Article
Engineering, Biomedical
Claire E. Witherel, Kimheak Sao, Becky K. Brisson, Biao Han, Susan W. Volk, Ryan J. Petrie, Lin Han, Kara L. Spiller
Summary: This study investigates the role of macrophages in ECM assembly, showing that the phenotype of macrophages influences the formation and characteristics of fibrous tissues. By designing gelatin hydrogels containing cytokines, the shift in macrophage phenotype was promoted to affect the ECM composition and architecture.
Article
Pharmacology & Pharmacy
Heng Yang, Wanqi Lan, Wu Liu, Tingtao Chen, Yanhua Tang
Summary: Our study demonstrates that dapagliflozin significantly accelerates blood flow recovery and reduces limb necrosis in a mouse model of hindlimb ischemia. This effect is mediated through enhanced angiogenesis, reduced muscle fibrosis, and induction of macrophage phenotypic shift from M1 to M2 and decreased expression of inflammatory factors. Dapagliflozin may exert these effects partially through modulation of the NF-κB signaling pathway. Furthermore, dapagliflozin enhances endothelial cell proliferation, migration, and tube formation in vitro.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Erskine Chu, Richelle Mychasiuk, Evelyn Tsantikos, April L. Raftery, Elan L'Estrange-Stranieri, Larissa K. Dill, Bridgette D. Semple, Margaret L. Hibbs
Summary: Chronic neuroinflammation and glial activation are associated with the development of many neurodegenerative diseases and neuropsychological disorders. This study investigated the roles of Lyn and SHIP-1 in microglial responses in the steady-state adult mouse brain. The findings suggest that Lyn activity appears dispensable for maintaining brain homeostasis, while SHIP-1 regulates neuroinflammation and microglial activation in the steady-state adult brain.
Article
Immunology
Xuemin Jin, Xue Bai, Ying Zhao, Zijian Dong, Jianda Pang, Mingyuan Liu, Xiaolei Liu
Summary: This study revealed that Nrf2 is essential for M2 polarization induced by T. spiralis ES to alleviate colitis in mice. Adoptive transfer of ES-treated M2 decreased IFN-gamma levels and increased IL-4 and IL-10 levels in vivo, while ES-treated Nrf2 KO macrophages showed impaired ability to treat colitis with deficient elevation of IL-4 and IL-10 levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Gui-lin Jin, Hai-ping Liu, Ya-xin Huang, Qing-quan Zeng, Jin-xing Chen, Xiao-bing Lan, Zhi-ming Xin, Bo -jun Xiong, Rong-cai Yue, Chang-xi Yu
Summary: This study revealed the critical role of TSPO in sepsis-associated liver injury by regulating the polarization of liver macrophages and reducing the inflammatory response. KM, as a TSPO ligand, showed potential as a desirable candidate for the treatment of SALI and may exert its effect by regulating the M1/M2 polarization of macrophages in the liver.
Article
Medicine, Research & Experimental
Hui Teng, Sijia Chen, Kaijian Fan, Qishan Wang, Bingxin Xu, Di Chen, Futao Zhao, Tingyu Wang
Summary: This study investigated the effects and mechanisms of dexamethasone liposome (Dex-Lips) on osteoarthritis (OA) in miR-204/-211-deficient mice. Dex-Lips alleviated OA symptoms, reduced pain and inflammation, regulated PGE2, and repolarized synovial macrophages to M2 phenotypes.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Riki Toita, Eiko Shimizu, Masaharu Murata, Jeong-Hun Kang
Summary: The study suggests that phosphatidylserine-containing liposomes can promote the generation of M2-like macrophages to protect against pressure ulcer formation and accelerate healing. Older animals demonstrate slower wound healing, but PSL treatment significantly accelerates wound closure.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Medicine, Research & Experimental
Huai-Fu Wang, Li Chen, Ya Xie, Xiao-Fang Wang, Kun Yang, Ying Ning, Jia-Yue He, Wei-Jun Ding
Summary: Electroacupuncture treatment can prevent weight gain in obese adipose tissues by modulating inflammatory response and macrophage polarization.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Yimin Huang, Kongyang Ma, Rencai Qin, Yaxiong Fang, Jingquan Zhou, Xiaoyan Dai
