Article
Microbiology
Tae Yeul Kim, Hee Jae Huh, Ga Yeong Lee, Min Ji Choi, Hui-Jin Yu, Sun Young Cho, Yun Sil Chang, Yae-Jean Kim, Jong Hee Shin, Nam Yong Lee
Summary: This study investigated the mechanisms of fluconazole resistance and clonal types of Candida parapsilosis isolates in a South Korean tertiary care hospital. The results revealed that Y132F and N1132D were the major mechanisms of fluconazole resistance. The clonal evolution of Y132F isolates with MRR1 mutations persisted and spread in the hospital setting, leading to an increase in fluconazole resistance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Jung Ho Kim, Hi Jae Lee, Nam Su Ku, Seung Hyun Lee, Sak Lee, Jun Yong Choi, Joon-Sup Yeom
Summary: The incidence of infective endocarditis is increasing in South Korea, while the mortality rate has slightly decreased but remains high. Surgical intervention has a protective effect on in-hospital mortality and long-term prognosis for patients with IE.
Article
Infectious Diseases
Sosina Ayalew, Teklu Wegayehu, Hawult Taye, Liya Wassie, Selfu Girma, Stefan Berg, Adane Mihret
Summary: Tuberculosis lymphadenitis (TBLN) is a growing public health concern in Ethiopia. Limited information is available on gene mutations conferring drug resistance in M. tuberculosis isolates from TBLN patients. Drug resistance mutations were detected in 2.2% and 6.6% of isolates for rifampicin (RIF) and isoniazid (INH) respectively. Dominant spoligotyping patterns were observed in 43% of strains and resistant isolates were found among clustered strains, suggesting potential transmission of resistant strains in the community.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Biotechnology & Applied Microbiology
Pejman Bakhtiyariniya, Azar Dokht Khosravi, Mohammad Hashemzadeh, Mohammad Savari
Summary: This study investigated the genetic diversity of MTB isolates resistant to first-line anti-tuberculosis drugs using 24-locus MIRU-VNTR in southwestern Iran. The results showed a high degree of genetic diversity among drug-resistant MTB isolates, with the recommendation of using 15-locus MIRU-VNTR for preliminary genotyping.
Article
Pharmacology & Pharmacy
Aqeela Iqbal, Muhammad Ashraf, Ahsan Waheed Rathore, Muhammad Ovais Omer, Aftab Ahmad Anjum, Saiqa Ishtiaq, Rana Adnan Ali, Usman Arshad, Muhammad Zaman
Summary: The present study investigated the distribution of tuberculosis in children and evaluated the antimycobacterial sensitivity pattern of Mycobacterium tuberculosis isolates from pediatric patients. The study found that children aged 11 to 15 years were more prone to MTB, while the lowest percentage of multidrug-resistant isolates was recorded in the age group of birth to 12 months.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Microbiology
Seong Eun Kim, Su-Mi Choi, Yohan Yu, Sung Un Shin, Tae Hoon Oh, Seung-Ji Kang, Kyung-Hwa Park, Jong Hee Shin, Uh Jin Kim, Sook In Jung
Summary: The clonal dissemination of carbapenem-resistant Acinetobacter baumannii (CRAB) bacteremia is a serious problem in hospitals, and the factors related to the emergence and replacement of predominant CRAB clones are unclear. This study used multilocus sequence typing to evaluate the genetic relatedness of CRAB bloodstream isolates and investigated their clinical and microbiologic characteristics. The results showed that ST369 clone replaced the ST191 clone as the predominant type, and it had faster growth rate and higher virulence.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Carmen A. Molina-Torres, Frederick D. Quinn, Jorge Castro-Garza, Anaximandro Gomez-Velasco, Jorge Ocampo-Candiani, Alied Bencomo-Alerm, Hector Javier Sanchez-Perez, Sergio Munoz-Jimenez, Adrian Rendon, Afzal Ansari, Mukul Sharma, Pushpendra Singh, Lucio Vera-Cabrera
Summary: This study reports the genetic diversity of Mycobacterium tuberculosis complex isolates in a Mexican-Amerindian setting, showing the dominance of sub-lineage 4.8 in Mexico and sub-lineage 4.3.3 in Central and South America. The findings highlight the importance of sub-lineage characterization for understanding the distribution and transmission of tuberculosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Remya Nambiar, Jeffrey Tornheim, Margo Diricks, Katrien De Bruyne, Meeta Sadani, Anjali Shetty, Camilla Rodrigues
