Article
Medicine, General & Internal
Feng Zhu, Yan Ji, Jiang-Hua Song, Guo-Xiang Huang, Yun-Feng Zhang
Summary: This study investigates the relationship between neutrophil/lymphocyte ratio (NLR) and neutrophil/high-density lipoprotein cholesterol ratio (NHR) and acute ischemic stroke (AIS) severity and short-term prognosis. The findings suggest that NLR and NHR are independent risk factors for stroke severity and poor short-term prognosis in AIS patients. Furthermore, the combination of NLR and NHR shows a strong correlation with disease severity in AIS.
Article
Endocrinology & Metabolism
Xianjing Feng, Fang Yu, Minping Wei, Yunfang Luo, Tingting Zhao, Zeyu Liu, Qin Huang, Ruxin Tu, Jiaxin Li, Boxin Zhang, Liuyang Cheng, Jian Xia
Summary: This study found that neutrophil counts and neutrophil-to-lymphocyte ratio (NLR) are associated with stress hyperglycemia ratio (SHR) in patients with acute ischemic stroke (AIS). The correlation between neutrophil counts and NLR and different SHR levels varies according to TOAST classification and functional prognosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Health Care Sciences & Services
Farzaneh Sadeghi, Ferenc Sarkady, Katalin S. Zsori, Istvan Szegedi, Rita Orban-Kalmandi, Edina G. Szekely, Nikolett Vasas, Ervin Berenyi, Laszlo Csiba, Zsuzsa Bagoly, Amir H. Shemirani
Summary: This study demonstrated for the first time that a high NLR-low LMR combination observed at 24 hours after thrombolysis can serve as an independent predictor of poor 3-months outcome in acute ischemic stroke patients. This simple and readily available data may help clinicians to improve the prognostic estimation of patients and may provide guidance in selecting patients for personalized and intensified care post-thrombolysis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Yuanlin Ying, Fang Yu, Yunfang Luo, Xianjing Feng, Di Liao, Minping Wei, Xi Li, Qin Huang, Zeyu Liu, Lin Zhang, Tingting Zhao, Ruxin Tu, Jian Xia
Summary: The study found that elevated admission Neutrophil-to-Lymphocyte Ratio (NLR) levels were significantly associated with the initial stroke severity and poor short-term prognosis in patients with symptomatic intracranial atherosclerotic stenosis (sICAS). This suggests that NLR may serve as an early predictor for severity and unfavorable outcomes in AIS patients with ICAS.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Cuiping Chen, Lei Gu, Luyun Chen, Wangwang Hu, Xiaowen Feng, Fengzhen Qiu, Zijian Fan, Qitao Chen, Jiayou Qiu, Bei Shao
Summary: The study found that both NLR and PLR are independent predictors of functional outcomes after AIS, and may help to identify high-risk patients more effectively when used together.
FRONTIERS IN NEUROLOGY
(2021)
Article
Behavioral Sciences
Chongxi Xu, Linrui Cai, Tong Yi, Xingyang Yi, Yu Hu
Summary: The objective of this research was to examine the correlation between the neutrophil-to-lymphocyte ratio (NLR) and stroke progression (SP) as well as the functional outcome following an ischemic stroke (IS). The results showed that NLR was independently associated with SP and poor functional outcomes. NLR may be a valuable prognostic indicator in clinical practice.
BRAIN AND BEHAVIOR
(2023)
Article
Cell Biology
Xiaoming Rong, Jingjuan Chen, Dong Pan, YuKai Wang, Chengguo Zhang, Yamei Tang
Summary: This study investigates the impact of APOE alleles on the functional outcome in acute ischemic stroke (AIS) patients. It also explores the relationship between inflammation and stroke-related disability based on APOE genotypes. The results indicate that APOE e4 carriers have a worse functional outcome after AIS compared to non-e4 carriers. Additionally, the study finds that the APOE genotype may modify the relationship between neutrophil-to-lymphocyte ratio (NLR) and 3-month stroke outcome.
