Review
Pharmacology & Pharmacy
Jill E. Elwing, Hadi Atassi, Benjamin D. Rogers, Gregory S. Sayuk
Summary: Irritable bowel syndrome (IBS) is a multifactorial disorder with limited effectiveness of current therapies, leading to the need for novel treatment options. Future development focuses on serotonergic and endogenous opioid receptor systems, as well as emerging therapies like the endogenous cannabinoid system. The diverse etiologies of IBS present a great potential for the development of new therapies in the future.
EXPERT OPINION ON EMERGING DRUGS
(2022)
Article
Medicine, Research & Experimental
Haomeng Wu, Kai Zhan, Kehan Rao, Huan Zheng, Shumin Qin, Xudong Tang, Shaogang Huang
Summary: The effects of different rat models of diarrhea-predominant irritable bowel syndrome (IBS-D) on the brain-gut-microbiota (BGM) axis were evaluated in this study. The results showed that these models caused changes in brain gut peptides, cytokine levels, spinal cord neuronal activity, intestinal mucosal barrier function, and gut microbiota composition and structure.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Gastroenterology & Hepatology
Christopher Ma, Stephen E. Congly, Kerri L. Novak, Paul J. Belletrutti, Maitreyi Raman, Matthew Woo, Christopher N. Andrews, Yasmin Nasser
Summary: The management of chronic symptomatic functional bowel disorders (FBDs) in the United States incurs considerable healthcare resource use and cost, with pharmacologic therapies being more commonly prescribed than nonpharmacologic interventions. Combination treatment strategies are more likely to be implemented by primary care physicians, highlighting the need to improve comprehensive FBD management.
Review
Nutrition & Dietetics
Annamaria Altomare, Claudia Di Rosa, Elena Imperia, Sara Emerenziani, Michele Cicala, Michele Pier Luca Guarino
Summary: The study explores the effects of different nutritional protocols on IBS-D symptoms and intestinal microbiota variations. An ideal nutritional protocol does not yet exist for IBS-D patients, but it is crucial to consider the impact of different nutritional approaches on the composition of the intestinal microbiota for better management of this functional disorder.
Article
Gastroenterology & Hepatology
Sameer K. Berry, Rani Berry, David Recker, Jeffrey Botbyl, Lucy Pun, William D. Chey
Summary: Digital gut-directed hypnotherapy (GDH) treatment program can improve symptoms of IBS, including abdominal pain and stool problems. There was no significant difference in effectiveness between digital GDH and digital muscle relaxation (MR), but the GDH treatment group had more abdominal pain responders.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Plant Sciences
Zhaoqin Wang, Manwen Xu, Zheng Shi, Chunhui Bao, Huirong Liu, Cili Zhou, Yilu Yan, Chunye Wang, Guona Li, Wei Zhang, Anqi Gao, Huangan Wu
Summary: This study aimed to evaluate the effects of mild moxibustion (MM) for the treatment of irritable bowel syndrome with diarrhea (IBS-D) and compare them with placebo moxibustion. The findings suggest that mild moxibustion may be more effective than placebo moxibustion for the treatment of IBS-D, with effects lasting up to 12 weeks.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Claudia Di Rosa, Annamaria Altomare, Vittoria Terrigno, Florencia Carbone, Jan Tack, Michele Cicala, Michele Pier Luca Guarino
Summary: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by abdominal pain and altered bowel habits. The exact cause of IBS is not fully understood, but it is believed to involve a combination of factors such as abnormal gut motility, inflammation, increased intestinal permeability, and sensitivity. Diet and gut microbiota have also been identified as important contributors to IBS. This review examines the effects of dietary components, functional foods, prebiotics, probiotics, and symbiotics on symptoms and gut microbiota in individuals with IBS-C.
Article
Gastroenterology & Hepatology
Theodora Kalli, Tilemachos Koutouratsas, George Karamanolis, Maria Gazouli
Summary: The study found a significant association between the rs696217 genetic polymorphism and IBS susceptibility, with the GG and GT genotypes as well as the G allele being linked to IBS risk, while the T allele may have a protective effect. There was no correlation between ghrelin gene polymorphisms and different IBS subtypes.
