Article
Peripheral Vascular Disease
Brent M. Egan, Jianing Yang, Michael K. Rakotz, Susan E. Sutherland, Kenneth A. Jamerson, Jackson T. Wright, Keith C. Ferdinand, Gregory D. Wozniak
Summary: The study found that initial therapy with calcium channel blockers or thiazide-type diuretics had better antihypertensive effects in non-Hispanic Black adults than renin-angiotensin system blockers. Despite the recommendation to use this treatment approach, there is still a gap between the recommended and actual use. Evidence-based monotherapy appears insufficient to improve hypertension control in non-Hispanic Black adults.
Article
Transplantation
Sara Sokooti, Frank Klont, Sok Cin Tye, Daan Kremer, Rianne M. Douwes, Gerard Hopfgartner, Robin P. F. Dullaart, Hiddo J. L. Heerspink, Stephan J. L. Bakker
Summary: The study found that the use of diuretics is associated with an increased risk of developing PTDM in KTRs, independent of established risk factors for PTDM development.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Cell Biology
Nevena Dragasevic, Maja Savic, Katarina Mihajlovic, Vladimir Zivkovic, Marijana Andjic, Nevena Draginic, Nebojsa Zdravkovic, Sergey Bolevich, Stefani Bolevich, Vladimir Jakovljevic, Tamara Nikolic Turnic
Summary: This study aimed to investigate the effects of various diuretics on the ischemia/reperfusion dysfunction of the heart in hypertensive rats. The results showed that treatment with hydrochlorothiazide, spironolactone, or indapamide reduced oxidative damage to the myocardium and mitigated left ventricular hypertrophy. However, there were no significant changes in blood pressure or ejection fraction. In addition, spironolactone had a cardiodepressant effect on spontaneously hypertensive rats.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Transplantation
Bart J. Kramers, Iris W. Koorevaar, Rudolf De Boer, Ewout J. Hoorn, Michelle J. Pena, Ron T. Gansevoort, Esther Meijer
Summary: This study found that the use of thiazide diuretics in ADPKD patients does not have a detrimental effect on disease progression rate, suggesting that these drugs can be prescribed as second-line antihypertensives. Users of thiazide diuretics may have higher vasopressin concentrations and RAAS activity, but this difference disappears after adjustment for age and sex.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Review
Pharmacology & Pharmacy
Athanasios Manolis, Manolis Kallistratos, Michael Doumas
Summary: Loop diuretics are recommended for heart failure patients by ESC to reduce hospitalizations and improve symptoms and exercise capacity. Torasemide is recommended for the first time in hypertensive patients by ESH guidelines. This review emphasizes the importance of torasemide in the management of arterial hypertension and heart failure.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Peripheral Vascular Disease
Zhen-Yu Zhang, Yu-Ling Yu, Kei Asayama, Tine W. Hansen, Gladys E. Maestre, Jan A. Staessen
Summary: Additional digital content is available in the text.
