Article
Clinical Neurology
Fatemeh Fadaie, Hyo M. Lee, Benoit Caldairou, Ravnoor S. Gill, Viviane Sziklas, Joelle Crane, Boris C. Bernhardt, Seok-Jun Hong, Andrea Bernasconi, Neda Bernasconi
Summary: The study revealed bidirectional disruptions of sensory-paralimbic functional organization in TLE patients, which might contribute to cognitive impairments in multiple domains. Associations with paralimbic microstructure and sensorimotor atrophy suggest that system-level imbalance likely reflects complementary structural processes, ultimately leading to a broad spectrum of cognitive impairments.
Article
Clinical Neurology
A. M. de Sain, M. H. M. Mantione, I. M. C. Huenges Wajer, M. J. E. van Zandvoort, P. W. A. Willems, P. A. Robe, C. Ruis
Summary: The aim of this study was to compare preoperative, early postoperative, and late postoperative cognitive functioning in patients with suspected gliomas who underwent awake brain tumor surgery. The results showed that overall cognitive functioning remained stable in the early and late postoperative phase, except for the inhibition task.
ACTA NEUROCHIRURGICA
(2023)
Review
Clinical Neurology
Nicholas B. Dadario, Bledi Brahimaj, Jacky Yeung, Michael E. Sughrue
Summary: Surgical management of brain tumors aims to improve patient outcomes, with neurosurgeons traditionally considering non-eloquent lesions as more aggressively operable. Advances in imaging technology have increased resection rates while minimizing neurologic risks, but post-operative cognitive morbidity remains a challenge due to the complexity of understanding cognitive functions and brain networks. Connectomic data offers potential for improving surgical decisions and reducing cognitive morbidity, but further research and optimization are needed.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Stine Schei, Ole Solheim, Oyvind Salvesen, Tor Ivar Hansen, Lisa Millgard Sagberg
Summary: Background: Little is known about subjective changes in cognitive function experienced by glioma patients following surgery. Methods: We assessed patient-reported cognitive function before and after glioma surgery in 182 patients and explored potential factors associated with cognitive change. Results: Many glioma patients experience subjective changes in cognitive function after surgery. HGG patients reported improved cognitive function after surgery, while LGG patients reported stable cognitive function. Preoperative use of corticosteroids and large tumor volume were independently associated with postoperative improvement.
ACTA NEUROCHIRURGICA
(2022)
Review
Biology
Nazmin Ahmed, Gianluca Ferini, Kanak Kanti Barua, Rathin Halder, Sudip Barua, Stefano Priola, Ottavio Tomasi, Giuseppe Emmanuele Umana, Nathan A. Shlobin, Gianluca Scalia, Kanwaljeet Garg, Bipin Chaurasia
Summary: This review focused on the clinical characteristics, treatment, and prognosis of adult-onset pilocytic astrocytoma (APA). The majority of APAs showed benign clinical courses, but some cases exhibited aggressive behavior. Further research is needed to understand the pathogenesis and develop effective treatments for APAs.
Review
Clinical Neurology
Martin A. Merenzon, Shovan Bhatia, Adam Levy, Tiffany Eatz, Alexis A. Morell, Lekhaj C. Daggubati, Evan Luther, Ashish H. Shah, Ricardo J. Komotar, Michael E. Ivan
Summary: Seizures are common in patients with low-grade brain tumors, and frontal lobe epilepsy has worse seizure outcomes compared to temporal lobe epilepsy. This study conducted a systematic review, reported a case series, and performed a pooled analysis to identify clinical predictors of seizure outcomes in frontal lobe low-grade brain tumors.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Neuroimaging
Andrea Zangrossi, Erica Silvestri, Marta Bisio, Alessandra Bertoldo, Serena De Pellegrin, Antonino Vallesi, Alessandro Della Puppa, Domenico D'Avella, Luca Denaro, Renato Scienza, Sara Mondini, Carlo Semenza, Maurizio Corbetta
Summary: Cognitive impairment in glioma patients 1-week after surgery is only partially explained by preoperative brain damage, with pre-operative cognitive performance being the main predictor of early post-surgical cognitive outcome, while tumor topography and volume do not significantly improve prediction accuracy.
