Article
Oncology
Alexandra Q. Bartlett, Nathan D. Pennock, Alex Klug, Pepper Schedin
Summary: This study discusses the mechanisms of breast cancer cells invading the liver and forming metastatic niches. The research found that the process of liver involution increases liver metastasis, which is associated with unique immunological properties in the involuting liver.
Article
Biochemistry & Molecular Biology
Qiaoyun Hou, Shuohua Chen, Qi An, Boya Li, Yan Fu, Yongzhang Luo
Summary: The study confirms plasma Hsp90 alpha as a biomarker for breast cancer, providing insights into its prognostic value across different clinical stages, and suggests that eHsp90 alpha plays a role in promoting lymphangiogenesis in breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xinzhao Wang, Zhaoyun Liu, Jujie Sun, Xiang Song, Mengxue Bian, Fukai Wang, Feng Yan, Zhiyong Yu
Summary: Nox4 is a factor that promotes lymphangiogenesis, potentially by attracting breast cancer cells to enter lymphatic vessels and distant organs via the ROS/ERK/CCL21 pathway. Inhibition of Nox4 can reduce tumor lymphangiogenesis and metastasis.
Article
Peripheral Vascular Disease
Anqi Li, Linyu Zhu, Ningjing Lei, Jiajia Wan, Xixi Duan, Shuangqing Liu, Yanru Cheng, Ming Wang, Zhuoyu Gu, Huilei Zhang, Yueyue Bai, Li Zhang, Fazhan Wang, Chen Ni, Zhihai Qin
Summary: The expression of S100A4 in lymphatic endothelial cells promotes lymphatic vessel sprouting in growing tumors by regulating glycolysis. S100A4 plays a crucial role in the position and motility of tip cells, and its expression is upregulated under hypoxic conditions. These findings suggest that S100A4 is a novel regulator of tumor-induced lymphangiogenesis.
Article
Oncology
Emilly S. Villodre, Xiaoding Hu, Richard Larson, Pascal Finetti, Kristen Gomez, Wintana Balema, Shane R. Stecklein, Ginette Santiago-Sanchez, Savitri Krishnamurthy, Juhee Song, Xiaoping Su, Naoto T. Ueno, Debu Tripathy, Steven Van Laere, Francois Bertucci, Pablo Vivas-Mejia, Wendy A. Woodward, Bisrat G. Debeb
Summary: The study found that lipocalin 2 (LCN2) is expressed at significantly higher levels in inflammatory breast cancer (IBC) and is associated with poor prognosis features and shorter overall survival in IBC patients. Depletion of LCN2 can inhibit aggressive behavior of IBC cells in vivo and suppress tumor growth and invasion in mouse models of IBC. Analysis of proteomics data showed reduced expression of proteins involved in cell cycle and DNA repair in LCN2-silenced IBC cells, indicating LCN2 promotes IBC tumor aggressiveness and could be a potential therapeutic target for IBC.
MOLECULAR ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tingting Zhu, Zhangding Wang, Tianhui Zou, Lei Xu, Shu Zhang, Yali Chen, Chen Chen, Weijie Zhang, Shouyu Wang, Qingqing Ding, Guifang Xu
Summary: Metabolic reprogramming is a hallmark of malignancies such as gastric cancer, with the rate-limiting enzyme SOAT1 identified as highly expressed in cancerous tissues and associated with advanced tumor stage and lymph node metastasis. Inhibition of SOAT1 suppresses GC cell proliferation, cholesterol ester synthesis, and lymphangiogenesis, while overexpression promotes these processes by regulating cholesterol metabolism genes. Therefore, SOAT1 may serve as a promising prognostic biomarker for guiding clinical management and treatment decisions in gastric cancer.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Rong Deng, Hai-Liang Zhang, Jun-Hao Huang, Rui-Zhao Cai, Yan Wang, Yu-Hong Chen, Bing-Xin Hu, Zhi-Peng Ye, Zhi-Ling Li, Jia Mai, Yun Huang, Xuan Li, Xiao-Dan Peng, Gong-Kan Feng, Jun-Dong Li, Jun Tang, Xiao-Feng Zhu
Summary: ULK1 deficiency impairs mitophagy in breast cancer cells under hypoxia, leading to accumulation of damaged mitochondria, NLRP3 inflammasome activation, and bone metastasis. Phosphorylation of ULK1 triggers its degradation, and a negative correlation between ULK1 expression levels and p-MAPK1/3 was observed. The use of MAP2K/MEK inhibitor trametinib can restore mitophagy function and inhibit NLRP3 inflammasome activation to reduce bone metastasis.
