期刊
JOURNAL OF CLINICAL IMMUNOLOGY
卷 33, 期 3, 页码 567-576出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10875-012-9834-5
关键词
Myasthenia gravis; miR-320a; MAPK1; cytokine; COX-2
类别
资金
- Shanghai Science and Technology Commission [10JC1414500]
- Shanghai Committee of Science and Technology [11DZ2260600]
Myasthenia gravis (MG) are T-cell dependent antibody-mediated autoimmune disorders, microRNAs are important regulators of human autoimmune disease pathogenesis. Here, we investigated the miRNAs expression profiles in MG for the first time and found that miR-320a was significantly downregulated in MG patients compared to normal healthy people. Meanwhile, pro-inflammatory cytokins in MG patients were overexpressed. Furthermore, we identified MAPK1 as a direct target of miR-320a. Downregulation of miR-320a induced the overexpression of pro-inflammatory cytokins through promoting COX-2 expression. This process was modulated by ERK/NF-kappa B pathways. Taken together, our findings suggested that miR-320a could play a role in modulation of inflammatory cytokins production.
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