Depleting tumor-specific Tregs at a single site eradicates disseminated tumors

Phase III randomized study of ipilimumab (IPI) plus dacarbazine (DTIC) versus DTIC alone as first-line treatment in patients with unresectable stage III or IV melanoma.

(2017) J. D. Wolchok et al.   JOURNAL OF CLINICAL ONCOLOGY

IL-12 Is Required for Anti-OX40-Mediated CD4 T Cell Survival

(2014) C. E. Ruby et al.   JOURNAL OF IMMUNOLOGY

Targeting Regulatory T Cells in Cancer

(2011) W. L. Byrne et al.   CANCER RESEARCH

TNF optimally activatives regulatory T cells by inducing TNF receptor superfamily members TNFR2, 4-1BB and OX40

(2011) Ryoko Hamano et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-12 Converts Foxp3+ Regulatory T Cells to Interferon–γ-Producing Foxp3+ T Cells That Inhibit Colitis

(2011) Ting Feng et al.   GASTROENTEROLOGY

Split Immunity: Immune Inhibition of Rat Gliomas by Subcutaneous Exposure to Unmodified Live Tumor Cells

(2011) Ilan Volovitz et al.   JOURNAL OF IMMUNOLOGY

Monoclonal antibodies in neuro-oncology

(2011) Lois A. Lampson   mAbs

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

(2011) Margarita Dominguez-Villar et al.   NATURE MEDICINE

Efficacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter single-arm phase II study

(2010) S. J. O'Day et al.   ANNALS OF ONCOLOGY

Control of Immunity by the TNFR-Related Molecule OX40 (CD134)

(2010) Michael Croft   Annual Review of Immunology

Chemotherapy rescues tumor-driven aberrant CD4+ T-cell differentiation and restores an activated polyfunctional helper phenotype

(2010) Z.-C. Ding et al.   BLOOD

Successful Treatment of Melanoma Brain Metastases with Adoptive Cell Therapy

(2010) J. J. Hong et al.   CLINICAL CANCER RESEARCH

Trafficking of immune cells in the central nervous system

(2010) Emma H. Wilson et al.   JOURNAL OF CLINICAL INVESTIGATION

In Situ Vaccination With a TLR9 Agonist Induces Systemic Lymphoma Regression: A Phase I/II Study

(2010) Joshua D. Brody et al.   JOURNAL OF CLINICAL ONCOLOGY

TNF Activates a NF- B-Regulated Cellular Program in Human CD45RA- Regulatory T Cells that Modulates Their Suppressive Function

(2010) M. Nagar et al.   JOURNAL OF IMMUNOLOGY

Firefly Luciferase–Based Dynamic Bioluminescence Imaging

(2010) Amy Sun et al.   NEUROSURGERY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Emerging Toxicity Profiles of Anti–CTLA-4 Antibodies Across Clinical Indications

(2010) Anna Maria Di Giacomo et al.   SEMINARS IN ONCOLOGY

Generation of CD8+ T cell-mediated immunity against idiotype-negative lymphoma escapees

(2009) B. Varghese et al.   BLOOD

T-regulatory cell modulation: the future of cancer immunotherapy?

(2009) S Nizar et al.   BRITISH JOURNAL OF CANCER

FOXP3 Defines Regulatory T Cells in Human Tumor and Autoimmune Disease

(2009) I. Kryczek et al.   CANCER RESEARCH

Differences in Tumor Regulatory T-Cell Localization and Activation Status Impact Patient Outcome

(2009) C. Menetrier-Caux et al.   CANCER RESEARCH

Interleukin 12 Stimulates IFN- -Mediated Inhibition of Tumor-Induced Regulatory T-Cell Proliferation and Enhances Tumor Clearance

(2009) X. Cao et al.   CANCER RESEARCH

A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Comparing the Tolerability and Efficacy of Ipilimumab Administered with or without Prophylactic Budesonide in Patients with Unresectable Stage III or IV Melanoma

(2009) J. Weber et al.   CLINICAL CANCER RESEARCH

Immunological considerations of modern animal models of malignant primary brain tumors

(2009) Michael E Sughrue et al.   Journal of Translational Medicine

Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study

(2009) Jedd D Wolchok et al.   LANCET ONCOLOGY

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy

(2008) R. Houot et al.   BLOOD

Phase I/II Study of Ipilimumab for Patients With Metastatic Melanoma

(2008) Jeffrey S. Weber et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer Immunotherapy — The Endgame Begins

(2008) Louis M. Weiner   NEW ENGLAND JOURNAL OF MEDICINE

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE