Article
Food Science & Technology
Hongji Ye, Xinyi Zhang, Yang Jiang, Min Guo, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Wei Chen
Summary: This study investigated the peptidomic patterns of fermented milk by different strains of Lactobacillus delbrueckii ssp. bulgaricus and ssp. lactis before and after simulated gastrointestinal digestion. Variations in peptidomics were found among samples, with different subspecies displaying distinct peptide profiles. Digestion appeared to reduce peptidomics variations and the strain L. delbrueckii ssp. bulgaricus DQHXNS8L6 was the most efficient in generating bioactive peptides.
Review
Immunology
Virginia Perez-Carrasco, Ana Soriano-Lerma, Miguel Soriano, Jose Gutierrez-Fernandez, Jose A. Garcia-Salcedo
Summary: The application of next generation sequencing techniques has revealed that the urinary tract is not sterile, contrary to previous beliefs. Microbial communities in the urinary tract play a crucial role in maintaining health and are associated with various urinary pathologies. Understanding the urinary microbiome in health and disease could lead to the development of new therapeutic strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Biochemical Research Methods
Amrutha Hasandka, Ankita Ramchandran Singh, Anusha Prabhu, Hardik Ramesh Singhal, M. S. Giri Nandagopal, Naresh Kumar Mani
Summary: Economic and societal barriers in low-resource areas hinder accessibility to traditional UTI testing methods, while cellulose-based materials offer a portable and adaptable substrate for simple and reproducible UTI diagnosis. Strategies aimed at commercial penetration could significantly increase accessibility to more healthcare options for at-risk populations.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Min-gyung Baek, Kwan Woo Kim, Hana Yi
Summary: This study investigated the evolution of the six subspecies of L. delbrueckii using comparative genomics. It found that the defining feature of the species was the gene number increment driven by mobile elements and gene fragmentation, but the repertoire of subspecies-specific gene gains and losses differed among the six subspecies. Horizontal gene transfer analyses indicated frequent gene transfers between different subspecies at the time of divergence, but recent gene exchange was confined to a subspecies, implying independent evolution of the six subspecies. The results explained the differences in habitat and nutritional requirements among the subspecies of L. delbrueckii.
SCIENTIFIC REPORTS
(2023)
Article
Agriculture, Dairy & Animal Science
Jiayuan Mo, Yujie Lu, Shan Jiang, Gang Yan, Tianqi Xing, Di Xu, Yaoyin He, Bingkun Xie, Ganqiu Lan, Baojian Chen, Jing Liang
Summary: This study found that feeding Lactobacillus delbrueckii subsp. bulgaricus (LDB) diets has positive effects on pig growth performance, gastrointestinal microbiota, and metabolites, supporting its potential as an antibiotic replacement in pig production.
Article
Biotechnology & Applied Microbiology
Gwenael Jan, Florian Tarnaud, Fillipe Luiz Rosa do Carmo, Nassima Illikoud, Fanny Canon, Julien Jardin, Valerie Briard-Bion, Fanny Guyomarc'h, Valerie Gagnaire
Summary: Lactobacillus delbrueckii subsp. bulgaricus, a commonly used yogurt starter, shows poor adaptation to soy milk. It does not grow in soy milk, but can accelerate its acidification when co-cultured with Streptococcus thermophilus. Comparison with cow's milk reveals significant differences in cell morphology and proteome composition in soy milk, indicating stress response and downregulation of cell division machinery.
Review
Biochemistry & Molecular Biology
Anna Kawalec, Danuta Zwolinska
Summary: The urinary tract microbiome is crucial for maintaining health and preventing urinary tract infections. However, the characteristics and role of the urobiome in children, as well as strategies for treating pediatric patients with recurrent urinary tract infections, are still not completely understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Curtis Warren, Jaclyn D. Fosnacht, Elizabeth E. Tremblay
Summary: The introduction of external female urinary catheters has successfully decreased the utilization of indwelling urinary catheters, particularly in intensive care units. Therefore, it is recommended that healthcare facilities focus on implementing this device first in ICUs.