Summary: This study aimed to assess Linezolid resistance in Mycobacterium tuberculosis isolates in a tertiary care center in Mumbai, India. The results revealed that mutations in the rplC gene and the rrl gene were major determinants of Linezolid resistance.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Sanghee Park, Jihee Jung, Jiyeon Kim, Sang Bong Han, Sungweon Ryoo
Summary: This study aimed to investigate the resistance and genetic mutations of drug-resistant Mycobacterium tuberculosis (DR-Mtb) isolates to clofazimine (CFZ), in order to improve the diagnosis and treatment of drug-resistant tuberculosis (TB) patients. The results showed that the rate of CFZ resistance in drug-resistant Mtb isolates was 4.1%, and it was not related to treatment with CFZ or bedaquiline. Four novel mutation sites related to CFZ resistance were identified in this study.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
S. M. Mazidur Rahman, Arfatur Rahman, Rumana Nasrin, Md Fahim Ather, Sara Sabrina Ferdous, Shahriar Ahmed, Mohammad Khaja Mafij Uddin, Razia Khatun, Mohammad Shahnewaz Sarker, Asif Mujtaba Mahmud, Md Mojibur Rahman, Sayera Banu
Summary: This study characterized the MDR tuberculosis isolates circulating in Bangladesh and investigated their mode of transmission. The majority of the MDR M. tuberculosis isolates were of the modern virulent type, with the Beijing and T lineages being the predominant types and implicated in the majority of MDR-TB transmission. The findings suggest that the emergence of MDR-TB in Bangladesh is largely due to acquired resistance, emphasizing the importance of rapid diagnosis and adherence to appropriate treatment.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
H. M. Adnan Hameed, Cuiting Fang, Zhiyong Liu, Yanan Ju, Xingli Han, Yamin Gao, Shuai Wang, Gift Chiwala, Yaoju Tan, Ping Guan, Jinxing Hu, Xiaoli Xiong, Jiacong Peng, Yongping Lin, Muzammal Hussain, Nanshan Zhong, Dmitry A. Maslov, Gregory M. Cook, Jianxiong Liu, Tianyu Zhang
Summary: This study investigated the prevalence of mutations in the rpoB gene of Mycobacterium tuberculosis clinical isolates and their association with rifampicin resistance. The results showed that mutations in the gene were common in rifampicin-resistant strains, with some mutations occurring in the RRDR region and others occurring outside the RRDR. GeneXpert MTB/RIF and sequencing analysis were effective in the rapid molecular diagnosis of rifampicin resistance. These findings are important for the early detection of tuberculosis and the recommendation of appropriate treatment regimens.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Microbiology
Afsatou Ndama Traore, Mpumelelo Casper Rikhotso, Marry Avheani Mphaphuli, Sana Mustakahmed Patel, Hafsa Ali Mahamud, Leonard Owino Kachienga, Jean-Pierre Kabue, Natasha Potgieter
Summary: This review and meta-analysis investigated the prevalence and molecular insights into isoniazid (INH) and rifampicin (RIF) resistance-conferring mutations in Mycobacterium tuberculosis isolates from South Africa. High prevalence of specific mutations, including S450L in rpoB and S315T, linked to resistance against RIF and INH respectively, were found. These findings contribute to understanding drug resistance mechanisms and provide valuable insights for targeted interventions against drug-resistant TB.
Article
Infectious Diseases
Dana Auganova, Sabina Atavliyeva, Asylulan Amirgazin, Akmaral Akisheva, Anna Tsepke, Pavel Tarlykov
Summary: In this study, whole-genome sequencing was used to examine drug resistance, compensatory mutations, population structure, and transmission patterns in clinical isolates of L2/Beijing Mtb collected in Kazakhstan. The study found that the genotypic prediction of Mtb susceptibility to anti-TB agents was consistent with the phenotypic susceptibility, except for bedaquiline. Most of the isolates were characterized as pre-extensively drug-resistant tuberculosis (pre-XDR-TB), and the high prevalence of the Central Asia outbreak (CAO) clade in the population structure of Mtb may explain the rapid spread of MDR-TB in Kazakhstan.
