Article
Endocrinology & Metabolism
Guohua Li, Yang Liu, Xiujuan Su, Shijia Huang, Xiaosong Liu, Qiaoling Du
Summary: This study aimed to evaluate the effects of L-T4 on maternal and perinatal outcomes in pregnant women with hypothyroxinemia. The results showed that L-T4 treatment significantly reduced the miscarriage rate and the proportion of newborns admitted to the NICU, but did not significantly reduce the incidence of hypertensive disorder of pregnancy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Asako Tsunemi, Toyoyoshi Uchida, Keiji Kuroda, Yuko Ikemoto, Asako Ochiai, Hiromasa Goto, Rikikazu Sugiyama, Hiroaki Satoh, Atsuo Itakura, Hirotaka Watada
Summary: Recent randomized controlled studies have shown that levothyroxine treatment only improves pregnancy outcomes in infertile women with subclinical hypothyroidism who have thyroid autoantibodies, but not for those with high TSH levels within the normal range who have TA. The retrospective study on infertile Japanese women with 2.5 ?IU/mL ? TSH < URL did not find significant differences in pregnancy outcomes with LT4 treatment regardless of TA status.
Article
Medicine, General & Internal
Alessandro Dal Lago, Francesco Galanti, Donatella Miriello, Antonella Marcoccia, Micol Massimiani, Luisa Campagnolo, Costanzo Moretti, Rocco Rago
Summary: The study showed that adjuvant therapy with LT4 in women with autoimmune thyroid disease significantly improved pregnancy outcomes, reduced miscarriage rates, and increased full-term pregnancies. In women over 35 years old, LT4 treatment significantly decreased the miscarriage rate.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Chieh-Chen Wu, Md Mohaimenul Islam, Phung-Anh Nguyen, Tahmina Nasrin Poly, Ching-Huan Wang, Usman Iqbal, Yu-Chuan (Jack) Li, Hsuan-Chia Yang
Summary: The study found a significant association between levothyroxine use and increased risk of cancer, particularly brain, skin, pancreatic, and female breast cancers.
Article
Medicine, Research & Experimental
Liya Wang, Yaozhu J. Chen, Michael Grabner, Bal Nepal, Amit Bodhani, Ramon Espaillat, James Hennessey
Summary: The study demonstrates that Synthroid is associated with better TSH target achievement compared to generic levothyroxine (GL) in a US managed care population. Achieving TSH goals may provide substantial economic value by reducing hypothyroidism-related healthcare resource utilization and costs.
ADVANCES IN THERAPY
(2022)
Article
Obstetrics & Gynecology
Rima K. Dhillon-Smith, Kristien Boelaert, Yadava B. Jeve, Abha Maheshwari, Arri Coomarasamy
Summary: Thyroid problems are common in women of reproductive age, including underactivity and thyroid autoimmunity. Mild thyroid problems and high levels of thyroid antibodies are associated with miscarriage and premature birth. There is debate about routine testing and management strategies for thyroid function, particularly in women with a history of subfertility or recurrent miscarriages.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Endocrinology & Metabolism
Wang-Yu Cai, Xi Luo, Erxidi Chen, Houyi Lv, Kaiyou Fu, Xiao-Ke Wu, Jian Xu
Summary: Serum lipid levels are associated with treatment outcomes in women undergoing assisted reproduction. Higher levels of HDL-C are related to more oocytes retrieved, while lower levels of TC, LDL-C, and TG are independently predictive of clinical pregnancy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Raffaella Bocale, Giovambattista Desideri, Angelina Barini, Annamaria D'Amore, Mauro Boscherini, Stefano Necozione, Celestino Pio Lombardi
Summary: This study evaluated the long-term adherence to two different formulations of levothyroxine (L-T4) replacement therapy. The results showed that the adherence was generally satisfactory, with better adherence observed in patients using the liquid formulation compared to the solid formulation. Patients using tablets were more likely to forget or be careless about taking their medication, and about half of the patients preferred tablets for lifelong treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Casey Crump, Jan Sundquist, Kristina Sundquist
Summary: This study found that preterm delivery is associated with an increased risk of stroke, which remains elevated for at least 40 years after delivery and is independent of other factors and familial influences.
Article
Cardiac & Cardiovascular Systems
Casey Crump, Jan Sundquist, Mary Ann McLaughlin, Siobhan M. Dolan, Weiva Sieh, Kristina Sundquist
Summary: Women who deliver preterm have increased future risks of heart failure, with preterm and early term delivery associated with significantly higher hazards in the next 10 years compared to full-term delivery. These risks persist for up to 40 years and are not explained by shared familial factors. Preterm and early term delivery should be recognized as lifelong risk factors for heart failure.
