Article
Oncology
Weili Yang, Chao Guo, James G. G. Herman, Cheng Zhu, Honghui Lv, Xiaomo Su, Lirong Zhang, Meiying Zhang, Mingzhou Guo
Summary: JAM3 is frequently methylated in human esophageal cancer and its expression is regulated by promoter region methylation. JAM3 methylation is an early detection and prognostic marker of esophageal cancer. JAM3 suppresses esophageal cancer growth by inhibiting Wnt signaling.
CLINICAL EPIGENETICS
(2022)
Article
Biochemistry & Molecular Biology
Guo-Chao Zhong, Zhi-Bo Zhao, Yao Cheng, Yun-Bing Wang, Chan Qiu, Lin-Hong Mao, Jie-Jun Hu, Dong Cai, Yan Liu, Jian-Ping Gong, Sheng-Wei Li
Summary: The study reveals that epigenetic silencing of GCH1 promotes HCC growth by inhibiting BH4 de novo biosynthesis, while BH4 metabolite inhibits HCC growth.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Oncology
Wen-Kai Shi, Qiao-Li Shang, Yong-Fu Zhao
Summary: This study investigates the role of SPC25 in promoting hepatocellular carcinoma (HCC) progression. It is found that SPC25 is highly expressed in HCC and associated with poor prognosis and metastasis. Silencing SPC25 inhibits invasion and migration of HCC cells in vitro and in vivo. The study also reveals that SPC25 affects genes associated with extracellular matrix-integrin interactions, and upregulation of ITGB4 partially reverses the decline in cell invasion and migration capacities caused by SPC25 silencing. Blocking both SPC25 and ITGB4 reduces phosphorylation of downstream elements in the integrin pathway. Overall, this research highlights the important role of SPC25 as both a prognostic indicator and a promoter of metastasis in HCC.
Article
Medicine, Research & Experimental
Yifu Hou, Kai Chen, Rui Liao, Youzan Li, Hongji Yang, Jun Gong
Summary: In this study, the authors demonstrate that the long noncoding RNA LINC01419 enhances the methylation of the ZIC1 promoter, suppresses ZIC1 expression, and activates the PI3K/Akt signaling pathway, thereby promoting the malignant characteristics of hepatocellular carcinoma cells in vitro and facilitating tumor formation and metastasis.
LABORATORY INVESTIGATION
(2021)
Article
Oncology
Guru P. Maiti, Sutapa Sinha, Hasan Mahmud, Justin Boysen, Mariana T. Mendez, Sara K. Vesely, Jennifer Holter-Chakrabarty, Neil E. Kay, Asish K. Ghosh
Summary: Mitochondrial metabolism in CLL cells is the key source of abundant ROS, with SOD2 and catalase being abnormally activated leading to increased H2O2 accumulation. Aberrant CpG island methylation in CLL cells can be targeted with demethylating agents to increase catalase levels and reduce ROS accumulation.
BLOOD CANCER JOURNAL
(2021)
Article
Cell Biology
Xu Chen, Zheng-Qian Guo, Dan Cao, Yong Chen, Jian Chen
Summary: The study revealed that overexpression of PNO1 in glioma is associated with poor prognosis, and that PNO1 contributes to glioma progression by activating THBS1/FAK/Akt signaling pathway.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Jian Xu, Wei Zhang
Summary: This study revealed that EZR accelerates the progression of pancreatic cancer through the FAK/AKT signaling pathway, promoting proliferation and migration of PC cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Yabing Hu, Yongchu Huang, Xiaohang Xie, Longshan Li, Yong Zhang, Xiaochao Zhang
Summary: In this study, we found that high expression of ARF6 is associated with poor prognosis and promotes the proliferation of hepatocellular carcinoma (HCC). ARF6 was upregulated in HCC tissues and correlated with poor tumor differentiation, incomplete tumor encapsulation, advanced tumor TNM stage, and poor prognosis. ARF6 activated the STAT3 signaling pathway to enhance HCC cell proliferation and tumor growth. These findings suggest that ARF6 may serve as a potential prognostic and therapeutic target for HCC patients.
