Article
Biochemistry & Molecular Biology
Maria S. S. Hadjiagapiou, George Krashias, Elie Deeba, Christina Christodoulou, Marios Pantzaris, Anastasia Lambrianides
Summary: Antibodies against coagulation components contribute to thrombotic and inflammatory signaling pathways in diseases similar to multiple sclerosis. A preclinical study examined the effects of IgG antibodies from MS patients on astrocytic activation and found an upregulation of pro-inflammatory factors. However, serum samples from patients and controls did not show significant differences, possibly due to medication.
Article
Biochemistry & Molecular Biology
Lilya U. Dzhemileva, Regina A. Tuktarova, Usein M. Dzhemilev, Vladimir A. D'yakonov
Summary: The paper describes the complete stereoselective synthesis of four natural acetogenins, chatenaytrienins-1, -2, -3, and -4, and their biological activity. The authors developed novel organometallic reactions for the synthesis using Ti-catalyzed cross-cyclomagnesiation. The synthesized chatenaytrienins were found to affect mitochondria and induce apoptosis.
Article
Genetics & Heredity
Kiely N. James, Shimul Chowdhury, Yan Ding, Sergey Batalov, Kelly Watkins, Yong Hyun Kwon, Lucitia Van Der Kraan, Katarzyna Ellsworth, Stephen F. Kingsmore, Lucia Guidugli
Summary: This study used genome sequencing to detect a wide range of copy-number variants (CNVs) and other non-single nucleotide variant/indel variant types. These genetic alterations accounted for 15.8% of reported variants, with deletions being the most common type. The study also found that additional genetic tests were ordered in some cases, but failed to report the variants detected by genome sequencing.
GENETICS IN MEDICINE
(2024)
Article
Immunology
Laila A. A. Damiati, Iuliana Denetiu, Sami Bahlas, Samar Damiati, Peter Natesan Pushparaj
Summary: This study aimed to understand the role of different cytokines, chemokines, and growth factors in the pathogenicity of SLE by determining their concentrations in human plasma using xMAP technology. Higher levels of various cytokines were detected in SLE patients compared to osteoarthritis patients and healthy individuals. The use of xMAP analysis helps to study the differential regulation of clinical heterogeneity and immunological phenotypes in SLE patients, providing valuable information for personalized treatment development.
Review
Microbiology
Simon D. P. Baugh
Summary: This review focuses on antifungal agents containing guanidine groups, which have been shown in the literature to be effective in treating human-related fungal pathogens.
Article
Microbiology
Fergus Watson, C. William Keevil, John Chewins, Sandra A. Wilks
Summary: This study developed a novel culture medium, artificial human sweat (AHS), to mimic the biofilm formation on dry hospital surfaces. The AHS model showed similar characteristics to clinical biofilms and can be used for efficacy testing of cleaning products against dry surface biofilms. Accurate modeling of dry surface biofilms is crucial for understanding their role in hospital-acquired infections and surface contamination.
MICROBIOLOGY SPECTRUM
(2022)
Article
Multidisciplinary Sciences
Nicola Cosgrove, Damir Vareslija, Stephen Keelan, Ashuvinee Elangovan, Jennifer M. Atkinson, Sinead Cocchiglia, Fiona T. Bane, Vikrant Singh, Simon Furney, Chunling Hu, Jodi M. Carter, Steven N. Hart, Siddhartha Yadav, Matthew P. Goetz, Arnold D. K. Hill, Steffi Oesterreich, Adrian Lee, Fergus J. Couch, Leonie S. Young
Summary: The authors conducted a comprehensive study on the molecular landscape of breast cancer brain metastases, focusing on different breast cancer subtypes. They identified homologous recombination deficiency as a significant therapeutic vulnerability. The study revealed distinct transcriptional programs enriched in brain metastases and identified important hub genes and functional processes associated with the disease.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Christopher E. Lietz, Erik T. Newman, Andrew D. Kelly, David H. Xiang, Ziying Zhang, Caroline A. Luscko, Santiago A. Lozano-Calderon, David H. Ebb, Kevin A. Raskin, Gregory M. Cote, Edwin Choy, G. Petur Nielsen, Benjamin Haibe-Kains, Martin J. Aryee, Dimitrios Spentzos
Summary: The study found that genomic hypomethylation in patients with primary osteosarcoma is predictive of response to standard chemotherapy. Recurrence and survival were also associated with genomic methylation patterns. These findings provide insights into potential alternative therapies for osteosarcoma patients.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maurice Steenhuis, Gregory M. Koningstein, Julia Oswald, Tillman Pick, Sarah O'Keefe, Hans-Georg Koch, Adolfo Cavalie, Roger C. Whitehead, Eileithyia Swanton, Stephen High, Joen Luirink
Summary: ES24 is an inhibitor that affects bacterial protein secretion and insertion by targeting the SecYEG translocon. This compound has a complex mode of action, potentially involving multiple targets, and exhibits antibacterial activity which requires activation by nitroreductases.
