Article
Microbiology
A. C. Westgeest, E. F. Schippers, N. M. Delfos, L. J. Ellerbroek, T. Koster, V Hira, L. G. Visser, M. G. J. de Boer, M. M. C. Lambregts
Summary: This study evaluated the efficacy of recommended decolonization treatments for MRSA carriage, finding that antimicrobial combinations yielded high success rates; prolonged treatment did not affect outcomes; compromised immune status was an independent risk factor for treatment failure at the first attempt.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Microbiology
Mona Katrine Alberthe Holm, Kristina Melbardis Jorgensen, Kristian Bagge, Peder Worning, Michael Pedersen, Henrik Westh, Jonathan M. Monk, Mette Damkjaer Bartels
Summary: This study aimed to identify bacterial genome and clinical factors influencing MRSA decolonization, predicting chronic MRSA carriage with 68% accuracy using a combination of bacterial genome data and patient clinical data.
MICROBIOLOGY SPECTRUM
(2022)
Article
Public, Environmental & Occupational Health
Sara Quero, Marina Serras-Pujol, Noemi Parraga-Nino, Carmen Torres, Marian Navarro, Anna Vilamala, Emma Puigoriol, Javier Diez de los Rios, Elisenda Arque, Judit Serra-Pladevall, Alba Romero, Daniel Molina, Roger Paredes, Maria Luisa Pedro-Botet, Esteban Reynaga
Summary: This study investigated the prevalence of methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) among workers in the pork production chain. The results showed that the prevalence of MRSA was high among workers in contact with live animals, especially in pig farms, livestock transporters, and slaughterhouses.
Review
Infectious Diseases
Joshua. B. Parsons, Annette. C. Westgeest, Brian. P. B. Conlon, Vance. G. Fowler
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) is a deadly pathogen that can persist in the bloodstream for days despite appropriate antibiotics. Persistent MRSA bacteremia is common and associated with poor clinical outcomes. This review explores the factors related to host-pathogen interaction and discusses the clinical relevance of each element. Treatment options and diagnostic approaches for managing persistent MRSA bacteremia are also discussed.
Article
Orthopedics
Itay Ashkenazi, Jeremiah Thomas, Kyle W. Lawrence, Joshua C. Rozell, Claudette M. Lajam, Ran Schwarzkopf
Summary: This study aimed to evaluate the impact of preoperative nasal colonization with MRSA on TJA outcomes. The results showed that MRSA+ patients had longer hospital stays, lower discharge rates, higher readmission rates, and higher rates of septic and aseptic revisions. Surgeons should consider preoperative MRSA colonization status when counseling patients on the risks of TJA.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Microbiology
Shengnan Jiang, Hemu Zhuang, Feiteng Zhu, Xiang Wei, Junxiong Zhang, Lu Sun, Shujuan Ji, Haiping Wang, Dandan Wu, Feng Zhao, Rushuang Yan, Yunsong Yu, Yan Chen
Summary: The emergence of daptomycin-resistant Staphylococcus aureus strains is a global problem caused by point mutations in the mprF gene. This study found that specific mprF mutations lead to the seesaw effect of distinct beta-lactams in MRSA strains and the combination therapy of daptomycin and beta-lactams has synergistic activity. The cell surface positive charge is not affected by mprF mutations. Understanding the mechanism of restoring susceptibility to beta-lactam antibiotics mediated by mprF mutations is important for the treatment of MRSA infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Zahoua Mentfakh Laceb, Seydina M. Diene, Rym Lalaoui, Mabrouk Kihal, Fella Hamaidi Chergui, Jean-Marc Rolain, Linda Hadjadj
Summary: This study determined the prevalence of Staphylococcus aureus in a hospital environment in western Algeria and investigated nasal carriage among healthcare workers and patients. The study found a high prevalence of S. aureus in all three groups, as well as the presence of resistance and virulence genes. It also identified the hospital environment and nasal carriage as potential reservoirs for the persistence and spread of the same pathogenic clone.
Article
Biochemistry & Molecular Biology
Mark Hutchins, Richard A. Bovill, Peter J. Stephens, John A. Brazier, Helen M. I. Osborn
Summary: The increasing number of antibiotic-resistant bacteria poses a serious threat to global human health. This study examines the glycosylation of nadifloxacin to improve its solubility and finds that one glycoside derivative has the potential to be an effective antibacterial agent.
