Article
Multidisciplinary Sciences
Hoda Gad, Ibrahim Mohammed, Saras Saraswathi, Bara Al-Jarrah, Maryam Ferdousi, Ioannis N. Petropoulos, Georgios Ponirakis, Adnan Khan, Parul Singh, Souhaila Al Khodor, Mamoun Elawad, Wesam Almasri, Hatim Abdelrahman, Khalid Hussain, Mohamed A. Hendaus, Fatma Al-Mudahka, Khaled Abouhazima, Anthony K. Akobeng, Rayaz A. Malik
Summary: This study aims to investigate whether quantification of corneal Langerhans cells (LCs) using corneal confocal microscopy (CCM) can serve as a surrogate marker for antigen presenting cell status and disease activity in children with CeD. The results showed no difference in LC density between the CeD group and the control group, but LC density correlated with anti-TtG levels.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Rakel Nurmi, Ilma Korponay-Szabo, Kaija Laurila, Heini Huhtala, Onni Niemela, Jukka Mustonen, Satu Makela, Katri Kaukinen, Katri Lindfors
Summary: IgA-tTG deposits were found in the kidney biopsies of IgAN patients with celiac disease and non-celiac IgAN patients consuming gluten, suggesting limited specificity to celiac disease.
Article
Nutrition & Dietetics
Giulia N. Catassi, Alfredo Pulvirenti, Chiara Monachesi, Carlo Catassi, Elena Lionetti
Summary: The combination of DGP IgG and TTG IgA antibodies can improve the diagnostic sensitivity of celiac disease in children under 2 years of age, although TTG IgA has higher specificity.
Review
Medicine, General & Internal
Gabriela V. Flores Monar, Hamza Islam, Sri Madhurima Puttagunta, Rabia Islam, Sumana Kundu, Surajkumar B. Jha, Ana P. Rivera, Ibrahim Sange
Summary: Type 1 diabetes mellitus and celiac disease are two common related autoimmune disorders that share a common genetic background, and celiac disease has been found to be an independent risk factor for diabetes. Celiac disease is often asymptomatic but can lead to growth retardation and anemia. Gluten may be the primary trigger for these autoimmune responses.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Hossein Moravej, Daniel Zamanfar, Fatemeh Aghamahdi, Mahin Hashemipour, Fatemeh Sadat Mirrashidi, Nosrat Ghaemi, Peyman Eshraghi, Homa Ilkhanipoor, Anis Amirhakimi, Negar Yazdani, Samaneh Noroozi Asl, Somayyeh Hashemian, Atefeh Raoofat, Majid Vares Vazirian, Hadis Ebrahimzadeh
Summary: This study evaluated the optimal interval and frequency of screening tests for CD among patients with T1DM. Results showed that CD was diagnosed at different stages after the onset of diabetes. It was concluded that screening tests for CD should continue for at least eight years, especially for patients affected at a younger age.
PRIMARY CARE DIABETES
(2021)
Article
Pharmacology & Pharmacy
E. Kostopoulou, M. Lagadinou, A. Avgeri, A. Varvarigou
Summary: The case report describes a 12-year-old female patient with T1DM who was diagnosed with CD three years after experiencing glucose dysregulation, suggesting that CD enteropathy may precede positive serology and could cause severe glucose dysregulation in patients with T1DM. Compliance to a gluten-free diet resulted in improved glucose control and sero-negativity 9 months post diagnosis.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Mara Cerqueiro Bybrant, Elin Uden, Filippa Frederiksen, Anna L. Gustafsson, Carl-Goran Arvidsson, Anna-Lena Fureman, Gun Forsander, Helena Elding Larsson, Sten A. Ivarsson, Marie Lindgren, Johnny Ludvigsson, Claude Marcus, Auste Pundziute Lycka, Martina Persson, Ulf Samuelsson, Stefan Sarnblad, Karin Akesson, Eva Ortqvist, Annelie Carlsson
Summary: Children with type 1 diabetes who have tissue transglutaminase antibodies greater than or equal to 10 times the upper limit of normal are highly likely to have celiac disease, indicating a strong relationship between the two conditions.
