Review
Cardiac & Cardiovascular Systems
Alberto Palazzuoli, Sergio Caravita, Stefania Paolillo, Stefano Ghio, Carlo Gabriele Tocchetti, Gaetano Ruocco, Michele Correale, Giuseppe Ambrosio, Pasquale Perrone Filardi, Michele Senni
Summary: HFpEF is a prevalent clinical condition associated with cardiovascular aging, with differences in diagnostic criteria and patient selection in recent trials. Lack of standardization and population heterogeneity may explain the failure to show improved outcomes with different therapeutic interventions in HFpEF patients. The characterization of patients, cardiovascular risk, associated diseases, and disease progression features could provide insights for tailored treatments and mechanistic understanding.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Review
Medicine, General & Internal
Ioannis T. Farmakis, Eftychia Demerouti, Panagiotis Karyofyllis, George Karatasakis, Maria Stratinaki, Dimitrios Tsiapras, George Athanassopoulos, Vassilios Voudris, George Giannakoulas
Summary: PAH is characterized by insult in pulmonary vasculature leading to RV adaptation and ultimately RV failure. Echocardiography is crucial for evaluating right heart in PAH, with certain parameters having prognostic implications, though its role in risk assessment is limited under current guidelines.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Melody Kasher, Maxim B. Freidin, Frances Mk Williams, Stacey S. Cherny, Ida Malkin, Gregory Livshits
Summary: This study investigated the genetic association between rheumatoid arthritis (RA) and osteoporosis (OP), and found evidence of pleiotropy. Shared genetic variants associated with both RA and OP were identified.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Peripheral Vascular Disease
Paolo Palatini
Summary: Recent evidence suggests that orthostatic hypertension is associated with an increased risk of hypertension-related complications and mortality. The clinical relevance of diastolic orthostatic hypertension is still unclear. The reproducibility of orthostatic blood pressure measurements can be improved by shortening the between-assessment interval and increasing the number of readings. The pathogenetic mechanisms leading to orthostatic hypertension may vary according to age.
Article
Cardiac & Cardiovascular Systems
Xinxin Ye, Qian Yi, Jing Shao, Yan Zhang, Mingming Zha, Qingwen Yang, Wei Xia, Zhihong Ye, Peige Song
Summary: Blood pressure levels and hypertension prevalence increased dramatically in Chinese children and adolescents from 1991 to 2015. Age, body mass index, waist circumference, and overweight/obesity status were associated factors of hypertension among youths.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Beata Korosi, Helga Gyongyosi, Dora Batta, Andrea Laszlo, Illes Kovacs, Andras Tisler, Orsolya Cseprekal, Zsofia Nemcsik-Bencze, Xenia Gonda, Zoltan Rihmer, Janos Nemcsik
Summary: White-coat and resistant hypertensive patients exhibit specific affective temperament patterns, and evaluating these patterns can provide insight into the psychopathological background of these conditions.
HYPERTENSION RESEARCH
(2021)
Article
Medicine, General & Internal
Zhuoqing Hu, Kevin Yang, Zhihui Hu, Miaosheng Li, Hao Wei, Zheng Tang, Baitong Chen, Chengbiao Su, De Cai, Jinrong Xu
Summary: The study found an association between hypertension and bone metabolism markers in osteoporotic patients, with lower levels of OC and 25-OHD in hypertensive individuals. This may contribute to reduced bone turnover and could be a mechanism for hypertension-related osteoporosis.
Article
Peripheral Vascular Disease
Jie Dong, Hongbo Dong, Yinkun Yan, Hong Cheng, Xiaoyuan Zhao, Jie Mi
Summary: This study evaluated the prevalence of hypertension and hypertension subtypes among Chinese children aged 6-17 years. The results showed that approximately 4% of urban Chinese children and adolescents had hypertension, with isolated systolic hypertension being the most common subtype.