Summary: This study found that pristane can decrease atherosclerotic lesion formation and increase stability of plaques, while inhibiting the frequency of B cells and increasing the frequency of plasma cells and M2 macrophages. Pristane induces IL-4-producing CD138+ regulatory plasma cell generation, which promotes M2 macrophage polarization via IL-4 secretion.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ryuhei Takemoto, Tetsuro Kamiya, Taku Atobe, Hirokazu Hara, Tetsuo Adachi
Summary: In M2-like macrophages, both HIF1α and STAT3 are essential for LOX induction, while the loss of FOXO1 facilitates HIF1α binding to the lox promoter region, promoting LOX induction.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Nan Yang, Xiang Li
Summary: EGCG treatment relieves asthmatic symptoms in mice by suppressing HIF-1 alpha/VEGFA-mediated M2 skewing of macrophages.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Guo-Rao Wu, Min Zhou, Yi Wang, Qing Zhou, Lei Zhang, Long He, Shu Zhang, Qilin Yu, Yongjian Xu, Jianping Zhao, Weining Xiong, Cong-Yi Wang
Summary: This study found that Mbd2 plays an important role in the pathogenesis of asthma, mainly through regulating the polarization of M2 macrophages. The results suggest that Mbd2 could be a potential target for the treatment of asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yulin Sun, Lu Liu, Chen Qiu
Summary: This study investigates the protective effect of tangeretin against diet-induced metabolic inflammation. Tangeretin protects against insulin resistance, ATMs activation, and M1 macrophage polarization in mice fed a high-fat diet. The mechanism involves the rerouting of carbon metabolism and lactate accumulation, which promote M2 macrophage polarization and reduce inflammation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Ziyou Bao, Xiaotong Chen, Yan Li, Wenshan Jiang, Di Pan, Lushun Ma, Yunxiao Wu, Yunling Chen, Chaojia Chen, Liyuan Wang, Songbo Zhao, Tixiao Wang, Wei-Yang Lu, Chunhong Ma, Shuanglian Wang
Summary: Macrophages in the liver can change their function in response to hepatitis B virus (HBV) infection. This study shows that GABA signaling in macrophages can promote a specific type of macrophage polarization (M2-like), which leads to increased replication of HBV in mice. The activation of GABA receptors enhances HBV replication by suppressing the immune response of liver macrophages.
ANTIVIRAL RESEARCH
(2023)
Article
Cell Biology
Jie Wang, Qian Chen, Zhixiong Zhang, Shangshang Wang, Yilun Wang, Mengmeng Xiang, Jun Liang, Jinhua Xu
Summary: The study showed that azithromycin could alleviate lupus symptoms by promoting M2 macrophage polarization in vivo, indicating a potential new treatment strategy for SLE.
CELL DEATH DISCOVERY
(2021)
Article
Microbiology
Jocelyn R. Hauser, Hong Hong, N. Esther Babady, Genovefa A. Papanicolaou, Yi-Wei Tang
JOURNAL OF CLINICAL MICROBIOLOGY
(2020)
Article
Oncology
Friederike Pastore, Neha Bhagwat, Alessandro Pastore, Aliaksandra Radzisheuskaya, Abdul Karzai, Aishwarya Krishnan, Bing Li, Robert L. Bowman, Wenbin Xiao, Aaron D. Viny, Anouar Zouak, Young C. Park, Keith B. Cordner, Stephanie Braunstein, Jesper L. Maag, Alexander Grego, Jaanvi Mehta, Min Wang, Hong Lin, Benjamin H. Durham, Richard P. Koche, Raajit K. Rampal, Kristian Helin, Peggy Scherle, Kris Vaddi, Ross L. Levine
Article
Hematology
Wenbin Xiao, Alexander Chan, Michael R. Waarts, Tanmay Mishra, Ying Liu, Sheng F. Cai, Jinjuan Yao, Qi Gao, Robert L. Bowman, Richard P. Koche, Isabelle S. Csete, Nicole L. DelGaudio, Andriy Derkach, Jeeyeon Baik, Sophia Yanis, Christopher A. Famulare, Minal Patel, Maria E. Arcila, Maximilian Stahl, Raajit K. Rampal, Martin S. Tallman, Yanming Zhang, Ahmet Dogan, Aaron D. Goldberg, Mikhail Roshal, Ross L. Levine
Summary: Plasmacytoid dendritic cell expansion in acute myeloid leukemia is poorly studied, and pDC-AML patients often have adverse risk stratification with RUNX1 mutations. CD123 targeting represents a potential treatment approach for pDC-AML.
