Article
Medicine, Research & Experimental
Joeke L. Nollet, Per Cajander, Lara F. Ferris, Jordache Ramjith, Taher Omari, Johanna Savilampi
Summary: The study aimed to investigate the effects of bolus volume and viscosity on pharyngeal swallow using circumferential pressure sensor technology and found that larger volumes increased intrabolus pressure and all upper esophageal sphincter metrics, while thicker viscosity decreased UES relaxation time and flow timing metrics. The use of this technology provides consistent results with previous reports, offering insights into aberrant pharyngo-esophageal motor responses over time.
Article
Medicine, General & Internal
Faiz Tuma, Jafar Aljazeeri, Zhamak Khorgami, Leena Khaitan
Summary: This study reviewed esophageal function testing results over a 12-month period and found that the most likely levels of impaired bolus transit in the esophagus were 15 and 20 cm above the gastroesophageal junction (GEJ). Common symptoms among the study sample included dysphagia, chest pain, and regurgitation. The study suggests that focusing on the levels of impaired bolus transit identified in the esophagus may be important for future research on the pathophysiology of esophageal dysmotility.
ANNALS OF MEDICINE AND SURGERY
(2021)
Article
Gastroenterology & Hepatology
Paul T. Heitmann, Reizal Mohd Rosli, Lyn Maslen, Lukasz Wiklendt, Raghu Kumar, Taher I. Omari, David Wattchow, Marcello Costa, Simon J. Brookes, Phil G. Dinning
Summary: This study utilized high-resolution impedance manometry to investigate colonic motor patterns and gas transit in healthy volunteers. Results showed an increase in the prevalence of the 2-8/minute cyclic motor pattern and propagation of impedance events after a meal or gas insufflation. The temporal association between propagating contractions and gas transit supports the hypothesis that the 2-8/minute cyclic motor pattern acts as a physiological brake modulating rectal filling.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Physiology
Eden Koo, John O. Clarke, Boli Yang, Pankaj J. Pasricha, Nina Zhang
Summary: This study aimed to quantify the characteristics of acid reflux episodes in patients with extraesophageal GERD symptoms, hiatal hernia, and erosive esophagitis using multichannel intraluminal impedance pH (MII-pH), and investigate the correlation between impedance parameters and high resolution esophageal manometry (HREM). The findings showed that patients with extraesophageal GERD symptoms had an increased average height of reflux, while patients with hiatal hernia had a longer total reflux duration. The average composite reflux index was significantly different in all three subgroups. Impedance metrics were weakly correlated with lower esophageal sphincter rest pressure and distal contractile integral.
PHYSIOLOGICAL REPORTS
(2022)
Article
Gastroenterology & Hepatology
Boram Cha, Kyungmin Choi, Kee Wook Jung, Hwa Jung Kim, Ga Hee Kim, Hee Kyong Na, Ji Yong Ahn, Jeong Hoon Lee, Kee Don Choi, Do Hoon Kim, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Segyeong Joo
Summary: This study compared two diagnostic tools for non-obstructive dysphagia (NOD) and found that the volume of inverted impedance (VII) ratio is more reliable than the esophageal impedance integral (EII) ratio.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Lara Ferris, Sebastian Doeltgen, Charles Cock, Nathalie Rommel, Mistyka Schar, Silvia Carrion, Ingrid Scholten, Taher Omari
Summary: The study evaluated the neuromodulation of healthy oropharyngeal swallowing using high-resolution pharyngeal manometry with impedance, finding significant modulation effects of bolus volume and viscosity on hypopharyngeal intrabolus pressure and upper esophageal sphincter metrics. Increased bolus volumes led to elevated pharyngeal contractility and postswallow pressures, while bolus viscosity only affected UES preopening pressure. These findings contribute to the diagnostic framework for oropharyngeal dysphagia.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Dustin A. Carlson, Christina Shehata, Nirmala Gonsalves, Ikuo Hirano, Stephanie Peterson, Jacqueline Prescott, Domenico A. Farina, Jacob M. Schauer, Wenjun Kou, Peter J. Kahrilas, John E. Pandolfino