NEUROIMAGE-CLINICAL
(2022)
Article
Psychiatry
Willeke M. Kitselaar, Helma M. de Morree, Marjan W. Trompenaars, Margriet M. Sitskoorn, Geert-Jan Rutten, Marjan Willem J. Kop
Summary: This study examines the role of autonomic nervous system dysregulation and objective sleep characteristics in fatigue among post-surgical patients. The results suggest that multiple nocturnal awakenings may result in mental fatigue and longer sleep time may reflect compensatory sleep patterns and be associated with physical fatigue. Future intervention studies addressing sleep quality may be beneficial in treating fatigue in patients following neurosurgery for tumor resection.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Article
Medicine, General & Internal
Gerardo Romero-Luna, Sonia Iliana Mejia-Perez, Jacqueline Ramirez-Cruz, Keren Magaly Aguilar-Hidalgo, Karla Marisol Ocampo-Diaz, Julia Moscardini-Martelli, Viviana Ramirez-Stubbe, Jose Omar Santellan-Hernandez
Summary: Psychiatric symptoms caused by brain lesions are common and can be caused by various pathologies. Gliomas are the most common primary brain tumors, and they can cause neuropsychiatric symptoms such as depression, anxiety disorder, schizophrenia-like psychosis, anorexia nervosa, or cognitive dysfunction. This article presents a case of a 46-year-old male with no psychiatric familial history who developed schizophrenia-like psychosis with hallucinations, leading to the murder of his mother, which was later attributed to a brain tumor.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Clinical Neurology
Ian E. McCutcheon, Mark C. Preul
Summary: The treatment of glioblastoma has evolved from early brain surgery in the nineteenth century to the introduction of modern chemotherapeutics, leading to incremental improvements in survival outcomes. Advances in surgical techniques, adjuvant therapies, and imaging have contributed to improved outcomes over the past century.
WORLD NEUROSURGERY
(2021)
Article
Neurosciences
Anne M. Buunk, Marleen J. J. Gerritsen, Hanne-Rinck Jeltema, Michiel Wagemakers, Jan D. M. Metzemaekers, Rob J. M. Groen, Jacoba M. Spikman
Summary: This study found impairments in social cognition, particularly in facial emotion recognition, in patients with low-grade gliomas (LGGs). The surgery did not cause additional deficits in emotion recognition, and these impairments were not related to general cognitive deficits or tumor location.
Article
Neurosciences
Chengru Song, Xiaonan Zhang, Shaoqiang Han, Keran Ma, Kefan Wang, Xinyue Mao, Yajun Lian, Xianchang Zhang, Jinxia Zhu, Yong Zhang, Jingliang Cheng
Summary: This study comprehensively explored the potential brain activity abnormalities affected by temporal lobe epilepsy (TLE) and found significant differences in several brain regions between TLE patients and healthy volunteers. These abnormalities were associated with cognitive impairment and correlated with epilepsy duration and cognitive scale scores.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Review
Clinical Neurology
Nathan A. Shlobin, Eric Y. Montgomery, Laila M. Mohammad, Viswajit Kandula, Molly Beestrum, Michael DeCuypere, Sandi K. Lam
Summary: The objective of this study was to summarize the effects of treatment strategies on visual outcomes in pediatric patients with sporadic OPG. The results showed that vision in most patients remained stable to poor after observation, chemotherapy, radiotherapy, or surgery. Chemotherapy may be associated with the most favorable visual outcomes.
WORLD NEUROSURGERY
(2022)
Article
Neuroimaging
Natalie L. Voets, Oiwi Parker Jones, Claire Isaac, Rogier B. Mars, Puneet Plaha
Summary: Large individual differences exist in how brain networks respond to treatment, with some patients showing unique network adaptations post-treatment. Language symptoms are the strongest predictor of adaptation in fluency networks.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Victoria J. Hodgson, Matthew A. Lambon Ralph, Rebecca L. Jackson
Summary: The posterior lateral temporal cortex is involved in various verbal, nonverbal, and social cognitive domains. Through comparing different domains, it is found that some processes engage distinct subregions while others may engage shared neural correlates and processes.