EUROPEAN HEART JOURNAL
(2022)
Article
Surgery
Jan Peter Yska, Inge J. Arfman, Maarten A. van Oijen, Loek J. M. de Heide, Marloes Emous, Nic J. G. M. Veeger, Eric N. van Roon
Summary: In female patients with hypothyroidism who underwent bariatric surgery, dose adjustments were mainly concentrated in the first 2 years post-surgery, with the majority of patients maintaining stable dosages between 24-48 months post-surgery. No significant changes in TSH and fT4 levels were observed after 48 months in the Roux-en-Y gastric bypass group.
Article
Endocrinology & Metabolism
Lennart Blomqvist, Helena F. Nystrom, Margareta Hellgren, Annika Strandell
Summary: The presence of TPO-ab may contribute to an increased risk of first-trimester miscarriage in women with at least three recurrent unexplained pregnancy losses. TSH levels in the range of 2.5-4.0 mU/L do not seem to increase the risk of miscarriage.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Sarah Floud, Angela Balkwill, Sian Sweetland, Anna Brown, Elsa Mauricio Reus, Albert Hofman, Deborah Blacker, Mika Kivimaki, Jane Green, Richard Peto, Gillian K. Reeves, Valerie Beral
Summary: Prospective studies with long-term follow-up show that non-participation in cognitive or social activities is associated with a higher relative risk of dementia detection only during the first decade after participation was recorded. This association diminishes during the second decade, suggesting that inactivity may not directly cause dementia.
LANCET PUBLIC HEALTH
(2021)
Article
Nutrition & Dietetics
Andres Diaz-Lopez, Blanca Ribot, Josep Basora, Victoria Arija
Summary: This population-based cohort study found that women with anaemia or high haemoglobin levels in early pregnancy are at higher risk of miscarriage, with miscarriage rates of 8.4% and 10.2% respectively. Compared to women with normal Hb levels, those with anaemia and high Hb levels had a 2.11-fold and 1.83-fold increased risk of miscarriage. The study also showed a U-shaped association between Hb concentrations and miscarriage, with the lowest risk among women with Hb levels of 120-130 g/L.
Article
Hematology
Kristina R. Pohl, Lukas Hobohm, Valentin J. Krieg, Carmen Sentler, Nina I. J. Rogge, Laura Steimke, Matthias Ebner, Markus Lerchbaumer, Gerd Hasenfuss, Stavros Konstantinides, Mareike Lankeit, Karsten Keller
Summary: Thyroid dysfunction has a significant impact on outcomes in patients with acute pulmonary embolism. Both hypothyroidism and hyperthyroidism are associated with adverse in-hospital outcomes and increased long-term mortality.
THROMBOSIS RESEARCH
(2022)
Editorial Material
Gastroenterology & Hepatology
Colin J. Rees, Willie Hamilton
Article
Oncology
Sarah Price, Bianca Wiering, Luke T. A. Mounce, Willie Hamilton, Gary Abel
Summary: Current methods for estimating the timeliness of cancer diagnosis are not robust due to the uncertainty of key defining milestone dates. When patients have other conditions (multimorbidity) that share symptoms with cancer, the problem becomes more complex. Independent methods are needed to accurately estimate the timeliness of cancer diagnosis and understand the impact of multimorbidity on the diagnostic process.
CANCER EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Filippo Biscarini, Giulia Masetti, Ilaria Muller, Hedda Luise Verhasselt, Danila Covelli, Giuseppe Colucci, Lei Zhang, Mohd Shazli Draman, Onyebuchi Okosieme, Pete Taylor, Chantal Daumerie, Maria-Cristina Burlacu, Michele Marino, Daniel George Ezra, Petros Perros, Sue Plummer, Anja Eckstein, Mario Salvi, Julian R. Marchesi, Marian Ludgate
Summary: This study compared the fecal microbiota in patients with hyperthyroidism caused by Graves disease (GD) and varying severity of Graves orbitopathy (GO) with healthy controls. The results showed an increase in Actinobacteria and a decrease in Bacteroidetes in GD/GO patients compared to controls. A higher Firmicutes to Bacteroidetes ratio was observed in GD/GO. Longitudinal analysis revealed a correlation between the presence of certain bacteria (Clostridiales) at diagnosis and the persistence of thyroid antibodies even after antithyroid drug treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Primary Health Care
Ben Shaw, Fiona M. Walter, William Hamilton, Tanimola Martins
Summary: The high mortality rate of prostate cancer in Black males can be reduced by addressing delays in the pathway to diagnosis before initial medical help seeking. A greater understanding of symptom appraisal and help seeking is crucial for developing targeted interventions to improve early presentation among Black males.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Rupa Ahluwalia, Stephanie E. Baldeweg, Kristien Boelaert, Krishna Chatterjee, Colin Dayan, Onyebuchi Okosieme, Julia Priestley, Peter Taylor, Bijay Vaidya, Nicola Zammitt, Simon H. Pearce
