Article
Immunology
Milena J. Tosiek, Kerstin Groesser, Anton Pekcec, Monika Zwirek, Gavuthami Murugesan, Eric Borges
Summary: CLEC5A is a pattern recognition receptor involved in the immune response to viral and bacterial infections. Its activation can lead to inflammation and is associated with disease severity. Activation of CLEC5A may induce phenotypic changes in macrophages, promoting inflammation or anti-inflammatory responses.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Immunology
Atul K. Verma, Michael McKelvey, Md Bashir Uddin, Sunil Palani, Meng Niu, Christopher Bauer, Shengjun Shao, Keer Sun
Summary: This study investigates the role of IFN-gamma receptor signaling in Acute Respiratory Distress Syndrome (ARDS) using a mouse model. By analyzing single-cell RNA sequencing data, the researchers find that IFN-gamma signaling induces transcriptional changes in airway immune cells, and conditional knockout mouse models reveal that it directly promotes excessive expression of inflammatory genes in myeloid cells, leading to inflammatory lung damage.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lorene J. Lebrun, Alois Dusuel, Marion Xolin, Naig Le Guern, Jacques Grober
Summary: The gastrointestinal tract acts as a critical barrier against gut microbiota and pathogens, and the activation of toll-like receptors (TLRs) plays a role in recognizing pathogen-associated molecular patterns (PAMPs). Glucagon-like peptide 1 (GLP-1), originally involved in glucose metabolism, has been found to be induced by luminal lipopolysaccharides (LPS) through TLR4 activation. This study shows that not only TLR4, but also other TLRs, can increase GLP-1 secretion, highlighting the importance of microbial-induced GLP-1 secretion in inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Min-Hee Yi, Yong U. Liu, Anthony D. Umpierre, Tingjun Chen, Yanlu Ying, Jiaying Zheng, Aastha Dheer, Dale B. Bosco, Hailong Dong, Long-Jun Wu
Summary: The study demonstrated that optogenetic activation of spinal microglia induced chronic pain hypersensitivity through increased neuronal activity via IL-1 signaling pathway.
Article
Multidisciplinary Sciences
Chenghua Yan, Wendong Kuang, Liang Jin, Rongliang Wang, Ling Niu, Chuanqi Xie, Jian Ding, Yongcui Liao, Liyuan Wang, Hongjiao Wan, Guangqiang Ma
Summary: Macrophages have a crucial role in sepsis development, and carvacrol, a phenolic compound, has anti-inflammatory activity. This study found that carvacrol reduced sepsis-induced body weight loss and damage to the liver, lung, and heart, inhibited the production of inflammatory cytokine IL-6, and improved survival in septic mice.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Fausto Chiazza, Heather Bondi, Irene Masante, Federico Ugazio, Valeria Bortolotto, Pier Luigi Canonico, Mariagrazia Grilli
Summary: Adolescence is a critical period for brain maturation, and unhealthy dietary patterns early in life can lead to inferior cognitive outcomes later on. This study focused on the effects of short-term hypercaloric diet on immature neurons in the hippocampus of adolescent mice. Results showed that high fat diet significantly reduced dendritic complexity of immature neurons in the dorsal hippocampus, which was reversed by switching back to a low fat diet.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Ya Zhang, Peidong Yuan, Xiaoping Ma, Qiming Deng, Jiangang Gao, Jianmin Yang, Tianran Zhang, Cheng Zhang, Wencheng Zhang
Summary: This study found that LGL1 inhibits VSMC proliferation and migration by promoting proteasomal degradation of STAT3, thereby suppressing neointimal hyperplasia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Samira Marx, Beate M. Kuemmerer, Christian Grutzner, Hiroki Kato, Martin Schlee, Marcel Renn, Eva Bartok, Gunther Hartmann
Summary: The therapeutic use of the RIG-I activator 3pRNA improves survival and reduces disease severity in mice infected with SARS-CoV-2. Mice treated with 3pRNA show lower viral load, reduced lung inflammation, and develop a specific neutralizing antibody response against SARS-CoV-2.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Biochemistry & Molecular Biology
Fuyao Wei, Hong Zhu, Na Li, Chunlei Yu, Zhenbo Song, Shuyue Wang, Ying Sun, Lihua Zheng, Guannan Wang, Yanxin Huang, Yongli Bao, Luguo Sun
Summary: Stevioside, a diterpenoid glycoside, shows anti-inflammatory activities by down-regulating pro-inflammatory cytokines and mediators in macrophages and increasing anti-inflammatory cytokines. It activates the AMPK pathway to attenuate LPS-induced inflammatory responses in both in vitro and in vivo models.