Article
Clinical Neurology
Dhiego Chaves de Almeida Bastos, Ganesh Rao, Isabella Claudia Glitza Oliva, Jonathan M. Loree, David T. Fuentes, R. Jason Stafford, Vivek B. Beechar, Jeffrey S. Weinberg, Komal Shah, Vinodh A. Kumar, Sujit S. Prabhu
Article
Clinical Neurology
E. D. H. Gates, J. S. Weinberg, S. S. Prabhu, J. S. Lin, J. Hamilton, J. D. Hazle, G. N. Fuller, V. Baladandayuthapani, D. T. Fuentes, D. Schellingerhout
Summary: The study aimed to discover the best MR imaging techniques for quantitative and spatially specific estimates of cellular density in gliomas. The random forest methodology provided the best estimates with moderate-to-strong correlations between predicted and observed values. These spatially specific estimates of cellular density could be useful in guiding diagnosis and treatment.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Clinical Neurology
Rasheed Zakaria, Jeffrey S. Weinberg
NEUROSURGERY CLINICS OF NORTH AMERICA
(2021)
Review
Oncology
Cara Marie Rogers, Pamela S. Jones, Jeffrey S. Weinberg
Summary: This article reviews the history of intraoperative MRI, its clinical application in neurosurgery, and future directions. Intraoperative MRI has been shown to improve extent of tumor resection and prevent injury to important structures during tumor surgery.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Oncology
Marcel A. Kamp, Bastian Malzkorn, Christiane von Sass, Francesco DiMeco, Constantinos G. Hadjipanayis, Christian Senft, Marion Rapp, Irina Gepfner-Tuma, Konstantinos Fountas, Sandro M. Krieg, Martin Neukirchen, Ioan Stefan Florian, Oliver Schnell, Hendrik-Jan Mijderwijk, Alessandro Perin, Peter Baumgarten, Jasper H. van Lieshout, Niklas Thon, Miriam Renovanz, Ulf Kahlert, Jochem K. H. Spoor, Daniel Haenggi, Aaron Lawson McLean, Matthias Maeurer, Silvio Sarrubbo, Christian F. Freyschlag, Nils O. Schmidt, Francesco Vergani, Christine Jungk, Marco Stein, Marie-Therese Forster, Jeffrey S. Weinberg, John Sinclair, Evgenii Belykh, Lorenzo Bello, Emmanuel Mandonnet, Aliasgar Moiyadi, Michael Sabel
Summary: The study proposed a total of 70 competencies and 8 EPAs for training in surgical neuro-oncology, covering skills such as management of deteriorating patients, resections of brain tumors, and postoperative patient care. This work aims to initiate discussions and contribute to the development of new training concepts in surgical neuro-oncology.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ali Baiomy, Dawid Schellingerhout, Brian F. Chapin, Jeffrey S. Weinberg, Shaan M. Raza, Homer Macapinlac, Gregory Ravizzini
Summary: Incidental detection of abnormal focal intracranial F-18-fluciclovine uptake was found in 2.8% of patients undergoing PET/CT imaging for prostate cancer, with most cases being CNS meningiomas.
NUCLEAR MEDICINE COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Anne-Cecile Lesage, Alexis Simmons, Anando Sen, Simran Singh, Melissa Chen, Guillaume Cazoulat, Jeffrey S. Weinberg, Kristy K. Brock
Summary: This study evaluated the accuracy and efficiency of various FEM models in predicting inward brain-shift during neurosurgery. Including non-rigid modeling of the meninges was found to be statistically significant for patients with low-grade gliomas.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Oncology
Michael A. Vogelbaum, Paul D. Brown, Hans Messersmith, Priscilla K. Brastianos, Stuart Burri, Dan Cahill, Ian F. Dunn, Laurie E. Gaspar, Na Tosha N. Gatson, Vinai Gondi, Justin T. Jordan, Andrew B. Lassman, Julia Maues, Nimish Mohile, Navid Redjal, Glen Stevens, Erik Sulman, Martin van den Bent, H. James Wallace, Jeffrey S. Weinberg, Gelareh Zadeh, David Schiff
Summary: The purpose of this study is to provide guidelines for clinicians on treating patients with brain metastases from solid tumors. The study conducted a systematic review of the literature and found that surgery is a reasonable option for patients with brain metastases. Local therapy should be given to patients with symptomatic brain metastases, regardless of the systemic therapy used. For patients with asymptomatic brain metastases, local therapy should not be deferred unless specifically recommended. Several regimens were recommended for different types of cancer. For patients with no systemic therapy options, stereotactic radiosurgery (SRS) alone should be offered. Memantine and hippocampal avoidance should be considered for patients receiving whole brain radiation therapy. Patients with low Karnofsky Performance Status and no systemic therapy options do not benefit from radiation therapy.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Matthew J. Shepard, Ali S. Haider, Sujit S. Prabhu, Raymond Sawaya, Franco DeMonte, Ian E. McCutcheon, Jeffrey S. Weinberg, Sherise D. Ferguson, Dima Suki, Gregory N. Fuller, Frederick F. Lang
Summary: This is the first modern surgical series providing long term follow-up for patients undergoing surgical resection of pineal region tumors. Obtaining a gross total resection of these challenging tumors is beneficial for improving progression free survival and overall survival. Higher grade tumors have decreased survival rates and are often treated with adjuvant chemotherapy and/or radiotherapy.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Clinical Neurology
James L. Rogers, Julianie De la Cruz Minyety, Elizabeth Vera, Alvina A. Acquaye, Samuel S. Payen, Jeffrey S. Weinberg, Terri S. Armstrong, Shiao-Pei S. Weathers
Summary: This study describes the preliminary utility and feasibility of using the Timed-Up-and-Go (TUG) and Five-Times Sit-to-Stand (TSS) tests to assess the mobility status of primary brain tumor (PBT) patients. The results show that older age, being newly diagnosed, using corticosteroids, poor KPS, and high activity-related interference are associated with significant mobility impairment.
