Unexpected Targets and Triggers of Autoimmunity

Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms

(2014) Sheng Xiao et al.   IMMUNITY

Single-Cell RNA-Seq Reveals Dynamic, Random Monoallelic Gene Expression in Mammalian Cells

(2014) Q. Deng et al.   SCIENCE

Highly Multiplexed Subcellular RNA Sequencing in Situ

(2014) J. H. Lee et al.   SCIENCE

Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

(2013) Alex K. Shalek et al.   NATURE

Dynamic regulatory network controlling TH17 cell differentiation

(2013) Nir Yosef et al.   NATURE

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

(2013) Chuan Wu et al.   NATURE

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

(2013) Markus Kleinewietfeld et al.   NATURE

Entering the era of single-cell transcriptomics in biology and medicine

(2013) Rickard Sandberg   NATURE METHODS

The promise of single-cell sequencing

(2013) James Eberwine et al.   NATURE METHODS

A Validated Regulatory Network for Th17 Cell Specification

(2012) Maria Ciofani et al.   CELL

Th17 Cells in Immunity to Candida albicans

(2012) Nydiaris Hernández-Santos et al.   Cell Host & Microbe

Immunoregulation in cutaneous allergy

(2012) Christina E. Zielinski et al.   Current Opinion in Allergy and Clinical Immunology

IL-23: One cytokine in control of autoimmunity

(2012) Andrew L. Croxford et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

Induction and molecular signature of pathogenic TH17 cells

(2012) Youjin Lee et al.   NATURE IMMUNOLOGY

Targeting IL-17 and TH17 cells in chronic inflammation

(2012) Pierre Miossec et al.   NATURE REVIEWS DRUG DISCOVERY

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

(2012) Craig Leonardi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-23: A key cytokine in inflammatory diseases

(2011) Emilie Duvallet et al.   ANNALS OF MEDICINE

IL-23R rs11209026 polymorphism modulates IL-17A expression in patients with rheumatoid arthritis

(2011) J Hazlett et al.   GENES AND IMMUNITY

IL-17 signaling in host defense against Candida albicans

(2011) Sarah L. Gaffen et al.   IMMUNOLOGIC RESEARCH

Control of TH17 cells occurs in the small intestine

(2011) Enric Esplugues et al.   NATURE

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

(2011) Jun R. Huh et al.   NATURE

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study

(2010) M. C. Genovese et al.   ARTHRITIS AND RHEUMATISM

Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors

(2010) Jinfang Zhu et al.   IMMUNOLOGICAL REVIEWS

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

The dual nature of TH17 cells: shifting the focus to function

(2010) William O'Connor et al.   NATURE IMMUNOLOGY

Targeting IL-17 and Th17 Cells in Rheumatoid Arthritis

(2010) Sujata Sarkar et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Effector and Regulatory T-cell Subsets in Autoimmunity and Tissue Inflammation

(2010) A. Jäger et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

(2010) W. Hueber et al.   Science Translational Medicine

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Heterogeneity and plasticity of T helper cells

(2009) Jinfang Zhu et al.   CELL RESEARCH

Role of IL-23-Th17 Cell Axis in Allergic Airway Inflammation

(2009) Hidefumi Wakashin et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

(2009) William O'Connor Jr et al.   NATURE IMMUNOLOGY

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

CD4 T cells: fates, functions, and faults

(2008) J. Zhu et al.   BLOOD

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

(2008) Lauren A. Zenewicz et al.   IMMUNITY

Induction and effector functions of TH17 cells

(2008) Estelle Bettelli et al.   NATURE