Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome

Promotion and maintenance of leukemia by ERG

(2011) S. Tsuzuki et al.   BLOOD

ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer

(2011) J. A. I. Thoms et al.   BLOOD

Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome

(2010) K. A. Alford et al.   BLOOD

The oncogenic role of the ETS transcription factors MEF and ERG

(2010) Goro Sashida et al.   CELL CYCLE

DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles

(2010) Sergi Aranda et al.   FASEB JOURNAL

Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis

(2010) J.-H. Klusmann et al.   GENES & DEVELOPMENT

miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia

(2010) J.-H. Klusmann et al.   GENES & DEVELOPMENT

Tumour angiogenesis is reduced in the Tc1 mouse model of Down’s syndrome

(2010) Louise E. Reynolds et al.   NATURE

Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome

(2010) S De Vita et al.   ONCOGENE

Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome

(2009) S. Malinge et al.   BLOOD

ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells

(2009) M. J. Stankiewicz et al.   BLOOD

Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models

(2009) M. G. Cornejo et al.   BLOOD

Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome

(2009) A. P. Ng et al.   BLOOD

Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: a multi-step model of myeloid leukaemogenesis

(2009) Anindita Roy et al.   BRITISH JOURNAL OF HAEMATOLOGY

ERG Is a Megakaryocytic Oncogene

(2009) S. Salek-Ardakani et al.   CANCER RESEARCH

Function and regulation of Dyrk1A: towards understanding Down syndrome

(2009) Joongkyu Park et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

MPLW515L mutation in acute megakaryoblastic leukaemia

(2009) K Hussein et al.   LEUKEMIA

GATA-2 Reinforces Megakaryocyte Development in the Absence of GATA-1

(2009) Z. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

(2009) Kwan-Hyuck Baek et al.   NATURE

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

(2009) J. O. Korbel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DYRK1A-Dosage Imbalance Perturbs NRSF/REST Levels, Deregulating Pluripotency and Embryonic Stem Cell Fate in Down Syndrome

(2008) Claudia Canzonetta et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Hematopoietic defects in the Ts1Cje mouse model of Down syndrome

(2008) C. L. Carmichael et al.   BLOOD

Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations

(2008) O. Tunstall-Pedoe et al.   BLOOD

Trisomy 21 enhances human fetal erythro-megakaryocytic development

(2008) S. T. Chou et al.   BLOOD

Activating mutations in human acute megakaryoblastic leukemia

(2008) S. Malinge et al.   BLOOD

Characterization of the human DYRK1A promoter and its regulation by the transcription factor E2F1

(2008) Barbara Maenz et al.   BMC MOLECULAR BIOLOGY

Regulation of Down Syndrome Critical Region 1 expression by Nuclear Factor of Activated T cells in megakaryocytes

(2008) Satu Kyttälä et al.   BRITISH JOURNAL OF HAEMATOLOGY

Targeted Deletion of the Calcineurin Inhibitor DSCR1 Suppresses Tumor Growth

(2008) Sandra Ryeom et al.   CANCER CELL

Trisomy represses Apc Min -mediated tumours in mouse models of Down’s syndrome

(2008) Thomas E. Sussan et al.   NATURE

Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome

(2007) G. Kirsammer et al.   BLOOD