Review
Allergy
Carmen Riggioni, Cristian Ricci, Beatriz Moya, Dominic Wong, Evi van Goor, Irene Bartha, Betul Buyuktiryaki, Mattia Giovannini, Sashini Jayasinghe, Hannah Jaumdally, Andreina Marques-Mejias, Alexandre Piletta-Zanin, Anna Berbenyuk, Margarita Andreeva, Daria Levina, Ekaterina Iakovleva, Graham Roberts, Derek Chu, Rachel Peters, George du Toit, Isabel Skypala, Alexandra F. Santos
Summary: This study conducted a systematic review and meta-analysis on diagnostic tests for IgE-mediated food allergy. It found that skin prick test and specific IgE to extracts had high sensitivity, while specific IgE to components and basophil activation test had high specificity for the diagnosis of individual food allergies.
Review
Infectious Diseases
Andrew B. Dagens, Amanda Rojek, Louise Sigfrid, Annette Pluddemann
Summary: A systematic review assessed the diagnostic accuracy of rapid diagnostic tests (RDTs) for Ebola virus disease (EVD). The results showed that lateral flow assays had a sensitivity of 86.1% and specificity of 97%, while rapid PCR devices had a sensitivity of 96.2% and specificity of 96.8%. These RDTs can be used as a 'rule in' test to expedite treatment and vaccination.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Infectious Diseases
Basilua Andre Muzembo, Kei Kitahara, Anusuya Debnath, Keinosuke Okamoto, Shin-Ichi Miyoshi
Summary: This study systematically evaluated the accuracy of cholera rapid diagnostic tests (RDTs) and found that they have moderate sensitivity and specificity, especially when enriched with alkaline peptone water (APW). Although they are less useful for clinical management, the current generation of RDTs can be valuable for surveillance efforts if used in a principled manner.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Allergy
Bernardo Sousa-Pinto, Isabel Tarrio, Kimberly G. Blumenthal, Luis Araujo, Luis Filipe Azevedo, Luis Delgado, Joao Almedia Fonseca
Summary: The diagnostic accuracy of skin tests and specific IgE quantification in identifying patients reporting a penicillin/B-lactam allergy is low, with low sensitivity and high specificity. More research is needed to assess the role of these tests in stratifying patients for delabeling.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Allergy
Jon Genuneit, Sashini Jayasinghe, Carmen Riggioni, Rachel Louise Peters, Derek K. Chu, Daniel Munblit, Robert J. Boyle, George Du Toit, Isabel Skypala, Alexandra F. Santos
Summary: The European Academy of Allergy and Clinical Immunology is updating guidelines on food allergy diagnosis and management by conducting a new systematic review to assess the accuracy of index tests for IgE-mediated food allergy. The protocol aims to evaluate various tests' accuracy in diagnosing food allergy, which can be beneficial in both clinical and research settings.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Review
Acoustics
Q. Li, W. Hou, L. Li, J. Xu, Y. Ren, K. Zou, R. Tian, X. Sun
Summary: This study compared the reporting quality of systematic reviews of diagnostic test accuracy studies using the PRISMA-DTA and original PRISMA checklists. The results showed that PRISMA-DTA identified more reporting issues, especially in critical sections such as title, abstract, and methods, compared to PRISMA-2009 and PRISMA-2020. However, PRISMA-DTA was not commonly used by researchers and was inadequately endorsed by imaging journals. Therefore, there is a strong need for authors and journals to more widely adopt PRISMA-DTA for reporting diagnostic test accuracy systematic reviews.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Review
Medicine, General & Internal
Tiara Josephine Gracienta, Ryan Herardi, Frans Santosa, Taufiq Fredrik Pasiak, Yanto Sandy Tjang
Summary: This systematic review study indicates that antibody-based rapid diagnostic tests are not suitable as primary diagnostic tests but have utility as a screening tool.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Review
Medicine, General & Internal
Maniya Arshadi, Fatemeh Fardsanei, Behnaz Deihim, Zahra Farshadzadeh, Farhad Nikkhahi, Farima Khalili, Giovanni Sotgiu, Amir Hashem Shahidi Bonjar, Rosella Centis, Giovanni Battista Migliori, Mohammad Javad Nasiri, Mehdi Mirsaeidi
Summary: This study evaluated the accuracy of rapid antigen tests (RATs) in diagnosing COVID-19. The results showed that RATs had high sensitivity and specificity compared to the reference test (real-time PCR), making them suitable for early detection and resource-limited countries.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, General & Internal
Anne-Marieke van Dijk, Yasaman Vali, Anne Linde Mak, Jenny Lee, Maarten E. Tushuizen, Mohammad Hadi Zafarmand, Quentin M. Anstee, M. Julia Brosnan, Max Nieuwdorp, Patrick M. Bossuyt, Adriaan G. Holleboom
Summary: In this study, FibroMeter versions were systematically reviewed for their performance in detecting different levels of fibrosis in patients with NAFLD. The findings indicated that FibroMeter VCTE had the highest diagnostic accuracy in detecting advanced fibrosis, followed by FibroMeter V2G and FibroMeter NAFLD, with no significant differences between the different versions. Head-to-head comparison studies are needed to further evaluate the performance of these tests.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Shruti Jayakumar, Viknesh Sounderajah, Pasha Normahani, Leanne Harling, Sheraz R. Markar, Hutan Ashrafian, Ara Darzi
Summary: Artificial intelligence (AI) centred diagnostic systems are recognized as robust solutions in healthcare, but there is a lack of quality assessment and inconsistent reporting in secondary research studies, potentially hindering their clinical implementation.
