Article
Nutrition & Dietetics
Oscar Geovanny Enriquez-Martinez, Taisa Sabrina Silva Pereira, Jose Geraldo Mill, Maria de Jesus Mendes da Fonseca, Maria del Carmen Bisi Molina, Rosane Harter Griep
Summary: According to a cross-sectional analysis, excessive alcohol consumption is positively associated with extremely high HDL-C levels, especially among women and higher-income individuals.
Review
Biochemistry & Molecular Biology
Kyung-Hyun Cho
Summary: This article summarizes the changes in the quantity, quality, and functionality of high-density lipoproteins (HDL) in the context of health and disease, and discusses their potential role in the diagnosis and treatment of diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ewa Wieczorek, Agnieszka Cwiklinska, Agnieszka Kuchta, Barbara Kortas-Stempak, Anna Gliwinska, Maciej Jankowski
Summary: The study focused on evaluating the impact of HDL-2 and HDL-3 on VLDL degradation related to hypertriglyceridemia. The findings showed that HDL-3 had a significant effect on the composition and electrophoretic mobility of VLDL, compared to HDL-2.
Article
Public, Environmental & Occupational Health
Jorg G. Morland, Per Magnus, Stein Emil Vollset, David A. Leon, Randi Selmer, Aage Tverdal
Summary: The benefits of elevated high-density lipoprotein cholesterol (HDL-C) levels are challenged by U-shaped relations with all-cause mortality. The association with cause-specific mortality is less studied. Higher HDL-C levels were associated with increased mortality risk for several diseases, which have also been associated with heavy drinking.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jie Gao, Jun Lu, Wenjun Sha, Bilin Xu, Cuiping Zhang, Hongping Wang, Juan Xia, Hong Zhang, Wenjun Tang, Tao Lei
Summary: This study evaluated the association between the neutrophil to HDL-C ratio (NHR) and the degree of coronary stenosis in patients with stable coronary artery disease (CAD). The results showed that NHR was not only associated with the occurrence and seriousness of CAD, but also a better predictor of severe CAD than neutrophil, HDL-C or LDL-C/HDL-C.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Knut Tore Lappegard, Christian Abendstein Kjellmo, Anders Hovland
Summary: HDL is a diverse group of plasma molecules with varying lipid content and protein composition. Understanding the function of specific HDL subgroups and their clinical relevance is of increasing interest in relation to coronary heart disease risk. Pharmacologically manipulating beneficial and harmful HDL subgroups may potentially reduce CHD risk in the future.
Article
Endocrinology & Metabolism
Gaiqin Pei, Aiya Qin, Lingqiu Dong, Siqing Wang, Xiang Liu, Dandan Yang, Jiaxing Tan, Xiaoyuan Zhou, Yi Tang, Wei Qin
Summary: This study highlights the importance of the TG/HDL-C ratio as a predictive marker for IgAN progression. A high TG/HDL-C ratio is strongly associated with worse renal survival in IgAN patients and is correlated with proteinuria, hypertension, and severity of pathological lesions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hitomi Ohinata, Takashi Obama, Tomohiko Makiyama, Yuichi Watanabe, Hiroyuki Itabe
Summary: This study found that high-density lipoproteins (HDL) partially decreased neutrophil extracellular trap (NET) formation induced by copper-oxidized low-density lipoprotein (oxLDL). It was also discovered that oxidized phosphatidylcholines and lysophosphatidylcholine in oxLDL promoted NET formation, which could be completely blocked by native HDL. Furthermore, an electronegative subfraction of LDL, LDL(-), was found to promote NET formation. These findings suggest that plasma lipoproteins and their oxidative modifications play multiple roles in promoting NET formation, and HDL acts as a suppressor of this response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Beata Franczyk, Jacek Rysz, Janusz Lawinski, Magdalena Rysz-Gorzynska, Anna Gluba-Brzozka
Summary: The interest in HDL cholesterol (HDL-C) lies in its role in preventing cardiovascular diseases by transporting surplus cholesterol from peripheral tissues back to the liver. However, high levels of HDL-C may not necessarily be protective against cardiovascular diseases and can even be harmful in extreme quantities.
Article
Biochemical Research Methods
Ching-Ying Tsai, Deng-Ying Huang, Ja-An Annie Ho, Li-Chen Wu
Summary: In this study, an electrochemical aptasensor was successfully developed for the simultaneous quantification of apoE-HDL, apoE-HDL-C, and HDL-C. This sensing platform offers an efficient, convenient, and purification-free strategy for predictive biomarkers of coronary heart disease.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Chang Liu, Devinder Dhindsa, Zakaria Almuwaqqat, Yan Sun, Arshed A. Quyyumi
Summary: The study found that very high levels of HDL-C are associated with an increased risk of all-cause death and cardiovascular death among men, but not women, in the general population.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Hongyan Jiang, Pengcheng Chen, Chihong Zhu, Xiaoqian Qian, Danying Wan, Jianguo Feng
Summary: This study found that serum HDL levels are associated with the prognosis of patients with ovarian cancer, with patients having higher HDL levels experiencing longer survival.
Article
Pharmacology & Pharmacy
Yaqin Zhang, Yanju Ding, Wen Jiang
Summary: This study aimed to explore the level and significance of neutrophils to high-density lipoprotein cholesterol ratio (NHR) and monocytes to high-density lipoprotein cholesterol ratio (MHR) in patients with non-dipping hypertension. The results showed that both NHR and MHR were significantly higher in the non-dipping hypertension group compared to the control group and the dipping hypertension group. According to ROC curve analysis, NHR>73.35 and MHR>7.54 were considered high-risk groups. Multivariate analysis revealed that only MHR was recognized as a marker for detecting non-dipping hypertension.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Medical Laboratory Technology
Silvia de la Cruz-Ares, Ana Leon-Acuna, Elena M. Yubero-Serrano, Jose D. Torres-Pena, Antonio P. Arenas-de Larriva, Magdalena P. Cardelo, Oriol A. Rangel-Zuniga, Raul M. Luque, Juan F. Alcala-Diaz, Jose M. Ordovas, Pablo Perez-Martinez, Jose Lopez-Miranda, Javier Delgado-Lista
Summary: This study investigated the association between lipoprotein subfractions and the severity of coronary heart disease (CHD) using high-throughput nuclear magnetic resonance (NMR) spectroscopy. The results showed that small and medium HDL subclasses concentration, as measured by NMR, were inversely related to angiographic CHD severity. These particles were also found to be independent predictors of multivessel coronary disease (MVD) and improved the prediction of this condition compared to traditional risk factors.
CLINICA CHIMICA ACTA
(2022)
Article
Public, Environmental & Occupational Health
Yihua Yue, Nisha Nair, Sarah Quinones, Katarzyna Kordas, Gauri Desai
Summary: The study found a positive association between estimated unmethylated inorganic arsenic exposure with total cholesterol and high-density lipoprotein cholesterol levels, and no effect modification by weight status was observed.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)