AMERICAN JOURNAL OF INFECTION CONTROL
(2021)
Article
Microbiology
Meital Elbaz, Amanda Chikly, Ronnie Meilik, Ronen Ben-Ami
Summary: The urinary tract is an uncommon source of Candida bloodstream infection (CBSI), but the frequency of U-CBSI may be increasing. Patients with U-CBSI are typically older with a higher incidence of dementia, and risk factors include bladder catheterization and urologic procedures. U-CBSI tends to occur earlier and have a lower mortality rate compared to CBSI of undetermined origin.
Article
Medicine, General & Internal
Jung Ki Jo, Dong Seob Kim, Younghun Sim, Soorack Ryu, Kyu Shik Kim
Summary: The study found that the severity of UTI is higher in patients with catheters, and the infecting strains vary depending on the presence of a catheter. Fosfomycin has a success rate of over 50% in treating UTIs, even in patients with catheters.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Immunology
Sofia Sanchez, Nicolas Navarro, Johanna Catalan-Figueroa, Javier O. Morales
Summary: Urinary tract infection is a common reason for antibiotic treatment, but uropathogens are increasingly becoming resistant to current therapies. Nanotechnology presents an innovative and promising approach for UTI treatment, with various nanoparticles showing potential impact against uropathogens both in vivo and in vitro.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Infectious Diseases
Jian Liu, Ying Jiang, Zhe Liu, Qun Song, Zhuo Li
Summary: Upper urinary tract obstruction caused by fungal balls is a rare disease. This article reports a case of an elderly man who was initially misdiagnosed with emphysematous pyelonephritis with Aerogenes infection. The patient eventually underwent surgery and antifungal therapy.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Agricultural Engineering
Periyasamy Sivagurunathan, Prakash C. Sahoo, Manoj Kumar, Ravi Prakash Gupta, Debasis Bhattacharyya, S. S. V. Ramakumar
Summary: The positive interaction between Clostridium sp. and lactic acid-producing bacteria is commonly observed in high-rate hydrogen production systems. However, the role of Lactobacillus sp. in dark fermentation production systems has been rarely studied. This study demonstrated, for the first time, the biohydrogen production ability of Lactobacillus delbrueckii under anaerobic conditions. By optimizing pH at 6.5 and adding nanoparticles, the maximum hydrogen yield was increased by 18% compared to the control, supported by the external electron transfer mechanism.
BIORESOURCE TECHNOLOGY
(2023)
Article
Chemistry, Applied
Ao Liu, Qiqi Liu, Yushan Bu, Haining Hao, Tongjie Liu, Pimin Gong, Lanwei Zhang, Chen Chen, Huaixiang Tian, Huaxi Yi
Summary: The aroma of fermented milk produced by 28 strains of Lactobacillus delbrueckii subsp. bulgaricus was evaluated and classified into different types. A total of 12 key aroma compounds were identified, which can be used to develop fermented milk products with specific aroma profiles.
Article
Pediatrics
Orli Megged
Summary: The study found that CoNS is a rare urinary pathogen among children, but can cause pyelonephritis, especially in young males. 37% of the children had known or newly diagnosed underlying urinary tract abnormalities.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Surgery
C. P. Thomas, M. A. Mansilla, R. Sompallae, S. O. Mason, C. J. Nishimura, M. J. Kimble, C. A. Campbell, A. E. Kwitek, B. W. Darbro, Z. A. Stewart, R. J. H. Smith
AMERICAN JOURNAL OF TRANSPLANTATION
(2017)
Article
Genetics & Heredity
Lisa A. Lansdon, Benjamin W. Darbro, Aline L. Petrin, Alissa M. Hulstrand, Jennifer M. Standley, Rachel B. Brouillette, Abby Long, M. Adela Mansilla, Robert A. Cornell, Jeffrey C. Murray, Douglas W. Houston, J. Robert Manak