NPJ DIGITAL MEDICINE
(2022)
Review
Infectious Diseases
Hidehiro Someko, Yuji Okazaki, Yasushi Tsujimoto, Masahiro Ishikane, Kenji Kubo, Tomoki Kakehashi
Summary: This study aimed to investigate the usefulness of rapid antigen tests in cerebrospinal fluid (CSF) for triaging pneumococcal meningitis. The meta-analysis of 44 studies found that the sensitivity of rapid antigen tests in CSF was 99.5% and the specificity was 98.2%. The results suggest that this testing method can be utilized for triaging pneumococcal meningitis, but further research is needed to validate its clinical benefits.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Medicine, General & Internal
Marco Haertle, Louisa Kolbeck, Christian Macke, Tilman Graulich, Ricarda Stauss, Mohamed Omar
Summary: The study aimed to investigate if the combined semiquantitative determination of glucose and LE in synovial fluid can improve the diagnosis of PJI. The results showed that the combined test had high specificity but lower sensitivity compared to LE analysis alone, indicating it may not be sufficient to rule out PJI with certainty.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Orthopedics
Tobias Saueressig, Patrick J. Owen, Frank Diemer, Jochen Zebisch, Daniel L. Belavy
Summary: Pain provocation tests for the sacroiliac joint have moderate diagnostic accuracy, with positive results providing 35% certainty and negative results providing 92% certainty in ruling out the sacroiliac joint as the source of pain.
JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
(2021)
Article
Multidisciplinary Sciences
Juliana de Andrade Reboucas Guimaraes, Silvania da Conceicao Furtado, Ana Cyra dos Santos Lucas, Bruno Mori, Jose Fernando Marques Barcellos
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with multiorgan inflammatory involvement. Lupus nephritis, which affects about 50% of SLE patients, is associated with delayed diagnosis and poor outcomes. This overview aims to summarize systematic reviews on the accuracy of novel serum and urinary biomarkers for diagnosing lupus nephritis in patients with SLE. The results suggest that anti-C1q, urinary MCP-1, TWEAK, and NGAL show promise as potential biomarkers for lupus nephritis, but further research is needed for validation and clinical use.
Article
Medicine, General & Internal
Clara Wollenhaupt, Thomas Sudhop, Werner Knoess
Summary: The EU's IVDR introduces companion diagnostics (CDx) as a new legal term, aimed at identifying patient subgroups most likely to benefit from a treatment. A systematic search in a clinical trials database identified 3643 trials conducted between 2004 and 2022, analyzing the use of biomarker testing in patient stratification, with PD-L1 and HER2 being the most frequently tested biomarkers. The findings also suggest overlap with non-European authorities implementing the CDx concept, indicating potential CDx candidates under the IVDR.