MOLECULAR MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Dorota Chrobak-Chmiel, Ewelina Kwiecien, Anna Golke, Beata Dolka, Krzysztof Adamczyk, Malgorzata J. Bieganska, Marina Spinu, Marian Binek, Magdalena Rzewuska
Summary: The study reveals that pigeons can carry multidrug-resistant pathogens, including antibiotic-resistant Staphylococcus aureus, Escherichia coli, and Candida albicans. Further data is needed to understand how pigeons acquire highly resistant strains.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Infectious Diseases
Felix L. Santana, Karel Estrada, Morgan A. Alford, Bing C. Wu, Melanie Dostert, Lucas Pedraz, Noushin Akhoundsadegh, Pavneet Kalsi, Evan F. Haney, Suzana K. Straus, Gerardo Corzo, Robert E. W. Hancock
Summary: Host defense peptides (HDPs) are an alternative approach to combat antibiotic resistance. Crocodylians have a robust immune system and researchers have discovered novel cathelicidin sequences with broad-spectrum antimicrobial and antibiofilm activities. Among them, As-CATH8 exhibited similar activity profiles to last-resort antibiotics, killed planktonic and biofilm cells, caused cell membrane depolarization and binding to DNA. As-CATH8 also showed superior antibiofilm activity against methicillin-resistant Staphylococcus aureus (MRSA) compared to human cathelicidin LL-37. Moreover, As-CATH8 demonstrated strong antibacterial effects against clinical isolates of S. aureus and Acinetobacter baumannii in a murine abscess model. This study expands the understanding of cathelicidin peptides in crocodylians and highlights the therapeutic potential of As-CATH8 for common skin infections.
Article
Multidisciplinary Sciences
A. L. Padilla-Cruz, J. A. Garza-Cervantes, X. G. Vasto-Anzaldo, Gerardo Garcia-Rivas, A. Leon-Buitimea, J. R. Morones-Ramirez
Summary: This study explores the synthesis of Ag-Fe bimetallic nanoparticles using a green chemistry approach and demonstrates their antimicrobial properties against clinically relevant multi-drug-resistant microbial strains through a synergistic effect between the two metals. The bimetallic nanoparticles show promise for developing more efficient combinatorial antimicrobials with potential applications in both industrial processes and the treatment of infections caused by drug-resistant strains.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Guillermo Reboledo, Astrid Agorio, Lucia Vignale, Alfonso Alvarez, Ines Ponce De Leon
Summary: This study reveals the presence of a pathogen-inducible ERF gene family PpERF24 in moss plants, which is absent in liverworts, ferns, and angiosperms. PpERF24 enhances plant defenses against fungal pathogens by regulating the expression of defense genes involved in transcriptional regulation, phenylpropanoid and jasmonate pathways, oxidative burst, and pathogenesis-related genes. These findings provide novel insights into the defense mechanisms of moss plants.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Engineering, Biomedical
Connor W. Barth, Vidhi M. Shah, Lei G. Wang, Anas M. Masillati, Adel Al-Fatease, Syed Zaki Husain Rizvi, Alexander L. Antaris, Jonathan Sorger, Deepa A. Rao, Adam W. G. Alani, Summer L. Gibbs
Summary: Fluorescence guided surgery (FGS) enables improved nerve sparing by visualizing nerve tissue directly, but the clinical translation of related probes still faces regulatory challenges. This study developed a gel-based formulation for direct administration of nerve-specific probes, facilitating the clinical translation of nerve sparing FGS.
