Article
Immunology
Chien-Hung Chen, Cheng-Yuan Peng, Yuan-Hung Kuo, Tsung-Hui Hu, Chao-Hung Hung, Jing-Houng Wang, Sheng-Nan Lu
Summary: Tenofovir disoproxil fumarate (TDF) therapy, HBeAg loss without seroconversion during treatment, and higher end-of-treatment hepatitis B core-related antigen were significant predictors of HBV relapse in HBeAg-positive patients who discontinued ETV or TDF.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Minghui Li, Yuanjiao Gao, Liu Yang, Yanjie Lin, Wen Deng, Tingting Jiang, Xiaoyue Bi, Yao Lu, Lu Zhang, Ge Shen, Ruyu Liu, Shuling Wu, Min Chang, Mengjiao Xu, Leiping Hu, Rui Song, Yuyong Jiang, Wei Yi, Yao Xie
Summary: This study investigated the kinetic changes of serum, virological, and immunological markers during entecavir (ETV) antiviral therapy in HBeAg-positive chronic hepatitis B (CHB) patients. Findings suggest that baseline HBV DNA load, HBeAg, and IL-10 levels were significantly associated with ALT normalization after 48 weeks of ETV treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Chien-Hung Chen, Cheng-Yuan Peng, Tsung-Hui Hu, Jing-Houng Wang, Chao-Hung Hung, Sheng-Nan Lu
Summary: This study compared the rates of HBsAg loss after discontinuation of entecavir and tenofovir disoproxil fumarate in patients with chronic hepatitis B. The results showed that patients who discontinued TDF had higher risks of virological and clinical relapse, as well as retreatment, compared to those who discontinued entecavir.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Hye Yeon Chon, Jae Seung Lee, Hye Won Lee, Ho Soo Chun, Beom Kyung Kim, Won Young Tak, Jun Yong Park, Young-Oh Kweon, Do Young Kim, Sang Hoon Ahn, Se Young Jang, Soo Young Park, Seung Up Kim
Summary: Both SAGE-B and CAGE-B models showed acceptable performance in predicting HCC after 5 years of AVT in Asian patients with CHB.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Han Ah Lee, Hyun Woong Lee, Younhee Park, Hyon-Suk Kim, Yeon Seok Seo
Summary: The level of HBcrAg is important in predicting the clinical phase and NA-induced HBeAg seroconversion in patients with CHB.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Mark S. Sulkowski, Kosh Agarwal, Xiaoli Ma, Tuan T. Nguyen, Eugene R. Schiff, Hie-Won L. Hann, Douglas T. Dieterich, Ronald G. Nahass, James S. Park, Sing Chan, Steven-Huy B. Han, Edward J. Gane, Michael Bennett, Katia Alves, Marc Evanchik, Ran Yan, Qi Huang, Uri Lopatin, Richard Colonno, Julie Ma, Steven J. Knox, Luisa M. Stamm, Maurizio Bonacini, Ira M. Jacobson, Walid S. Ayoub, Frank Weilert, Natarajan Ravendhran, Alnoor Ramji, Paul Yien Kwo, Magdy Elkhashab, Tarek Hassanein, Ho S. Bae, Jacob P. Lalezari, Scott K. Fung, Man-Fung Yuen
Summary: The combination of VBR and ETV demonstrated greater antiviral activity than ETV alone in treatment-naive patients with cHBV, and it was well-tolerated and safe.
JOURNAL OF HEPATOLOGY
(2022)
Article
Immunology
Minghui Li, Luxue Zhang, Si Xie, Fangfang Sun, Zhan Zeng, Wen Deng, Tingting Jiang, Xiaoyue Bi, Yanjie Lin, Liu Yang, Yao Lu, Ge Shen, Ruyu Liu, Shuling Wu, Min Chang, Leiping Hu, Jianping Dong, Wei Yi, Yao Xie
Summary: This study investigated the dynamic changes of cytokines and virological markers during HBsAg loss, and found that these changes were associated with the efficacy of PEG-IFN alpha-2a treatment in HBeAg-positive chronic hepatitis B (CHB) patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chengguang Hu, Yangda Song, Cuirong Tang, Meng Li, Junwei Liu, Jia Liu, Minjun Liao, Fuyuan Zhou, Yong-Yuan Zhang, Yuanping Zhou
Summary: In patients with chronic hepatitis B, the combination of pegylated interferon with tenofovir disoproxil fumarate or monotherapy with each agent showed a higher rate of HBsAg loss at week 72, with the combination group and interferon group demonstrating better outcomes compared to the tenofovir group.
