Article
Transplantation
Satoshi Inotani, Yoshinori Taniguchi, Keisyun Nakamura, Hirofumi Nishikawa, Tatsuki Matsumoto, Taro Horino, Shimpei Fujimoto, Shigetoshi Sano, Motoko Yanagita, Yoshio Terada
Summary: Zeb2 plays a regulatory role in the pathogenesis of acute kidney injury (AKI) and AKI-to-chronic kidney disease (CKD) transition by regulating fibrotic pathways. Inhibition of Zeb2 could be a potential therapeutic strategy for AKI.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Peripheral Vascular Disease
Lingyan Fei, Minze Xu, Honghong Wang, Cheng Zhong, Shan Jiang, Falk-Bach Lichtenberger, Cem Erdogan, Han Wang, Julia S. Bonk, En Yin Lai, Pontus B. Persson, Richard Kovacs, Zhihua Zheng, Andreas Patzak, Pratik H. Khedkar
Summary: Acute hyperglycemia is a risk factor for acute kidney injury, and our study suggests that hyperglycemia-induced hyperosmolarity facilitates vasodilation through Piezo1-mediated eNOS activation. Our findings indicate that inhibiting Piezo1 and CaMKII can prevent the vasodilation induced by hyperglycemia and hyperosmotic mannitol solution.
Article
Multidisciplinary Sciences
Andrea Sanchez-Navarro, Rosalba Perez-Villalva, Adrian Rafael Murillo-de-Ozores, Miguel angel Martinez-Rojas, Jesus Rafael Rodriguez-Aguilera, Norma Gonzalez, Maria Castaneda-Bueno, Gerardo Gamba, Felix Recillas-Targa, Norma A. Bobadilla
Summary: Chronic hypoxia is a major factor leading to Chronic Kidney Disease (CKD) after Acute Kidney Injury (AKI). Our study showed that renal hypoperfusion, inefficient hypoxic response, increased oxidative stress, DNA hypomethylation, and hypermethylation of the Vegfa promoter gene at the HIF1 alpha binding site are early determinants of the AKI-to-CKD transition.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Brittney J. Brown, Kimber L. Boekell, Brian R. Stotter, Brianna E. Talbot, Johannes S. Schlondorff
Summary: Mutations in TRPC6 gene are responsible for autosomal dominant focal segmental glomerulosclerosis in humans. A gain-of-function TRPC6 mutation in mice only confers mild susceptibility to glomerular injury.
Article
Chemistry, Analytical
Jun Wang, Menglei Zha, Hui Zhao, Wentong Yue, Decheng Wu, Kai Li
Summary: This research successfully synthesized a class of renal-clearable gadolinium nanoparticles and achieved the diagnosis of kidney dysfunction in a mice model with a damaged kidney through noninvasive magnetic resonance imaging. This provides a new tool for exploring translational strategies for kidney dysfunction.
ANALYTICAL CHEMISTRY
(2022)
Review
Medicine, Research & Experimental
Elsayed G. E. Elsakka, Mahmoud Mohamed Mokhtar, Maghawry Hegazy, Ahmed Ismail, Ahmed S. Doghish
Summary: The endocytosis mechanism is a complex system essential for cell signaling and survival. Megalin and its related proteins play important roles in receptor-mediated endocytosis and have significant implications for kidney function and injury.
Article
Medicine, General & Internal
Filippo Mariano, Consuelo De Biase, Zsuzsanna Hollo, Ilaria Deambrosis, Annalisa Davit, Alberto Mella, Daniela Bergamo, Stefano Maffei, Francesca Rumbolo, Alberto Papaleo, Maurizio Stella, Luigi Biancone
Summary: The study found that burn patients treated with CRRT had a long-term expectation of preserved renal function, but were more predisposed to microalbuminuria, diabetes, and the presence of risk factors for intercurrent comorbidities and chronic renal disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jose R. Godoy, Grace Watson, Carly Raspante, Oscar Illanes
Summary: This paper presents an effective mouse model of unilateral renal IRI, providing insights into the sequential physiological and histopathological changes post-IRI through data analysis at different reperfusion times.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Review
Medicine, General & Internal
Lakshmi Kannan
Summary: Drug abuse is a major problem in the modern world, with both prescribed drugs and illegal drugs causing kidney injury. This review examines the renal effects of recreational drugs, highlighting the importance of understanding their adverse effects. The study conducted a thorough search of published case reports and case series to provide comprehensive information on renal complications associated with drug abuse.
