Article
Cardiac & Cardiovascular Systems
Ella Grilz, Florian Posch, Stephan Nopp, Oliver Koenigsbruegge, Irene M. Lang, Peter Klimek, Stefan Thurner, Ingrid Pabinger, Cihan Ay
Summary: Patients with cancer have a significantly higher risk of both arterial thromboembolism (ATE) and venous thromboembolism (VTE) compared to those without cancer. Different types of cancer show variations in the incidence of ATE and VTE.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Ella Grilz, Florian Posch, Stephan Nopp, Oliver Konigsbrugge, Irene M. Lang, Peter Klimek, Stefan Thurner, Ingrid Pabinger, Cihan Ay
Summary: This study in Austria found a significantly higher risk of arterial and venous thrombosis in cancer patients using International Classification of Disease 10th Revision (ICD-10) diagnosis codes, indicating a strong association between cancer, ATE, and VTE.
EUROPEAN HEART JOURNAL
(2021)
Review
Medicine, General & Internal
Mateo Porres-Aguilar, Victor F. Tapson, Belinda N. Rivera-Lebron, Parth M. Rali, David Jimenez, Mateo Porres-Munoz, Sarah Barraza, Oscar C. Munoz, Debabrata Mukherjee
Summary: Venous thromboembolism associated with COVID-19, especially acute pulmonary embolism, poses challenges in clinical management. Establishing a multidisciplinary pulmonary embolism response team (PERT) can play a crucial role in providing fast, appropriate, team-based care for these patients.
JOURNAL OF INVESTIGATIVE MEDICINE
(2021)
Review
Medicine, General & Internal
George Keramidas, Konstantinos I. Gourgoulianis, Ourania S. Kotsiou
Summary: Chronic lung inflammation contributes to various chronic pulmonary diseases, which are associated with an increased risk of VTE. Understanding the role of chronic lung inflammation as a predisposing factor for VTE can help determine optimal management and aid in the development of future preventative strategies. Early suspicion is crucial for diagnosing thrombotic events, as clinical presentations often overlap with respiratory disorders.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Mattes Becher, Thomas Heller, Sarah Schwarzenboeck, Jens-Christian Kroeger, Marc-Andre Weber, Felix G. Meinel
Summary: In this study, the prevalence of negative venous leg ultrasound in acute PE was investigated, with almost half of patients showing no signs of DVT. Negative venous ultrasound was more common in patients without DVT history, lower D-dimer levels, PE diagnosed with V/P-SPECT rather than CT, and more peripherally located PE.
Article
Radiology, Nuclear Medicine & Medical Imaging
Giovanni Foti, Ronaldo Silva, Niccolo Faccioli, Alessandro Fighera, Rossella Menghini, Arianna Campagnola, Giovanni Carbognin
Summary: In a selected, high-prevalence population, VP-DECT is considered an accurate imaging tool for diagnosing PE compared to CTPA. The sensitivity of VP-DECT images in per-patient analysis was 90.0%, with 100% specificity; while in per-lobe analysis, sensitivity ranged from 100% for the right lower lobe to 50% for the left upper lobe.
EUROPEAN RADIOLOGY
(2021)
Review
Hematology
Megan Purdy, Andrea Obi, Daniel Myers, Thomas Wakefield
Summary: Venous thromboembolism (VTE) is a common and costly health problem worldwide. Current anticoagulant treatments have limitations in terms of bleeding risks and prevention of post-thrombotic syndrome or chronic thromboembolic pulmonary hypertension. Inhibition of selectins, a family of glycoproteins that modulate thrombosis, has shown promise as a potential therapy for VTE, with the ability to decrease thrombosis and vein wall fibrosis without increasing bleeding risks.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Biochemistry & Molecular Biology
Olga Porembskaya, Vsevolod Zinserling, Vladimir Tomson, Yana Toropova, Eleonora A. Starikova, Vitaliy V. Maslei, Nika Bulavinova, Olga Kirik, Marina A. Syrtsova, Leonid Laberko, Maxim Galchenko, Vyacheslav Kravchuk, Sergey Saiganov, Alexander Brill
Summary: This study demonstrated that thrombi in the lung vasculature can form in situ by mechanisms that require local neutrophil recruitment taking place in the deep vein thrombosis (DVT) setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Nils Skajaa, Dora Koermendine Farkas, Kasper Adelborg, Henrik Toft Sorensen
Summary: Patients with CVT do not have an overall increased risk of cancer diagnosis, except for the first three months after diagnosis when the risk increases by more than 7-fold. However, a prior diagnosis of CVT does not negatively impact cancer survival.
