Cannabinoids in Neurodegenerative Disorders and Stroke/Brain Trauma: From Preclinical Models to Clinical Applications
出版年份 2015 全文链接
标题
Cannabinoids in Neurodegenerative Disorders and Stroke/Brain Trauma: From Preclinical Models to Clinical Applications
作者
关键词
Cannabinoids, Endocannabinoid signaling system, CB<sub>1</sub> and CB<sub>2</sub> receptors, FAAH and MAGL enzymes, Neurodegenerative disorders, Neuroprotection
出版物
Neurotherapeutics
Volume 12, Issue 4, Pages 793-806
出版商
Springer Nature
发表日期
2015-08-11
DOI
10.1007/s13311-015-0381-7
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Biomarkers of Alzheimer's disease and mild cognitive impairment: A current perspective
- (2015) Piotr Lewczuk et al. Advances in Medical Sciences
- Endocannabinoids modulate human blood-brain barrier permeabilityin vitro
- (2015) William H Hind et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cannabinoids in Experimental Stroke: A Systematic Review and Meta-Analysis
- (2015) Timothy J England et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Changes in the endocannabinoid signaling system in CNS structures of TDP-43 transgenic mice: relevance for a neuroprotective therapy in TDP-43-related disorders
- (2015) Francisco Espejo-Porras et al. Journal of Neuroimmune Pharmacology
- Endocannabinoids regulate the activity of astrocytic hemichannels and the microglial response against an injury: In vivo studies
- (2015) Carmen Vázquez et al. NEUROBIOLOGY OF DISEASE
- Identification of CB2 receptors in human nigral neurons that degenerate in Parkinson’s disease
- (2015) María Concepción García et al. NEUROSCIENCE LETTERS
- Update on Huntington's disease: Advances in care and emerging therapeutic options
- (2015) Daniel Zielonka et al. PARKINSONISM & RELATED DISORDERS
- Neuroprotection for ischaemic stroke: Current status and challenges
- (2015) Antonio Moretti et al. PHARMACOLOGY & THERAPEUTICS
- Inflammation and Neuroprotection in Traumatic Brain Injury
- (2015) Kara N. Corps et al. JAMA Neurology
- Ageing and Parkinson's disease: Why is advancing age the biggest risk factor?
- (2014) Amy Reeve et al. AGEING RESEARCH REVIEWS
- Changes in Endocannabinoid Receptors and Enzymes in the Spinal Cord of SOD1G93ATransgenic Mice and Evaluation of a Sativex®-like Combination of Phytocannabinoids: Interest for Future Therapies in Amyotrophic Lateral Sclerosis
- (2014) Miguel Moreno-Martet et al. CNS Neuroscience & Therapeutics
- Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders
- (2014) Orrin Devinsky et al. EPILEPSIA
- Long-Term Effectiveness and Safety of Nabiximols (Tetrahydrocannabinol/Cannabidiol Oromucosal Spray) in Clinical Practice
- (2014) Peter Flachenecker et al. EUROPEAN NEUROLOGY
- Investigational drugs in Alzheimer's disease: current progress
- (2014) Camryn Berk et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Cannabinoid receptor CB2 is expressed on vascular cells, but not astroglial cells in the post-mortem human Huntington's disease brain
- (2014) Megan J. Dowie et al. JOURNAL OF CHEMICAL NEUROANATOMY
- Chorea associated with Huntington's disease: To treat or not to treat?
