, Antonio Oliver, Bartolome Moya
Summary: The lack of effective treatment options against Pseudomonas aeruginosa is a major contributor to the silent pandemic. This study provides insights into the mechanisms of action of beta-lactam antibiotics and beta-lactamase inhibitors in P. aeruginosa PAO1, aiding in the design of optimized therapies.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Silvia Lopez-Argueello, Maria Montaner, Alaa R. M. Sayed, Antonio Oliver, Jurgen B. Bulitta, Bartolome Moya
Summary: Beta-lactam antibiotics have been effective against susceptible Pseudomonas aeruginosa, but their penetration ability and binding to penicillin-binding proteins (PBPs) in intact bacteria have not been well studied. This research investigated the time course of PBP binding and target site penetration of 15 compounds in P. aeruginosa PAO1. The results showed that PBPs 1-4 were considerably bound in lysed bacteria, but the binding was attenuated in intact bacteria for slow penetrating beta-lactams. Imipenem showed the highest killing effect, while other drugs had lower killing rates. The study also found a correlation between PBP5/6 binding and the rate of net influx and PBP access.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Microbiology
Silvia Lopez-Arguello, Maria Montaner, Amanda Marmol-Salvador, Ana Velazquez-Escudero, Fernando Docobo-Perez, Antonio Oliver, Bartolome Moya
Summary: The lack of effective antibiotics for Neisseria gonorrhoeae and the worldwide spread of resistant strains are the main causes of a worsening global health crisis. Beta-lactam antibiotics have been the main treatment for gonococci, but we need more insights to design optimized therapies.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Maria Bonilla-Moreno, Miriam Torrecillas, Julia Laporte-Amargos, Aida Gonzalez-Diaz, Alberto Mussetti, Fe Tubau, Carlota Gudiol, M. Angeles Dominguez, Sara Marti, Graciela Rodriguez-Sevilla, Carmen Ardanuy
Summary: This article reports a case of a patient with persistent blood infection due to a multidrug-resistant C. coli strain over a 3-month period, highlighting the association between monotherapy with meropenem and the development of resistance to it. Improving immunity status and a combined therapy for intestinal decolonization were found to be effective in controlling the persistent C. coli infection in this patient.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Sara Grillo, Miquel Pujol, Josep M. Miro, Joaquin Lopez-Contreras, Gorane Euba, Oriol Gasch, Lucia Boix-Palop, Maria Jose Garcia-Pais, Maria Teresa Perez-Rodriguez, Silvia Gomez-Zorrilla, Isabel Oriol, Luis Eduardo Lopez-Cortes, Maria Luisa Pedro-Botet, Rafael San-Juan, Jose Maria Aguado, Francesca Gioia, Simona Iftimie, Laura Morata, Alfredo Jover-Saenz, Graciano Garcia-Pardo, Belen Loeches, Alvaro Izquierdo-Cardenas, Ane Josune Goikoetxea, Aina Gomila-Grange, Beatriz Dietl, Damaris Berbel, Sebastian Videla, Pilar Hereu, Ariadna Padulles, Natalia Pallares, Cristian Tebe, Guillermo Cuervo, Jordi Carratala, SAFO Study Grp
Summary: In hospitalized adults with MSSA bacteremia, combining cloxacillin with fosfomycin did not achieve better treatment success at day 7 compared to using cloxacillin alone. Further trials should consider the heterogeneity of the infection and use a personalized approach.
Review
Microbiology
Maria Escobar-Salom, Isabel Maria Barcelo, Elena Jordana-Lluch, Gabriel Torrens, Antonio Oliver, Carlos Juan
Summary: This review discusses the evidence and therapeutic potentials of a soluble peptidoglycan-dependent signaling that can impact the virulence of Gram-negative bacteria. It highlights the need for new therapeutic options against antibiotic-resistant pathogens and explores the potential of targeting bacterial pathogenic power. Studies have suggested the existence of peptidoglycan-derived signaling capable of regulating bacterial behavior and these findings could be exploitable for therapeutic purposes. The review aims to gather and integrate the current knowledge gaps in order to enable the development of potential therapeutic strategies.
FEMS MICROBIOLOGY REVIEWS
(2023)
Article
Microbiology
Isabel M. Barcelo, Gabriel Torrens, Maria Escobar-Salom, Elena Jordana-Lluch, Maria Magdalena Capo-Bauza, Carlos Ramon-Pallin, Daniel Garcia-Cuaresma, Pablo A. Fraile-Ribot, Xavier Mulet, Antonio Oliver, Carlos Juan
Summary: With the increasing antibiotic resistance, there is an urgent need for new weapons against top nosocomial pathogens like Pseudomonas aeruginosa. The interplay between beta-lactam resistance and virulence is promising for developing antivirulence therapies. In this study, the researchers demonstrated that peptidoglycan recycling blockade significantly attenuated the pathogenic power of P. aeruginosa strains hyperproducing AmpC beta-lactamase. However, the impact of peptidoglycan recycling disruption and different beta-lactamases on virulence varied. Cloning beta-lactamase OXA-2 derivatives were associated with outstanding virulence impairments, suggesting that mutations affecting the hydrolytic spectrum of these enzymes drastically impact the pathogenic power of P. aeruginosa.
MICROBIOLOGY SPECTRUM
(2022)