Article
Health Care Sciences & Services
Thomas Piggott, Miranda W. Langendam, Elena Parmelli, Jan Adolfsson, Elie A. Akl, David Armstrong, Jeffrey Braithwaite, Romina Brignardello-Petersen, Jan Brozek, Markus Follmann, Ina Kopp, Joerg J. Meerpohl, Luciana Neamtiu, Monika Nothacker, Amir Qaseem, Paolo Giorgi Rossi, Zuleika Saz-Parkinson, Philip J. van der Wees, Holger J. Schunemann
Summary: The study aimed to develop an extension of the GIN-McMaster Guideline Development Checklist and Tool for the integration of quality assurance and improvement (QAI) schemes with guideline development. A mixed-methods approach was used, incorporating evidence from a systematic review, an expert workshop, and a survey of experts. The result was a 40-item checklist extension, addressing steps for the integration of QAI into guideline development.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Allergy
Bernardo Sousa-Pinto, Holger J. Schunemann, Ana Sa-Sousa, Rafael Jose Vieira, Rita Amaral, Josep M. Anto, Ludger Klimek, Wienczyslawa Czarlewski, Joaquim Mullol, Oliver Pfaar, Anna Bedbrook, Luisa Brussino, Violeta Kvedariene, Desiree E. Larenas-Linnemann, Yoshitaka Okamoto, Maria Teresa Ventura, Ioana Agache, Ignacio J. Ansotegui, Karl C. Bergmann, Sinthia Bosnic-Anticevich, G. Walter Canonica, Victoria Cardona, Pedro Carreiro-Martins, Thomas Casale, Lorenzo Cecchi, Tomas Chivato, Derek K. Chu, Cemal Cingi, Elisio M. Costa, Alvaro A. Cruz, Stefano Del Giacco, Philippe Devillier, Patrik Eklund, Wytske J. Fokkens, Bilun Gemicioglu, Tari Haahtela, Juan Carlos Ivancevich, Zhanat Ispayeva, Marek Jutel, Piotr Kuna, Igor Kaidashev, Musa Khaitov, Helga Kraxner, Daniel Laune, Brian Lipworth, Renaud Louis, Michael Makris, Riccardo Monti, Mario Morais-Almeida, Ralph Mosges, Marek Niedoszytko, Nikolaos G. Papadopoulos, Vincenzo Patella, Nhan Pham-Thi, Frederico S. Regateiro, Sietze Reitsma, Philip W. Rouadi, Boleslaw Samolinski, Aziz Sheikh, Milan Sova, Ana Todo-Bom, Luis Taborda-Barata, Sanna Toppila-Salmi, Joaquin Sastre, Ioanna Tsiligianni, Arunas Valiulis, Olivier Vandenplas, Dana Wallace, Susan Waserman, Arzu Yorgancioglu, Mihaela Zidarn, Torsten Zuberbier, Joao A. Fonseca, Jean Bousquet
Summary: This study analyzed data from MASK-air (R) to explore rhinitis control and treatment patterns over time. It identified 16 weekly patterns of rhinitis control and revealed common co-medication and medication change schemes in uncontrolled weeks, supporting the hypothesis that patients self-treat based on their symptoms.
Editorial Material
Obstetrics & Gynecology
Janneke van 't Hooft, Charlotte E. E. van Dijk, Cathrine Axfors, Zarko Alfirevic, Martijn A. A. Oudijk, Khalid S. S. Khan, Ben W. J. Mol, Patrick M. M. Bossuyt, John P. A. Ioannidis
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Medical Laboratory Technology
Florent J. L. A. Vanstapel, Matthias Orth, Thomas Streichert, Ettore D. Capoluongo, Wytze P. Oosterhuis, Hikmet Can Cubukcu, Francisco A. Bernabeu-Andreu, Marc Thelen, Leo H. J. Jacobs, Solveig Linko, Harjit Pal Bhattoa, Patrick M. M. Bossuyt, Pika Mesko Brguljan, Guilaine Boursier, Christa M. Cobbaert, Michael Neumaier
Summary: The EU In-Vitro Diagnostic Device Regulation (IVDR) aims to ensure transparent validation of diagnostic devices, traceability of results, and post-market surveillance. Laboratory-developed tests (LDTs) may be used in the absence of suitable commercial devices. The implementation of IVDR may lead to the need for urgent replacement of commercial tests with LDTs, and the workload will depend on various factors.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Medicine, Research & Experimental
Rana Charide, Lisa Stallwood, Matthew Munan, Shahab Sayfi, Lisa Hartling, Nancy J. Butcher, Martin Offringa, Sarah Elliott, Dawn P. Richards, Joseph L. Mathew, Elie A. Akl, Tamara Kredo, Lawrence Mbuagbaw, Ashley Motillal, Ami Baba, Matthew Prebeg, Jacqueline Relihan, Shannon D. Scott, Jozef Suvada, Maicon Falavigna, Miloslav Klugar, Tamara Lotfi, Adrienne Stevens, Kevin Pottie, Holger J. Schunemann
Summary: This study aims to evaluate and compare the public's understanding and preference for different presentations of COVID-19 health recommendations. The study will involve online surveys and virtual interviews. The findings will provide guidance for improving the delivery of health recommendations.