Article
Cell Biology
Runliu Wu, Jiao Liu, Nian Wang, Ling Zeng, Chunhua Yu, Feng Chen, Haichao Wang, Timothy R. Billiar, Jianxin Jiang, Daolin Tang, Rui Kang
Summary: This study identifies an unexpected role of aconitate decarboxylase 1 (ACOD1) in sepsis, showing that its accumulation in monocytes and macrophages leads to a robust proinflammation response through tumor necrosis factor signaling pathway. Additionally, the CDK2-ACOD1 axis is correlated with disease severity in sepsis patients.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Hua Bai, Cong-Wen Fang, Ying Shi, Song Zhai, An Jiang, Ying-Na Li, Lin Wang, Qi-Ling Liu, Geng-Yao Zhou, Jia-Hao Cao, Jia Li, Xue-Kang Yang, Xu-Jun Qin
Summary: Reactive oxygen species (ROS) are often considered toxic byproducts but recent studies have shown their signaling functions. In a mouse liver regeneration model, it was found that mitochondrial hydrogen peroxide (H2O2) played a crucial role in liver regeneration after partial hepatectomy (PHx). Activation of the FoxO3a signaling pathway impaired H2O2-triggered liver regeneration, while liver-specific knockdown of FoxO3a abolished the inhibition of liver regeneration by overexpression of mitochondria-targeted catalase (mCAT). These findings shed light on the redox-regulated mechanisms of liver regeneration and the potential therapeutic interventions for liver injury.
CELL DEATH & DISEASE
(2023)
Article
Environmental Sciences
Ge Yang, Cunyi Gong, Xinyue Zheng, Fei Hu, Jie Liu, Tian Wang, Xinyue Chen, Min Li, Zhihong Zhu, Ling Zhang, Rui Li
Summary: Studies have shown that exposure to microplastics and DEHP can individually cause neurotoxicity in animals. However, it is still uncertain whether co-exposure to these substances can also induce neurotoxicity and to what extent. This study investigated the neurotoxicity and molecular mechanisms of combined exposure to DEHP and polypropylene microplastics in immature mice. The results showed that exposure to these substances caused neurotoxic effects, including cognitive deficits, hippocampal damage, oxidative stress, and decreased brain enzyme activity.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Bara'ah Khaleel, Eitan Lunenfeld, Joseph Kapelushnik, Mahmoud Huleihel
Summary: Acute myeloid leukemia (AML) accounts for 20% of diagnosed childhood leukemia. Cytarabine (CYT) has been found to impair spermatogenesis in both human and rodents. In this study, an AML disease model was successfully developed in sexually immature mice. The results showed that AML treatment led to significant increases in monocytes and granulocytes in the immature mice, and AML cells were found in the blood vessels of the testes. AML and CYT treatments impaired the development of spermatogenesis in adult mice, with clear damage observed in the structure and histology of the seminiferous tubules. AML also decreased levels of growth factors, while CYT increased levels of certain growth factors. These findings suggest that AML and CYT affect the microenvironment of germ cells and can negatively impact fertility in adulthood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zhiguo Gong, Shuangyi Zhang, Baichen Gu, Jinshan Cao, Wei Mao, Yuan Yao, Jiamin Zhao, Peipei Ren, Kai Zhang, Bo Liu
Summary: This study demonstrated that Codonopsis pilosula polysaccharides (CPPS) have a protective effect on acute lung injury (ALI) induced by lipopolysaccharide (LPS) and Escherichia coli (E. coli) infection. CPPS can reduce the secretion of inflammatory molecules and the activation of signaling pathways, enhance bacterial phagocytosis, and inhibit bacterial growth. In addition, CPPS can attenuate lung damage in mice, reducing the production of tissue damage biomarkers.