CANCER CELL INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Bo You, Ting Zhang, Wei Zhang, Yinyin Pei, Danyi Huang, Yun Lei, Shaocong Zhang, Changyu Qiu, Jie Zhang, Zhifeng Gu, Lei Cheng, Jing Chen
Summary: This study reveals the important role of IGFBP2 in the pathogenesis of nasal polyps. Researchers extracted and cultured nasal epithelial cells and MSCs, isolated extracellular vesicles and soluble proteins to investigate the impact of PO-MSCs on epithelial-mesenchymal transition and epithelial barrier function. The results show that IGFBP2 plays a crucial role in EMT and barrier destruction, while extracellular vesicles from PO-MSCs do not. Furthermore, the FAK signaling pathway is necessary for IGFBP2 to exert its functions in nasal epithelial mucosa. Overall, these findings contribute to a better understanding of the role of PO-MSCs in the microenvironment of nasal polyps and may contribute to their prevention and treatment.
Article
Plant Sciences
Jose Roberto Torres, Javier F. Botto, Diego H. Sanchez
Summary: The canonical TGS machinery may contribute to plant acclimation and recovery from prolonged high temperatures, despite the stress-induced epigenetic disturbance.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Jan Zimak, Zachary W. Wagoner, Nellie Nelson, Brooke Waechtler, Hana Schlosser, Morgan Kopecky, Jie Wu, Weian Zhao
Summary: Epigenetic silencing leads to loss of function in multi-transcript unit constructs integrated via CRISPR-Cas9. Expression heterogeneity is not correlated with sequence alteration but with chromosomal accessibility. Partial reversal of epigenetic silencing was achieved using small-molecule inhibitors.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Xinxin Cheng, Jie Wang, Chunling Liu, Tianduo Jiang, Ningzhi Yang, Dan Liu, Huanhuan Zhao, Zhelong Xu
Summary: Zinc transporters have been found to be associated with the pathogenesis of various human diseases, including cancer. Among these, high expression of ZIP13 is an independent prognostic factor for poor survival in ovarian cancer patients. ZIP13 regulates intracellular zinc distribution, affecting gene expression related to extracellular matrix organization and cytokine-mediated signaling pathway, ultimately activating the Src/FAK pathway and promoting metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Zixu Yuan, Xihu Yu, Wenle Chen, Daici Chen, Jian Cai, Yingming Jiang, Xiaoxia Liu, Zhijie Wu, Lei Wang, William M. Grady, Hui Wang
Summary: This study identified HAND2 as a potential epigenetic driver gene in colorectal cancer (CRC). The researchers found a high frequency of HAND2 methylation in CRC patients, and this methylation was negatively correlated with gene silencing and poor survival. Demethylation treatment was able to restore HAND2 expression in CRC cells. Functional experiments showed that HAND2 reconstitution could inhibit cell proliferation, invasion, and migration in vitro. In a tumor xenograft model, HAND2 reconstruction significantly suppressed tumor growth. Furthermore, HAND2 was found to target the ERK signaling pathway and reduce ERK phosphorylation. Overall, this study suggests that HAND2 is a tumor suppressor gene that acts by targeting the ERK signaling pathway and has potential as an epigenetic driver gene in CRC.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Cell Biology
Jingquan Li, Zihao Zhang, Xu Feng, Zhuqing Shen, Ji Sun, Xiuwen Zhang, Fengjiao Bu, Midie Xu, Cong Tan, Ziliang Wang
Summary: STC2 plays a role in regulating cell growth, invasion, and glycolysis in nasopharyngeal carcinoma (NPC) and its expression is associated with clinical progression. The interaction of STC2 with ITGB2 and its involvement in the ITGB2/FAK/SOX6 axis suggest a potential therapeutic target for NPC.