PEDIATRIC DIABETES
(2021)
Article
Medicine, Research & Experimental
Lola Giner-Perez, Ester Donat, Paula Sinisterra-Sebastian, Etna Masip, Veronica Ballester, Begona Polo, Carmen Ribes-Koninckx, Maria Roca
Summary: This study aims to analyze the decreasing dynamics of IgG anti-tTG in CD patients who start a GFD. The results show that the normalization rates of IgG anti-tTG are slower for SIgAD CD patients compared to IgA competent CD patients, while IgA anti-tTG reaches lower values in a higher proportion of IgA competent patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, General & Internal
Chloe Girard, Aurelie De Percin, Carole Morin, Maeva Talvard, Francoise Fortenfant, Nicolas Congy-Jolivet, Claire Le Tallec, Jean-Pierre Olives, Emmanuel Mas
Summary: The purpose of this study was to determine the prevalence of celiac disease (CD) in children with type 1 diabetes (T1D) using the latest guidelines and avoiding intestinal biopsies. The study found a 4.8% prevalence of CD in 663 T1D children, with 95% of them expressing HLA-DQ2 and/or -DQ8 genes. Screening for CD is recommended for all patients, and regular TGA assessment is necessary for T1D patients who are genetically predisposed.
MEDICINA-LITHUANIA
(2023)
Article
Endocrinology & Metabolism
Peizhi Deng, Zhixin Li, Bin Yi, Yiping Leng
Summary: This study conducted a Mendelian randomization analysis to explore the relationship between T1DM and IgAN. The analysis provided evidence that T1DM may be a risk factor for the onset of IgAN, potentially driven by LDL-c. Strategies targeting LDL-c should be enhanced in T1DM patients to prevent IgAN.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Chiara Maria Trovato, Monica Montuori, Andrea Sansone, Annalisa Morelli, Giusy Russo, Nicoletta Pietropaoli, Salvatore Oliva
Summary: The study found that a high proportion of children with celiac disease had absent seroconversion to hepatitis B vaccine at the time of diagnosis. Factors such as elevated TGA-IgA titers and older age at diagnosis were associated with non-protective antibody titers against HBV.
Article
Medical Laboratory Technology
Mariam Ghozzi, Dorra Souguir, Sarra Melayah, Skander Abidi, Mariem Faleh, Ibtissem Ghedira
Summary: The study indicates a high frequency of type 1 diabetes antibodies in adult patients with active celiac disease. Screening for type 1 diabetes in this population, at risk for other autoimmune diseases, may be beneficial.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Gastroenterology & Hepatology
Francesco Valitutti, Maureen M. Leonard, Victoria Kenyon, Monica Montuori, Pasqua Piemontese, Ruggiero Francavilla, Basilio Malamisura, Lorenzo Norsa, Angela Calvi, Maria Elena Lionetti, Mariella Baldassarre, Chiara Maria Trovato, Michela Perrone, Tiziana Passaro, Naire Sansotta, Marco Crocco, Annalisa Morelli, Lidia Celeste Raguseo, Federica Malerba, Luca Elli, Fernanda Cristofori, Carlo Catassi, Alessio Fasano, CD-GEMM Team
Summary: The purpose of this study was to identify potential serum biomarkers predicting the onset of celiac disease (CD) in at-risk children. The results showed that 73.6% of the children had an increase in anti-deamidated gliadin peptides (DGPs) IgG levels before their first seroconversion of anti-tissue transglutaminase (anti-tTG) IgA antibodies, indicating that anti-DGPs IgG may serve as an early preclinical biomarker predicting CD onset in children.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medical Laboratory Technology
Daan A. R. Castelijn, A. H. Leontine Mulder, Pieter van der Pol, Jolien C. Hollander, Tietie Kuiper, Caroline Bijnens, Jan Damoiseaux, Hetty J. Bontkes
Summary: This study compared the diagnostic performance of three tTG-IgA assay methods for the diagnosis of celiac disease. The results showed that the chemiluminescence immunoassays (CLIA) were more sensitive compared to the fluorescence enzyme-linked immunoassay (FEIA). Lowering the cut-off threshold of the FEIA improved its diagnostic accuracy in adult cases. There were also differences in tTG-IgA levels between different age groups of patients.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Araz Rawshani, Naveed Sattar, Darren K. McGuire, Oskar Wallstrom, Ulf Smith, Jan Boren, Goran Bergstrom, Elmir Omerovic, Annika Rosengren, Bjorn Eliasson, Deepak L. Bhatt, Aidin Rawshani
Summary: The study found that the incidence of valvular disease is increasing among patients with diabetes. In type 2 diabetes, systolic blood pressure, body mass index, and renal function were found to be associated with valvular lesions.