CLINICAL THERAPEUTICS
(2021)
Article
Immunology
Jun Li, Xiao-Qin Dong, Li-Hua Cao, Zhan-Qing Zhang, Wei-Feng Zhao, Qing-Hua Shang, Da-Zhi Zhang, An-Lin Ma, Qing Xie, Hong-Lian Gui, Guo Zhang, Ying-Xia Liu, Jia Shang, Shi-Bin Xie, Yi-Qi Liu, Chi Zhang, Gui-Qiang Wang, Hong Zhao
Summary: This study investigated the factors associated with persistent viremia in patients with chronic hepatitis B receiving long-term antiviral therapy, and found that baseline HBV DNA level, Anti-HBc level, and HBeAg seropositivity were associated with persistent viremia.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Lu Zhang, Liu Yang, Yuanjiao Gao, Xiaoyue Bi, Yanjie Lin, Wen Deng, Tingting Jiang, Yao Lu, Hongxiao Hao, Gang Wan, Wei Yi, Yao Xie, Minghui Li
Summary: The purpose of this study was to develop an effective non-invasive nomogram for assessing liver inflammation in untreated HBeAg positive patients with chronic HBV infection. A nomogram was created using a model cohort of 292 treatment-naive HBeAg positive patients with normal ALT at Beijing Ditan Hospital. It was then validated in a separate cohort of 88 patients. The nomogram showed good consistency with real observations and performed well in predicting liver inflammation in HBV patients.
Article
Biotechnology & Applied Microbiology
Hui Dong, Yongqiang Zhu, Yan Shen, Shaoqing Xie, Yungang He, Lungen Lu
Summary: The study found a high prevalence of tryptophan-truncated S quasispecies and drug-resistant RT mutants in treatment-naive patients with chronic hepatitis B, providing new insights into the composition of the HBV population and potential optimization of treatment and management for these patients.
JOURNAL OF GENERAL VIROLOGY
(2021)
Review
Immunology
Amir M. Mohareb, Anne F. Liu, Arthur Y. Kim, Patrick A. Coffie, Menan Gerard Kouame, Kenneth A. Freedberg, Anders Boyd, Emily P. Hyle
Summary: Spontaneous loss of hepatitis B e antigen (HBeAg) occurs at a rate of 6.46/100 person-years (PYs) among untreated individuals with chronic HBV. The incidence rate of spontaneous HBeAg loss varies by age and geographic region.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
HeeKyoung Choi, Gi Hyeon Seo
Summary: This retrospective cohort study using nationwide claims data assessed the effects of ETV and TDF on preventing HCC in treatment-naive patients with chronic hepatitis B. The study found that in patients with chronic hepatitis B, ETV treatment did not result in a higher rate of HCC than TDF treatment.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Immunology
Yao-Chun Hsu, Ming-Lun Yeh, Grace Lai-Hung Wong, Chien-Hung Chen, Cheng-Yuan Peng, Maria Buti, Masaru Enomoto, Qing Xie, Huy Trinh, Carmen Preda, Li Liu, Ka-Shing Cheung, Yee Hui Yeo, Joseph Hoang, Chung-Feng Huang, Mar Riveiro-Barciela, Ritsuzo Kozuka, Doina Istratescu, Pei-Chien Tsai, Elena Vargas Accarino, Dong-Hyun Lee, Jia-Ling Wu, Jee Fu Huang, Chia-Yen Dai, Ramsey Cheung, Wan-Long Chuang, Man-Fung Yuen, Vincent Wai-Sun Wong, Ming-Lung Yu, Mindie H. Nguyen
Summary: In patients with chronic hepatitis B treated with ETV or TDF, the occurrence of HBsAg seroclearance is rare and is associated with low-level viremia, elevated alanine aminotransferase levels, bilirubin levels, and fatty liver.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Ed J. Gane, Christian Schwabe, Elina Berliba, Pisit Tangkijvanich, Alina Jucov, Nelea Ghicavii, Thierry Verbinnen, Oliver Lenz, Willem Talloen, Thomas N. Kakuda, Chris Westland, Megha Patel, Jeysen Z. Yogaratnam, Leonard Dragone, Pieter Van Remoortere
Summary: JNJ-64530440 showed good tolerability and potent antiviral activity in patients with chronic hepatitis B (CHB), indicating its potential as a treatment option.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Gastroenterology & Hepatology
Jihye Park, Jae Hee Cheon, Kang-Moon Lee, Young-Ho Kim, Byong Duk Ye, Chang Soo Eun, Sung Hyun Kim, Sun Hee Lee, Joon Ho Lee, Stefan Schreiber
Summary: This study aimed to compare the clinical efficacy and safety of CT-P13 and originator infliximab in Crohn's disease treatment. The study found a significant correlation between early serum infliximab trough levels and treatment outcomes, and there were no statistical differences in serum trough levels and anti-drug antibody levels between CT-P13 and originator infliximab.
