Article
Dentistry, Oral Surgery & Medicine
Caroline Loureiro, Marilia Afonso Rabelo Buzalaf, Talita Mendes Oliveira Ventura, Vinicius Taioqui Pela, Gladiston William Lobo Rodrigues, Julia Guerra Andrade, Juliano Pelim Pessan, Rogerio Castilho Jacinto
Summary: This study quantitatively and qualitatively analyzed the proteomic profile of teeth with acute apical abscesses (AAA) and chronic apical periodontitis (CAP). The results showed significant differences in protein expression between the two groups, with AAA group mainly associated with immune inflammatory response and oxidative stress response, and CAP group mainly associated with DNA/RNA regulation and repair, and structural function.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Alessio Buonavoglia, Fausto Zamparini, Gianvito Lanave, Francesco Pellegrini, Georgia Diakoudi, Andrea Spinelli, Maria Stella Lucente, Michele Camero, Violetta Iris Vasinioti, Maria Giovanna Gandolfi, Vito Marte, Carlo Prati
Summary: This study evaluated microbial communities in root canals using Nanopore sequencing and analyzed their relationship with peri-radicular inflammatory diseases. The results showed the presence of various microorganisms in root canals, which were closely related to clinical and endodontic conditions. Future studies should further evaluate these conditions and identify their role in inducing bone damage and local systemic diseases to better understand the relationship between microbes and endodontic pathologies.
JOURNAL OF ENDODONTICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Sandra R. Hernandez, Alejandro R. Perez, Alessandra C. Baasch, Karen Brisson-Suarez, Debora P. Sellera, Patricia H. P. Ferrari, Jorge C. Alberdi, Claudia M. Carreira, Susana Gomes-Azevedo, Flavio R. F. Alves, Isabela N. Rocas, Jose F. Siqueira Jr
Summary: This study evaluated the treatment approaches for 6 maxillary incisors with dens invaginatus and apical periodontitis. Cone-beam computed tomography was used for diagnosis and treatment planning, and sodium hypochlorite irrigation and thermoplasticized gutta-percha obturation were the key methods used. The results showed favorable clinical and radiographic outcomes.
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2022)
Article
Infectious Diseases
Zheng Wang, Ge Yang, Biao Ren, Yuan Gao, Xian Peng, Mingyun Li, Hockin H.K.Xu, Qi Han, Jiyao Li, Xuedong Zhou, Lei Cheng
Summary: This study investigated the antibacterial effect of root canal sealer containing DMADDM on persistent apical periodontitis in beagle dogs. The results showed that DMADDM-modified sealer significantly reduced the volume of periapical lesion and inflammatory grade, especially in cases of E. faecalis-induced reinfection.
Article
Biochemistry & Molecular Biology
Xiao Guo, Yan Sun, Zheng Wang, Biao Ren, Hockin H. K. Xu, Xian Peng, Mingyun Li, Suping Wang, Haohao Wang, Yao Wu, Michael D. Weir, Xuedong Zhou, Fang Lan, Lei Cheng
Summary: Persistent apical periodontitis is a critical challenge in root canal therapy. Developing root canal filling materials with continuous antibacterial effects and tight seal is important to prevent treatment failure and persistent apical periodontitis. In this study, we modified the EndoREZ root canal sealer by adding the antibacterial material DMADDM and magnetic nanoparticles (MNPs). The modified sealer showed good mechanical properties, biocompatibility, and enhanced antibacterial effects on multispecies biofilms under a magnetic field. In vivo study demonstrated its inhibitory effect on persistent apical periodontitis with minimal resorption and slight increase in periodontal ligament space.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Reem Alkhatri, Abdul Rahman Mohammed Saleh, Waad Kheder
Summary: This study compared the effects of zirconia, metal, and polymer-infiltrated ceramic network (PICN) materials on the restoration of teeth after root canal treatment. The results showed that the PICN group had the least extension of root fracture apically, making it suitable for post and core restoration of anterior teeth.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Review
Dentistry, Oral Surgery & Medicine
Stefano Corbella, Clemens Walter, Igor Tsesis
Summary: This study systematically analyzed the effectiveness of root resection techniques in managing apical periodontitis. The results showed limited data and high heterogeneity and bias among the included studies. Therefore, it is currently not possible to recommend or dismiss the use of root resection techniques for treating apical periodontitis.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Oncology
Larissa Vilas-Boas, Viviany Cozer, Peter Z. Tawil, Marcelo Santos Coelho