Article
Allergy
Emanuela Duca, Genel Sur, Ionel Armat, Gabriel Samasca, Lucia Sur
Summary: This study found that serum IL-31 levels were elevated in children with atopic dermatitis, and were positively correlated with disease severity and activity.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2022)
Article
Medicine, General & Internal
Melinda Matyas, Monica Hasmasanu, Ciprian N. Silaghi, Gabriel Samasca, Iulia Lupan, Kovacs Orsolya, Gabriela Zaharie
Summary: The study reveals that early preeclampsia increases the risk of complications in preterm neonates and is correlated with hematological changes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ioana S. Barac, Mihaela Iancu, Vitalie Vacaras, Angela Cozma, Vasile Negrean, Dorel Sampelean, Dafin F. Muresanu, Lucia M. Procopciuc
Summary: The study revealed a significant association between IL-27-A964G and IL-27-T4730C polymorphisms and increased risk of MS, as well as the protective role of the IL-23-R381Q polymorphism. The G-C (A924G, T4730C) haplotype was identified as a significant risk haplotype for the development of MS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Liliana Gozar, Mihaela Iancu, Horea Gozar, Anca Sglimbea, Andreea Cerghit Paler, Dorottya Gabor-Miklosi, Rodica Toganel, Amalia Fagarasan, Diana Ramona Iurian, Daniela Toma
Summary: The aim of this study was to compare the strain values of infants with severe and critical pulmonary stenosis (PS) with controls, both globally and regionally, and to assess the correlations between strain and conventional parameters. The results showed a significant difference in regional strain values between PS patients and controls. There were also significant changes in strain values from basal to apical location. However, there was no significant difference in strain values before and after intervention in PS patients. The study emphasizes the importance of using strain analysis, specifically RV global-4-chamber longitudinal strain, for evaluating RV function in infants with severe and critical PS.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biology
Andreea Crintea, Alina Gabriela Dutu, Anne-Marie Constantin, Zsolt Fekete, Gabriel Samasca, Iulia Lupan, Ioan Alexandru Florian, Ciprian Nicolae Silaghi, Alexandra Marioara Craciun
Summary: This study aimed to investigate the serum concentration of MGP, Gas6, and EGFR in lung cancer patients before and after the first cycle of chemotherapy, and to study how MGP, Gas6, and EGFR are modified after one cycle of chemotherapy. The results showed that there were no significant changes in the serum levels of MGP, Gas6, Vitamin K-1, and EGFR after the first cycle of chemotherapy. However, there was a strong positive correlation between MGP and VitK(1) serum values, and a moderate negative correlation between VitK(1) and EGFR in pre-treatment patients.
Article
Pediatrics
Maria Lucia Sur, Ionel Armat, Genel Sur, Diana-Cristina Pop, Gabriel Samasca, Iulia Lupan, Teodora-Larisa Timis, Ioan-Alexandru Florian, Daniel Sur
Summary: Neurofibromatosis has three types, associated with benign tumors of the skin and nervous system. In rare cases, malignant tumors may also occur. Distinguishing between the types is crucial for diagnosis and treatment. Neurofibromin, a product of the NF1 gene, inhibits cellular proliferation and could be a therapeutic target for tumor management.
Review
Physiology
Madalina Adriana Bordea, Carmen Costache, Alina Grama, Alexandru Ioan Florian, Iulia Lupan, Gabriel Samasca, Diana Deleanu, Peter Makovicky, Pavol Makovicky, Kvetoslava Rimarova
Summary: Kawasaki disease is a systemic vasculitis that mainly affects children under the age of five. Its main complications are coronary artery aneurysms and myocarditis. The exact cause is not fully understood, but genetic, infectious, and autoimmune factors are believed to play a role. There are similarities between Kawasaki-like syndrome associated with COVID-19 and Kawasaki disease, but the role of cytokines in its development is controversial. Accurate diagnosis and treatment of Kawasaki disease and Kawasaki-like syndrome are challenging.
PHYSIOLOGICAL RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Andreea Crintea, Alina Gabriela Dutu, Alina Sovrea, Anne-Marie Constantin, Gabriel Samasca, Aurelian Lucian Masalar, Brigitta Ifju, Eugen Linga, Lidia Neamti, Rares Andrei Tranca, Zsolt Fekete, Ciprian Nicolae Silaghi, Alexandra Marioara Craciun
Summary: Mounting evidence suggests that nanocarriers have great potential for the transportation of vitamin D and K in the treatment of various diseases. Nanotechnology-based dietary supplements and drugs can enhance the bioavailability of vitamins and overcome issues associated with traditional vitamin administration.