- (2014) Joseph Jankovic et al. MOVEMENT DISORDERS
- Clinical trials in Huntington's disease: Interventions in early clinical development and newer methodological approaches
- (2014) Cristina Sampaio et al. MOVEMENT DISORDERS
- The ongoing pursuit of neuroprotective therapies in Parkinson disease
- (2014) Dilan Athauda et al. Nature Reviews Neurology
- The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury
- (2014) Flaubert Tchantchou et al. NEUROPHARMACOLOGY
- Neuroprotective Properties of Cannabigerol in Huntington’s Disease: Studies in R6/2 Mice and 3-Nitropropionate-lesioned Mice
- (2014) Sara Valdeolivas et al. Neurotherapeutics
- A restricted population of CB1 cannabinoid receptors with neuroprotective activity
- (2014) A. Chiarlone et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cerebroprotective effects of TAK-937, a novel cannabinoid receptor agonist, in permanent and thrombotic focal cerebral ischemia in rats: Therapeutic time window, combination with t-PA and efficacy in aged rats
- (2013) Koji Murakami et al. BRAIN RESEARCH
- Δ9-THC-Caused Synaptic and Memory Impairments Are Mediated through COX-2 Signaling
- (2013) Rongqing Chen et al. CELL
- N-arachidonoyl-L-serine (AraS) Possesses Proneurogenic Properties in Vitro and in Vivo after Traumatic Brain Injury
- (2013) Ayelet Cohen-Yeshurun et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- The epidemiology of ALS: a conspiracy of genes, environment and time
- (2013) Ammar Al-Chalabi et al. Nature Reviews Neurology
- Mechanisms of cannabidiol neuroprotection in hypoxic–ischemic newborn pigs: Role of 5HT1A and CB2 receptors
- (2013) M. Ruth Pazos et al. NEUROPHARMACOLOGY
- Cannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5YAPP+Cells Through PPARγ Involvement
- (2013) Caterina Scuderi et al. PHYTOTHERAPY RESEARCH
- Understanding cognitive deficits in Alzheimer's disease based on neuroimaging findings
- (2013) Meredith N. Braskie et al. TRENDS IN COGNITIVE SCIENCES
- Current insights into the C9orf72 repeat expansion diseases of the FTLD/ALS spectrum
- (2013) Marc Cruts et al. TRENDS IN NEUROSCIENCES
- Parkinson's Disease and Parkinsonism: Neuropathology
- (2013) D. W. Dickson Cold Spring Harbor Perspectives in Medicine
- Sativex-like Combination of Phytocannabinoids is Neuroprotective in Malonate-Lesioned Rats, an Inflammatory Model of Huntington’s Disease: Role of CB1 and CB2 Receptors
- (2012) Sara Valdeolivas et al. ACS Chemical Neuroscience
- WIN55, 212-2 promotes differentiation of oligodendrocyte precursor cells and improve remyelination through regulation of the phosphorylation level of the ERK 1/2 via cannabinoid receptor 1 after stroke-induced demyelination
- (2012) Jing Sun et al. BRAIN RESEARCH
- β−Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB1 or CB2 receptors
- (2012) Cristina Benito et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cannabinoids and Parkinsons Disease
- (2012) Moises Garcia-Arencibia et al. CNS & Neurological Disorders-Drug Targets
- Motor and Non-Motor Features of Parkinson’s Disease – A Review of Clinical and Experimental Studies
- (2012) Marcelo M.S. Lima et al. CNS & Neurological Disorders-Drug Targets
- Small-animal PET imaging of the type 1 and type 2 cannabinoid receptors in a photothrombotic stroke model
- (2012) Caroline Vandeputte et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- The therapeutic potential of the endocannabinoid system for Alzheimer's disease
- (2012) Tim Karl et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Prolonged oral cannabinoid administration prevents neuroinflammation, lowers β-amyloid levels and improves cognitive performance in Tg APP 2576 mice
- (2012) Ana María Martín-Moreno et al. Journal of Neuroinflammation
- Cannabinoid Receptor 2 Signaling in Peripheral Immune Cells Modulates Disease Onset and Severity in Mouse Models of Huntington's Disease
- (2012) J. Bouchard et al. JOURNAL OF NEUROSCIENCE
- A cannabinoid type 2 receptor agonist attenuates blood-brain barrier damage and neurodegeneration in a murine model of traumatic brain injury
- (2012) Peter S. Amenta et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Selective Inhibition of Alpha/Beta-Hydrolase Domain 6 Attenuates Neurodegeneration, Alleviates Blood Brain Barrier Breakdown, and Improves Functional Recovery in a Mouse Model of Traumatic Brain Injury
- (2012) Flaubert Tchantchou et al. JOURNAL OF NEUROTRAUMA
- WIN55212-2 attenuates amyloid-beta-induced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-γ pathway
- (2012) Gohar Fakhfouri et al. NEUROPHARMACOLOGY
- Cannabidiol administration after hypoxia–ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
- (2012) M.R. Pazos et al. NEUROPHARMACOLOGY
- Cannabinoid receptor subtypes 1 and 2 mediate long-lasting neuroprotection and improve motor behavior deficits after transient focal cerebral ischemia