Article
Microbiology
You-Ming Mei, Wen-Yue Zhang, Ji-Ya Sun, Hai-Qin Jiang, Ying Shi, Jing-Shu Xiong, Le Wang, Yan-Qing Chen, Si-Yu Long, Chun Pan, Tao Luo, Hong-Sheng Wang
Summary: This study investigated the pathogens associated with the occurrence and different types of cutaneous tuberculosis through the analysis of genomic characteristics of 58 Mycobacterium tuberculosis strains isolated over the last 20 years. The findings revealed that cutaneous tuberculosis and pulmonary tuberculosis shared similar genotypes and genomic composition. The drug-resistance rate was lower in cutaneous tuberculosis strains, and several SNPs in metabolism-related genes showed a strong correlation with different infection sites. Thus, while large genomic changes in M. tuberculosis isolates may not significantly affect the different infection sites of TB, the significant difference in SNPs of drug resistance genes and metabolism-related genes should be given more attention.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Lih-Ying Leong, Po-Chang Lin, Chih-Yu Chi, Chia-Huei Chou, Min-Chi Lu, Wei-Chih Liao, Mao-Wang Ho, Jen-Hsien Wang, Long-Bin Jeng
Summary: TB incidence is high in LT recipients, with long-term immunosuppression, abnormal pre-transplant imaging findings, and exposure to mTOR inhibitors potentially being risk factors for TB.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Editorial Material
Critical Care Medicine
Christoph Lange, Clifton E. Barry, C. Robert Horsburgh
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Biology
Kira S. Makarova, Brittney Blackburne, Yuri Wolf, Anastasia Nikolskaya, Svetlana Karamycheva, Marlene Espinoza, Clifton E. Barry, Carole A. Bewley, Eugene Koonin
Summary: This study comprehensively analyzed BGCs encoding graspetides and reported several novel graspetide groups and associated proteins involved in their biosynthesis and expression. The results revealed previously unsuspected diversity in graspetide sequences and expanded the known diversity of RiPPs. The findings of this study are important for advancing approaches to identify RiPPs.
Article
Cardiac & Cardiovascular Systems
Ludovic Meunier, Matthieu Godin, Geraud Souteyrand, Benoit Mottin, Yann Valy, Vincent Lordet, Christian Benoit, Ronan Bakdi, Virginie Laurencon, Philippe Genereux, Matthias Waliszewski, Caroline Allix-Beguec
Summary: We evaluated a decision algorithm for percutaneous coronary interventions (PCI) based on a no-stent strategy and found it to be effective and safe. The combination of scoring balloon angioplasty (SCBA) and drug-coated balloon (DCB) was the preferred approach. The incidence of major adverse cardiac events (MACE) was low during the one-year follow-up period.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Correction
Cardiac & Cardiovascular Systems
Ludovic Meunier, Matthieu Godin, Geraud Souteyrand, Benoit Mottin, Yann Valy, Vincent Lordet, Christian Benoit, Ronan Bakdi, Virginie Laurencon, Philippe Genereux, Matthias Waliszewski, Caroline Allix-Beguec
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
[Anonymous]
Summary: This study presents a comprehensive resistance prediction for tuberculosis using a large dataset of Mycobacterium tuberculosis isolates. The data includes whole-genome sequencing and minimum inhibitory concentrations to 13 antitubercular drugs. The dataset provides valuable information on the genotypic and phenotypic characteristics of drug resistance, and has the potential to advance our understanding of rare resistance phenotypes. The open-source nature of the data compendium encourages future research in the field.
Article
Biochemistry & Molecular Biology
Camilla Rodrigues, David Moore, Derrick W. Crook, Daniela M. Cirillo, Philip W. Fowler, Zamin Iqbal, Nazir A. Ismail, Nerges Mistry, Stefan Niemann, Tim E. A. Peto, Guy Thwaites, A. Sarah Walker, Timothy MWalker, Daniel J. Wilson, Sarah G. Earle, Daniel J. Wilson, Clara Grazian, A. Sarah Walker, Martin Hunt, Jeff Knaggs, Zamin Iqbal
Summary: The emergence of drug-resistant tuberculosis is a global health concern. Whole-genome sequencing can uncover new resistance mechanisms. This study identified uncatalogued variants associated with minimum inhibitory concentration and improved our knowledge of antimicrobial resistance in M. tuberculosis.
Article
Infectious Diseases
Sofie Marijke Braet, Agathe Jouet, Alexandra Aubry, Magalie Van Dyck-Lippens, Esteban Lenoir, Younoussa Assoumani, Abdallah Baco, Aboubacar Mzembaba, Emmanuelle Cambau, Sidra Ezidio Goncalves Vasconcellos, Leen Rigouts, Philip Noel Suffys, Epco Hasker, Philip Supply, Bouke Catherine de Jong
Summary: This study aimed to investigate drug resistance among leprosy patients in the Comoros and examine whether post-exposure prophylaxis led to the emergence of drug-resistant strains.