Article
Immunology
Renyan Wu, Jiawei Li, Guowei Tu, Ying Su, Xuepeng Zhang, Zhe Luo, Ruiming Rong, Yi Zhang
Summary: This study analyzed RNA sequencing data to reveal the cellular and molecular features of fibrosis progression at different stages of AKI. It was found that T-cell activation mainly occurred in immune cells, while fatty acid metabolism and arachidonic acid metabolism happened in tubule cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Liyang Chen, Zhijian Han, Zhiguang Shi, Chao Liu, Qiulun Lu
Summary: Melatonin has been shown to have a protective effect against kidney injury induced by sepsis, by repressing oxidant stress and alleviating inflammatory response. Its therapeutic effect is achieved through regulation of ROS production in the kidneys.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Ram B. Jain
Summary: Analysis of data from the National Health and Nutrition Examination Survey for US adults aged 20 years and older between 2005 and 2016 showed variations in concentrations of arsenobetaine, monomethylarsonic acid, dimethylarsenic acid, and total arsenic in urine across different stages of renal function. Differences were observed in concentrations based on gender and racial/ethnic groups, with levels decreasing over the survey years.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Medicine, General & Internal
Yi-Ping Chang, Chen-Mao Liao, Li-Hsin Wang, Hsiu-Hua Hu, Chih-Ming Lin
Summary: This study followed 1042 chronic kidney disease patients with Stage 3-5 kidney disease and found that estimated glomerular filtration rate and urine protein to creatinine ratio had strong predictive abilities for disease progression. Additionally, differences in predictive variables were observed among patients at different stages of kidney disease, suggesting the potential for tailored prevention strategies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Physiology
Carlos Hernando, Carla Hernando, Nayara Panizo, Eladio Collado-Boira, Ana Folch-Ayora, Ignacio Martinez-Navarro, Barbara Hernando
Summary: Long distance races have physiological impacts on runners, with the use of elliptical machines for marathon recovery delaying renal function recovery. Light-intensity continuous running might be a better strategy for recovery after finishing a marathon.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Andrea Ochoa, Antonio Herrera, Anghara Menendez, Maria Estefanell, Carlota Ramos, Sebastian Pons
Summary: Vinculin is an actin-binding protein that plays a crucial role in cell adhesion and cytoskeleton connection. Beta-catenin targets vinculin to the apical adherens junctions and centrosome in the embryonic neural tube. Suppression of vinculin affects neural stem cell division and disrupts the integrity of the cell cytoskeleton.
JOURNAL OF CELL BIOLOGY
(2023)
Review
Endocrinology & Metabolism
Katharina Detjen, Linda Hammerich, Burcin Oezdirik, Munevver Demir, Bertram Wiedenmann, Frank Tacke, Henning Jann, Christoph Roderburg
Summary: GEP-NENs are rare and heterogeneous tumors originating from the endocrine system of the gastrointestinal tract and pancreas. Limited data from large prospective clinical trials are available for treatment recommendations, which are mainly based on retrospective analyses or case series. More tractable disease models are needed to better understand and predict treatment response in patients.
NEUROENDOCRINOLOGY
(2021)
Article
Immunology
Yu Anne Yap, Keiran H. McLeod, Craig McKenzie, Patrick G. Gavin, Mercedes Davalos-Salas, James L. Richards, Robert J. Moore, Trevor J. Lockett, Julie M. Clarke, Vik Ven Eng, Jaclyn S. Pearson, Emma E. Hamilton-Williams, Charles R. Mackay, Eliana Marino
Summary: The study demonstrated that a high acetate-producing diet can rectify the deficiency of SCFAs, protect against enteric infection, and promote changes in gut microbiota similar to healthy microbiota. The diet also influenced host proteins critical in glycolysis, wound healing, and epithelial architecture, indicating potential therapeutic benefits for inflammation and enteric infections.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Article
Biochemical Research Methods
Patrick G. Gavin, Justin Wong, Dorothy Loo, Danny Zipris, Michelle M. Hill, Emma E. Hamilton-Williams
Summary: The study compared three different methods for stool protein enrichment and found that methods enriching for host proteins identified more host proteins than differential centrifugation method. Combining two methods could maximize identification of host and microbial proteins from different cellular compartments and taxa.