JOURNAL OF HYPERTENSION
(2022)
Review
Peripheral Vascular Disease
Ruixing Zhang, Hongtao Yin, Mengdi Yang, Xianqiong Lei, Donghu Zhen, Zheng Zhang
Summary: Hypertension and osteoporosis are common comorbidities in the elderly. The effects of antihypertensive drugs on bone metabolism are controversial, with different drugs having different effects. Some drugs may improve bone density by stimulating osteoblast differentiation and reducing osteoclast generation, while others may not have a significant relationship with bone density or strength, and may even increase fracture risk.
Review
Medicine, General & Internal
Aneta Kacprzak, Witold Tomkowski, Monika Szturmowicz
Summary: Sarcoidosis is a recognized risk factor for pulmonary hypertension, but our understanding of this connection is incomplete. Sarcoidosis-associated pulmonary hypertension is a serious complication that increases morbidity and mortality among sarcoidosis patients. The epidemiology and pathophysiology of this condition are not fully understood, and multiple factors are believed to play a role in its development. Phenotyping SAPH is challenging due to gaps in our understanding of the underlying processes and the inability to assess pulmonary vasculature in living patients. Additionally, SAPH is a dynamic condition with multiple phenotypes that can switch during the course of sarcoidosis.
Article
Endocrinology & Metabolism
Su-Qin Shi, Shan-Shan Li, Xiao-Ya Zhang, Zhe Wei, Wen-Zhen Fu, Jin-Wei He, Yun-Qiu Hu, Miao Li, Li-Li Zheng, Zhen-Lin Zhang
Summary: This study found that genetic variations of the LGR4 gene are associated with peak bone mineral density, BMI, and trunk fat mass.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Andrzej Januszewicz, Paolo Mulatero, Piotr Dobrowolski, Silvia Monticone, Patricia Van der Niepen, Martin Reincke, Emrush Rexhaj, Graeme Eisenhofer, Magdalena Januszewicz, Alexandros Kasiakogias, Reinhold Kreutz, Jacques W. M. Lenders, Maria Lorenza Muiesan, Alexandre Persu, Enrico Agabiti-Rosei, Rodrigo Soria, Mateusz Spiewak, Aleksander Prejbisz, Franz H. Messerli
Summary: Secondary hypertension carries a higher risk of cardiac morbidity and mortality. Studying cardiac phenotypes in secondary hypertension helps understand the underlying mechanisms affecting the heart. The higher prevalence of heart damage in these patients compared to those with primary hypertension can be attributed to specific clinical and biochemical phenotypes, providing an opportunity for early screening and monitoring of heart damage and personalized treatment.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Anping Cai, Zhou Dan, Yingling Zhou, Yinqing Feng, Zhiqiang Nie
Summary: This study aimed to evaluate the prognostic implications of echocardiographic phenotypes in community hypertensive patients. Two distinct echocardiographic phenotypes were identified, namely mild-remodeling HTN and severe-remodeling HTN. The Cluster 2 (severe-remodeling HTN) had higher incidence of cardiovascular and all-cause death compared to the Cluster 1 (mild-remodeling HTN), indicating the potential of echocardiographic variables-based algorithm in identifying high-risk asymptomatic community hypertensive patients.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Geriatrics & Gerontology
Jean-Pierre Gutzwiller, Krisztina Mueller-Bolla, Carlo Ferrari, Zeno Stanga, Urs. E. E. Nydegger, Lorenz Risch, Martin Risch
Summary: This study conducted a long-term follow-up on Swiss pensioners and identified potential risk factors associated with increased mortality in healthy older adults. This has important implications for understanding healthy ageing populations and reducing their global economic burden.
Article
Peripheral Vascular Disease
Fernando Martinez, Josep Redon, Francisco Aguilar, Jose Miguel Calderon, Empar Lurbe
Summary: This study aimed to assess the persistence of blood pressure phenotypes over time and the factors related to their persistence. The study found that the majority of children and adolescents had persistent blood pressure phenotypes, but there were cases of white coat hypertension and masked hypertension. The main factor predicting lack of persistence was the baseline hypertensive phenotype, while high systolic blood pressure and waist circumference were related to lack of persistence.