Article
Microbiology
Alexandra E. Chittams-Miles, Areej Malik, Erin B. Purcell, Claudia Muratori, Brian Conlon
Summary: Treatment with short electric pulses can enhance the effects of multiple antibiotics against methicillin-resistant Staphylococcus aureus (MRSA). This combination therapy reduces the necessary antibiotic dosage and improves the efficacy of treating S. aureus infections such as skin and soft-tissue infections (SSTIs). SSTIs are accessible to physical intervention, making electric pulse co-treatment a potential option for wound and abscess debridement.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Kevin Simon, Wolfgang Pier, Alex Kruettgen, Hans-Peter Horz
Summary: The combination of Sb-1 phage and oxacillin showed enhanced antibacterial effects against most S. aureus isolates, with rare antagonism observed. This heterologous antimicrobial pair provides a robust approach for controlling MRSA.
Article
Infectious Diseases
Nicholas M. Brown, Erwin M. Brown
Summary: The UK guidelines for MRSA infection treatment have been updated, incorporating new evidence and antibiotics for Gram-positive bacterial infections. However, the current literature review found a lack of strong evidence, resulting in a hybrid of varying degrees of evidence and expert opinion in the guidelines.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Immunology
Loren G. Miller, Raveena Singh, Samantha J. Eells, Daniel Gillen, James A. McKinnell, Steven Park, Tom Tjoa, Justin Chang, Syma Rashid, Raul Macias-Gil, Lauren Heim, Adrijana Gombosev, Diane Kim, Eric Cui, Jennifer Lequieu, Chenghua Cao, Suzie S. Hong, Ellena M. Peterson, Kaye D. Evans, Bryn Launer, Steven Tam, Michael Bolaris, Susan S. Huang
Summary: This study examined the microbiologic outcomes of a clinical trial on post-hospitalization decolonization and found that a repeated decolonization regimen significantly reduced methicillin-resistant Staphylococcus aureus colonization at key body sites.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Stefan Monecke, Amira K. Bedewy, Elke Mueller, Sascha D. Braun, Celia Diezel, Amel Elsheredy, Ola Kader, Martin Reinicke, Abeer Ghazal, Shahinda Rezk, Ralf Ehricht
Summary: The study characterised MRSA isolates from a tertiary care centre in Alexandria, Egypt. The isolates belonged to 11 different clonal complexes and 14 strains, with CC15-MRSA-[V+fus] and CC1-MRSA-[V+fus+tir+ccrA/B-1] (PVL+) being the most common strains. Most isolates carried variant SCCmec elements and the fusidic acid resistance gene fusC. PVL genes were also prevalent. The study revealed an increase in fusC and PVL carriage and a decrease in the prevalence of the CC239 strain when compared to data from a previous study.
Article
Immunology
Syong H. Nam-Cha, Elena Dominguez-Jurado, Selena L. Tinoco-Valencia, Ramon Perez-Tanoira, Noelia Morata-Moreno, Rocio Alfaro-Ruiza, Agustin Lara-Sanchez, Jaime Esteban, Rafael Lujan, Carlos Alonso-Moreno, Pedro Segui, Alberto Ocana, Angel Lopez Gonzalez, John J. Aguilera-Correa, Francisco C. Perez-Martinez, Milagros Molina Alarcon
Summary: This study aimed to translate clinical research outcomes based on metallodrugs into clinical practice for the treatment of MRSA. The novel metallodrug 2P-Pt showed antibacterial effect against MRSA and inhibited biofilm formation. These findings suggest that 2P-Pt may be a promising therapeutic alternative for MRSA infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Infectious Diseases
Wei-Yao Wang, Po-Ren Hsueh, Shih-Ming Tsao
Summary: The aim of this study was to investigate invasive MRSA isolates and correlate the molecular typing results with antibiotic susceptibility testing results, in order to help physicians select appropriate antibiotics for the treatment of invasive MRSA infections. The study collected 670 non-duplicate mecA-positive MRSA isolates from patients with invasive infections, identified 58 spa types, and categorized them as healthcare-associated MRSA (HA-MRSA) and community-associated MRSA (CA-MRSA).
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