JOURNAL OF PROTEOMICS
(2021)
Review
Nutrition & Dietetics
Emma E. Hamilton-Williams, Graciela L. Lorca, Jill M. Norris, Jessica L. Dunne
Summary: Recent research has highlighted the important role of the intestinal microbiota in diseases like T1D, with diet and nutrition potentially playing a key role in shaping the composition and function of the microbiota. While the specific mechanisms behind the link between the microbiota and T1D remain unclear, a deeper understanding of the complex interactions between the microbiota and various body systems could offer rational approaches to prevent diseases like T1D. Further research into the effects of diet and other modifiable factors on the microbiota ecosystem may provide insights into preventing childhood immune and allergic diseases, as well as assessing the efficacy of interventions.
FRONTIERS IN NUTRITION
(2021)
Article
Endocrinology & Metabolism
Madeleine Hall, Helena Oakey, Megan A. S. Penno, Kelly McGorm, Amanda J. Anderson, Pat Ashwood, Peter G. Colman, Maria E. Craig, Elizabeth A. Davis, Mark Harris, Leonard C. Harrison, Aveni Haynes, Claire Morbey, Richard O. Sinnott, Georgia Soldatos, Peter J. Vuillermin, John M. Wentworth, Rebecca L. Thomson, Jennifer J. Couper
Summary: Overall, there was no significant difference in mental health between women with and without type 1 diabetes during late pregnancy and postpartum, and mental health scores were not correlated with glycemic control.
Article
Cell Biology
Irina Buckle, Jeniffer D. Loaiza Naranjo, Anne-Sophie Bergot, Vivian Zhang, Meghna Talekar, Raymond J. Steptoe, Ranjeny Thomas, Emma E. Hamilton-Williams
Summary: The study showed that liposome delivery of IGRP (206-214) and calcitriol can delay the progression of type 1 diabetes and inhibit further destruction by CD8(+) T cells.
IMMUNOLOGY AND CELL BIOLOGY
(2022)
Article
Microbiology
Kirstine J. Bell, Sonia Saad, Bree J. Tillett, Helen M. McGuire, Sara Bordbar, Yu Anne Yap, Long T. Nguyen, Marc R. Wilkins, Susan Corley, Shannon Brodie, Sussan Duong, Courtney J. Wright, Stephen Twigg, Barbara Fazekas de St Groth, Leonard C. Harrison, Charles R. Mackay, Esteban N. Gurzov, Emma E. Hamilton-Williams, Eliana Marino
Summary: The study investigates the effects of HAMSAB supplementation on individuals with T1D. It finds that the supplement leads to changes in gut microbiota composition and function, as well as the immune profile, resulting in increased SCFA levels. These changes are associated with improved glycemic control.
Article
Cell Biology
Mirei Okada, Vivian Zhang, Jeniffer D. Loaiza Naranjo, Bree J. Tillett, F. Susan Wong, Raymond J. Steptoe, Anne-Sophie Bergot, Emma E. Hamilton-Williams
Summary: This study found that islet-specific CD8(+) T cells undergo early activation and proliferation in the pancreatic draining lymph nodes, and previously activated islet-specific effector memory cells migrate into the Peyer's patches where they gain additional cytotoxic function. Additionally, oral delivery of the microbiota-derived anti-inflammatory metabolite butyrate can reduce specific cytotoxic function.
IMMUNOLOGY AND CELL BIOLOGY
(2023)
Article
Microbiology
Patrick G. G. Gavin, Ki Wook Kim, Maria E. E. Craig, Michelle M. M. Hill, Emma E. Hamilton-Williams
Summary: The study demonstrates the interconnectedness of the gut microbiota, metaproteome, and virome in young children. A functional remodeling of the gut microbiota accompanies both islet autoimmunity and viral infection, with a switch in function in Faecalibacterium occurring at the onset of islet autoimmunity.