CELL BIOLOGY AND TOXICOLOGY
(2022)
Article
Oncology
Ke Wang, Xunliang Jiang, Yu Jiang, Jun Liu, Yongtao Du, Zecheng Zhang, Yunlong Li, Xinhui Zhao, Jipeng Li, Rui Zhang
Summary: This study revealed the role of the EZH2/miR-139-5p/TOP2A axis in regulating cellular senescence and cell proliferation in HCC, enriching the molecular mechanisms of EZH2-mediated epigenetic regulation in HCC. Therapeutically targeting EZH2 to induce cellular senescence and destroy senescent cells could be a potential treatment strategy for HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Jing Xie, Li Huang, You-Guang Lu, Da-Li Zheng
Summary: Head and neck squamous cell carcinoma is a common and aggressive type of tumor with low survival rates. The Wnt signaling pathway has been shown to play a vital role in the pathobiological process of HNSCC by affecting cellular progression and enabling tumor growth and invasiveness. Genetic defects in the components of the Wnt pathway may contribute to the development of HNSCC.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Rui-huan Gan, Li-song Lin, Dan-ping Zheng, Yong Zhao, Lin-can Ding, Da-li Zheng, You-guang Lu
Summary: Abnormal expression of Notch2 is associated with proliferation, invasion, and migration of tongue squamous cell carcinoma. Inhibition of Notch2 can suppress the malignant behavior of TSCC cells, while overexpression of Notch2 has a promoting effect on tongue cancer cells.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Genetics & Heredity
Jiao-Xiang Wu, Kun-Yan He, Zhuang-Zhuang Zhang, Yu-Lan Qu, Xian-Bin Su, Yi Shi, Na Wang, Lan Wang, Ze-Guang Han
Summary: The liver-specific zona pellucida domain-containing protein (LZP) deficiency inhibits VLDL secretion, leading to hepatic TG accumulation and lower serum TG levels, primarily due to decreased levels of apoB protein.
Article
Nanoscience & Nanotechnology
Qiao-Jun Zhang, Yue Liu, Wen-Ting Zhang, Jing-Jing Huang, Hao-Hong Li, You-Guang Lu, Ming Zheng, Da-Li Zheng
Summary: The study found that AgBr nanoparticles @CTMAB have significant antifungal activity against Candida albicans, making them a promising denture cleaner. PMMA specimens containing AgBr-NP@CTMAB did not show long-term antifungal effects against Candida albicans biofilm, but were able to quickly remove them in a short period of time.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Bi-Tan Zheng, Qing-Ling Li, Ting Lan, Jian Xie, You-Guang Lu, Da-Li Zheng, Bo-Hua Su
Summary: This study found that CDH11 acts as a tumor suppressor in tongue squamous cell carcinoma by inhibiting the invasion and migration of tongue cancer cells, suggesting it may serve as an effective clinical target for new tongue cancer treatments.
ONCOTARGETS AND THERAPY
(2021)
Article
Multidisciplinary Sciences
Yuchun Zou, Senxin Cai, Hanyu Lin, Jingwen Cai, Da-Li Zheng, You-Guang Lu, Linyu Xu
Summary: This study evaluated the effects of mandibular functional deviation on the temporomandibular joint (TMJ) using a rat model, focusing on the functional roles of integrin beta family members. The results showed that functional deviation changed the shape of condyles, thinned the cartilage, and led to osteoarthritis-like changes in the TMJ.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hua Wei, Qi Ge, Ling-Yu Zhang, Jing Xie, Rui-Huan Gan, You-Guang Lu, Da -Li Zheng
Summary: EGCG, as an effective chemotherapeutic agent for tongue cancer, targets the Notch pathway to induce cell apoptosis and inhibit cell proliferation, thereby prolonging the lifespan of mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Dan-Dan He, Xue-Ying Shang, Na Wang, Guang-Xing Wang, Kun-Yan He, Lan Wang, Ze-Guang Han
Summary: This study identifies a potential therapeutic strategy for HCC patients with ARID2 mutations by discovering that BRD4 inhibition induces synthetic lethality in ARID2-deficient HCC cells. JQ1, a selective inhibitor, is found to selectively suppress the growth of ARID2-deficient HCC cells by exacerbating DNA damage. Functional assays demonstrate that both BRD4 inhibition and ARID2 deficiency synergistically impede DNA damage repair pathways by attenuating the transcription of core molecules responsible for repair. This study provides insight into a potential therapeutic option for HCC patients with ARID2 mutations.