Review
Hematology
Gina Perrella, Magdolna Nagy, Steve P. Watson, Johan W. M. Heemskerk
Summary: GPVI is a receptor expressed on megakaryocytes and platelets that plays a role in both arterial and venous thrombus formation, as well as in the formation of platelet-leukocyte complexes. It is emerging as a potential therapeutic target for venous thrombosis, pulmonary thromboembolism, and cancer metastasis due to its involvement in venous thrombus formation and thromboinflammation. Circulating soluble GPVI is also being explored as a biomarker for thrombosis-related complications.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Obstetrics & Gynecology
Zhen-Yi Jin, Chun-Min Li, Kai Zheng, Hong Qu, Wen-Tao Yang, Jia-Hao Wen, Wang-De Zhang, Hua-Liang Ren
Summary: This study found a high incidence of isolated distal deep venous thrombosis (IDDVT) concurrent with pulmonary embolism (PE) in gynecologic inpatients. Glucocorticoid therapy, hypertension, diabetes, and body mass index (BMI) were identified as independent risk factors for IDDVT patients with PE. A nomogram risk prediction model based on these factors was developed to facilitate early detection of concurrent PE.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Anesthesiology
E. Li
Summary: Surgical patients with peri-operative or recent SARS-CoV-2 infection are at increased risk of postoperative venous thromboembolism compared to those without a history of SARS-CoV-2. However, the optimal prophylaxis and treatment for venous thromboembolism in this patient population remains unknown. Venous thromboembolism is independently associated with 30-day mortality.
Article
Medicine, General & Internal
Chiara Di Blasi, Matteo Renzi, Paola Michelozzi, Francesca De' Donato, Matteo Scortichini, Marina Davoli, Francesco Forastiere, Pier Mannuccio Mannucci, Massimo Stafoggia
Summary: This study investigated the association between air temperature, particulate matter air pollution, and hospital admissions for pulmonary embolism (PE) and venous thrombosis (VT) in Italy. The results showed a significant effect of air temperature on PE hospitalizations in the cold seasons and summer, with no effect of particulate matter.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Hematology
Simon Soudet, Gaelle Le Roy, Estelle Cadet, Audrey Michaud, Pierre Morel, Jean Pierre Marolleau, Marie Antoinette Sevestre
Summary: This study investigated the relationship between JAK2 mutation allele burden and the risk of cardiovascular events (CVE) and/or venous thrombosis (VTE) in patients with confirmed MPN and those without confirmed MPN. The findings showed that a higher JAK2V617F allele burden was associated with an increased risk of VTE, but not with CVE.
THROMBOSIS RESEARCH
(2022)
Article
Nutrition & Dietetics
Shuai Yuan, Xue Li, Pierre-Emmanuel Morange, Maria Bruzelius, Susanna C. Larsson
Summary: This study used Mendelian randomization to investigate the causal associations between circulating fatty acids and risk of venous thromboembolism (VTE). The results showed that several fatty acids were negatively associated with VTE risk, while a few fatty acids were positively associated. The study provides guidance for prevention strategies targeting fatty acids.
