Article
Surgery
Satoshi Karasawa, Talza-alzi Nalzada, Mamoru Sato, Talzu Miyasho, Tadanaga Shimada, Talzu Oshima, Koichi Suda, Koichiro Shinozalzi, Shigeto Oda
Summary: The study demonstrated that blood levels of cell-free DNA were significantly higher in the AMI model than in sham and abdominal sepsis models, and they were positively correlated with the pathologic ischemia severity score. Additionally, higher levels of paraoxonase-1 were found in the AMI models compared to the abdominal sepsis models, suggesting a potential role in the differential diagnosis of mesenteric ischemia.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Rainer Grotelueschen, Verena Miller, Lena M. Heidelmann, Nathaniel Melling, Tarik Ghadban, Katharina Grupp, Matthias Reeh, Maria-Noemi Welte, Faik Guntac Uzunoglu, Jakob R. Izbicki, Kai A. Bachmann
Summary: Diagnosing acute mesenteric ischemia is challenging due to low sensitivity and specificity of established parameters. Exploratory laparotomy remains the most reliable diagnostic method for detecting mesenteric infarction. New diagnostic parameters are needed to improve accuracy in diagnosis.
Review
Agriculture, Dairy & Animal Science
Elsa K. Ludwig, Kallie J. Hobbs, Caroline A. McKinney-Aguirre, Liara M. Gonzalez
Summary: Biomarkers are measurable substances that can identify ongoing injury or disease. Colic associated with intestinal ischemia is a major cause of morbidity and mortality in horses. Lactate, specifically the L isomer, is commonly used as a biomarker in colic evaluations. Although L-lactate is currently the most reliable marker for intestinal ischemia, further exploration of other biomarkers may improve outcomes for horses suffering from severe colic.
Article
Multidisciplinary Sciences
Ingeborg E. van Zeggeren, Liora ter Horst, Hans Heijst, Charlotte E. Teunissen, Diederik van de Beek, Matthijs C. Brouwer
Summary: In this study, the diagnostic accuracy of neurofilament light chain (NfL) for diagnosing central nervous system (CNS) infections was evaluated. The results showed that NfL cannot discriminate between different types of CNS infections, but high concentrations of NfL are associated with severe neurological diseases.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Keiko Hosohata, Denan Jin, Shinji Takai
Summary: The study aimed to determine the potential of urinary vanin-1 as a novel biomarker for AKI induced by I/R, showing significant increase in urinary vanin-1 levels in experimental models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Endocrinology & Metabolism
Ruslan Rust
Summary: The study revealed that blood neurofilament light chain proteins can serve as a biomarker for predicting neuronal damage, functional outcome, and mortality in stroke patients. These findings have the potential to revolutionize future prognosis and management strategies for individuals who have suffered a stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Immunology
YaQing Zhan, YiHong Ling, Qiwen Deng, YuXin Qiu, JianTong Shen, HanJin Lai, ZhaoRong Chen, ChanYan Huang, LiQun Liang, Xiang Li, JianFeng Wu, WenQi Huang, ShiHong Wen
Summary: The influx of activated neutrophils into the lungs is a histopathologic hallmark of acute lung injury (ALI) after intestinal ischemia/reperfusion (I/R). Neutrophils can release cytotoxic neutrophil extracellular traps (NETs), while high-mobility group protein B1 (HMGB1) released from necroptotic enterocytes plays a crucial role in inducing NETosis and causing ALI. Targeting NETosis and the HMGB1 pathway could be effective therapeutic strategies to minimize ALI induced by intestinal I/R.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Mukhtiar Ahmad, Mehran Khan, Rizwan Asif, Nuzhat Sial, Usman Abid, Tahira Shamim, Zahid Hameed, Muhammad Junaid Iqbal, Uroosa Sarfraz, Hina Saeed, Zara Asghar, Madeeha Akram, Qamar Ullah, Qurat ul Ain Younas, Laraib Rauf, Alishba Hadi, Sajida Maryam, Yasir Hameed, Muhammad Rashid Khan, Eman Tariq, Saba Saeed
Summary: In this study, ANLN's role in 24 human cancers was investigated using various databases and bioinformatic tools. The results showed that ANLN was differentially expressed in different cancers, and its overexpression was associated with poor prognosis in CESC, ESCA, HNSC, and KIRC patients. Further analysis revealed correlations between ANLN expression and gene regulation, immune cell infiltration, and chemotherapeutic drugs. Therefore, ANLN may serve as a potential biomarker for diagnosis and prognosis, and provide new targets for the treatment of related cancers.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Surgery
Antonio Brillantino, Michele Lanza, Massimo Antropoli, Alfonso Amendola, Simone Squillante, Vincenzo Bottino, Adolfo Renzi, Maurizio Castriconi
Summary: For non-critical patients with limited acute mesenteric ischemia, the damage control approach by two-step surgical procedure may provide better clinical outcomes compared to one-step surgical treatment, reducing the risks of anastomosis dehiscence and the need for ileostomy.