Article
Cell Biology
Xue-Ying Shang, Yi Shi, Dan-Dan He, Lan Wang, Qing Luo, Chuan-Huai Deng, Yu-Lan Qu, Na Wang, Ze-Guang Han
Summary: This study reveals the impact of ARID1A deficiency on chromatin structure, and shows that ARID1A depletion enhances the invasion capacity of liver cancer cells by regulating the expression of key genes in chromatin organization.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Qingling Li, Ting Lan, Jian Xie, Youguang Lu, Dali Zheng, Bohua Su
Summary: Integrins, a family of adhesion molecules on the cell surface, play a crucial role in regulating cell growth and function. Recent advances have revealed their significance in tumorigenesis and progression, making them a potential therapeutic target for cancer treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ting Lan, Qi Ge, Ke Zheng, Li Huang, Yuxiang Yan, Lixin Zheng, Youguang Lu, Dali Zheng
Summary: Previous studies have shown that FAT1 plays a role in tumor suppression or tumorigenesis depending on the context in various cancers. However, its functions in oral squamous cell carcinoma (OSCC) are still unclear. This study aimed to investigate the role of FAT1 in OSCC. The results showed that FAT1 was significantly upregulated in OSCC and correlated with a poor prognosis. Functional experiments revealed that FAT1 promoted cell proliferation and migration while inhibiting apoptosis in OSCC cells. RNA sequencing analysis indicated that FAT1 may affect the cell cycle and DNA repair process in OSCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Senxin Cai, Yuchun Zou, Yong Zhao, Hanyu Lin, Dali Zheng, Linyu Xu, Youguang Lu
Summary: This study found that mechanical stress plays a significant role in the growth and development of the tempormandibular joint (TMJ), and is involved in the progression of TMJ osteoarthritis (TMJOA) through the regulation of Wnt/β-catenin signaling and secreted frizzled-related proteins (SFRPs).
Review
Nanoscience & Nanotechnology
Shujun Zhang, Linghuang Lin, Xuanhao Huang, You-Guang Lu, Da-Li Zheng, Yan Feng
Summary: Metal nanoparticles have excellent antibacterial properties and show great potential in the treatment of oral infections.
JOURNAL OF NANOMATERIALS
(2022)
Article
Gastroenterology & Hepatology
Yangyang Zhai, Kunyan He, Liyu Huang, Xuyang Shang, Guangxing Wang, Guandou Yuan, Ze-Guang Han
Summary: DLK1-directed CAR-T cells specifically eliminate DLK1-positive HCC cells and inhibit tumor growth in vitro and in vivo.
LIVER INTERNATIONAL
(2022)
Article
Toxicology
Lan Wang, Shi-Hao Bai, Shu-Jin Song, Zhao-Ning Lu, Jian Huang, Ze-Guang Han
Summary: A study found that the most common and persistent DNA damage, dA-AL-I adduct, was present in liver cancer patients, suggesting their exposure to aristolochic acids prior to the development of the disease and indicating a worse prognosis. This emphasizes the importance of increasing public awareness to avoid the use of herbal medicine containing aristolochic acids or their derivatives.
TOXICOLOGY RESEARCH
(2022)