- (2012) W. Schmidt et al. NEUROSCIENCE
- Effects of Cannabinoid Receptor Agonist WIN 55,212-2 on Blood-Brain Barrier Disruption in Focal Cerebral Ischemia in Rats
- (2012) Oak Z. Chi et al. PHARMACOLOGY
- A Dysregulated Endocannabinoid-Eicosanoid Network Supports Pathogenesis in a Mouse Model of Alzheimer's Disease
- (2012) Justin R. Piro et al. Cell Reports
- Monoacylglycerol Lipase Is a Therapeutic Target for Alzheimer's Disease
- (2012) Rongqing Chen et al. Cell Reports
- Cerebroprotective effects of TAK-937, a cannabinoid receptor agonist, on ischemic brain damage in middle cerebral artery occluded rats and non-human primates
- (2011) Noriko Suzuki et al. BRAIN RESEARCH
- Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ9-THCV in animal models of Parkinson's disease
- (2011) C García et al. BRITISH JOURNAL OF PHARMACOLOGY
- Emerging drugs for amyotrophic lateral sclerosis
- (2011) Ali Aamer Habib et al. EXPERT OPINION ON EMERGING DRUGS
- N-Arachidonoyl-l-Serine is Neuroprotective after Traumatic Brain Injury by Reducing Apoptosis
- (2011) Ayelet Cohen-Yeshurun et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Cannabinoid Receptor Type 1 Protects Nigrostriatal Dopaminergic Neurons against MPTP Neurotoxicity by Inhibiting Microglial Activation
- (2011) Y. C. Chung et al. JOURNAL OF IMMUNOLOGY
- Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington's disease
- (2011) Onintza Sagredo et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Acute Effects of a Selective Cannabinoid-2 Receptor Agonist on Neuroinflammation in a Model of Traumatic Brain Injury
- (2011) Melanie B. Elliott et al. JOURNAL OF NEUROTRAUMA
- Treatment advances in neonatal neuroprotection and neurointensive care
- (2011) Michael V Johnston et al. LANCET NEUROLOGY
- The immunology of stroke: from mechanisms to translation
- (2011) Costantino Iadecola et al. NATURE MEDICINE
- Clinical diagnosis and management of amyotrophic lateral sclerosis
- (2011) Orla Hardiman et al. Nature Reviews Neurology
- Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis
- (2011) Laura Ferraiuolo et al. Nature Reviews Neurology
- An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease
- (2011) Kwang-Mook Jung et al. NEUROBIOLOGY OF AGING
- The Cannabinoid WIN 55212-2 Mitigates Apoptosis and Mitochondrial Dysfunction After Hypoxia Ischemia
- (2011) D. Alonso-Alconada et al. NEUROCHEMICAL RESEARCH
- A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
- (2011) Alan E. Renton et al. NEURON
- Cannabidiol Reduces Brain Damage and Improves Functional Recovery After Acute Hypoxia-Ischemia in Newborn Pigs
- (2011) Hector Lafuente et al. PEDIATRIC RESEARCH
- Cannabinoid Type 2 Receptor Activation Downregulates Stroke-Induced Classic and Alternative Brain Macrophage/Microglial Activation Concomitant to Neuroprotection
- (2011) Juan G. Zarruk et al. STROKE
- Cannabis and Amyotrophic Lateral Sclerosis: Hypothetical and Practical Applications, and a Call for Clinical Trials
- (2010) Gregory T. Carter et al. American Journal of Hospice & Palliative Medicine
- Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington’s disease
- (2010) Cristina Blázquez et al. BRAIN
- The Multiplicity of Action of Cannabinoids: Implications for Treating Neurodegeneration
- (2010) Aoife Gowran et al. CNS Neuroscience & Therapeutics
- The endocannabinoid system in the inflammatory and neurodegenerative processes of multiple sclerosis and of amyotrophic lateral sclerosis
- (2010) Silvia Rossi et al. EXPERIMENTAL NEUROLOGY
- Tetrahydrocannabinol (THC) for cramps in amyotrophic lateral sclerosis: a randomised, double-blind crossover trial
- (2010) M. Weber et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Overexpression of CB2 cannabinoid receptors results in neuroprotection against behavioral and neurochemical alterations induced by intracaudate administration of 6-hydroxydopamine
- (2010) Alexander Ternianov et al. NEUROBIOLOGY OF AGING
- The Science of Stroke: Mechanisms in Search of Treatments
- (2010) Michael A. Moskowitz et al. NEURON
- The Cannabinoid WIN55212-2 Promotes Neural Repair After Neonatal Hypoxia–Ischemia
- (2010) David Fernández-López et al. STROKE
- Glutamate Transporters and the Excitotoxic Path to Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis
- (2009) Emily Foran et al. ANTIOXIDANTS & REDOX SIGNALING
- Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity
- (2009) Javier Palazuelos et al. BRAIN
- The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages
- (2009) Rosa María Tolón et al. BRAIN RESEARCH
- The endocannabinoid system as a target for the treatment of motor dysfunction
- (2009) Javier Fernández-Ruiz BRITISH JOURNAL OF PHARMACOLOGY
- Cannabidiol: A Promising Drug for Neurodegenerative Disorders?