Letter
Gastroenterology & Hepatology
Daniele Piovani, Andreas G. Tsantes, Holger J. Schunemann, Stefanos Bonovas
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Health Care Sciences & Services
Martin Ragusaa, Fernando Tortosaa, Gabriel Radab, Camilo Vergarab, Leslie Zaragozaa, Jenee Farrella, Marcela Torresa, Veronica Abdalaa, Ariel Izcovicha, Michelle Habya, Holger J. Schunemannc, Sebastian Garcia-Saisoa, Ludovic Reveiza
Summary: This article describes the establishment and maintenance of a living database of recommendations developed by the PAHO/WHO using the GRADE assessment system. The database provides a valuable resource for health professionals and organizations to make evidence-informed decisions. It allows searching and filtering recommendations by various criteria.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Health Care Sciences & Services
Gordon Guyatt, Yunli Zhao, Martin Mayer, Matthias Briel, Reem Mustafa, Ariel Izcovich, Monica Hultcrantz, Alfonso Iorio, Ana Carolina Alba, Farid Foroutan, Xin Sun, Holger Schunemann, Hans DeBeer, Elie A. Akl, Robin Christensen, Stefan Schandelmaier
Summary: This study updates previous GRADE guidance by addressing inconsistencies and interpreting subgroup analyses through an iterative process of consultation with members of the GRADE working group.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Review
Health Care Sciences & Services
Elie A. Akl, Rayane El Khoury, Assem M. Khamis, Ibrahim K. El Mikati, Hector Pardo-Hernandez, Sarah Farran, Rand Ibrahim, Mohamed Khamis, Layal Hneiny, Holger J. Schunemann, Lara A. Kahale
Summary: The objectives of this study are to describe the characteristics of living systematic reviews (LSRs) and to understand their life cycles. The majority of LSRs included in the study were from the clinical field, COVID-19 related, and had a funding source specified. While most LSRs complied with the planned period of producing updates, a substantive proportion lagged since their last update.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Health Care Sciences & Services
Rachel E. Christensen, Michael D. Yi, Bianca Y. Kang, Sarah A. Ibrahim, Noor Anvery, McKenzie Dirr, Stephanie Adams, Yasser S. Amer, Alexandre Bisdorff, Lisa Bradfield, Steve Brown, Amy Earley, Lisa A. Fathere, Pierre Fayoux, Thomas Getchius, Pamela Ginex, Amanda Graham, Courtney R. Green, Paolo Gresele, Helen Hanson, Norrisa Haynes, Laszlo Hegedus, Heba Hussein, Priya Jakhmola, Lucia Kantorova, Rathika Krishnasamy, Alex Kristz, Gregory Landry, Erika D. Lease, Luis Ley, Gemma Marsden, Tim Meek, Martin Meremikwu, Carmen Moga, Saphia Mokrane, Amol Mujoomdar, Skye Newton, Norma O'Flynn, Gavin D. Perkins, Emma-Jane Smith, Chatura Prematunge, Jenna Rychert, Mindy Saraco, Holger J. Schunemann, Emily Senerth, Alan Sinclair, James Shwayder, Carla Stec, Suzana Tanni, Nichole Taske, Robyn L. Temple-Smolkin, Louise Thomas, Sherene Thomas, Britt Tonnessen, Amy S. Turner, Anne Van Dam, Mitchell van Doormaal, Yung Liang Wan, Christina B. Ventur, Emma McFarlane, Rebecca L. Morgan, Toju Ogunremi, Murad Alam
Summary: This study aimed to develop a glossary of terms related to collaboration in guideline development, with the goal of improving communication, minimizing conflicts, and increasing efficiency in guideline production. The glossary was developed through literature review, expert input, and consensus-building processes.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Review
Psychiatry
Aline Marileen Wiegersma, Amber Boots, Miranda w W. Langendam, Jacqueline Limpens, Susan D. D. Shenkin, Aniko Korosi, Tessa J. J. Roseboom, Susanne R. de Rooij
Summary: This systematic review examined the association between prenatal factors and later risk for dementia, finding that prenatal factors related to a suboptimal prenatal environment are associated with an increased risk of dementia.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Hematology
Ignacio Neumann, Ariel Izcovich, Ricardo Aguilar, Guillermo Leon Basantes, Patricia Casais, Cecilia C. Colorio, Maria Cecilia Guillermo Esposito, Pedro P. Garcia Lazaro, Jaime Pereira, Luis A. Meillon Garcia, Suely Meireles Rezende, Juan Carlos Serrano, Mario L. Tejerina Valle, Diana Altuna, Pamela Zuniga, Felipe Vera, Lorena Karzulovic, Holger J. Schunemann
Summary: This study aims to provide evidence-based recommendations for the diagnosis and management of venous thromboembolism (VTE) in children and during pregnancy in Latin American settings. By collaborating with the American Society of Hematology (ASH) and local hematology societies, a guideline panel was formed and recommendations were adapted based on the Latin American context. This study emphasizes the importance of contextualizing guidelines in different settings to ensure feasibility and equity in healthcare.
