Article
Infectious Diseases
Maria Garcia-Castillo, Sergio Garcia-Fernandez, Rosa Gomez-Gil, Cristina Pitart, Marina Oviano, Irene Gracia-Ahufinger, Jazmin Diaz-Reganon, Marta Tato, Rafael Canton
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2018)
Article
Infectious Diseases
Zaineb Hamzaoui, Alain Ocampo-Sosa, Marta Fernandez Martinez, Sarrah Landolsi, Sana Ferjani, Elaa Maamar, Mabrouka Saidani, Amine Slim, Luis Martinez-Martinez, Ilhem Boutiba-Ben Boubaker
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2018)
Article
Infectious Diseases
Marta Fernandez-Martinez, Belen Ruiz del Castillo, Maria Jesus Lecea-Cuello, Jesus Rodriguez-Bano, Alvaro Pascual, Luis Martinez-Martinez
MICROBIAL DRUG RESISTANCE
(2018)
Article
Infectious Diseases
Francisco Jose Perez-Llarena, Juan Carlos Vazquez-Ucha, Frederic Kerff, Laura Zamorano, Elisenda Miro, Maria Povoa Cabral, Ana Fleites, Marta Lantero, Luis Martinez-Martinez, Antonio Oliver, Moreno Galleni, Ferran Navarro, Alejandro Beceiro, German Bou
MICROBIAL DRUG RESISTANCE
(2018)
Article
Infectious Diseases
Zaineb Hamzaoui, Alain Ocampo-Sosa, Elaa Maamar, Marta Fernandez Martinez, Sana Ferjani, Samia Hammami, Sarra Harbaoui, Nathalie Genel, Guillaume Arlet, Mabrouka Saidani, Amine Slim, Ilhem Boutiba-Ben Boubaker, Luis Martinez-Martinez
MICROBIAL DRUG RESISTANCE
(2018)
Article
Infectious Diseases
Margarita Martinez-Medina, Francesco Strozzi, Belen Ruiz Del Castillo, Natalia Serrano-Morillas, Nuria Ferrer Bustins, Luis Martinez-Martinez
Article
Infectious Diseases
Teresa Lopez-Vinau, German Penalva, Lucrecia Garcia-Martinez, Juan Jose Caston, Montserrat Munoz-Rosa, Angela Cano, Manuel Recio, Jose Miguel Cisneros, Elena Perez-Nadales, Jose Rumbao Aguirre, Elena Garcia-Martinez, Inmaculada Salcedo, Jose Ramon del Prado, Carmen de la Fuente, Luis Martinez-Martinez, Irene Gracia-Ahufinger, Julian Torre-Cisneros
Summary: The study evaluated the impact of a multifaceted Antimicrobial Stewardship Program (ASP) on carbapenem use and incidence of Carbapenem-resistant Gram-negative bacilli (CR-GNB). The results showed that the ASP significantly reduced carbapenem consumption and led to a decrease in the incidence density of CR-GNB, especially in CR-Klebsiella pneumoniae and CR-Escherichia coli, reversing the pre-intervention upward trend.
