Article
Multidisciplinary Sciences
Marcin Wegrecki, Tonatiuh A. Ocampo, Sachith D. Gunasinghe, Anouk von Borstel, Shin Yi Tin, Josephine F. Reijneveld, Thinh-Phat Cao, Benjamin S. Gully, Jerome Le Nours, D. Branch Moody, Ildiko Van Rhijn, Jamie Rossjohn
Summary: In this study, the authors reveal a novel geometrically alternate sideways mode of recognition of the antigen-presenting molecule CD1a by a gamma delta T cell receptor. The gamma delta TCR binds CD1a in a lipid-independent manner and induces clustering of TCRs and T cell signaling.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Zachary C. Stensland, John C. Cambier, Mia J. Smith
Summary: Targeted therapies focusing on autoantigen-specific B cells have shown potential for more precise treatment of autoimmune disorders, while also presenting challenges that need to be addressed for their clinical applicability.
Article
Medicine, Research & Experimental
M. J. van Weijsten, K. R. Venrooij, L. P. W. M. Lelieveldt, T. Kissel, E. van Buijtenen, F. J. van Dalen, M. Verdoes, R. E. M. Toes, K. M. Bonger
Summary: Many autoimmune diseases involve B cells that mistakenly identify autoantigens and produce antibodies against self-proteins. Current therapies seek to suppress the immune system, but can have adverse effects. A more targeted approach is to selectively target autoreactive B cells using autoantigens coupled to effector molecules. This study found that dimeric antigen constructs showed superior targeting properties compared to monomeric and multimeric counterparts, making them a potential basis for future antigen-specific targeting studies in the treatment of rheumatoid arthritis.
MOLECULAR PHARMACEUTICS
(2023)
Article
Medicine, Research & Experimental
Peter S. Linsley, Fariba Barahmand-Pour-Whitman, Elisa Balmas, Hannah A. DeBerg, Kaitlin J. Flynn, Alex K. Hu, Mario G. Rosasco, Janice Chen, Colin O'Rourke, Elisavet Serti, Vivian H. Gersuk, Keshav Motwani, Howard R. Seay, Todd M. Brusko, William W. Kwok, Cate Speake, Carla J. Greenbaum, Gerald T. Nepom, Karen Cerosaletti
Summary: This study identified a specific population of IAR T cells in autoimmune type 1 diabetes, characterized by restricted TCR alpha junctions and shared TCR alpha chains, showing specificity for islet antigen epitopes. These innate-like TCRs have implications for understanding disease mechanisms and should be considered in investigations of TCRs in T1D.
Article
Multidisciplinary Sciences
Samyuktha Ramesh, Soohyung Park, Wonpil Im, Melissa J. Call, Matthew E. Call
Summary: The B cell receptor (BCR) and T cell receptor (TCR) share a common core transmembrane (TM) structure, which is vital for optimal receptor assembly and stability in the cell membrane.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Nicolas Schall, Laura Talamini, Maud Wilhelm, Evelyne Jouvin-Marche, Sylviane Muller
Summary: In systemic lupus erythematosus, T cells display multiple abnormalities. P140, a synthetic peptide, can deplete these abnormal cells and restore normal immune homeostasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Eva-Maria Cox, Mohamed El-Behi, Stefanie Ries, Johannes F. Vogt, Vivien Kohlhaas, Thomas Michna, Benoit Manfroi, Mona Al-Maarri, Florian Wanke, Boaz Tirosh, Corinne Pondarre, Harry Lezeau, Nir Yogev, Romy Mittenzwei, Marc Descatoire, Sandra Weller, Jean-Claude Weill, Claude-Agnes Reynaud, Pierre Boudinot, Luc Jouneau, Stefan Tenzer, Ute Distler, Anne Rensing-Ehl, Christoph Koenig, Julian Staniek, Marta Rizzi, Aude Magerus, Frederic Rieux-Laucat, F. Thomas Wunderlich, Nadine Hoevelmeyer, Simon Fillatreau
Summary: This study reveals that AKT is involved in the formation of marginal zone (MZ) B cells in both mice and humans. By manipulating AKT signaling in B cells and its impact on FoxO transcription factors, the AKT-FoxO axis is identified as a switch for MZ B cell formation in mice. This developmental pathway is conserved in humans, where AKT-dependent splenic IgD+CD27+ B cells are proposed as the equivalent of MZ B cells.