Article
Medicine, General & Internal
Girish K. Pati, Chinmayee Kar, Jimmy Narayan, Kanishka Uthansingh, Manas Behera, Manoj K. Sahu, Debakanta Mishra, Ayaskanta Singh
Summary: This study evaluated the variation in symptoms of female IBS patients during different phases of the menstrual cycle, finding that they were more symptomatic during the menstrual phase, particularly experiencing constipation, significant limitations in daily activities, and lower quality of life.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Gastroenterology & Hepatology
MaryJane O. Williams, Mary Sedarous, Brittany Dennis, Vanessa Dlamini, Obioma Nwaiwu, Linda Nguyen, Philip N. Okafor
Summary: Analysis of 12 irritable bowel syndrome trials revealed a median FI of 6, suggesting how easily statistical significance based on a threshold p-value may be overturned.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
James K. Ruffle, Linda Tinkler, Christopher Emmett, Alexander C. Ford, Parashkev Nachev, Qasim Aziz, Adam D. Farmer, Yan Yiannakou
Summary: Machine learning analysis of a large prospective cohort of patients with chronic constipation revealed that irritable bowel syndrome with constipation (IBS-C) and functional constipation (FC) only differ significantly in the presence of abdominal pain, suggesting that they may not be distinct syndromes but rather a single syndrome varying along a single clinical dimension. This has implications for patient recruitment into clinical trials, future disease classifications, and management guidelines.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Medicine, General & Internal
Sai Suseel Sarvepalli, Shree Laya Vemula, Saikumar Aramadaka, Raam Mannam, Rajagopal Sankara Narayanan, Arpit Bansal, Vishnu R. Yanamaladoddi
Summary: Irritable bowel syndrome (IBS) is a chronic illness that is strongly influenced by diet. Recent research has shown that short-chain fermentable carbohydrates can cause gastrointestinal symptoms in those with IBS. Restricting certain food items from the diet can relieve symptoms and may be more effective than pharmacotherapy. However, the low FODMAP diet is not suitable for all patients.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Gabriella Yazbeck, Diana Malaeb, Hamid Shaaban, Abir Sarray El Dine, Souheil Hallit, Rabih Hallit
Summary: This study aimed to assess the rate of unidentified IBS among Lebanese adults and investigate the role of socio-demographic factors, anxiety, depression, insomnia, and eating attitudes on IBS diagnosis. A cross-sectional study was conducted using a self-reporting questionnaire distributed via social media. The study found that higher psychological distress and insomnia severity were significantly associated with higher odds of having possible unidentified IBS.
Review
Medicine, General & Internal
Giusi Desire Sciume, Ginevra Berti, Christian Lambiase, Italia Paglianiti, Vincenzo Villanacci, Francesco Rettura, Antonio Grosso, Angelo Ricchiuti, Nicola de Bortoli, Paolo Usai Satta, Gabrio Bassotti, Massimo Bellini
Summary: Irritable bowel syndrome with predominant diarrhea (IBS-D) and functional diarrhea (FD) are disorders of gut-brain interaction that have a significant impact on the patient's quality of life. Bile acid malabsorption (BAM) and microscopic colitis (MC) are often responsible for the lack of response to conventional treatments in these patients. Therefore, considering these factors and finding appropriate treatments should be part of the diagnostic process.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Mohamed G. Shiha, Zohaib Asghar, Mo Thoufeeq, Matthew Kurien, Alex J. Ball, Anupam Rej, Foong Way David Tai, Shima Afify, Imran Aziz
Summary: IBS patients, according to Rome IV criteria, show higher levels of psychological distress and somatization compared to FD or FC patients. Abdominal pain frequency is positively correlated with extra-intestinal symptoms. No significant differences were found in mood and somatization scores between individual IBS subtypes or between FC and FD.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Review