Editorial Material
Infectious Diseases
Annelies Van Rie, Timothy Walker, Bouke de Jong, Praharshinie Rupasinghe, Emmanuel Riviere, Veronique Dartois, Lindsay Sonnenkalb, Diana Machado, Sebastien Gagneux, Philip Supply, Viola Dreyer, Stefan Niemann, Galo Goig, Conor Meehan, Elisa Tagliani, Daniela Maria Cirillo
LANCET INFECTIOUS DISEASES
(2022)
Article
Health Care Sciences & Services
Isdore Chola Shamputa, Alison Luke, Clara Kelly, Loretta Waycott, Christy Bishop, John Doucet, Meagan Hatfield, Diana Dupont, Betty Lydon, Tammie Fournier, Marc Nicholson, Shelley Doucet
Summary: Interprofessional education (IPE) allows students in health professional programs to practice collaborative patient care before graduating. Understanding the perceptions and experiences of health care professionals' IPE received prior to entering the workforce is crucial for improving IPE programs.
JOURNAL OF INTERPROFESSIONAL CARE
(2023)
Article
Multidisciplinary Sciences
Isdore Chola Shamputa, Duyen Thi Kim Nguyen, Doaa Higazy, Amani Abdelhadi, Hope MacKenzie, Michelle Reddin, Kimberley Barker, Duncan Webster
Summary: The objective of this study is to improve LTBI screening among immigrants from high tuberculosis incidence countries and introduce a pilot program for LTBI screening. The study aims to identify individuals with LTBI using QuantiFERON-TB Gold Plus assay, offer treatment and support, and assess satisfaction among immigrants and healthcare providers. The findings will provide insights into the feasibility and acceptability of LTBI screening and inform the expansion of the program.
Article
Health Care Sciences & Services
Caroline Gibbons, Isdore Chola Shamputa, Michelle Le, Rose McCloskey
Summary: This study describes the strategies used in Canadian nursing programs to prepare students for the NCLEX-RN. Most programs use one to three strategies, including purchasing commercial products, administering computer-based exams, offering preparation courses or workshops, and dedicating time in courses for NCLEX-RN preparation. There is variation among programs in the level of effort invested in preparation activities.
Review
Health Care Sciences & Services
Borum Yang, Clara Kelly, Isdore Chola Shamputa, Kimberley Barker, Duyen Thi Kim Nguyen
Summary: Despite evidence of racial and institutional discrimination and its impact on health, there are still gaps in understanding health disparities among minoritized communities. This review focuses on identifying health barriers faced by less studied migrant subgroups, such as temporary foreign workers and refugees in high-income OECD countries, and explores the structural origins of differential health outcomes. The review analyzed 27 articles and identified housing conditions, immigration policies, structural discrimination, and exploitative labor practices as key factors influencing the health and access to healthcare services of these populations. The findings emphasize the importance of considering the broader context in understanding health inequities among migrant populations.
Article
Infectious Diseases
Lindsay Sonnenkalb, Joshua James Carter, Andrea Spitaleri, Zamin Iqbal, Martin Hunt, Kerri Marie Malone, Christian Utpatel, Daniela Maria Cirillo, Camilla Rodrigues, Kayzad Soli Nilgiriwala, Philip William Fowler, Matthias Merker, Stefan Niemann
Summary: This study identified genetic variations that confer resistance to bedaquiline and clofazimine, and established a mutation catalogue using experimental evolution, protein modelling, genome sequencing, and phenotypic data analysis. The findings advance the understanding of drug resistance mechanisms in Mycobacterium tuberculosis complex strains and provide important genetic testing evidence for the design of effective treatments.
Article
Cardiac & Cardiovascular Systems
Antoine Milhem, Caroline Allix-Beguec, Virginie Laurencon, Frederic Treguer, Olivier Cesari
Summary: Analyzing changes in the pressure curve can monitor the adhesion between the cryoballoon and the pulmonary vein, which is a simple and efficient method to detect balloon movement during the early stages of treatment.
JOURNAL OF ARRHYTHMIA
(2023)
Article
Immunology
Florence Hoefler, Xavier Pouget-Abadie, Mariam Roncato-Saberan, Romain Lemarie, Eve-Marie Takoudju, Francois Raffi, Stephane Corvec, Morgane Le Bras, Charles Cazanave, Philippe Lehours, Thomas Guimard, Caroline Allix-Beguec
Summary: Noncholera vibriosis is a rare bacterial infection caused by Vibrio spp. other than V. cholerae O1/O139, which mainly occurs in patients after seaside activities during the hot summer months. Understanding the circulating pathogenic strains and variabilities in infection outcomes and disease dynamics can aid in patient management.
EMERGING INFECTIOUS DISEASES
(2022)