Article
Environmental Sciences
Nicolas Francisco Fernandez-Martinez, Sheila Carcel-Fernandez, Carmen De la Fuente-Martos, Rafael Ruiz-Montero, Bernardo R. Guzman-Herrador, Rafael Leon-Lopez, Francisco Javier Gomez, Julia Guzman-Puche, Luis Martinez-Martinez, Inmaculada Salcedo-Leal
Summary: This study aimed to identify risk factors for carriage of multidrug-resistant Gram-negative bacteria (MDR-GNB) upon admission to an intensive care unit (ICU). Through a case-control study, the researchers collected sociodemographic, clinical, and microbiological data and found that liver cirrhosis was the main comorbidity associated with MDR-GNB carriage.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Isabel Machuca, Julia Guzman-Puche, E. Perez-Nadales, I Gracia-Ahufinger, A. Mendez, A. Cano, J. J. Caston, A. Dominguez, J. Torre-Cisneros, L. Martinez-Martinez
Summary: This study describes the clinical and microbiological features of a community-acquired infection caused by KPC-producing K. pneumoniae resistant to ceftazidime/avibactam. The bacteria isolates were resistant to carbapenems and ceftazidime/avibactam, but susceptible to trimethoprim-sulfamethoxazole. Whole genome sequencing revealed genetic differences and the presence of a plasmid associated with trimethoprim-sulfamethoxazole resistance.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Pharmacology & Pharmacy
Sandra Patricia Rivera-Sanchez, Ivan Dario Ocampo-Ibanez, Yamil Liscano, Natalia Martinez, Isamar Munoz, Marcela Manrique-Moreno, Luis Martinez-Martinez, Jose Onate-Garzon
Summary: This study investigates the interaction between a cationic antimicrobial peptide (CAMP) derived from Cecropin D-like and bacterial-like model membranes of colistin-resistant Pseudomonas aeruginosa (CRPa) strains. The experimental analysis shows that the peptide interacts with the lipids of CRPa membranes, resulting in an increase in the phase transition temperature of the lipid systems and a transition in the peptide's secondary structure.
Article
Microbiology
T. Blanco-Martin, J. Guzman-Puche, C. Riazzo, M. Gasca-Santiyan, M. Hernandez-Garcia, R. Canton, J. Torre-Cisneros, C. Herrera, L. Martinez-Martinez
Summary: IMI carbapenemases confer an unusual resistance pattern, making them difficult to detect. Commercial molecular methods usually do not include bla(IMI) genes, contributing to the hidden dissemination of bacteria producing these enzymes. We report a plasmid-encoded IMI-6 carbapenemase in an Enterobacter ludwigii isolate, providing insights into its genetic characteristics.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Irene Sanchez-Leon, Teresa Garcia-Martinez, Seydina M. Diene, Elena Perez-Nadales, Luis Martinez-Martinez, Jean-Marc Rolain
Summary: This study aimed to investigate heteroresistance in nine clinical isolates of Klebsiella pneumoniae producing OXA-48 and describe genomic changes in vitro. It was found that the heteroresistance in K. pneumoniae isolates was mainly attributed to insertions in the mgrB gene and point mutations in colistin resistance proteins. These findings contribute to the understanding of colistin resistance mechanisms in OXA-48-producing K. pneumoniae mutants.
Article
Microbiology
Irene Sanchez-Leon, Elena Perez-Nadales, Juan Antonio Marin-Sanz, Teresa Garcia-Martinez, Luis Martinez-Martinez
Summary: This study investigated heteroresistance in 10 wild-type Klebsiella pneumoniae isolates of clinical origin. The results showed the importance of persistent variants and stable mutants in heteroresistance, and described the genomic changes observed in mutants obtained in population analysis profiling (PAP) assays.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Angela Cano, Belen Gutierrez-Gutierrez, Isabel Machuca, Irene Gracia-Ahufinger, Elena Perez-Nadales, Manuel Causse, Juan Jose Caston, Julia Guzman-Puche, Julian Torre-Gimenez, Lara Kindelan, Luis Martinez-Martinez, Jesus Rodriguez-Bano, Julian Torre-Cisneros
CLINICAL INFECTIOUS DISEASES
(2018)
Correction
Microbiology
Ester del Barrio-Tofino, Carla Lopez-Causape, Gabriel Cabot, Alba Rivera, Natividad Benito, Concepcion Segura, Maria Milagro Montero, Luisa Sorli, Fe Tubau, Silvia Gomez-Zorrilla, Nuria Tormo, Raquel Dura-Navarro, Esther Viedma, Elena Resino-Foz, Marta Fernandez-Martinez, Claudia Gonzalez-Rico, Izaskun Alejo-Cancho, Jose Antonio Martinez, Cristina Labayru-Echverria, Carlos Duenas, Ignacio Ayestaran, Laura Zamorano, Luis Martinez-Martinez, Juan Pablo Horcajada, Antonio Oliver
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)