Summary: This study found that photodynamic therapy after root canal preparation can effectively reduce pain in posterior teeth presenting with symptomatic apical periodontitis, especially within 24 hours. There were no significant differences in pain levels between the two groups at 72 hours and 1 week, and there was no noticeable change in the number of pain relief tablets taken.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Chiara Pirani, Josette Camilleri
Summary: This systematic review aimed to investigate the impact of different obturation techniques and materials on the management of apical periodontitis (AP). The results showed that the obturation techniques and materials used did not affect the outcome of AP. Vertical compaction resulted in faster resolution of periapical lesions, while patients treated with lateral condensation had poorer oral health-related quality of life.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Medicine, Research & Experimental
Gustavo M. Almeida, Vitor Hugo M. Carvalho, Erika B. P. Silva, Marco Antonio F. Cancado, Leonardo S. Barroso, Erica L. Queiroz, Tien Li An, Ana Paula D. Ribeiro, Jacy R. Carvalho-Junior, Andre F. Leite
Summary: This study aims to explore whether the use of intracanal dressing during endodontic treatment promotes periradicular repair in teeth with apical periodontitis. Three different clinical approaches will be used and patients' postoperative pain levels and long-term follow-up evaluations will be recorded. The results may lead to changes in the clinical approaches of endodontic therapy for teeth with apical periodontitis and reveal the potential of complementary approaches for enhanced root canal system decontamination during preparation.
Review
Dentistry, Oral Surgery & Medicine
Daniel Cabanillas-Balsera, Victoria Areal-Quecuty, Cristiane Cantiga-Silva, C. B. M. de Cardoso, Luciano Tavares Angelo Cintra, Jenifer Martin-Gonzalez, Juan J. Segura-Egea
Summary: There is no association between the prevalence of AP and hypertension, but hypertensive patients have significantly increased odds of losing root-filled teeth. Given the high prevalence of hypertension, it is very common to perform root canal treatments on hypertensive patients. It is imperative to communicate this heightened risk to patients and recommend periodic monitoring of oral health and hypertension, paying special attention to this subset of patients.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Medicine, General & Internal
Izabela Korona-Glowniak, Dominika Piatek, Emilia Fornal, Anna Lukowiak, Yuriy Gerasymchuk, Anna Kedziora, Gabriela Bugla-Ploskonska, Ewelina Grywalska, Teresa Bachanek, Anna Malm
Summary: This study investigated the microbial diversity of root canal microbiota related to different endodontic infections. Results showed different microbial compositions in various types of endodontic infections, with specific bacterial species correlating with the health condition of teeth.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Dentistry, Oral Surgery & Medicine
Xinyue Liu, Guiying He, Zhengjie Qiu, Feng Chen, Jiapeng Wang, Zheng Huang, Pengtao Zhang, Jian Zhang, Liangjun Zhong, Cheng Ding, Xing Chen
Summary: This study found through meta-analysis that diabetes mellitus may increase the risk of apical periodontitis in teeth undergoing root canal treatment. In teeth with preoperative apical periodontitis, diabetes mellitus may promote the development of apical periodontitis.
JOURNAL OF ENDODONTICS
(2023)
Article
Microbiology
Alessio Buonavoglia, Francesco Pellegrini, Gianvito Lanave, Georgia Diakoudi, Maria Stella Lucente, Fausto Zamparini, Michele Camero, Maria Giovanna Gandolfi, Vito Martella, Carlo Prati
Summary: Periodontal diseases can damage the supporting structures of teeth and are believed to be caused by dysbiosis of oral microbiota. This study found bacteria in the pulp cavity of teeth with severe periodontal disease, even when the external surface appeared intact. Streptococcus was the predominant genus in the pulp samples, while Porphyromonas, Tannerella, and Treponema were significantly more present in the periodontal samples. It was also observed that the microbial composition differed between some samples, while Streptococcus was consistently present in others.
JOURNAL OF ORAL MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Marjory Xavier Rodrigues, Nadine Fiani, Rodrigo Carvalho Bicalho, Santiago Peralta
Summary: This study investigated the functional potential of subgingival microbial communities in domestic cats using shotgun metagenomic approach, comparing findings between periodontally healthy cats and cats with various periodontal diseases. The study revealed significant differences in the Respiration category among groups, indicating potential associations between microbial functional features and disease development.
SCIENTIFIC REPORTS
(2021)