HYPERTENSION RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Georgia Kaiafa, Ilias Kanellos, Christos Savopoulos, Nikolaos Kakaletsis, George Giannakoulas, Apostolos I. Hatzitolios
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2015)
Article
Clinical Neurology
Konstantinos N. Fountoulakis, Christos Savopoulos, Martha Apostolopoulou, Roxani Dampali, Eleni Zaggelidou, Eleni Karlafti, Ilias Fountoukidis, Pavlos Kountis, Vasilis Limenopoulos, Eustratios Plomaritis, Pavlos Theodorakis, Apostolos I. Hatzitolios
JOURNAL OF AFFECTIVE DISORDERS
(2015)
Article
Peripheral Vascular Disease
Konstantinos Tziomalos, Vasilios Giampatzis, Stella D. Bouziana, Marianna Spanou, Maria Papadopoulou, Pavlina Kazantzidou, Stavroula Kostaki, Antonios Kouparanis, Christos Savopoulos, Apostolos I. Hatzitolios
JOURNAL OF CLINICAL HYPERTENSION
(2015)
Article
Medicine, General & Internal
Christos Savopoulos, Nikolaos Kakaletsis, Georgia Kaiafa, Fotios Iliadis, Anna Kalogera-Fountzila, Apostolos I. Hatzitolios
Review
Hematology
Nikolaos Kakaletsis, Georgia Kaiafa, Christos Savopoulos, Fotios Iliads, Vasilios Perifanis, Vasilios Tzalokostas, Alexandra Grekou, Angeliki Giannouli, Apostolos I. Hatzitolios
ACTA HAEMATOLOGICA
(2014)
Article
Hematology
Efthymia Vlachaki, Nikolaos Sousos, Vasilios Perifanis, Georgia Kaiafa, Ilias Onoufriadis, Apostolos Hatzitolios, Panagiota Boura
ACTA HAEMATOLOGICA
(2015)
Article
Cardiac & Cardiovascular Systems
Konstantinos Tziomalos, Stella D. Bouziana, Marianna Spanou, Vasilios Giampatzis, Maria Papadopoulou, Pavlina Kazantzidou, Stavroula Kostaki, Vasiliki Dourliou, Christos Savopoulos, Apostolos I. Hatzitolios
Letter
Clinical Neurology
Apostolos I. Hatzitolios, Marianna Spanou, Roxani Dambali, Katerina Vraka, Eugenios Doumarapis, Konstantinos Petratos, Christos Savopoulos, Konstantinos Tziomalos
INTERNATIONAL JOURNAL OF STROKE
(2014)
Article
Peripheral Vascular Disease
Konstantinos Tziomalos, Vasilios Giampatzis, Maria Baltatzi, Elias Efthymiou, Konstantia Psianou, Natalia Papastergiou, Dimitra Magkou, Vagia Bougatsa, Christos Savopoulos, Apostolos I. Hatzitolios
JOURNAL OF CLINICAL HYPERTENSION
(2014)
Article
Pharmacology & Pharmacy
G. Kaiafa, N. Kakaletsis, C. Savopoulos, V. Perifanis, A. Giannouli, N. Papadopoulos, S. Zisekas, A. I. Hatzitolios
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2014)
Article
Peripheral Vascular Disease
Konstantinos Tziomalos, Vasilios Giampatzis, Stella Bouziana, Athinodoros Pavlidis, Marianna Spanou, Maria Papadopoulou, Giannis Kagelidis, Chrysoula Boutari, Christos Savopoulos, Apostolos Hatzitolios
VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE
(2014)
Article
Endocrinology & Metabolism
Charalampos Dokos, Christos Tsakalidis, Kyriakoula Manaridou, George Koliakos
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2018)
Editorial Material
Pediatrics
Charalampos Dokos
SEMINARS IN FETAL & NEONATAL MEDICINE
(2020)
Article
Endocrinology & Metabolism
Charalampos Dokos, Christos Tsakalidis, Kyriakoula Manaridou, Paraskevi Karayianni, Ioannis Kyrkos, Israel Roussos
CLINICAL CASES IN MINERAL AND BONE METABOLISM
(2017)
Letter
Medicine, General & Internal
E. Karlafti, A. Hatzitolios, Ch Savopoulos