- (2009) Teresa Iuvone et al. CNS Neuroscience & Therapeutics
- WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease
- (2009) David A. Price et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment
- (2009) Sasidhar Murikinati et al. FASEB JOURNAL
- Cannabinoid CB2receptor agonists protect the striatum against malonate toxicity: Relevance for Huntington's disease
- (2009) Onintza Sagredo et al. GLIA
- Modulation of Cannabinoid Receptor Activation as a Neuroprotective Strategy for EAE and Stroke
- (2009) Ming Zhang et al. Journal of Neuroimmune Pharmacology
- CB2 receptor activation attenuates microcirculatory dysfunction during cerebral ischemic/reperfusion injury
- (2009) Ming Zhang et al. MICROVASCULAR RESEARCH
- The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic–ischemic brain damage in mice is mediated by CB2 and adenosine receptors
- (2009) A. Castillo et al. NEUROBIOLOGY OF DISEASE
- Intracellular mechanisms of N-acylethanolamine-mediated neuroprotection in a rat model of stroke
- (2009) P. Garg et al. NEUROSCIENCE
- Arrested oligodendrocyte lineage maturation in chronic perinatal white matter injury
- (2008) Kristen N. Segovia et al. ANNALS OF NEUROLOGY
- Endocannabinoids mediate neuroprotection after transient focal cerebral ischemia
- (2008) Markus Schomacher et al. BRAIN RESEARCH
- Altered presymptomatic AMPA and cannabinoid receptor trafficking in motor neurons of ALS model mice: implications for excitotoxicity
- (2008) Pingwei Zhao et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism
- (2008) Kazuhide Hayakawa et al. NEUROPHARMACOLOGY
- Modulation of the balance between cannabinoid CB1 and CB2 receptor activation during cerebral ischemic/reperfusion injury
- (2008) M. Zhang et al. NEUROSCIENCE
- The cannabinoid CP55,940 prolongs survival and improves locomotor activity in Drosophila melanogaster against paraquat: Implications in Parkinson's disease
- (2008) M. Jimenez-Del-Rio et al. NEUROSCIENCE RESEARCH
- Astrocyte Responses after Neonatal Ischemia: The Yin and the Yang
- (2008) Sonia Villapol et al. NEUROSCIENTIST
- Neuroprotective Effects of the Nonpsychoactive Cannabinoid Cannabidiol in Hypoxic-Ischemic Newborn Piglets
- (2008) Francisco J Alvarez et al. PEDIATRIC RESEARCH
- Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619
- (2007) C J Hillard et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cannabidiol in vivo blunts β-amyloid induced neuroinflammation by suppressing IL-1β and iNOS expression
- (2007) G Esposito et al. BRITISH JOURNAL OF PHARMACOLOGY
- Accumulation of the anandamide precursor and other N-acylethanolamine phospholipids in infant rat models of in vivo necrotic and apoptotic neuronal death
- (2003) Henrik H. Hansen et al. JOURNAL OF NEUROCHEMISTRY
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