Summary: This study evaluated the characteristics of secondary peristalsis in patients with EoE and found that abnormal esophageal contractions were associated with disease severity.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Deepika Razia, Amy Trahan, Chengcheng Hu, Luca Giulini, Ross M. Bremner, Sumeet K. Mittal
Summary: The study aimed to investigate the correlation between upright and prone bolus transit time (BTT) on barium esophagography (BE), esophageal peristalsis on high-resolution manometry (HRM), and self-reported dysphagia in patients. The results showed that prone BTT correlated with the proportion of normal esophageal swallows and dysphagia.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Benjamin D. Rogers, Daniel Cisternas, Arvind Rengarajan, Ingrid Marin, Luiz Abrahao, Albis Hani, Ana M. Lequizamo, Jose M. Remes-Troche, Julio Perez de la Serna, Antonio Ruiz de Leon, Frank Zerbib, Jordi Serra, C. Prakash Gyawali
Summary: In healthy asymptomatic subjects, breaks in peristaltic integrity predict abnormal bolus clearance better than DCI or IRP.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Otorhinolaryngology
Hee Jin Kang, Jung Min Park, Soo Young Choi, Su Il Kim, Young Chan Lee, Young-Gyu Eun, Seong-Gyu Ko
Summary: The study compared manual and automated analyses of 24-hour multichannel intraluminal impedance-pH monitoring for laryngopharyngeal reflux diagnosis. Results showed that automated analysis tended to overestimate the number of proximal reflux episodes compared to manual analysis, with exceptions in cases of acid reflux. It is crucial to improve the accuracy of diagnosis through manual analysis, especially in heartburn cases.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Surgery
Yazmin Johari, Anagi Wickremasinghe, Pradipta Kiswandono, Helen Yue, Geraldine Ooi, Cheryl Laurie, Geoffrey Hebbard, Paul Beech, Kenneth Yap, Wendy Brown, Paul Burton
Summary: Following sleeve gastrectomy, esophago-gastric transit is primarily driven by isobaric pressurization of the stomach induced by repeated esophageal peristaltic contractions, with a strong association with reflux. Transit of food from the esophagus to the small bowel post-operatively is rapid and substantial.
Article
Gastroenterology & Hepatology
Wei-Yi Lei, Taher Omari, Tso-Tsai Liu, Ming-Wun Wong, Jui-Sheng Hung, Chih-Hsun Yi, Shu-Wei Liang, Charles Cock, Chien-Lin Chen
Summary: This study measured the effect of esophageal outflow obstruction induced by a leg-lift protocol on intrabolus pressures. The results showed an increase in relaxation pressure and distal contractile integral at the esophagogastric junction, as well as increased pressures in all bolus categories. Measuring pressures within the intrabolus domain can aid in confirming a diagnosis of EGJ outflow obstruction.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Review
Gastroenterology & Hepatology
Mentore Ribolsi, Matteo Ghisa, Edoardo Savarino
Summary: The article discusses investigations conducted using conventional manometry and high-resolution manometry (HRM) to explore the field of esophageal motility and understand the potential link between motor features and gastroesophageal reflux disease (GERD) pathogenesis. HRM studies have provided insights into the esophageal motor function in patients with various esophageal disorders, as well as the correlation between reduced esophageal motility, disruption of the esophagogastric junction, and gastroesophageal reflux burden.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Medicine, General & Internal
Sergey Morozov, Tatyana Sentsova
Summary: This study aims to explore the gene expression of inflammatory cytokines in esophageal mucosa of patients with EE and NERD, and its association with esophageal MII-pH measurements.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Review
Gastroenterology & Hepatology
Yanhong Wu, Zihao Guo, Chuan Zhang, Yutao Zhan
Summary: Gastroesophageal reflux disease (GERD) is a common and increasingly prevalent disease worldwide. The diagnosis of GERD is currently challenging due to the lack of definitive criteria. A novel impedance parameter called mean nocturnal baseline impedance (MNBI) has been proposed, which can reflect the burden of longitudinal reflux and the integrity of the esophageal mucosa. MNBI shows great promise in improving the diagnostic rate of multichannel intraluminal impedance-pH (MII-pH) monitoring and in predicting the response to treatment in patients with reflux symptoms.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)