期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 99, 期 12, 页码 E2628-E2634出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2014-2475
关键词
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资金
- National Health and Medical Research Council (NHMRC) of Australia
- Australian Postgraduate Award
- Dawes scholarship from the Royal Adelaide Hospital
- NHMRC Senior Career Development Award
- NHMRC Senior Research Fellowship
- Merck
- Eli Lilly
- Novartis
Context: Studies relating to the cardiovascular effects of glucagon-like peptide-1 (GLP-1) and its agonists, which slow gastric emptying, have not discriminated between fasting and postprandial, blood pressure (BP) and heart rate (HR). Objective: To determine whether exogenous GLP-1 modulates the effects of an intraduodenal (ID) glucose infusion on BP, HR, and splanchnic blood flow in healthy older subjects. Design: A double-blind randomized trial was conducted. Setting: Community-dwelling residents attended a clinical research laboratory. Patients: Ten healthy older subjects (9 male, 1 female; age 73.2 +/- 1.5 y) were studied. Interventions: Intravenous infusion of GLP-1 (0.9 pmol/kg/min), or saline (0.9%) for 90 min (t = -30-60 min). Between t = 0-60 min, ID glucose was infused at 3 kcal/min. Main Outcome Measures: BP, HR, superior mesenteric artery (SMA) flow, blood glucose, and serum insulin were measured. Results: During the fasting period (t = -30-0 min), GLP-1 had no effect on BP or HR. In response to ID glucose (t = 0-60 min), systolic BP decreased (P < .001), and both HR (P < .001) and SMA flow (P < .05) increased, on both days. GLP-1 attenuated the maximum decrease in systolic BP (P < .05), tended to increase HR (P = .09), and increased SMA flow (P < .01). GLP-1 diminished the glycemic response (P < .05). Conclusions: In healthy older subjects, acute administration of GLP-1 attenuates the hypotensive response to ID glucose, and potentiates the increase in SMA flow.
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