Article
Gastroenterology & Hepatology
Jae-Young Lee, Hyun Woo Ma, Ji Hyung Kim, I. Seul Park, Mijeong Son, Keun Ho Ryu, Jieun Shin, Seung Won Kim, Jae Hee Cheon
Summary: The study found that CKD-506 has anti-inflammatory effects on PBMCs and CD4+ T cells, and improves gut barrier function. These findings suggest that CKD-506 may be a potential small molecule therapeutic option for inflammatory bowel disease.
Article
Biotechnology & Applied Microbiology
Hyun Woo Ma, Jung Min Kim, Da Hye Kim, I. Seul Park, Ji Hyung Kim, Ki Cheong Park, Dong Hyuk Seo, Jae Hyeon Kim, Xiumei Che, Tae Il Kim, Jae Hee Cheon, Seung Won Kim
Summary: This study investigated the role of OLFM4 in colorectal cancer (CRC) and found that it plays different regulatory roles in tumor development and metastasis.
CANCER GENE THERAPY
(2023)
Article
Gastroenterology & Hepatology
Jae Hee Cheon, Hyun-Soo Kim, Dong Soo Han, Sung Kook Kim, Sung Jae Shin, Joo Sung Kim, Byong Duk Ye, Geun Am Song, YoungJa Lee, Youngdoe Kim, Yoosun Lee, Won Ho Kim
Summary: This study provides evidence that infliximab is effective and well-tolerated in patients with moderate-to-severe active intestinal Behcet's disease.
Article
Gastroenterology & Hepatology
Han Ah Lee, Young-Sun Lee, Young Kul Jung, Ji Hoon Kim, Hyung Joon Yim, Jong Eun Yeon, Yeon Seok Seo, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Seung Up Kim
Summary: This study aimed to investigate whether antiviral therapy improves outcomes in patients with HBV-related decompensated cirrhosis and undetectable HBV-DNA. The results showed that antiviral therapy did not reduce the risk of death or hepatocellular carcinoma.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Yoonseok Lee, Seryun Bae, Ji Hoon Kim, Minjung Kwak, So Yeon Jeon, Taehyung Kim, Sun Young Yim, Young-Sun Lee, Young Kul Jung, Yeon Seok Seo, Hyung Joon Yim, Jong Eun Yeon, Kwan Soo Byun
Summary: This study evaluated the diagnostic efficacy of serum Asialo alpha 1-acid glycoprotein (AsAGP) levels in classifying the severity of liver fibrosis in patients with chronic hepatitis B (CHB) and distinguishing them from healthy controls. The results showed significant differences in serum AsAGP levels between the CHB group, healthy control group, and CHB with liver cirrhosis group. Serum AsAGP levels were also positively correlated with liver stiffness. Therefore, serum AsAGP levels may serve as a potential biomarker for predicting the progression of liver disease in CHB.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Dongwoo Kim, Ja Seol Koo, Soon Ha Kim, Yeong Seo Park, Jung Wan Choe, Seung Young Kim, Jong Jin Hyun, Sung Woo Jung, Young Kul Jung, Hyung Joon Yim
Summary: This study aimed to investigate the effect of necrosis inhibitor (NI, NecroX-7) on a DSS-induced chronic colitis model of mice. The results showed that NI reduced body weight change and disease activity index (DAI) score. Colon length and histological score were longer and lower in the NI-treated groups, respectively. The NI decreased the expression of pro-inflammatory cytokines, particularly TNF-alpha and p-NF-kappa B. Therefore, NI use is a potential, novel treatment approach for IBD.