Article
Immunology
Sarah Tubiana, Jose Labarere, Jacques Levraut, Pierre Michelet, Fleur Jourda de Vaux, Benoit Doumenc, Pierre Hausfater, Christophe Choquet, Patrick Plaisance, Jeannot Schmidt, Veronique Mattei, Olivier Gacia, Didier Storme, Patrick Ray, Guillaume Der Sahakian, Marie-Clement Kouka, Laure Jainsky, Jocelyn Raude, Xavier Duval, Yann-Erick Claessens
Summary: This study aimed to evaluate the impact of a multifaceted intervention in improving pneumococcal and influenza vaccinations among patients aged 65 years and older after an emergency department visit. The results showed that the intervention increased influenza vaccination rates, but did not affect pneumococcal vaccination rates. At 12 months, there was no difference in mortality between the intervention and control groups.
Article
Medicine, General & Internal
Alexandre Bellier, Jose Labarere, Zaza Putkaradze, Guillaume Cavalie, Sylvain Carras, Felix Pelen, Adeline Paris, Philippe Chaffanjon
Summary: This study aims to evaluate the effectiveness of a standardised, multifaceted interpersonal skills development programme for hospital physicians. The study is a prospective, randomised controlled trial conducted at a single university hospital, with the primary outcome measure being the overall 4-Habits Coding Scheme score.
Correction
Ophthalmology
Aurelia Gave, Lucile Cotella, Jose Labarere, Florent Aptel, Christophe Chiquet
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Education & Educational Research
Alexandre Bellier, Philippe Chaffanjon, Patrice Morand, Olivier Palombi, Patrice Francois, Jose Labarere
Summary: This study assessed the interpersonal skills of medical students during simulated medical consultations and found that factors associated with these skills include gender and completion of international clinical placements or research laboratory clerkships.
BMC MEDICAL EDUCATION
(2022)
Article
Medicine, General & Internal
Thibaud Mautuit, Pierre Cunnac, Carol Y. Cheung, Tien Y. Wong, Stephen Hogg, Emanuele Trucco, Vincent Daien, Thomas J. MacGillivray, Jose Labarere, Christophe Chiquet
Summary: This study aims to compare measurements from three widely used software packages and generate conversion algorithms for CRAE and CRVE. The results show poor to moderate agreement between VAMPIRE and IVAN, poor to moderate agreement between VAMPIRE and SIVA, and good to excellent agreement between IVAN and SIVA. An algorithm is proposed to convert measurements between different software packages.
Article
Critical Care Medicine
Johanna C. Moore, Paul E. Pepe, Kenneth A. Scheppke, Charles Lick, Sue Duval, Joseph Holley, Bayert Salverda, Michael Jacobs, Paul Nystrom, Ryan Quinn, Paul J. Adams, Mack Hutchison, Charles Mason, Eduardo Martinez, Steven Mason, Armando Clift, Peter M. Antevy, Charles Coyle, Eric Grizzard, Sebastian Garay, Remle P. Crowe, Keith G. Lurie, Guillaume P. Debaty, Jose Labarere
Summary: Compared with conventional CPR, rapid initiation of ACE-CPR is associated with a higher likelihood of survival to hospital discharge after OHCA.
Article
Medicine, General & Internal
Tatiana Raskovalova, Laura Scheffen, Marie-Christine Jacob, Simon Chevalier, Sylvie Tondeur, Benedicte Bulabois, Mathieu Meunier, Gautier Szymanski, Christine Lefebvre, Charlotte Planta, Chantal Dumestre-Perard, Nicolas Gonnet, Frederic Garban, Raymond Merle, Sophie Park, Jose Labarere
Summary: This study aims to compare the accuracy and agreement between a single-use dry reagent and a liquid reagent in quantifying peripheral blood neutrophil myeloperoxidase expression in suspected MDS patients.