Article
Oncology
Whijae Roh, Yifat Geffen, Hongui Cha, Mendy Miller, Shankara Anand, Jaegil Kim, David Heiman, Justin F. Gainor, Peter W. Laird, Andrew D. Cherniack, Chan-Young Ock, Se-Hoon Lee, Gad Getz
Summary: Through consensus hierarchical clustering analysis, we identified five robust expression subtypes of lung adenocarcinoma. Integrating genomic and proteomic data, we defined biomarkers of response to targeted therapies and immunotherapies. These subtypes and biomarkers could help identify patients likely to respond to CDK4/6, MET, or PD-L1 inhibitors.
Article
Oncology
Karoline V. Gleixner, Irina Sadovnik, Mathias Schneeweiss, Gregor Eisenwort, Konstantin Byrgazov, Gabriele Stefanzl, Daniela Berger, Harald Herrmann, Emir Hadzijusufovic, Thomas Lion, Peter Valent
Article
Oncology
H. Pfeifer, G. Cazzaniga, V. H. J. van der Velden, J. M. Cayuele, B. Schafer, O. Spinelli, S. Akiki, S. Avigad, I Bendit, K. Borg, H. Cave, L. Elia, S. C. Reshmi, G. Gerrard, S. Hayette, M. Hermanson, A. Juh, T. Jurcek, M. C. Chillon, C. Homburg, G. Martinelli, V Kairisto, T. Langen, T. Lion, M. C. Mueller, F. Pane, L. Rai, C. Damm-Welk, T. Sacha, S. Schnittger, T. Touloumenidou, H. Valerhaugen, P. Vandenberghe, J. Zuna, H. Server, E. Herrmann, S. Markovic, J. J. M. van Dongen, O. G. Ottmann
Article
Microbiology
Karin Kosulin, Herbert Pichler, Anita Lawitschka, Rene Geyeregger, Thomas Lion
FRONTIERS IN MICROBIOLOGY
(2019)
Review
Hematology
Peter Valent, Attilio Orazi, Michael R. Savona, Mrinal M. Patnaik, Francesco Onida, Arjan A. van de Loosdrecht, Detlef Haase, Torsten Haferlach, Chiara Elena, Lisa Pleyer, Wolfgang Kern, Tea Pemovska, Gregory Vladimer, Julie Schanz, Alexandra Keller, Michael Luebbert, Thomas Lion, Karl Sotlar, Andreas Reiter, Theo De Witte, Michael Pfeilstoecker, Klaus Geissler, Eric Padron, Michael Deininger, Alberto Orfao, Hans-Peter Horny, Peter L. Greenberg, Daniel A. Arber, Luca Malcovati, John M. Bennett
Review
Oncology
Simona Soverini, Renato Bassan, Thomas Lion
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2019)
Letter
Oncology
Michele Baccarani, Ilaria Iacobucci, Sabina Chiaretti, Robin Foa', Poonkuzhali Balasubramanian, Elisabeth Paietta, Letizia Foroni, Sabine Jeromin, Barbara Izzo, Orietta Spinelli, Neelam Varma, Samia Menif, Carolina Terragna, Tulika Seth, Audrey Bidet, Daniel Coriu, Francesca Lunghi, Jiri Mayer, Barbara Scappini, Stephen Langabeer, Jacqueline Maier, Emma Burt, Anna Candoni, Francesco Albano, Mario Luppi, Irena Zupan, Thomas Lion, Renata Zadro, Francesco di Raimondo, Behzad Poopak, Giovanna Rege-Cambrin, Mario Annunziata, Ana Ayala, Victor Salinas-Viedma, Ana Ines Pado, Benedict Milner, Sara Galimberti, Jeroen Janssen, Valentina Polli, Lorenzo Comba, Beatrice Borsellino, Ombretta Annibali, Monica Crugnola, Francesco Passamonti
Review
Microbiology
