Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

(2011) Florian Wiede et al.   JOURNAL OF CLINICAL INVESTIGATION

The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

(2011) Jinyi Zhang et al.   NATURE GENETICS

An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4+ T cells

(2010) S A Long et al.   GENES AND IMMUNITY

Increased Susceptibility to Dextran Sulfate Sodium Induced Colitis in the T Cell Protein Tyrosine Phosphatase Heterozygous Mouse

(2010) Syed-Wajahat Hassan et al.   PLoS One

CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells

(2009) Michelle L. Hermiston et al.   IMMUNOLOGICAL REVIEWS

T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease

(2009) Karen M. Doody et al.   IMMUNOLOGICAL REVIEWS

PTPN22 Deficiency Cooperates with the CD45 E613R Allele to Break Tolerance on a Non-Autoimmune Background

(2009) J. Zikherman et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling

(2009) A. F. Arechiga et al.   JOURNAL OF IMMUNOLOGY

Antigen receptor signaling in the rheumatic diseases

(2009) Julie Zikherman et al.   ARTHRITIS RESEARCH & THERAPY