UPDATES IN SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Lina Wirestam, Pernilla Benjaminsson Nyberg, Todor Dzhendov, Thomas Gasslander, Per Sandstrom, Christopher Sjowall, Bergthor Bjornsson
Summary: The study found a relationship between plasma levels of Osteopontin (OPN) and the severity of acute pancreatitis (AP). OPN levels can reflect tissue injury and changes in OPN over time can help assess the disease progression and identify at-risk patients.
Article
Biochemistry & Molecular Biology
Yan Zhou, Jingwen Liu, Xiong Li, Luman Wang, Lirong Hu, Aiping Li, Jianwei Zhou
Summary: A compound called JAC4 has been found to protect the intestine from radiation-induced damage by increasing the expression of JWA protein. The study showed that JAC4 significantly reduced radiation-induced intestinal mucosal damage, oxidative stress, and systemic inflammation, while maintaining intestinal epithelial cell proliferation.
Article
Pharmacology & Pharmacy
Bruno A. Lopes, Caroline Pires Poubel, Cristiane Esteves Teixeira, Aurelie Caye-Eude, Helene Cave, Claus Meyer, Rolf Marschalek, Mariana Boroni, Mariana Emerenciano
Summary: Using a machine learning model, we accurately predicted KMT2A-r leukemia and identified 20 genes that can estimate KMT2A-r. The overexpression of SKIDA1 and LAMP5 were found to be better markers associated with KMT2A-r compared to CSPG4. LAMP5 overexpression was also associated with all KMT2A-USP2 fusions. Additionally, drug sensitivity analysis revealed potential treatments for KMT2A-r leukemia, including Foretinib for AML patients with FLT3 activating mutations.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Xue Han, Bo Li, Shitai Zhang
Summary: This article summarizes the molecular mechanisms of MIR503HG in disease and its potential applications in diagnosis, prognosis, and treatment. It also raises some unanswered questions in this area, providing insights for future research.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
Jan Tilmann Vollrath, Felix Klingebiel, Felix Blasius, Johannes Greven, Eftychios Bolierakis, Aleksander J. Nowak, Marija Simic, Frank Hildebrand, Ingo Marzi, Borna Relja
Summary: Polytrauma and concomitant hemorrhagic shock can lead to intestinal damage and subsequent multiple organ dysfunction syndrome. This study investigates the dynamics of intestinal fatty acid-binding protein (I-FABP) in plasma and urine after polytrauma in a porcine animal model. The results suggest that I-FABP levels in plasma and urine are significantly increased after polytrauma, indicating intestinal damage. Immunohistological staining also shows decreased levels of I-FABP in the intestine of polytraumatized animals compared to sham animals.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Binghui Jin, Guangyao Li, Lin Zhou, Zhe Fan
Summary: This paper outlines the signal pathways and cytokines involved in acute liver injury induced by intestinal I/R, providing new ideas for the prevention and treatment of liver injury caused by reperfusion after intestinal I/R.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pediatrics
Dominique Catherine Olthof, Sophie Reemst, Christian Sleeboom, C. F. Kuijper, Joost van Schuppen, J. P. M. Derikx, R. R. Gorter