Article
Ophthalmology
Lucas Furnon, Jose Labarere, Emanuele Trucco, Stephen Hogg, Tom MacGillivray, Christophe Chiquet
Summary: This study aimed to identify the retinal vessel vasculature parameters associated with birdshot chorioretinopathy (BSCR). The results showed that BSCR was associated with lower fractal dimension (FD) of retinal vessels. Among BSCR patients, retinal vein vasculitis was associated with higher central retinal artery equivalent (CRAE), venous tortuosity, and FD. Resolution of retinal vein vasculitis was accompanied by changes in retinal vascular parameters. These findings suggest that retinal vascular parameters could be useful for assessing patients with BSCR.
ACTA OPHTHALMOLOGICA
(2023)
Article
Multidisciplinary Sciences
Tatiana Raskovalova, Laura Scheffen, Marie-Christine Jacob, Claire Vettier, Benedicte Bulabois, Gautier Szymanski, Simon Chevalier, Nicolas Gonnet, Sophie Park, Jose Labarere
Summary: This study aimed to simplify the gating strategy for peripheral blood neutrophil myeloperoxidase expression and evaluate its accuracy. The results showed that the simplified strategy performs as well as the original one in ruling out MDS and has the potential to save time and resources.
Article
Engineering, Biomedical
Alexandre Behouche, Lucie Gaide-Chevronnay, Juliette Piot, Maxime Durost, Anais Adolle, Yann Le Guen, Antoine Vilotitch, Jean-Luc Bosson, Alexandre Sebestyen, Michel Durand, Pierre Albaladejo
Summary: This study explores the impact of an early extubation strategy in assisted patients and finds that early extubation is associated with better survival and safety. However, due to the lack of prospective randomized studies, the causality remains uncertain.
Review
Health Care Sciences & Services
Florence Ranchon, Sebastie Chanoine, Sophie Lambert-Lacroix, Jean -Luc Bosson, Alexandre Moreau-Gaudry, Pierrick Bedouch
Summary: This systematic review analyzed the type and quality of research publications on indirect data linkage on health product use and care trajectories in France. The results showed that data linkage was performed at both national and local levels, mainly focusing on chronic diseases and infections. The objectives of data linkage included estimating the risk of adverse drug reactions, reconstructing patient care trajectories, describing therapeutic uses, evaluating treatment benefits, and evaluating treatment adherence. However, regulatory, technical, and human constraints remain major obstacles to the deployment of health data linkage.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Health Care Sciences & Services
Sabrina Paradis, Jeremy Roussel, Jean-Luc Bosson, Jean-Baptiste Kern
Summary: The frequency of health app use is high among patients in primary care settings in France, with a focus on wellness, prevention, and fitness. These apps are predominantly used by the younger population.
JMIR FORMATIVE RESEARCH
(2022)
Review
Hematology
Tatiana Raskovalova, Patrick B. Deegan, Pramod K. Mistry, Elena Pavlova, Ruby Yang, Ari Zimran, Juliette Berger, Celine Bourgne, Bruno Pereira, Jose Labarere, Marc G. Berger
Summary: Chitotriosidase activity and CCL18 concentration are both accurate biomarkers for assessing Gaucher disease severity, with CCL18 concentration showing comparable accuracy and measurability in all GD patients. This meta-analysis supports the use of CCL18 over chitotriosidase activity for monitoring GD activity in routine practice.
Article
Health Care Sciences & Services
Bastien Boussat, Hude Quan, Jose Labarere, Danielle Southern, Chantal M. Couris, William A. Ghali
Summary: By conducting a medical chart review on a limited number of medical charts at the hospital level, a method has been developed to estimate true hospital-level adverse event rates for producing health system report cards.
INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE
(2021)
Article
Ophthalmology
Gave Aurelia, Cotella Lucile, Labarere Jose, Aptel Florent, Chiquet Christophe
Summary: The study found that there is subtle structural deterioration of the optic nerve (RNFL) in BSCR patients during follow-up, but no significant changes in the visual field. Analyzing the data showed a significant linear relationship between visual field deficits and RNFL thickness, suggesting that RNFL thickness measurements could be useful for mid-term monitoring of BSCR patients.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