Summary: Persistent symptoms in patients treated for hypothyroidism are common. The use of liothyronine for this indication remains controversial. This consensus statement attempts to provide practical guidance for clinicians in managing patients with persistent symptoms during thyroid hormone replacement therapy.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Peter Taylor, Rathie Rajendram, Stephanie Hanna, Victoria Wilson, Julie Pell, Chunhei Li, Anne Cook, Rao Gattamaneni, Nicholas Plowman, Sue Jackson, Robert Hills, Robert French, Jimmy M. Uddin, Richard W. J. Lee, Colin M. Dayan
Summary: Graves orbitopathy is a disabling and disfiguring disease. The long-term outcomes of a clinical trial showed that after three years, there was no additional benefit for patients who received azathioprine or radiotherapy. Although clinical activity score, ophthalmopathy index, and total eye score improved over three years, quality of life remained poor and a high percentage of patients required surgery.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Caroline Minassian, Lowri A. Allen, Onyebuchi Okosieme, Bijay Vaidya, Peter Taylor
Summary: This study aimed to determine trends in the management and treatment of hyperthyroidism before and during pregnancy, and to assess the impact of different preconception treatment strategies on maternal thyroid status. The management of women with hyperthyroidism who become pregnant was found to be suboptimal, particularly among those who had received preconception definitive treatment, and urgent improvement is needed. Better thyroid monitoring and prenatal counseling are necessary to optimize thyroid status, reduce teratogenic drug exposure, and ultimately reduce the risk of adverse pregnancy outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Willie Hamilton, Luke Mounce, Gary A. Abel, Sarah Gerard Dean, John L. Campbell, Fiona C. Warren, Anne Spencer, Antonieta Medina-Lara, Martin Pitt, Elizabeth Shephard, Marijke Shakespeare, Emily Fletcher, Adrian Mercer, Raff Calitri
Summary: This study is a pragmatic randomized controlled trial in English primary care to assess the impact of electronic risk assessment tools (eRATs) on early cancer diagnosis. The study aims to compare the outcomes of patients diagnosed using eRATs with those diagnosed using usual care, and evaluate the effectiveness of eRATs in improving early cancer diagnosis.
Article
Medicine, General & Internal
Claudia M. Snudden, Natalia Calanzani, Stephanie Archer, Stephanie Honey, Merel M. Pannebakker, Anissa Faher, Aina Chang, Willie Hamilton, Fiona M. Walter
Summary: This study aimed to explore patients' care experience and acceptability of using FIT. The study found that patients were satisfied with doing the FIT themselves and recommending it to others, although some perceived it as a challenge for others. However, test explanation by healthcare professionals was often limited and many participants did not receive their results, leading to uncertainty.
Article
Oncology
Tanimola Martins, Obioha C. Ukoumunne, Georgios Lyratzopoulos, Willie Hamilton, Gary Abel
Summary: This UK population-based study aimed to investigate whether there are ethnic differences in the presenting features of cancer recorded in primary care before diagnosis. The study found that Asian and Black patients were more likely to have 'less concerning' features recorded before diagnosis compared to White patients, while no ethnic group was more likely to have alarm features recorded. Further research is needed to determine the underlying factors behind these ethnic differences, whether it is related to disease biology, patient, or healthcare factors.
Article
Endocrinology & Metabolism
Tessa A. Mulder, Purdey J. Campbell, Peter N. Taylor, Robin P. Peeters, Scott G. Wilson, Marco Medici, Colin Dayan, Vincent V. W. Jaddoe, John P. Walsh, Nicholas G. Martin, Henning Tiemeier, Tim I. M. Korevaar
Summary: This study found that the effects of many known thyroid function-related genes are already apparent in childhood, and some genes have a greater impact on children compared to adults. These findings provide new insights into the genetic regulation of thyroid function in early life.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Emily J. Cartwright, Chloe Pierret, Caroline Minassian, Denise A. Esserman, Janet P. Tate, Matthew B. Goetz, Debika Bhattacharya, David A. Fiellin, Amy C. Justice, Vincent Lo Re, Christopher T. Rentsch
Summary: This retrospective cohort study evaluated the association between alcohol use at the initiation of direct-acting antiviral (DAA) therapy and sustained virologic response (SVR) in patients with chronic hepatitis C virus (HCV) infection. The study found that alcohol use and alcohol use disorder (AUD) were not associated with lower odds of SVR.
Editorial Material
Health Care Sciences & Services
Willie Hamilton, Sarah Price
LANCET REGIONAL HEALTH-EUROPE
(2023)