Letter
Gastroenterology & Hepatology
Tae Hyung Kim, Young Kul Jung, Hyung Joon Yim
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Seung Won Kim, Jae-Young Lee, Han Cheol Lee, Jae Bum Ahn, Ji Hyung Kim, I. Seul Park, Jae Hee Cheon, Duk Hwan Kim
Summary: HSP72 is an important mediator in fibrosis of Crohn's disease, regulating myofibroblasts and epithelial-mesenchymal transition, and could be a target for antifibrotic therapy.
Article
Gastroenterology & Hepatology
I. Seul Park, Ji Hyung Kim, Jongwook Yu, YooJin Shin, Kibeom Kim, Tae Il Kim, Seung Won Kim, Jae Hee Cheon
Summary: This study investigated the mechanisms of action of B. breve CBT BR3 in relieving colitis. The results showed that B. breve CBT BR3 improved colitis symptoms, increased the number of goblet cells, and protected inflammation-induced epithelial cell permeability. It also enhanced the expressions of tight-junction protein and proteins related to butyrate metabolism.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Chung Hyun Tae, Ju Yup Lee, Moon Kyung Joo, Chan Hyuk Park, Eun Jeong Gong, Cheol Min Shin, Hyun Lim, Hyuk Soon Choi, Miyoung Choi, Sang Hoon Kim, Chul-Hyun Lim, Jeong-Sik Byeon, Ki-Nam Shim, Geun Am Song, Moon Sung Lee, Jong-Jae Park, Oh Young Lee
Summary: With an aging population, the use of nasogastric tubes for enteral nutrition in patients with swallowing difficulties is increasing. However, long-term use of nasogastric tubes leads to complications and reduced quality of life. Percutaneous endoscopic gastrostomy (PEG) is an alternative method that involves the percutaneous placement of a tube into the stomach for long-term enteral nutrition. This paper presents the first Korean clinical guideline for PEG, providing evidence-based recommendations for indications, timing, methods, and management of PEG.
CLINICAL ENDOSCOPY
(2023)
Article
Multidisciplinary Sciences
Geum-Young Lee, Kyungmin Park, Young-Sun Lee, Ji Hoon Kim, Kwan Soo Byun, Jongwoo Kim, Won-Keun Kim, Jin-Won Song
Summary: This study evaluated the use of multiplex PCR-based nanopore sequencing to obtain whole-genome sequences of HAV for rapid molecular diagnosis of viral genotypes. The results showed high genome coverage rates (90.4-99.5%) of HAV within 8 hours using singleplex nanopore sequencing. TaqMan qPCR demonstrated the ability to detect and quantify multiple HAV genes. This study provides valuable insights for rapid molecular diagnosis during hepatitis A outbreaks and may enhance public health disease surveillance in the hospital and epidemiology field.
Review
Gastroenterology & Hepatology
Chung Hyun Tae, Ju Yup Lee, Moon Kyung Joo, Chan Hyuk Park, Eun Jeong Gong, Cheol Min Shin, Hyun Lim, Hyuk Soon Choi, Miyoung Choi, Sang Hoon Kim, Chul-Hyun Lim, Jeong-Sik Byeon, Ki-Nam Shim, Geun Am Song, Moon Sung Lee, Jong-Jae Park, Oh Young Lee
Summary: With the increasing number of patients experiencing difficulty in swallowing due to medical conditions as a result of an aging population, percutaneous endoscopic gastrostomy (PEG) is being explored as an alternative to nasogastric tubes for long-term enteral nutrition. This paper presents the first clinical guideline for PEG in Korea, developed jointly by the Korean College of Helicobacter and Upper Gastrointestinal Research and led by the Korean Society of Gastrointestinal Endoscopy.
KOREAN JOURNAL OF GASTROENTEROLOGY
(2023)