Article
Immunology
Pengyu Gong, Yukai Liu, Yachi Gong, Gang Chen, Xiaohao Zhang, Siyu Wang, Feng Zhou, Rui Duan, Wenxiu Chen, Ting Huang, Meng Wang, Qiwen Deng, Hongchao Shi, Junshan Zhou, Teng Jiang, Yingdong Zhang
Summary: NLR, PLR, and LMR were shown to be associated with post-thrombolysis early neurological outcomes, with NLR and PLR potentially predicting early neurological deterioration, and NLR related to early neurological improvement.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Clinical Neurology
Feihui Zou, Jian Wang, Bin Han, Jiannan Bao, Yin Fu, Kefeng Liu
Summary: This study aimed to investigate the association between early neutrophil-to-lymphocyte ratio (ENLR) and prognosis in patients with anterior circulation large-vessel occlusion stroke (LVOS) after successful endovascular treatment (EVT). The results showed that increased ENLR was independently associated with poor prognosis at 3 months, with an ENLR greater than 9.75 significantly correlated with poor outcomes.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Haoye Cai, Honghao Huang, Chenguang Yang, Junli Ren, Jianing Wang, Beibei Gao, Wenjing Pan, Fangyue Sun, Xinbo Zhou, Tian Zeng, Jingyu Hu, Yilin Chen, Shunkai Zhang, Guangyong Chen
Summary: The study indicates that in AIS patients treated with intravenous thrombolysis, ENR levels are closely related to clinical prognosis, with higher ENR values associated with better outcomes and lower risk of mortality.
FRONTIERS IN NEUROLOGY
(2021)
Review
Green & Sustainable Science & Technology
Tissa Wijeratne, Carmela Sales, Rohit Menon, Leila Karimi, Mihajlo Jakovljevic
Summary: Stroke is a major cause of adult disability and death worldwide, with the immune system playing a significant role in the pathobiological process. The neutrophil to lymphocyte ratio (NLR) has been identified as a potential biomarker with implications for diagnosis, prognosis, and therapy in acute ischemic stroke (AIS). Studies have shown that an inflammatory response involving excessive neutrophils and reduced lymphocytes is associated with worse outcomes during acute interventions and recovery trajectory in stroke, highlighting the importance of a systems biology-based approach in stroke care.
Article
Biology
Simona Lattanzi, Davide Norata, Serena Broggi, Stefano Meletti, Milena Switonska, Artur Slomka, Mauro Silvestrini
Summary: The worsening of neurological status shortly after acute ischemic stroke (AIS) is a serious problem, and inflammation plays a key role in stroke pathology. A study found that the neutrophil-to-lymphocyte ratio (NLR) at admission in AIS patients undergoing endovascular treatment (EVT) is associated with early neurological deterioration (END). Higher NLR values predicted a higher risk of END.
Article
Immunology
Qian Song, Song-Xiao Xu, Jun-Zhou Wu, Lin Ling, Sheng Wang, Xin-Hua Shu, Dan-Ni Ying, Wang-Wei Pei, Yu-Chen Wu, Su-Fang Sun, Yi-Ning Zhang, Si-Hang Zhou, Zhu-Yan Shao
Summary: This study analyzed data from 991 ovarian cancer patients and found that the lymphocyte to monocyte ratio (LMR) and platelet to neutrophil ratio (PNR) were independent prognostic indicators of ovarian cancer. In contrast, the platelet to lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) had limited prognostic value. In conclusion, LMR and PNR are superior prognostic indicators in ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Jiali Leng, Fei Wu, Lihui Zhang
Summary: This meta-analysis found that pretreatment neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) may serve as biomarkers for predicting poor prognosis in patients with endometrial cancer, while monocyte-lymphocyte ratio (MLR) is not associated with prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Liu-Zhu Chen, Xiao-Qian Luan, Shu-Zhen Wu, Hu-Wei Xia, Yi-Si Lin, Lu-Qian Zhan, Jin-Cai He
Summary: This study aimed to explore the optimal time point for predicting stroke-associated pneumonia (SAP) using neutrophil-to-lymphocyte ratio (NLR) in patients receiving thrombolytic therapy. After assessing blood parameters at different time points, it was found that NLR measured within 24-36 hours after thrombolysis had a significant predictive effect on SAP and could also predict short-term and long-term poor functional outcomes, hemorrhagic transformation, and 1-year mortality.