Summary: The study demonstrates that the diagnostic accuracy of ultrasound for detecting underlying congenital abnormalities requiring surgery for umbilical discharge in pediatric population is limited, even with experienced pediatric radiologists. The sensitivity of ultrasound is 71.1% and specificity is 72.2%, indicating room for improvement in diagnostic capabilities for this condition.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Letter
Pediatrics
Kelly M. A. Dreuning, A. S. Paul van Trotsenburg, L. W. Ernest van Heurn, Joep P. M. Derikx
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Pediatrics
Sofia el Manouni el Hassani, Hendrik J. Niemarkt, Joep P. M. Derikx, Daniel J. C. Berkhout, Andrea E. Ballon, Margot de Graaf, Willem P. de Boode, Veerle Cossey, Christian V. Hulzebos, Anton H. van Kaam, Boris W. Kramer, Richard A. van Lingen, Daniel C. Vijlbrief, Mirjam M. van Weissenbruch, Marc A. Benninga, Nanne K. H. de Boer, Tim G. J. de Meij
Summary: Lower gestational age, early clinical onset, and no maternal corticosteroids administration are predictors for surgical NEC. Low serum bicarbonate in the 3 days prior clinical onset and patent ductus arteriosus for which ibuprofen was administered predict surgical NEC.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Pediatrics
Laurens D. Eeftinck Schattenkerk, Gijsbert D. Musters, David J. Nijssen, Wouter J. de Jonge, Ralph de Vries, L. W. Ernest van Heurn, Joep P. M. Derikx
Summary: This study aggregated the incidence of different surgical site infections in infants who underwent surgery for abdominal birth defects, finding that complications like wound infection, wound dehiscence, and anastomotic leakage varied among different birth defects.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Review
Pediatrics
Francesco Morini, Kelly M. A. Dreuning, Maarten J. H. Janssen Lok, Tomas Wester, Joep P. M. Derikx, Florian Friedmacher, Hiromu Miyake, Haitao Zhu, Luca Pio, Martin Lacher, Stefania Sgro, Augusto Zani, Simon Eaton, L. W. Ernest van Heurn, Agostino Pierro
Summary: This study evaluated the evidence on pediatric inguinal hernia repair and compiled recommendations on six topics including surgical approach, timing, and anesthesia technique. Results suggest that laparoscopic repair may be beneficial for children with bilateral hernia, while preterm infants may benefit from regional anesthesia and delayed surgery. Evidence for other topics was less conclusive.
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
(2022)
Article
Pediatrics
Danielle Roorda, Jaap Oosterlaan, Ernest van Heurn, Joep P. M. Derikx
Summary: This study found a relatively low incidence of HAEC in patients with Hirschsprung disease, with preoperative and postoperative rates of 8% and 21% respectively. The median HAEC free interval after surgery was 226 days, with a decline in incidence over follow-up. No specific patient or clinical characteristics were associated with the risk of postoperative HAEC.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Review
Nutrition & Dietetics
Ilse H. de Lange, Charlotte van Gorp, Laurens D. Eeftinck Schattenkerk, Wim G. van Gemert, Joep P. M. Derikx, Tim G. A. M. Wolfs
Summary: This article summarizes the pathogenesis of necrotizing enterocolitis (NEC), highlighting the immaturity of the intestinal immune system in preterm infants and abnormal microbial colonization as key factors. Enteral feeding is considered an important factor influencing NEC pathogenesis, with bioactive components in breast milk being effective in preventing NEC.