NEURO-ONCOLOGY PRACTICE
(2022)
Article
Oncology
Elshad Hasanov, Debra Nana Yeboa, Mathew D. Tucker, Todd A. Swanson, Thomas Hendrix Beckham, Brian Rini, Chibawanye I. Ene, Merve Hasanov, Sophie Derks, Marion Smits, Shaan Dudani, Daniel Y. C. Heng, Priscilla K. Brastianos, Axel Bex, Sahin Hanalioglu, Jeffrey S. Weinberg, Laure Hirsch, Maria I. Carlo, Ayal Aizer, Paul David Brown, Mehmet Asim Bilen, Eric Lin Chang, Jerry Jaboin, James Brugarolas, Toni K. Choueiri, Michael B. Atkins, Bradley A. McGregor, Lia M. Halasz, Toral R. Patel, Scott G. Soltys, David F. McDermott, James Bradley Elder, Mustafa K. Baskaya, James B. Yu, Robert Timmerman, Michelle Miran Kim, Melike Mut, James Markert, Kathryn Beal, Nizar M. Tannir, George Samandouras, Frederick F. Lang, Rachel Giles, Eric Jonasch
Summary: Brain metastases are a challenging manifestation of renal cell carcinoma, and the optimal treatment approach remains unclear. This study aimed to improve patient care by establishing algorithms for the management of brain metastases through literature review and expert surveys.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Article
Clinical Neurology
E. D. H. Gates, D. Suki, A. Celaya, J. S. Weinberg, S. S. Prabhu, R. Sawaya, J. T. Huse, J. P. Long, D. Fuentes, D. Schellingerhout
Summary: The use of machine learning to estimate glioma cellularity based on imaging data is a promising biomarker for predicting patient survival. It demonstrates a similar prognostic ability to World Health Organization grading, with the added benefits of early availability, low risk, and low cost.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Clinical Neurology
Wajd N. Al-Holou, Dima Suki, Tiffany R. Hodges, Richard G. Everson, Jacob Freeman, Sherise D. Ferguson, Ian E. McCutcheon, Sujit S. Prabhu, Jeffrey S. Weinberg, Raymond Sawaya, Frederick F. Lang
Summary: This study describes the sulcus-guided resection (SGR) technique used for resecting low-grade gliomas (LGGs) and shows that SGR is independently associated with significantly higher rates of complete resection without an increase in neurological complications compared to the inside-out piecemeal resection (PMR) technique.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Sungho Lee, Aditya Srivatsan, Visish M. Srinivasan, Stephen R. Chen, Jan-Karl Burkhardt, Jeremiah N. Johnson, Daniel M. S. Raper, Jeffrey S. Weinberg, Peter Kan
Summary: Surgical evacuation of chronic subdural hematoma (SDH) is often contraindicated in cancer patients with refractory thrombocytopenia. Middle meningeal artery embolization (MMAE) has emerged as a potential alternative for these patients. This study evaluates the safety and efficacy of MMAE for chronic SDH in cancer patients with refractory thrombocytopenia.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Wajd N. Al-Holou, Tiffany R. Hodges, Richard G. Everson, Jacob Freeman, Shouhao Zhou, Dima Suki, Ganesh Rao, Sherise D. Ferguson, Amy B. Heimberger, Ian E. McCutcheon, Sujit S. Prabhu, Frederick F. Lang, Jeffrey S. Weinberg, David M. Wildrick, Raymond Sawaya