Editorial Material
Allergy
G. Walter Canonica, Ioana Agache, Holger J. Schunemann, Nicolas Roche, David Price, Stefano del Giacco
Review
Allergy
Jean Bousquet, Boleslaw Samolinski, Igor Kaidashev, Marcus Maurer, Nicolas Roche, Bernardo Sousa-Pinto, Andrii Kurchenko, Roman Stepanenko, Vladyslav Tsaryk, Ludger Klimek, Maria Teresa Ventura, Anna Bedbrook, Wienczyslawa Czarlewski, Yuliia Lysanets, Maciej Kupczyk, Lukasz Skolimowski, Marek Kulus, Stefano Del Giacco, Markus Ollert, Judith Garcia-Aymerich, Carlos Robalo Cordeiro, Arzu Yorgancioglu, Christoph Schlapbach, Rita Amaral, Cristina Bonaglia, Isabelle Bosse, Rosalba Buquicchio, Demetrios Christou, Galyna Fedoruk, Pietro Fontanesi, Bilun Gemicioglu, Antonio F. M. Giuliano, Paolo Lepore, Alla Nakonechna, Sophia Neisinger, Ana M. Pereira, Aiste Ramanauskaite, Filip Raciborski, Brigita Sitkauskiene, Oksana Sokhatska, Viktor Stepanenko, Katarina Stevanovic, Orysya Syzon, Violeta Kvedariene, Govert de Vries, Michiel van Eerd, Arunas Valiulis, Joao A. Fonseca, Josep M. Anto, Tari Haahtela, Holger Schunemann, Torsten Zuberbier
Summary: Eight million Ukrainians have sought refuge in the EU, many of whom have asthma and/or allergic rhinitis and/or urticaria, with around 100,000 potentially having severe diseases. Language and cultural barriers hinder proper management, but two mHealth apps, MASK air and CRUSE, have been updated with Ukrainian versions to aid physicians in providing treatment in the patients' own language.
Article
Medicine, General & Internal
Peter Tugwell, Vivian Welch, Olivia Magwood, Alex Todhunter-Brown, Elie A. Akl, Thomas W. Concannon, Joanne Khabsa, Richard Morley, Holger Schunemann, Lyubov Lytvyn, Arnav Agarwal, Alba Antequera, Marc T. Avey, Pauline Campbell, Christine Chang, Stephanie Chang, Leonila Dans, Omar Dewidar, Davina Ghersi, Ian D. Graham, Glen Hazlewood, Jennifer Hilgart, Tanya Horsley, Denny John, Janet Jull, Lara J. Maxwell, Chris McCutcheon, Zachary Munn, Francesco Nonino, Jordi Pardo Pardo, Roses Parker, Kevin Pottie, Gabriel Rada, Alison Riddle, Anneliese Synnot, Elizabeth Tanjong Ghogomu, Eve Tomlinson, Karine Toupin-April, Jennifer Petkovic
Summary: This study aims to identify and synthesize qualitative and quantitative findings related to engagement in evidence syntheses, explore how engagement promotes health equity, and develop guidance for conducting, evaluating, and reporting engagement. Through reviews, methods study, interviews, and surveys, our international team will develop guidance in collaboration with partners and improve adoption by key organizations.
SYSTEMATIC REVIEWS
(2023)