Article
Endocrinology & Metabolism
Jelana Repac, Bojan Bozic, Biljana Bozic Nedeljkovic
Summary: This study explores the underestimated role of molecular mimicry in the etiology and progression of type 1 diabetes (T1D). The comprehensive immunoinformatics analysis of T1D-specific T-cell epitopes across bacterial, fungal, and viral proteomes reveals potential bacterial triggers and heat-shock proteins as the most potent autoantigens for T-cell priming via molecular mimicry. The re-analysis of T1D gut microbiota datasets suggests that the pre-T1D stage shows significant dysbiosis, indicating the importance of molecular mimicry in T1D.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Oncology
Amita Patnaik, S. Peter Kang, Drew Rasco, Kyriakos P. Papadopoulos, Jeroen Elassaiss-Schaap, Muralidhar Beeram, Ronald Drengler, Cong Chen, Lon Smith, Guillermo Espino, Kevin Gergich, Liliana Delgado, Adil Daud, Jill A. Lindia, Xiaoyun Nicole Li, Robert H. Pierce, Jennifer H. Yearley, Dianna Wu, Omar Laterza, Manfred Lehnert, Robert Iannone, Anthony W. Tolcher
CLINICAL CANCER RESEARCH
(2015)
Article
Biotechnology & Applied Microbiology
Robert H. Pierce, Jean S. Campbell, Sara I. Pai, Joshua D. Brody, Holbrook E. K. Kohrt
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2015)
Article
Biochemistry & Molecular Biology
C. Burkart, A. Mukhopadhyay, S. A. Shirley, R. J. Connolly, J. H. Wright, A. Bahrami, J. S. Campbell, R. H. Pierce, D. A. Canton
Article
Immunology
I. H. Chan, R. Jain, M. S. Tessmer, D. Gorman, R. Mangadu, M. Sathe, F. Vives, C. Moon, E. Penaflor, S. Turner, G. Ayanoglu, C. Chang, B. Basham, J. B. Mumm, R. H. Pierce, J. H. Yearley, T. K. McClanahan, J. H. Phillips, D. J. Cua, E. P. Bowman, R. A. Kastelein, D. LaFace
MUCOSAL IMMUNOLOGY
(2014)
Article
Multidisciplinary Sciences
Paul C. Tumeh, Christina L. Harview, Jennifer H. Yearley, I. Peter Shintaku, Emma J. M. Taylor, Lidia Robert, Bartosz Chmielowski, Marko Spasic, Gina Henry, Voicu Ciobanu, Alisha N. West, Manuel Carmona, Christine Kivork, Elizabeth Seja, Grace Cherry, Antonio J. Gutierrez, Tristan R. Grogan, Christine Mateus, Gorana Tomasic, John A. Glaspy, Ryan O. Emerson, Harlan Robins, Robert H. Pierce, David A. Elashoff, Caroline Robert, Antoni Ribas
Editorial Material
Immunology
Ian N. Crispe, Robert H. Pierce
Article
Biochemistry & Molecular Biology
Jonathan P. Sherlock, Barbara Joyce-Shaikh, Scott P. Turner, Cheng-Chi Chao, Manjiri Sathe, Jeff Grein, Daniel M. Gorman, Edward P. Bowman, Terrill K. McClanahan, Jennifer H. Yearley, Gerard Eberl, Christopher D. Buckley, Robert A. Kastelein, Robert H. Pierce, Drake M. LaFace, Daniel J. Cua
Article
Biochemistry & Molecular Biology
Anandaroop Mukhopadhyay, Jocelyn Wright, Shawna Shirley, David A. Canton, Christoph Burkart, Richard J. Connolly, Jean S. Campbell, Robert H. Pierce
Article
Oncology
Ingunn M. Stromnes, Adam L. Burrack, Ayaka Hulbert, Patrick Bonson, Cheryl Black, J. Scott Brockenbrough, Jackson F. Raynor, Ellen J. Spartz, Robert H. Pierce, Philip D. Greenberg, Sunil R. Hingorani
CANCER IMMUNOLOGY RESEARCH
(2019)
Article
Oncology
Samantha K. Greaney, Alain P. Algazi, Katy K. Tsai, Kathryn T. Takamura, Lawrence Chen, Christopher G. Twitty, Li Zhang, Alan Paciorek, Robert H. Pierce, Mai H. Le, Adil Daud, Lawrence Fong
