期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 118, 期 2, 页码 445-453出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI34006
关键词
-
Over the past century, understanding the mechanisms underlying muscle fatigue and weakness has been the focus of much investigation. However, the dominant theory in the field, that lactic acidosis causes muscle fatigue, is unlikely to tell the whole story. Recently, dysregulation of sarcoplasmic reticulum (SR) Ca2+ release has been associated with impaired muscle function induced by a wide range of stressors, from dystrophy to heart failure to muscle fatigue. Here, we address current understandings of the altered regulation of SR Ca2+ release during chronic stress, focusing on the role of the SR Ca2+ release channel known as the type 1 ryanodine receptor.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据