Article
Hematology
Wenbin Xiao, Linde A. Miles, Robert L. Bowman, Vidushi Durani, Helen S. Tian, Nicole L. DelGaudio, Tanmay Mishra, Menglei Zhu, Yanming Zhang, Sarah E. Stump, Martin S. Tallman, Ross L. Levine, Sheng F. Cai
Article
Hematology
Maximilian Stahl, Kamal Menghrajani, Andriy Derkach, Alexander Chan, Wenbin Xiao, Jacob Glass, Amber C. King, Anthony F. Daniyan, Christopher Famulare, Bernadette M. Cuello, Troy Z. Horvat, Omar Abdel-Wahab, Ross L. Levine, Aaron D. Viny, Eytan M. Stein, Sheng F. Cai, Mikhail Roshal, Martin S. Tallman, Aaron D. Goldberg
Summary: Combination therapy of venetoclax is effective in many patients with relapsed or refractory AML, with azacitidine+venetoclax showing higher response rates compared to low-dose cytarabine+venetoclax. Clinical and molecular characteristics of patients may predict treatment outcomes in this population.
Article
Hematology
Barbara Spitzer, Filemon S. Dela Cruz, Glorymar D. Ibanez Sanchez, Yanming Zhang, Wenbin Xiao, Ryma Benayed, Alina Markova, M. Irene Rodriguez-Sanchez, Nancy Bouvier, Mikhail Roshal, Andrew L. Kung, Neerav Shukla
Summary: MLN-Eo is a WHO-established category of hematologic malignancies, and we report a case of an 8-month-old infant diagnosed with ETV6-FLT3 driven MLN-Eo who achieved complete remission after treatment. This case highlights the clinical utility of ex vivo drug testing in targeted therapies.
Article
Hematology
Bing Li, Wenbin An, Hua Wang, Timour Baslan, Shoron Mowla, Aishwarya Krishnan, Wenbin Xiao, Richard P. Koche, Ying Liu, Sheng F. Cai, Zhijian Xiao, Andriy Derkach, Ilaria Iacobucci, Charles G. Mullighan, Kristian Helin, Scott W. Lowe, Ross L. Levine, Raajit K. Rampal
Summary: Leukemic transformation (LT) of myeloproliferative neoplasm (MPN) is often fatal, with TP53 mutational inactivation being the most common event. This study demonstrates that biallelic inactivation of Trp53 leads to LT, specifically a pure erythroleukemia (PEL), arising from the megakaryocyte-erythroid progenitor population. Activation of the bone morphogenetic protein 2/SMAD pathway contributes to abnormal self-renewal of megakaryocyte-erythroid progenitors during LT. The Jak2/Trp53 mutant PEL is characterized by recurrent copy number alterations and DNA damage, and combination WEE1 and poly(ADP-ribose) polymerase inhibition shows potential as a therapeutic strategy.