Article
Genetics & Heredity
Patrick D. Brophy, Maria Rasmussen, Mrutyunjaya Parida, Greg Bonde, Benjamin W. Darbro, Xiaojing Hong, Jason C. Clarke, Kevin A. Peterson, James Denegre, Michael Schneider, Caroline R. Sussman, Lone Sunde, Dorte L. Lildballe, Jens Michael Hertz, Robert A. Cornell, Stephen A. Murray, J. Robert Manak
Article
Cell Biology
David K. Meyerholz, Georgina K. Ofori-Amanfo, Mariah R. Leidinger, J. Adam Goeken, Rajesh Khanna, Jessica C. Sieren, Benjamin W. Darbro, Dawn E. Quelle, Jill M. Weimer
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2017)
Correction
Multidisciplinary Sciences
Allison J. Cox, Benjamin W. Darbro, Ronald M. Laxer, Gabriel Velez, Xinyu Bing, Alexis L. Finer, Albert Erives, Vinit B. Mahajan, Alexander G. Bassuk, Polly J. Ferguson
Article
Genetics & Heredity
Lisa A. Lansdon, Benjamin W. Darbro, Aline L. Petrin, Alissa M. Hulstrand, Jennifer M. Standley, Rachel B. Brouillette, Abby Long, M. Adela Mansilla, Robert A. Cornell, Jeffrey C. Murray, Douglas W. Houston, J. Robert Manak
Article
Genetics & Heredity
Patrick D. Brophy, Maria Rasmussen, Mrutyunjaya Parida, Greg Bonde, Benjamin W. Darbro, Xiaojing Hong, Jason C. Clarke, Kevin A. Peterson, James Denegre, Michael Schneider, Caroline R. Sussman, Lone Sunde, Dorte L. Lildballe, Jens Michael Hertz, Robert A. Cornell, Stephen A. Murray, J. Robert Manak
Article
Clinical Neurology
J. Uthoff, F. A. De Stefano, K. Panzer, B. W. Darbro, T. S. Sato, R. Khanna, D. E. Quelle, D. K. Meyerholz, J. Weimer, J. C. Sieren
JOURNAL OF NEURORADIOLOGY
(2019)
Article
Clinical Neurology
Brianna N. Brun, Tobias Willer, Benjamin W. Darbro, Hernan D. Gonorazky, Sergey Naumenko, James J. Dowling, Kevin P. Campbell, Steven A. Moore, Katherine D. Mathews
NEUROMUSCULAR DISORDERS
(2018)
Article
Surgery
Kendall J. Keck, Patrick Breheny, Terry A. Braun, Benjamin Darbro, Guiying Li, Joseph S. Dillon, Andrew M. Bellizzi, Thomas M. O'Dorisio, James R. Howe
Article
Genetics & Heredity
Catherina T. Pinnaro, Travis Henry, Heather J. Major, Mrutyunjaya Parida, Lucy E. DesJardin, John R. Manak, Benjamin W. Darbro
MOLECULAR GENETICS & GENOMIC MEDICINE
(2020)
Article
Genetics & Heredity
Moon Ley Tung, Bharatendu Chandra, Jaclyn Kotlarek, Marcelo Melo, Elizabeth Phillippi, Cristina M. Justice, Anthony Musolf, Simeon A. Boyadijev, Paul A. Romitti, Benjamin Darbro, Hatem El-Shanti
Summary: The case report describes a one-year-old female with Ulnar-mammary syndrome (UMS) presenting with limb anomalies and a novel variant in TBX3 gene, inherited from her father who also had UMS. Whole genome analysis in the father revealed a variant in the EFNA4 gene associated with sagittal craniosynostosis.
Article
Genetics & Heredity
Catherina T. Pinnaro, Chloe B. Beck, Heather J. Major, Benjamin W. Darbro
Summary: Turner syndrome (TS) is a chromosomal disorder characterized by the loss of the second sex chromosome and displays phenotypic heterogeneity. Congenital heart defects (CHD), including bicuspid aortic valve (BAV), are common in TS. Recent studies have shown the impact of X chromosome haploinsufficiency on the TS epigenome and transcriptome and suggested that genetic modifiers outside the X chromosome may influence CHD risk in TS. This study aimed to identify genetic variants associated with BAV in TS and found that rare variants in CRELD1 were significantly enriched in TS individuals with BAV.
Article
Oncology
Brandon R. McNew, Benjamin W. Darbro, Deqin Ma, David J. Gordon
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2017)
Article
Neurosciences
Michael Lutter, Michael Z. Khan, Kenji Satio, Kevin C. Davis, Ian J. Kidder, Latisha McDaniel, Benjamin W. Darbro, Andrew A. Pieper, Huxing Cui
BIOLOGICAL PSYCHIATRY
(2017)
