期刊
JOURNAL OF CLINICAL IMMUNOLOGY
卷 33, 期 2, 页码 368-377出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10875-012-9821-x
关键词
Dectin-1; monocytes; systemic lupus erythematosus; rheumatoid arthritis
类别
资金
- Fondo de Cooperacion Internacional en Ciencia y Tecnologia (FONCICYT-European Union, Mexico) [95395]
- Instituto de Salud Carlos III, Spain [ISCIII, PI081772]
- ISCIII-FEDER, Spanish Network for the Research in Infectious Diseases, Spain [REIPI RD07/0008/2006]
- CONACYT, Mexico
- Consejer a de Educacion de la Comunidad de Madrid and Fondo Social Europeo (FSE, Spain)
The aim of this work was to study the expression and function of the innate immune receptor dectin-1 in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). We studied twenty-six patients with SLE not receiving immunosuppressive therapy, twenty-six patients with RA, and fifteen controls. We found that monocytes from SLE patients showed a diminished expression of dectin-1 compared to healthy controls, and an inverse correlation between percent of dectin-1+ cells and the disease activity score was detected. In addition, cells from SLE patients showed an abnormal calcium flux response induced by dectin-1 ligands as well as an enhanced release of IL-1 beta, IL-6 and TNF-alpha, but not IL-23, upon dectin-1 engagement. Monocytes from patients with RA also showed a diminished expression, and a defective function of dectin-1. Our data suggest that dectin-1 receptor defects could contribute to the pathogenesis of autoimmune inflammatory conditions.
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