Review
Biochemistry & Molecular Biology
Sofia Frigerio, Dalia A. Lartey, Geert R. D'Haens, Joep Grootjans
Summary: Patients with IBD have an increased risk of CRC, which develops in a background of chronic inflammation and pro-inflammatory immune cells. The role of the immunosuppressive microenvironment in these cancers is not well understood, but it has gained more attention in recent years.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Dimitrios Nikolakis, Floris A. E. de Voogd, Maarten J. Pruijt, Joep Grootjans, Marleen G. van de Sande, Geert R. D'Haens
Summary: This review summarizes the research findings on immune-mediated mechanisms in lymphoid tissues related to the pathogenesis and potential treatments of inflammatory bowel disease (IBD). Enhanced innate and adaptive immune responses were observed in patients with IBD and in animal models, and lymphatic obstruction correlated with disease activity. Abnormalities in lymphatic stromal components and lymph node microbiome were common in IBD and could be targeted therapeutically.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Merlijn H. Kaaij, Jasper Rip, Kim C. M. Jeucken, Yik Y. Kan, Charlotte C. N. van Rooijen, Job Saris, Desiree Pots, Silke Frey, Joep Grootjans, Georg Schett, Leonie M. van Duivenvoorde, Martijn A. Nolte, Rudi W. Hendriks, Odilia B. J. Corneth, Jan Piet van Hamburg, Dominique L. P. Baeten, Sander W. Tas
Summary: Overexpression of transmembrane TNF (tmTNF) in transgenic mice leads to the formation of lymphoid aggregates in the bone marrow, accompanied by increased serum IgA levels. This effect is mainly dependent on TNF-RI signaling and may play a crucial role in the pathology of SpA.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Anna M. Kip, Joep Grootjans, Marco Manca, M'hamed Hadfoune, Bas Boonen, Joep P. M. Derikx, Erik A. L. Biessen, Steven W. M. Olde Damink, Cornelis H. C. Dejong, Wim A. Buurman, Kaatje Lenaerts
Summary: The study highlights the crucial role of unfolded protein stress in the response to ischemia-reperfusion in human small intestine. Inhibition of unfolded protein response (UPR) activation during hypoxia-reoxygenation in an intestinal organoid model suggests that protein kinase R-like ER kinase (PERK) signaling may be a promising target for reducing intestinal ischemia-reperfusion injury.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Immunology
Jurij Hanzel, Melanie S. Hulshoff, Joep Grootjans, Geert D'Haens
Summary: This article introduces three categories of drugs recently approved or awaiting approval for the treatment of ulcerative colitis (UC), including antibodies against interleukin-23 (IL-23), sphingosine-1-phosphate receptor (S1PR) modulators, and selective inhibitors of Janus kinases (JAK). These drugs have demonstrated good efficacy and safety, but further research and development are needed.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2022)
Article
Pediatrics
Danielle Roorda, Jaap Oosterlaan, Ernest van Heurn, Joep Derikx
Summary: This retrospective study evaluated the effectiveness of BT injections in treating obstructive defecation problems in patients with Hirschsprung disease. The findings showed that BT injections can effectively improve symptoms with mild adverse effects.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Pediatrics
Kelly M. A. Dreuning, Joep P. M. Derikx, Johan E. van Limbergen, Frea Kruisinga, Ilan J. N. Koppen
Summary: The infant with chylous ascites was unexpectedly found during surgery for bilateral inguinal hernia repair. With treatment and monitoring, the condition was controlled and the symptoms disappeared, allowing the child to successfully transition to regular feeding.
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2021)
Article
Pediatrics
Fenne A. I. M. van den Bunder, Jan Hein Allema, Marc A. Benninga, Ivo de Blaauw, Tim van de Brug, Marcel den Dulk, Jan B. F. Hulscher, Claudia M. G. Keyzer-Dekker, Marieke J. Witvliet, Ernest L. W. van Heurn, Joep P. M. Derikx
Summary: The study found that the average incidence of IHPS in the Netherlands is 1.28 per 1,000 livebirths, with no changing trend or seasonal variation in incidence observed.
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
(2021)