CANCER IMMUNOLOGY RESEARCH
(2020)
Review
Oncology
James C. Lee, Michael D. Green, Laura A. Huppert, Christine Chow, Robert H. Pierce, Adil Daud
Summary: Liver metastases have a significant impact on the effectiveness of immune checkpoint inhibitors in patients with solid-tumor malignancies. Multiple clinical and translational studies have shown that liver metastasis leads to systemic immune suppression through the generation of suppressive macrophages and activation of regulatory T-cells. Various interventions, such as radiation therapy and combination checkpoint blockade, have been reported to address liver immune suppression.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Peter H. Goff, Laura Riolobos, Bonnie J. LaFleur, Matthew B. Spraker, Y. David Seo, Kimberly S. Smythe, Jean S. Campbell, Robert H. Pierce, Yuzheng Zhang, Qianchuan He, Edward Y. Kim, Stephanie K. Schaub, Gabrielle M. Kane, Jose G. Mantilla, Eleanor Y. Chen, Robert Ricciotti, Matthew J. Thompson, Lee D. Cranmer, Michael J. Wagner, Elizabeth T. Loggers, Robin L. Jones, Erin Murphy, Wendy M. Blumenschein, Terrill K. McClanahan, Jon Earls, Kevin C. Flanagan, Natalie A. LaFranzo, Teresa S. Kim, Seth M. Pollack
Summary: This study aims to characterize the changes in the soft-tissue sarcoma (STS) tumor immune microenvironment induced by standard neoadjuvant therapy and provides insights for neoadjuvant immunotherapy trial design. The results show that neoadjuvant therapy significantly increases immune cell infiltration in the tumor and affects the expression of immune-related genes and cytokines. These findings inform the incorporation of immune checkpoint inhibitors and novel immunotherapies into the neoadjuvant setting for STSs.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Robert H. I. Andtbacka, Yan Wang, Robert H. Pierce, Jean S. Campbell, Melinda Yushak, Mohammed Milhem, Merrick Ross, Katie Niland, Robert D. Arbeit, Sudha Parasuraman, Kris Bickley, Cecilia C. S. Yeung, Lauri D. Aicher, Kimberly S. Smythe, Lu Gan
Summary: The study found that treatment with single-agent mavorixafor can increase CD8+ T-cell infiltration, granzyme B signal, antigen presentation machinery, and both tumor inflammatory signature (TIS) and IFNγ gene expression signature scores. When mavorixafor was combined with pembrolizumab, the increases in the key serum cytokines CXCL9 and CXCL10 were further enhanced. Reported adverse events included diarrhea, fatigue, maculopapular rash, and dry eye, all of which were ≤ grade 3.
CANCER RESEARCH COMMUNICATIONS
(2022)
Meeting Abstract
Oncology
Adil Daud, Alain Patrick Algazi, Michelle T. Ashworth, Lawrence Fong, Jera Lewis, Stephen E. Chan, Michael Buljan, Manuel Alberto Molina, Kathryn Toshimi Takamura, Tuan Tu Diep, Richard Heller, Robert H. Pierce, Shailender Bhatia
JOURNAL OF CLINICAL ONCOLOGY
(2014)
Meeting Abstract
Medicine, General & Internal
Jonathan P. Sherlock, Barbara Joyce-Shaikh, Scott Turner, Manjiri Sathe, Jeff Grein, Daniel M. Gorman, Edward P. Bowman, Terrill K. McClanahan, Jennifer Yearley, Christopher D. Buckley, Robert A. Kastelein, Robert H. Pierce, Drake LaFace, Daniel J. Cua