Filomena Nogueira, Shirin Sharghi, Karl Kuchler, Thomas Lion
Article
Hematology
Michaela Fortschegger, Sandra Preuner, Dieter Printz, Anna R. Poetsch, Rene Geyeregger, Herbert Pichler, Anita Lawitschka, Thomas Lion
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2020)
Correction
Oncology
H. Pfeifer, G. Cazzaniga, V. H. J. van der Velden, J. M. Cayuela, B. Schafer, O. Spinelli, S. Akiki, S. Avigad, I. Bendit, K. Borg, H. Cave, L. Elia, S. C. Reshmi, G. Gerrard, S. Hayette, M. Hermanson, A. Juh, T. Jurcek, M. C. Chillon, C. Homburg, G. Martinelli, V. Kairisto, T. Lange, T. Lion, M. C. Mueller, F. Pane, L. Rai, C. Damm-Welk, T. Sacha, S. Schnittger, T. Touloumenidou, H. Valerhaugen, P. Vandenberghe, J. Zuna, H. Serve, E. Herrmann, S. Markovic, J. J. M. van Dongen, O. G. Ottmann
Article
Medicine, General & Internal
Mathias Schneeweiss-Gleixner, Konstantin Byrgazov, Gabriele Stefanzl, Daniela Berger, Gregor Eisenwort, Chantal Blanche Lucini, Susanne Herndlhofer, Sandra Preuner, Klara Obrova, Petra Pusic, Nadine Witzeneder, Georg Greiner, Gregor Hoermann, Wolfgang R. Sperr, Thomas Lion, Michael Deininger, Peter Valent, Karoline V. Gleixnera
Article
Allergy
Markus Debiasi, Herbert Pichler, Florian Klinglmuller, Heidrun Boztug, Klara Schmidthaler, Jonas Rech, David Scherer, Christian Lupinek, Rudolf Valenta, Ewa Kacinska-Pfaller, Rene Geyeregger, Gerhard Fritsch, Oskar A. Haas, Christina Peters, Thomas Lion, Mubeccel Akdis, Susanne Matthes, Cezmi A. Akdis, Zsolt Szepfalusi, Thomas Eiwegger
Article
Oncology
Tariq I. Mughal, Naveen Pemmaraju, Bethan Psaila, Jerald Radich, Prithviraj Bose, Thomas Lion, Jean-Jacques Kiladjian, Raajit Rampal, Tania Jain, Srdnan Verstovsek, Abdulraheem Yacoub, Jorge E. Cortes, Ruben Mesa, Giuseppe Saglio, Richard A. van Etten
HEMATOLOGICAL ONCOLOGY
(2020)
Article
Oncology
Sonja Heibl, Veronika Buxhofer-Ausch, Stefan Schmidt, Gerald Webersinke, Thomas Lion, Gudrun Piringer, Thomas Kuehr, Dominik Wolf, Thomas Melchardt, Richard Greil, Josef Thaler
HEMATOLOGICAL ONCOLOGY
(2020)
Article
Oncology
Johannes B. Jaeger, Thomas Jaeger, Sandra Preuner, Petra Pusic, Isabella Sponseiler, Thomas Lion, Thomas Winder, Bernd Lorenz Hartmann
Summary: This case study presents a 68-year-old woman with resistance to second- and third-generation TKI therapy due to BCR-ABL1(T315I) and BCR-ABL1(E255V) mutations. An individualized treatment approach using the third-generation TKI ponatinib in combination with palbociclib showed strong antineoplastic effects in this patient resistant to ponatinib monotherapy. Further characterization of the biological activity of this combination treatment is needed in prospective clinical trials.
MEMO-MAGAZINE OF EUROPEAN MEDICAL ONCOLOGY
(2021)
Letter
Hematology
Isabella Sponseiler, Anna-Maria Bandian, Petra Pusic, Thomas Lion
AMERICAN JOURNAL OF HEMATOLOGY
(2023)