Article
Biochemistry & Molecular Biology
Jiajun Shi, Qianyi Zhang, Xi Yin, Jiahui Ye, Shengqing Gao, Chen Chen, Yaxuan Yang, Baojuan Wu, Yuping Fu, Hongmei Zhang, Zhangding Wang, Bo Wang, Yun Zhu, Hongyan Wu, Yongzhong Yao, Guifang Xu, Qiang Wang, Shouyu Wang, Weijie Zhang
Summary: Metastasis in breast cancer is strongly related to N6-methyladenosine (m6A) modification and its associated regulators, particularly the overexpression of m6A reader IGF2BP1. Mechanistically, the study identified USP10 as the deubiquitinase for IGF2BP1 and established its role in stabilizing IGF2BP1, leading to increased breast cancer metastasis. Furthermore, IGF2BP1 directly recognized and bound to m6A sites on CPT1A mRNA, enhancing its stability and mediating breast cancer metastasis. Clinically, high levels of USP10, IGF2BP1, and CPT1A were associated with poor outcomes in breast cancer patients. These findings indicate the potential of the USP10/IGF2BP1/CPT1A axis as a prognostic biomarker and therapeutic target for breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Medical Laboratory Technology
Wanjun Li, Zhiwei Zhang, Baiyun Wang, Na Liang, Qier Zhou, Songkai Long
Summary: Breast cancer is among the most common cancers in women worldwide, and miRNAs and COX-2 are new diagnostic and therapeutic biomarkers for monitoring BC. COX-2 is associated with tumor growth and metastasis, while MiRs show differential expression in breast tumor tissue. Understanding the pathway between miRNAs and COX-2 can lead to the development of new therapeutic approaches for BC.
CLINICA CHIMICA ACTA
(2021)
Article
Cell Biology
Fan Li, Huizhi Sun, Yihui Yu, Na Che, Jiyuan Han, Runfen Cheng, Nan Zhao, Yuhong Guo, Chongbiao Huang, Danfang Zhang
Summary: In this study, it was found that RIPK1-dependent necroptosis promoted vasculogenic mimicry (VM) formation in triple-negative breast cancer (TNBC). The activation of RIPK1/p-AKT/eIF4E signaling pathway played a role in this process. Furthermore, eIF4E promoted epithelial-mesenchymal transition (EMT) and MMP2 expression and activity, contributing to VM formation. The findings suggest potential therapeutic targets for TNBC through necroptosis-mediated VM.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Qianyu Guo, Margarita Bartish, Christophe Goncalves, Fan Huang, Julian Smith-Voudouris, Sai Sakktee Krisna, Samuel E. J. Preston, Audrey Emond, Vivian Z. Li, Claudia U. Duerr, Yirui Gui, Aurelie Cleret-Buhot, Pamela Thebault, Hanne Lefrere, Liesbeth Lenaerts, Dany Plourde, Jie Su, Barbara C. Mindt, Shannon A. Hewgill, Tiziana Cotechini, Charles C. T. Hindmarch, William Yang, Elie Khoury, Yao Zhan, Valeria Narykina, Yuhong Wei, Giuseppe Floris, Mark Basik, Frederic Amant, Daniela F. Quail, Rejean Lapointe, Jorg H. Fritz, Sonia del Rincon, Wilson H. Miller
Summary: In postpartum breast cancer (PPBC), inhibition of the MNK1/2-eIF4E axis can reduce lung metastasis and impact the tumor and lung immune microenvironment; the repression of IL33 production and enhancing the efficacy of anti-PD-1 immunotherapy by blocking phospho-eIF4E are potential therapeutic approaches.