Article
Multidisciplinary Sciences
Katharina Wild, Maike Smits, Saskia Killmer, Shirin Strohmeier, Christoph Neumann-Haefelin, Bertram Bengsch, Florian Krammer, Martin Schwemmle, Maike Hofmann, Robert Thimme, Katharina Zoldan, Tobias Boettler
Summary: The effectiveness of seasonal influenza vaccines varies between individuals and can be influenced by factors such as vaccination history. Specific CD4 T cell and antibody responses are closely linked to pre-existing immunity and vaccine history. Pre-vaccination immune phenotype and vaccination history play crucial roles in determining influenza hemagglutinin-specific T and B cell responses.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Johanna L. Mehl, Ashley Earle, Jan Lammerding, Musa Mhlanga, Viola Vogel, Nikhil Jain
Summary: Mutations and defects in nuclear lamins can lead to inflammatory diseases, and recent research has revealed the underlying molecular mechanisms. The activation of macrophages during inflammation reduces the levels of Lamin-A/C, promoting the expression of pro-inflammatory genes and cytokine secretion. Additionally, the phosphorylation and degradation of Lamin-A/C in macrophages are mediated by CDK1 and Caspase-6, respectively, and are necessary for upregulating IFN-beta expression.
Article
Immunology
Lindsay E. Nyhoff, Amber S. Griffith, Emily S. Clark, James W. Thomas, Wasif N. Khan, Peggy L. Kendall
Summary: Bruton's tyrosine kinase (Btk) plays a crucial role in inhibiting the development of mature anti-insulin B cells, removal of Btk affects the functions of anti-insulin B cells in terms of protein expression, proliferation, etc.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jakrawadee Julamanee, Seitaro Terakura, Koji Umemura, Yoshitaka Adachi, Kotaro Miyao, Shingo Okuno, Erina Takagi, Toshiyasu Sakai, Daisuke Koyama, Tatsunori Goto, Ryo Hanajiri, Michael Hudecek, Peter Steinberger, Judith Leitner, Tetsuya Nishida, Makoto Murata, Hitoshi Kiyoi
Summary: CD19.79a.40z CAR-T cells showed enhanced activity in vitro and superior anti-tumor efficacy in a murine model, with increased proliferative capacity compared to CD19.28z and CD19.BBz CAR-T cells.
Article
Pharmacology & Pharmacy
Xianzheng Zhang, Dan Mei, Han Wang, Qianqian Yu, Zhongyang Hong, Li Xu, Jinru Ge, Le Han, Jinling Shu, Faqin Liang, Xiaoyu Cai, Yue Zhu, Feng Zhang, Qingtong Wang, Yu Tai, Hua Wang, Lingling Zhang, Wei Wei
Summary: The study found that the new fusion protein DG has a significant therapeutic effect in mice with CIA by inhibiting the activation of BCR signaling by IgD. This suggests that DG may be a potential biological agent for the treatment of RA in the future.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Immunology
Wen Lu, Ynes A. Helou, Krishna Shrinivas, Jen Liou, Byron B. Au-Yeung, Arthur Weiss
Summary: Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by phospholipase C-gamma (PLC gamma 1) is critical for T cell signaling. PI transfer protein (PITP) Nir3 (Pitpnm2) promotes PIP2 replenishment and is important for T cell development. Deficiency of Nir3 slows down PIP2 replenishment, weakens TCR signaling, and impairs thymocyte development and T cell fitness.
Article
Immunology
Nina Worel, Katharina Grabmeier-Pfistershammer, Bernhard Kratzer, Martina Schlager, Andreas Tanzmann, Arno Rottal, Ulrike Koermoeczi, Edit Porpaczy, Philipp B. Staber, Cathrin Skrabs, Harald Herkner, Venugopal Gudipati, Johannes B. Huppa, Benjamin Salzer, Manfred Lehner, Nora Saxenhuber, Eleonora Friedberg, Philipp Wohlfarth, Georg Hopfinger, Werner Rabitsch, Ingrid Simonitsch-Klupp, Ulrich Jaeger, Winfried F. Pickl
Summary: Studies have found that low levels of CD3(+)CD27(-)CD28(-) T cells in lymphoma patients are associated with a favorable response to CART cell therapy, both in terms of overall response and complete remission. This finding highlights the importance of this pre-infusion blood biomarker in predicting the outcome of CAR-T cell treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Kei Kato, Kei Haniuda, Saori Fukao, Daisuke Kitamura
Summary: This study demonstrates the essential role of DNA endonuclease DNase1L3 in B cell activation by T cell independent type II (TI-II) antigens. DNase1L3-deficient mice showed a significant reduction in antigen-specific antibody production upon immunization with TI-II antigens, but not with T cell dependent (TD) antigens. Further experiments revealed that B cell-intrinsic DNase1L3 is required for the TI-II response.
INTERNATIONAL IMMUNOLOGY
(2023)