Article
Health Care Sciences & Services
Claudia Banescu, Florin Tripon, Anca S. Bojan, Adrian P. Trifa, Carmen Muntean, George Andrei Crauciuc, Alina Boglis, Marcela Candea, Erzsebet Lazar, Laura Jimbu, Mihaela Iancu
Summary: This study aimed to evaluate the impact of single nucleotide polymorphisms (SNPs) of Toll-like receptor (TLR) genes on the risk of developing acute myeloid leukemia (AML) and its relation to somatic mutations, clinical features, and overall survival of adult AML patients. The results showed that TLR4 rs4986791 is associated with an increased risk of AML, and combined variant genotypes of TLR4 rs4986790 and rs4986791 further increase the risk. The TLR9 C-G-A haplotype may be a promising approach for predicting AML susceptibility.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Environmental Sciences
Daniela Toma, Rodica Toganel, Amalia Fagarasan, Manuela Cucerea, Dorottya Gabor-Miklosi, Andreea Cerghit-Paler, Diana-Ramona Iurian, Horea Gozar, Elena Moldovan, Mihaela Iancu, Liliana Gozar
Summary: The study aimed to establish reference intervals and reproducibility levels for myocardial function assessment in full-term newborns using 2D speckle-tracking echocardiography for longitudinal and regional strain measurements. The results showed that peak longitudinal LV and RV strains have good to excellent agreement, which may serve as a possible alternative for cardiac assessment in healthy newborns in clinical practice.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Kvetoslava Rimarova, Gabriel Samasca, Pavol Makovicky, Petra Zakova, Iulia Lupan, Erik Dorko, Jana Diabelkova, Livia Kanukova, Andrej Jenca, Adriana Petrasova, Dana Klukova, Ciprian Silaghi, Peter Makovicky
Summary: This article explores the relationships between celiac disease (CD) and non-celiac gluten sensitivity (NCGS), finding that both conditions have similar genetic backgrounds and can develop into serious autoimmune diseases. Animal models help to understand disorders associated with gastrointestinal damage.
CENTRAL EUROPEAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Daniela Toma, Dorottya Gabor-Miklosi, Andreea Cerghit-Paler, Carmen Corina Suteu, Marius-Catalin Cosma, Claudiu Marginean, Mihaela Iancu, Liliana Gozar
Summary: This study compared myocardial function between neonates with transposition of great arteries (TGA) and neonates without TGA. LVpGLS was found to be a parameter with a significant discriminatory ability for LV dysfunction, and it is useful in evaluating ventricular myocardial function in newborns with TGA.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Ioana Badiu Tisa, Lia Pepelea, Alexandru Pirvan, Iulia Lupan, Gabriel Samasca, Madalina Adriana Bordea
Summary: This study aims to determine the incidence and endoscopic grading of corrosive esophagitis in children in a developing country. A retrospective analysis of pediatric patients admitted for corrosive ingestion over 10 years was conducted. The study revealed a low incidence of corrosive esophagitis and emphasized the importance of endoscopic grading in predicting late complications like strictures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Lucia Maria Sur, Ionel Armat, Genel Sur, Ioana Badiu Tisa, Madalina Adriana Bordea, Iulia Lupan, Gabriel Samasca, Calin Lazar
Summary: Upper gastrointestinal bleeding is a potentially life-threatening condition in children, with causes varying by age. The impact on the child is often related to the amount of blood lost, ranging from mild to severe cases requiring intensive care unit admission. This article aims to summarize current research on the diagnosis and treatment of upper gastrointestinal bleeding in children.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Radek Matlach, Maria Makovicka, Maria Miklosova, Pavol Makovicky, Jozef Muri, Kvetoslava Rimarova, Gabriel Samasca, Patricie Michalcova, Peter Makovicky
Summary: This article discusses the topic of suicides, with a focus on the mechanisms and realization of suicides by mentally ill individuals. Through the analysis of ten suicide cases, differences have been identified between victims with and without mental disorders in terms of the ways they choose to end their lives. Prevention of suicides in cases of people with a history of mental disorders is based on medical treatment and cooperation between the client, family members, and a psychiatrist.
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
(2023)