NEUROLOGICAL SCIENCES
(2023)
Letter
Anesthesiology
Asuman Celikbilek
Article
Cell Biology
Serpil Taheri, Zuleyha Karaca, Minoo Rassoulzadegan, Ecmel Mehmetbeyoglu, Gokmen Zararsiz, Elif Funda Sener, Kezban Korkmaz Bayram, Esra Tufan, Mustafa Caglar Sahin, Mert Kahraman Marasli, Mehmet Memis, Halit Canatan, Figen Ozturk, Fatih Tanriverdi, Kursad Unluhizarci, Fahrettin Kelestimur
Summary: Activation of the HPA axis through an ITT shows distinct responses between males and females, with males showing activation of multiple transcripts in the hypothalamus and pituitary within 10 minutes, while females respond through the pituitary and adrenal immediately and sustainably for over 40 minutes. MicroRNA alterations precede mRNA responses in the HPA axis, with robust changes in specific transcripts suggesting differential transcriptional control between males and females via signaling in the pituitary and blood. The HPA axis responses to ITT involve complex regulatory signaling pathways of miRNAs and mRNAs, highlighting key markers in the stress-induced dynamics of the HPA, HPG and GH axes.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Medicine, General & Internal
Sare Merve Basaga, Zeynep Ture, Gamze Kalin Unuvar, Gokmen Zararsiz, Orhan Yildiz, Bilgehan Aygen
Summary: The study found that 5.14% of asymptomatic individuals tested positive for COVID-19 through PCR testing before surgery/intervention, with higher positivity rates during peak periods. By calculating case incidence rates, the transmission time of the virus was estimated and the pandemic attenuation time was predicted.
Article
Multidisciplinary Sciences
Goezde Ertuerk Zararsiz, Serkan Bolat, Ahu Cephe, Necla Kochan, Serra Ilayda Yerlitas, Halef Okan Dogan, Goekmen Zararsiz
Summary: This study aimed to validate a new formula for LDL-C estimation proposed by Sampson in a Turkish population. Results showed that the extended Martin-Hopkins approach provided the most concordant results with direct assays. Further investigation on the validity of other formulas like Martin Hopkins' and Sampson's is needed in different populations.
Article
Medicine, Research & Experimental
Feyza Izci, Zeynep Ture, Gamze Kalin Unuvar, Burcu Baran Ketencioglu, Gokmen Zararsiz, Bilgehan Aygen, Orhan Yildiz
Summary: This study evaluated the demographic, clinical, and laboratory findings of symptomatic and asymptomatic patients with COVID-19. The findings showed that asymptomatic infections play a significant role in the spread of the disease. Therefore, it is crucial to identify and quarantine asymptomatic patients to prevent transmission and allow for early diagnosis of pre-symptomatic cases.
CYPRUS JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Clinical Neurology
BE. Sahin, A. Celikbilek, Y. Kocak, L. Hizmali
Summary: This study investigated the characteristics of COVID-19-related headache and their relationship with clinical severity. The results showed that bilateral, prolonged, moderate to severe headaches that were resistant to analgesics were more frequent in COVID-19 infected patients. Older age, high body mass index, and low education level were associated with greater severity of the disease. Female sex and being a healthcare worker were more common in milder cases.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Clinical Neurology
B. E. Sahin, A. Celikbilek, Y. Kocak, G. T. Saltoglu, N. M. Konar, L. Hizmali
Summary: This study examined the plasma levels of biomarkers GFAP and S100B in relation to persistent neurological symptoms in COVID-19 patients. The results showed that elevated GFAP levels were associated with disease severity but not with neurological symptoms, while high serum S100B levels were associated with multiple neurological symptoms.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Selahattin Baris Cay, Yusuf Ulas Cinar, Selim Can Kuralay, Behcet Inal, Gokmen Zararsiz, Almila Ciftci, Rachel Mollman, Onur Obut, Vahap Eldem, Yakup Bakir, Osman Erol
Summary: The Crocus istanbulensis is an endangered species with a limited distribution range in Istanbul. This study determined the complete chloroplast genome sequences of six C. istanbulensis individuals and found low genetic diversity among them. The findings provide valuable information for further research on the molecular evolution and conservation of this species.