Article
Public, Environmental & Occupational Health
Julie Rouette, Emily G. McDonald, Tibor Schuster, Ilan Matok, James M. Brophy, Laurent Azoulay
Summary: This study aimed to determine the association between thiazide diuretics and colorectal cancer risk. The results showed that thiazide diuretics were not associated with an increased risk of colorectal cancer compared to dihydropyridine calcium channel blockers. However, an increased risk was observed among patients with inflammatory bowel disease and a history of polyps.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Medicine, General & Internal
Peter Chun-Yip Tong, Susanna Chi-Pun Chan, Wing-Bun Chan, Kelvin Kai-Leung Ho, Godwin Tat-Chi Leung, Stanley Hok-King Lo, Gary Yiu-Kwong Mak, Tak-Sun Tse
Summary: Hypertension and type 2 diabetes mellitus are significant health issues with increased risks of cardiovascular and renal complications. An expert panel reviewed recent evidence to provide recommendations for physicians in Hong Kong regarding optimal blood pressure targets, the role of angiotensin II receptor blockers, implications of albuminuria, and screening for microalbuminuria in hypertensive patients with T2DM. Through virtual meetings and a modified Delphi method, consensus statements were derived based on expert insights and current evidence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ming Gao, Wenrui Lin, Tianqi Ma, Yi Luo, Hejian Xie, Xunjie Cheng, Yongping Bai
Summary: This study compared cardiovascular risks of four different antihypertensive drugs in patients with isolated systolic hypertension (ISH) and type 2 diabetes mellitus (T2DM). The results showed that angiotensin receptor blockers (ARB) reduced the risk of cardiovascular mortality, while other drugs did not have the same effect.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Peripheral Vascular Disease
Catherine G. Derington, Adam P. Bress, Andrew E. Moran, William S. Weintraub, Jennifer S. Herrick, William C. Cushman, Ian M. Kronish, Barry Stults, Daichi Shimbo, Paul Muntner, Tom Greene, Jeffrey T. Bates, Tara I. Chang, Lois Anne Katz, Shakaib U. Rehman, Christianne L. Roumie, Leonardo Tamariz, Jordan B. King
Summary: In the SPRINT study, the use of ACE inhibitors or ARBs, thiazide diuretics, and calcium channel blockers in combination is favored to target systolic blood pressure (SBP) < 120 mm Hg, instead of using ACE/ARB monotherapy to target SBP < 140 mm Hg.
Article
Cardiac & Cardiovascular Systems
Ngoc-Yen T. Pham, Jonathan. G. G. Owen, Namita Singh, Saeed Kamran Shaffi
Summary: The use of thiazide diuretics in the treatment of hypertension in advanced chronic kidney disease is discussed in this review. Thiazides have been recommended as the first-line treatment for hypertension, but their use is limited in advanced CKD due to perceived ineffectiveness. Recent data suggest that thiazides may help control blood pressure and promote natriuresis. This review focuses on the pharmacology, common adverse effects, clinical uses, and evidence for efficacy of thiazide use in advanced CKD.
CARDIOLOGY IN REVIEW
(2023)
Article
Medicine, General & Internal
Julie Rouette, Emily G. McDonald, Tibor Schuster, James M. Brophy, Laurent Azoulay
Summary: This study describes the prescribing trends of antihypertensive drugs in primary care patients and assesses the treatment trajectory of patients with hypertension according to changes in the UK hypertension management guidelines. The findings suggest that most patients are prescribed guideline-recommended first-line agents, but not all patients receive recommended drugs, particularly females, potentially leading to suboptimal cardiovascular outcomes.
Review
Peripheral Vascular Disease
Vitor M. Martins, Patricia K. Ziegelmann, Filipe Ferrari, Leonardo G. Bottino, Marcelo B. Lucca, Henrique L. Ruchaud Correa, Gabriela B. Blum, Lucas Helal, Sandra C. Fuchs, Flavio D. Fuchs
Summary: This study aimed to compare the blood pressure-lowering effects and adverse effects of thiazide diuretics alone or in combination with potassium-sparing diuretics in patients with hypertension. The results showed that the combination of thiazide diuretics and potassium-sparing diuretics had better blood pressure-lowering efficacy compared to thiazide diuretics alone, and it also effectively reduced the risk of hypokalemia and hyperglycemia.
JOURNAL OF HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Julie Rouette, Emily G. G. McDonald, Tibor Schuster, James M. M. Brophy, Laurent Azoulay
Summary: In this population-based cohort study, new users of dihydropyridine calcium channel blockers (dCCBs) were not found to have an increased risk of pancreatic cancer compared to new users of thiazide diuretics after a median follow-up of 4.5 years. These findings provide reassurance regarding the long-term safety of these drugs in relation to pancreatic cancer risk.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Cardiac & Cardiovascular Systems
Gargi Sharma Priamvada, Divya Sharma Divyadarshini, Raven Voora
Summary: This review summarizes recent studies on the indications and safety of thiazide use in patients with CKD, and discusses the mechanism of how thiazides reduce blood pressure.
CURRENT CARDIOLOGY REPORTS
(2022)