Review
Oncology
Yuting Li, Xiaofan Gao, Yibao Huang, Xiaoran Zhu, Yingying Chen, Liru Xue, Qingqing Zhu, Bo Wang, Mingfu Wu
Summary: Although previous studies have revealed the etiology of cervical cancer, metastasis still remains the main cause of poor prognosis and high cancer-related mortality. Close communication between cervical cancer cells and immune cells in the tumor microenvironment (TME) has been shown to promote metastatic dissemination. Understanding the mechanisms of tumor metastasis is crucial for the development of effective therapies. This review interprets various characteristics of the TME that contribute to lymphatic metastasis of cervical cancer, and summarizes the complex interactions between tumor cells and immune cells, as well as potential therapeutic strategies to target the TME.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Xiang Xu, Na Li, Yugang Wang, Jinming Yu, Jun Mi
Summary: The upregulation of calcium channel TRPV6 is associated with poor prognosis in breast cancer by promoting invasion and metastasis, making it a potential target for therapy. TRPV6 expression is increased in metastatic breast cancers, accelerating primary breast cancer cell migration. Mechanistically, TRPV6 activates NFATC2 through NFATC2IP phosphorylation, leading to increased breast cancer metastasis via upregulation of ADAMTS6 expression.
Article
Cell Biology
Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou, Qiang Sun
Summary: The study identified miR-7641 as a key miRNA in cancer-derived exosomes promoting tumor progression and metastasis via intercellular communication. Exosomal miR-7641 may serve as a non-invasive diagnostic biomarker and potential therapeutic target in breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Peripheral Vascular Disease
Xiao-Jing Chen, Wen-Fei Wei, Zi-Ci Wang, Nisha Wang, Chu-Hong Guo, Chen-Fei Zhou, Luo-Jiao Liang, Sha Wu, Li Liang, Wei Wang
Summary: A novel lymphatic pattern LVEM encapsulating lymphatic vessels by TAMs in the hypoxic TME promotes metastasis of CSCC. IL-10 derived from hypoxic TAMs induces Sp1 upregulation in LECs, facilitating LVEM formation and a positive feedback loop that strengthens LNM. Knockdown of Sp1 or blockage of CCL1 disrupts LVEM formation and attenuates LNM.
Editorial Material
Gastroenterology & Hepatology
Leisha D. Nolen, Stephen M. Vindigni, Julie Parsonnet, Michael G. Bruce, Holly A. Martinson, Timothy K. Thomas, Frank Sacco, Sarah Nash, Matthew J. Olnes, Karen Miernyk, Dana Bruden, Maya Ramaswamy, Brian McMahon, Karen J. Goodman, Adam J. Bass, Chin Hur, Manami Inoue, M. Constanza Camargo, Soo-Jeong Cho, Kalani Parnell, Elizabeth Allen, Tina Woods, Stephanie Melkonian
Article
Oncology
Holly A. Martinson, Dominic Mallari, Christine Richter, Tsung-Teh Wu, James Tiesinga, Steven R. Alberts, Matthew J. Olnes
Article
Nursing
Courtney B. Betts, Alexandra Quackenbush, Weston Anderson, Nicole E. Marshall, Pepper J. Schedin
JOURNAL OF HUMAN LACTATION
(2020)
Article
Oncology
Sonali Jindal, Jayasri Narasimhan, Virginia F. Borges, Pepper Schedin
Article
Pharmacology & Pharmacy
Alexandra Francian, Ashley Widmer, Troy Olsson, Marisabel Ramirez, Darion Heald, Keaton Rasic, Luke Adams, Holly Martinson, Max Kullberg
Summary: The researchers have developed C3-liposomes that activate antigen presenting cells (APCs) and induce immune responses, demonstrating their ability to reduce tumor growth in a mouse model.