Article
Cell Biology
Emel Koseoglu, Neslihan Sungur, Sabahattin Muhtaroglu, Gokmen Zararsiz, Ahmet Eken
Summary: This study suggests that teriflunomide may be a beneficial treatment for myasthenia gravis, as it reduces disease symptoms, immune cell numbers, and selectively affects specific antibodies.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Virology
Burc E. Sahin, Asuman Celikbilek, Yusuf Kocak, Bilal Ilanbey, Gamze T. Saltoglu, Naime M. Konar, Lokman Hizmali
Summary: This study examined the levels of neuron-specific enolase (NSE) and neurofilament light chain (NFL) in the plasma of patients with COVID-19 and neurological symptoms. The results showed that high serum levels of NSE were associated with disease severity, while serum NFL levels may play a role in the subacute phase of COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Cell Biology
Ismail Kocyigit, Serpil Taheri, Cihan Uysal, Mehmet Memis, Salih Guntug Ozayturk, Gokmen Zararsiz, Minoo Rassoulzadegan
Summary: The study aims to find markers for the development of Autosomal Dominant Polycystic Kidney Disease (ADPKD) to track the disease's epigenetic changes. The study found that the length of telomeres was shortened and the expression levels of TERRA increased in ADPKD patients with PKD1 and PKD2 mutations compared to controls. Furthermore, ADPKD patients with rapid disease progression had higher expression levels of TERRA engaged in the R-loop and shorter telomeres.
Article
Clinical Neurology
Burc Esra Sahin, Asuman Celikbilek, Yusuf Kocak, Aydan Koysuren, Lokman Hizmali
Summary: This study found a significant relationship between neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) with neurological symptoms (NS) in COVID-19 patients. Advanced age, higher body mass index, and comorbidities were more common in severe cases. However, in the multivariate model, NLR and PLR were not independently associated with disease severity.
JOURNAL OF NEUROSCIENCES IN RURAL PRACTICE
(2023)
Article
Multidisciplinary Sciences
Vahap Eldem, Goekmen Zararsiz, Melike Erkan
Summary: Studying the ovarian transcriptome profile of European anchovy provides insights into the molecular processes of oocyte development. RNA sequencing revealed 535 genes potentially involved in oogenesis and associated with various cellular and molecular functions. These functions include RNA methylation and modification, ribosome biogenesis, DNA repair, cell cycle processing, and peptide/amide biosynthesis.
Article
Clinical Neurology
Celikbilek Asuman, Koysuren Aydan, Konar Naime Meric
Summary: This study investigated the association between serum vitamin D levels, pre-stroke sleep quality, and the occurrence of poststroke depression and anxiety in acute ischemic stroke patients. The results showed that decreased serum vitamin D levels at admission were associated with a higher risk for poststroke depression and anxiety in patients with poor pre-stroke sleep quality during the early stages of acute ischemic stroke.
SLEEP AND BREATHING
(2023)
Article
Nutrition & Dietetics
Seda Kaya, Zeynep Uzdil, Gokmen Zararsiz, Pinar Sokulmez Kaya, Murat Terzi
Summary: This study investigated the relationship between anxiety and nutritional habits during the Coronavirus disease 2019 outbreak in multiple sclerosis patients, and found that anxiety led to changes in multiple sclerosis patients' nutritional habits and food preferences.
REVISTA DE NUTRICAO-BRAZILIAN JOURNAL OF NUTRITION
(2022)