Gastroenterology & Hepatology
Eva Szigethy, Mitchell Knisely, Douglas Drossman
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2018)
Article
Gastroenterology & Hepatology
L. Vork, D. Keszthelyi, Z. Mujagic, J. W. Kruimel, C. Leue, I. Ponten, H. Tornblom, M. Simren, A. Albu-Soda, Q. Aziz, M. Corsetti, L. Holvoet, J. Tack, S. S. Rao, J. van Os, E. G. Quetglas, D. A. Drossman, A. A. M. Masclee
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Article
Anesthesiology
Egilius L. H. Spierings, Douglas A. Drossman, Byron Cryer, M. Mazen Jamal, Taryn Losch-Beridon, Shadreck M. Mareya, Martin Wang
Article
Gastroenterology & Hepatology
Douglas A. Drossman, Jan Tack, Alexander C. Ford, Eva Szigethy, Hans Tornblom, Lukas Van Oudenhove
Article
Gastroenterology & Hepatology
Peter B. Cotton, Qi Pauls, Jamila Keith, Andre Thornhill, Douglas Drossman, April Williams, Valerie Durkalski-Mauldin
GASTROINTESTINAL ENDOSCOPY
(2018)
Article
Gastroenterology & Hepatology
Yukari Tanaka, Motoyori Kanazawa, Olafur S. Palsson, Miranda A. Van Tilburg, Lisa M. Gangarosa, Shin Fukudo, Douglas A. Drossman, William E. Whitehead
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Editorial Material
Gastroenterology & Hepatology
Douglas A. Drossman
Review
Gastroenterology & Hepatology
Helen B. Murray, Adrienne S. Juarascio, Carlo Di Lorenzo, Douglas A. Drossman, Jennifer J. Thomas
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Psychology, Clinical
Jim D. Kantidakis, Simon R. Knowles, Antonina Mikocka-Walus, Tiffany H. Taft, Laurie Keefer, Olafur S. Palsson, Douglas A. Drossman
CLINICAL PSYCHOLOGIST
(2019)
Review
Gastroenterology & Hepatology
Douglas A. Drossman, Johannah Ruddy
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Antonina Mikocka-Walus, Alexander C. Ford, Douglas A. Drossman
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Ami D. Sperber, Shrikant Bangdiwala, Douglas A. Drossman, Uday C. Ghoshal, Magnus Simren, Jan Tack, William E. Whitehead, Dan L. Dumitrascu, Xuicai Fang, Shin Fukudo, John Kellow, Edith Okeke, Eamonn M. M. Quigley, Max Schmulson, Peter Whorwell, Timothy Archampong, Payman Adibi, Viola Andresen, Marc A. Benninga, Bruno Bonaz, Serhat Bor, Luis Bustos Fernandez, Suck Chei Choi, Enrico S. Corazziari, Carlos Francisconi, Albis Hani, Leonid Lazebnik, Yeong Yeh Lee, Agata Mulak, M. Masudur Rahman, Javier Santos, Mashiko Setshedi, Ari Fahrial Syam, Stephen Vanner, Reuben K. Wong, Aurelio Lopez-Colombo, Valeria Costa, Ram Dickman, Motoyori Kanazawa, Ammar Hassanzadeh Keshteli, Rutaba Khatun, Iradj Maleki, Pierre Poitras, Nitesh Pratap, Oksana Stefanyuk, Sandie Thomson, Judith Zeevenhooven, Olafur S. Palsson
Summary: FGIDs have a high prevalence globally, especially among women. Individuals with FGIDs experience lower quality of life and require more frequent medical visits. The proportion of irritable bowel syndrome patients diagnosed using the Rome IV criteria is lower compared to the Rome III criteria.
Review
Medicine, General & Internal
Christopher J. Black, Douglas A. Drossman, Nicholas J. Talley, Johannah Ruddy, Alexander C. Ford
Review
Gastroenterology & Hepatology
Jordyn H. Feingold, Douglas A. Drossman
Summary: Stigma is prevalent in healthcare, especially in disorders of gut-brain interaction. These disorders are often wrongly presumed to be psychiatric, leading to emotional distress, medication non-adherence, barriers to care, and worsening symptoms for patients.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Review
Gastroenterology & Hepatology
Douglas A. Drossman, Lin Chang, Jill K. Deutsch, Alexander C. Ford, Albena Halpert, Kurt Kroenke, Samuel Nurko, Johannah Ruddy, Julie Snyder, Ami Sperber
Summary: The changes in healthcare have negatively impacted the communication between patients and providers, but evidence shows that communication skills training can improve patient satisfaction and outcomes. More research is needed to confirm these findings and to further explore the role of communication skills in healthcare.