Review
Pathology
Magdalena Czader, Catalina Amador, James R. Cook, Devang Thakkar, Clay Parker, Sandeep S. Dave, Ahmet Dogan, Amy S. Duffield, Reza Nejati, German Ott, Wenbin Xiao, Mariusz Wasik, John R. Goodlad
Summary: This article discusses the progression and transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and B-cell prolymphocytic leukemia (B-PLL). The study highlights the complexity and diagnostic challenges of these diseases, as well as the importance of molecular genetic studies in diagnosis and treatment.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Review
Pathology
John R. Goodlad, Wenbin Xiao, Catalina Amador, James R. Cook, Lanie Happ, Devang Thakkar, Sandeep Dave, Ahmet Dogan, Amy Duffield, Reza Nejati, German Ott, Mariusz Wasik, Magdalena Czader
Summary: Session 2 of the 2021 Society for Hematopathology and European Association for Haematopathology Workshop presented examples of lineage infidelity and transdifferentiation in B-lineage neoplasms, including after targeted therapy. A total of 20 cases were examined, with whole-exome sequencing and genome-wide RNA expression analysis conducted on a subset. The findings demonstrated lineage switch to acute myeloid leukemia or mixed-phenotype acute leukemia in multiple cases of B-cell acute lymphoblastic leukemia (B-ALL) upon relapse, as well as changes in maturational state without lineage switch. Aberrant T-cell antigen expression was also observed in mature B-cell lymphoma cases, with correlations to alterations in tumor cell gene expression patterns.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Review
Pathology
Reza Nejati, Catalina Amador, Magdalena Czader, Elizabeth Thacker, Devang Thakkar, Sandeep S. Dave, Ahmet Dogan, Amy Duffield, John R. Goodlad, German Ott, Mariusz A. Wasik, Wenbin Xiao, James R. Cook
Summary: The 2021 Society for Hematopathology/European Association for Haematopathology Workshop summarized cases of progression in Hodgkin lymphoma, plasmablastic myeloma, and plasma cell myeloma. Whole-exome sequencing and whole-genome RNA expression analysis were performed on selected cases, providing valuable insights into the molecular characterization and progression mechanisms of these neoplasms and potential therapeutic targets.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Review
Pathology
Amy S. Duffield, Ahmet Dogan, Catalina Amador, James R. Cook, Magdalena Czader, John R. Goodlad, Reza Nejati, Wenbin Xiao, Lanie Happ, Clay Parker, Elizabeth Thacker, Devang Thakkar, Sandeep S. Dave, Mariusz A. Wasik, German Ott
Summary: The 2021 Society for Hematopathology and European Association for Haematopathology Workshop focused on the molecular and cytogenetic mechanisms of transformation and transdifferentiation in lymphoid neoplasms. Gene alteration analysis and expression profiling were performed on 45 cases, revealing distinct categories of transformation in diffuse large B-cell lymphoma/high-grade B-cell lymphoma with rearrangements of MYC and BCL2. Cytogenetic abnormalities, such as MYC and NOTCH1 rearrangements, as well as single gene alterations, including TP53, were identified as important factors in transformation.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Review
Pathology
James R. Cook, Catalina Amador, Magdalena Czader, Amy Duffield, John Goodlad, German Ott, Wenbin Xiao, Sandeep Dave, Devang Thakkar, Elizabeth Thacker, Ahmet Dogan, Mariusz Wasik, Reza Nejati
Summary: The conclusions of the 2021 Society for Hematopathology/European Association for Haematopathology workshop on transformations of marginal zone lymphoma (MZL) and lymphoplasmacytic lymphoma (LPL) were summarized. The most common transformation is to diffuse large B-cell lymphoma (DLBCL), but there are also other transformation events to different types of lymphomas. Comprehensive analysis, including sequencing studies, can aid in the diagnosis and classification of these rare cases.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Review
Pathology
Catalina Amador, James R. Cook, Magdalena Czader, Amy Duffield, John Goodlad, Reza Nejati, German Ott, Wenbin Xiao, Sandeep Dave, Mariusz A. Wasik, Ahmet Dogan
Summary: Objectives of sessions 8 and 9 were to study examples of transdifferentiation, lineage infidelity, and progression in T/NK-cell neoplasms. A total of 28 cases were analyzed, with a subset undergoing whole-exome sequencing and genome-wide RNA expression analysis. Transdifferentiation to mature myeloid neoplasms, phenotypic infidelity in mature T-cell lymphomas, and disease progression in T-cell lymphoproliferative disorders were observed. This cohort of cases provides insights into current concepts of transdifferentiation and progression in T/NK-cell neoplasms.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Editorial Material
Hematology
Krasimira A. Rozenova, Wenbin Xiao
Letter
Oncology
Priyadarshini Kumar, Qi Gao, Alexander Chan, Natasha Lewis, Allison Sigler, Janine Pichardo, Wenbin Xiao, Mikhail Roshal, Ahmet Dogan
BLOOD CANCER JOURNAL
(2020)