Review
Endocrinology & Metabolism
Ekua W. Brenu, Mark Harris, Emma E. Hamilton-Williams
Summary: This systematic review evaluates novel circulating biomarkers associated with future progression to type 1 diabetes (T1D). The study found that some circulating biomarkers are dysregulated before T1D diagnosis and may be useful in predicting the risk and rate of progression to T1D. However, further research is needed to validate these biomarkers and assess their predictive accuracy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Helena C. Oakey, Lynne L. Giles, Rebecca Thomson, Kim-Anh Le Cao, Pat D. Ashwood, James J. Brown, Emma C. Knight, Simon E. Barry, Maria G. Craig, Peter A. Colman, Elizabeth E. Davis, Emma C. Hamilton-Williams, Leonard Harrison, Aveni Haynes, Ki Wook Kim, Kylie-Ann Mallitt, Kelly McGorm, Grant D. Morahan, William O. Rawlinson, Richard Sinnott, Georgia M. Soldatos, John J. Wentworth, Jennifer Couper, Megan A. S. Penno, ENDIA Study Grp
Summary: The ENDIA nested case-control study will utilize longitudinal omics data to explore the developmental origins of type 1 diabetes (T1D) in 190 children at risk, including 54 who have developed islet autoimmunity (IA), by collecting data during pregnancy, at birth, and in early childhood.
ANNALS OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Leonard C. Harrison, Esther Bandala-Sanchez, Helena Oakey, Peter G. Colman, Kelly Watson, Ki Wook Kim, Roy Wu, Emma E. Hamilton-Williams, Natalie L. Stone, Aveni Haynes, Rebecca L. Thomson, Peter J. Vuillermin, Georgia Soldatos, William D. Rawlinson, Kelly J. McGorm, Grant Morahan, Simon C. Barry, Richard O. Sinnott, John M. Wentworth, Jennifer J. Couper, Megan A. S. Penno, ENDIA Study Grp
Summary: A study found that the production of pancreatic islet autoantibodies in children with genetic susceptibility may be related to enteric virus infection, indicating that enteric infection could be one of the environmental factors driving the development of autoimmune diseases.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Correction
Medicine, General & Internal
Helena Oakey, Lynne C. Giles, Rebecca L. Thomson, Kim-Anh Le Cao, Pat Ashwood, James D. Brown, Emma J. Knight, Simon C. Barry, Maria E. Craig, Peter G. Colman, Elizabeth A. Davis, Emma E. Hamilton-Williams, Leonard C. Harrison, Aveni Haynes, Ki Wook Kim, Kylie-Ann Mallitt, Kelly McGorm, Grant Morahan, William D. Rawlinson, Richard O. Sinnott, Georgia Soldatos, John M. Wentworth, Jennifer J. Couper, Megan A. S. Penno
ANNALS OF MEDICINE
(2023)
Article
Biochemical Research Methods
Inga Rodahl, James Gotley, Stacey B. Andersen, Meihua Yu, Ahmed M. Mehdi, Angelika N. Christ, Emma E. Hamilton-Williams, Ian H. Frazer, Samuel W. Lukowski, Janin Chandra
Summary: The detailed protocols outlined in this study demonstrate the isolation and profiling of murine splenic dendritic cells through advanced flow cytometry and CITE-seq technology, providing a generalizable method for different tissues and species. For more specific information on using this protocol, please refer to Lukowski et al. (2021).
Article
Immunology
Yassmin Musthaffa, Emma E. Hamilton-Williams, Hendrik J. Nel, Anne-Sophie Bergot, Ahmed M. Mehdi, Mark Harris, Ranjeny Thomas
Summary: Type 1 diabetes (T1D) is an autoimmune disorder characterized by the destruction of insulin-producing beta-cells by autoreactive T cells. This study found that CD4(+) T-cell proliferative responses to proinsulin-containing autoantigens are common before and immediately after diagnosis of T1D, but decrease thereafter. The Proinsulin(33-63)-specific CD4(+) T-cell response is a novel marker of estimated residual endogenous beta-cell function, predicting a better 2-year disease outcome.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)