JOURNAL OF DRUG TARGETING
(2021)
Article
Oncology
Sonali Jindal, Nathan D. Pennock, Alex Klug, Jayasri Narasimhan, Andrea Calhoun, Michelle R. Roberts, Rulla M. Tamimi, A. Heather Eliassen, Sheila Weinmann, Virginia F. Borges, Pepper Schedin
Review
Biotechnology & Applied Microbiology
Matthew J. Olnes, Holly A. Martinson
Summary: Gastric cancer (GC) is the third leading cause of cancer mortality worldwide, and while surgery is a cure for localized cases, most patients present with advanced non-operable disease. Recent advances in understanding the molecular and immune pathogenesis of GC have led to the development of novel therapeutics, including immune checkpoint inhibitors and chimeric antigen receptor T-cell therapies, offering new treatment options for select patients with GC.
CANCER GENE THERAPY
(2021)
Review
Oncology
Sarah M. Bernhardt, Virginia F. Borges, Pepper Schedin
Summary: Clinical studies and animal models suggest that vitamin D may protect against breast cancer development, especially during postpartum mammary gland involution when short-term vitamin D intervention could be effective. While preclinical evidence supports this theory, further research is needed to determine its actual efficacy in humans.
CANCER PREVENTION RESEARCH
(2021)
Article
Oncology
Sanah N. Vohra, Andrea Walens, Alina M. Hamilton, Mark E. Sherman, Pepper Schedin, Hazel B. Nichols, Katherine E. Reeder-Hayes, Andrew F. Olshan, Michael Love, Melissa A. Troester
Summary: Breast cancers in recently postpartum women may have worse outcomes compared to nulliparous women. Parity has a dominant effect on tumor molecular features, while the effect of pregnancy recency is smaller. The immune cell scores are altered according to the time since last childbirth.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Biotechnology & Applied Microbiology
Duanchen Sun, Xiangnan Guan, Amy E. Moran, Ling-Yun Wu, David Z. Qian, Pepper Schedin, Mu-Shui Dai, Alexey Danilov, Joshi J. Alumkal, Andrew C. Adey, Paul T. Spellman, Zheng Xia
Summary: Scissor is a method that identifies cell subpopulations associated with a given phenotype from single-cell data, by quantifying the similarity between single cells and bulk samples, and optimizing a regression model with sample phenotype. Applied in lung cancer, melanoma, facioscapulohumeral muscular dystrophy, and Alzheimer's disease datasets, Scissor effectively identifies biologically and clinically relevant cell subpopulations.
NATURE BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Sonali Jindal, Nathan D. Pennock, Duanchen Sun, Wesley Horton, Michelle K. Ozaki, Jayasri Narasimhan, Alexandra Q. Bartlett, Sheila Weinmann, Paul E. Goss, Virginia F. Borges, Zheng Xia, Pepper Schedin
Summary: The study reveals that postpartum breast cancer has distinct gene expression characteristics compared to other breast cancers, with poorer prognosis, suggesting it to be a unique entity within young women's breast cancer.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Elena Shagisultanova, Dexiang Gao, Eryn Callihan, Hannah J. Parris, Betsy Risendal, Lisa M. Hines, Martha L. Slattery, Kathy Baumgartner, Pepper Schedin, Esther M. John, Virginia F. Borges
Summary: Postpartum breast cancer is associated with poorer overall survival in women under 45 years old, with a more pronounced survival difference seen in cases diagnosed under 35 years old.
EUROPEAN JOURNAL OF CANCER
(2022)
Editorial Material
Oncology
Pepper Schedin, Julie R. Palmer
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Biotechnology & Applied Microbiology
Zuzana Tatarova, Dylan C. Blumberg, James E. Korkola, Laura M. Heiser, John L. Muschler, Pepper J. Schedin, Sebastian W. Ahn, Gordon B. Mills, Lisa M. Coussens, Oliver Jonas, Joe W. Gray
Summary: Testing the combinations of cancer immunotherapies and conventional drugs has yielded promising results. This study utilized high-throughput and high-content techniques to investigate the effects of different treatment regimens on tumor cells and immune responses. Through in vivo studies in mouse models, effective combinations of therapies were identified, with the panobinostat, venetoclax, and anti-CD40 triple therapy showing the most significant tumor remission. The successful drug combinations increased the spatial association of cancer stem cells with dendritic cells during immunogenic cell death, suggesting a crucial mechanism for long-term breast cancer control.
NATURE BIOTECHNOLOGY
(2022)