Article
Biochemistry & Molecular Biology
Pawel Brzeminski, Adrian Fabisiak, Radomir M. Slominski, Tae-Kang Kim, Zorica Janjetovic, Ewa Podgorska, Yuwei Song, Mohammad Saleem, Sivani B. Reddy, Shariq Qayyum, Yuhua Song, Robert C. Tuckey, Venkatram Atigadda, Anton M. Jetten, Rafal R. Sicinski, Chander Raman, Andrzej T. Slominski
Summary: This study established new routes for the chemical synthesis of vitamin D-3 and its hydroxy metabolites. The compounds showed similar properties in inhibiting cell proliferation and inducing cell differentiation, as well as effects on T-cell immune activity. They also interacted with nuclear receptors in a similar manner. The findings have important implications for studying the role of these compounds in the immune system and inflammatory diseases.
BIOORGANIC CHEMISTRY
(2022)
Article
Nutrition & Dietetics
RuTong Wang, Weijing Wang, Ping Hu, Ronghui Zhang, Xue Dong, Dongfeng Zhang
Summary: This study aimed to evaluate the association between dietary vitamin D intake and serum vitamin D concentrations with cognitive performance in older Americans. The results showed a positive association between dietary vitamin D intake, serum total 25-hydroxyvitamin D, and cognitive performance, with no significant gender differences in the associations. Further research is needed to clarify the effects of dietary vitamin D intake and specific serum D concentrations on cognitive performance.
Article
Cell Biology
Ping Zhou, Wai W. Cheung, Alex Gonzalez, Venya Vaddi, Eduardo A. Oliveira, Robert H. Mak
Summary: Supplementation of 25(OH)D-3 has metabolic advantages over 1,25(OH)(2)D-3 supplementation in improving muscle atrophy and fat browning.
Article
Immunology
Jennifer K. Mulligan, Dianna Nord, Maria V. Villanueva, Jeb Justice, Brian Lobo, Rodney J. Schlosser, Carl Atkinson
Summary: The study reveals the regulatory role of complement activation on vitamin D metabolism in airway epithelial cells, particularly the elevated C3/C3a in patients with chronic rhinosinusitis with nasal polyps, which may impair 1,25(OH)(2)D-3 metabolism and explain limited therapeutic benefits from oral vitamin D-3 supplementation.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Danchen Wang, Songlin Yu, Qi Zhang, Qian Cheng, Shaowei Xie, Yuanyuan Zhang, Xiuzhi Guo, Yutong Zou, Yicong Yin, Jialei Yu, Honglei Li, Liangyu Xia, Ling Qiu, Weibo Xia
Summary: This study successfully developed a robust and accurate method for simultaneous measurement of serum 25(OH)D, 1,25(OH)(2)D, and 24,25(OH)(2)D by LC-MS/MS with efficient separation of 3-epi analogs, 23R,25(OH)(2)D-3, and 4 beta,25(OH)(2)D-3.
JOURNAL OF MASS SPECTROMETRY
(2022)
Article
Nutrition & Dietetics
Andrea Hanel, Cor Veldhuizen, Carsten Carlberg
Summary: This study compared the modulation of the transcriptome of human peripheral blood mononuclear cells (PBMCs) by the vitamin D metabolites 25-hydroxyvitamin D-3 (25(OH)D-3), 25(OH)D-2, and 1 alpha,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3). The findings showed that 25(OH)D-3 and 25(OH)D-2 were equally potent in modulating the transcriptome of PBMCs at supra-physiological concentrations, possibly by directly activating the vitamin D receptor.
FRONTIERS IN NUTRITION
(2022)
Article
Pathology
Yi Xiao, Edward Ki Yun Leung
Summary: This study developed a rapid LC-MS/MS method for the simultaneous measurement of multiple fat-soluble vitamins. The method showed good linearity and low variability at various quality control levels.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Pohnratchada Mattrasongkram, Saharut Wongkaewkhiaw, Suwimol Taweechaisupapong, Sorujsiri Chareonsudjai, Teerasit Techawiwattanaboon, Thararin Ngamsiri, Sakawrat Kanthawong
Summary: The study found that pretreatment with 1 alpha,25(OH)(2)D-3 can reduce the internalization of B. pseudomallei and decrease the formation of MNGCs in A549 cells. In addition, 1 alpha,25(OH)(2)D-3 can enhance the expression of specific genes and reduce inflammation. Therefore, this study suggests that supplementation with 1 alpha,25(OH)(2)D-3 may be an effective supportive treatment for melioidosis patients.
Article
Multidisciplinary Sciences
Yvette C. Cozier, Nelsy Castro-Webb, Natasha S. Hochberg, Lynn Rosenberg, Michelle A. Albert, Julie R. Palmer
Summary: Limited evidence suggests that higher levels of serum vitamin D may protect against SARS-CoV-2 infection, with this study specifically focusing on Black women. Results indicate that Black women with lower levels of 25(OH)D are at increased risk of COVID-19 infection, highlighting the potential importance of vitamin D in COVID-19 susceptibility.
Article
Biochemistry & Molecular Biology
Jianhong Gu, Xueqing Zhang, Chuang Zhang, Yawen Li, Jianchun Bian, Xuezhong Liu, Yan Yuan, Hui Zou, Xishuai Tong, Zongping Liu
Summary: The study investigated the potential contribution of Gal-3 in the regulatory effects of 1α,25-(OH)(2)D-3 on osteoclastogenesis, with results showing that Gal-3 enhances the inhibitory effects of 1α,25-(OH)(2)D-3 on OC formation and bone resorption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Peng Li, Xinhai Zhu, Guangchao Cao, Ruan Wu, Ke Li, Wenhui Yuan, Biyun Chen, Guodong Sun, Xichun Xia, Hua Zhang, Xiao Wang, Zhinan Yin, Ligong Lu, Yunfei Gao
Summary: This study demonstrates that serum vitamin D level is negatively correlated with the expression of PD-1, TIGIT, and Tim-3, while positively correlated with the expression of CD28 on CD8(+) and V gamma 9V delta 2(+) T cells in patients with NSCLC. The active form of vitamin D, 1 alpha,25(OH)(2)D-3, promotes the nuclear translocation of VDR and inhibits the expression of ICRs by binding to their promoter regions. In addition, VDR-mediated Ca2+ influx enhances Th1 cytokine production and increases antitumor immunity in T cells. Overall, this research highlights the pleiotropic effects of 1 alpha,25(OH)(2)D-3 in rescuing exhausted cytotoxic T cells and promoting antitumor immunity in patients with tumor.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Chemistry, Medicinal
Anna Zielinska, Aleksandra Sobolewska-Wlodarczyk, Maria Wisniewska-Jarosinska, Anita Gasiorowska, Jakub Fichna, Maciej Salaga
Summary: This study found that in patients with IBD, levels of 25(OH)D3 increased while 1,25(OH)2D3 levels did not change, and supplementation of vitamin D3 did not affect their levels. There was no significant correlation between pain intensity and vitamin D levels.
Article
Cell Biology
Min Ai, Shuang-shuang Li, Hong Chen, Xi-ting Wang, Jiang-nan Sun, Bao Hou, Wei-wei Cai, Yue-tao Zhou, Li-ying Qiu
Summary: Clinical studies have shown that cancer patients often experience sleep disturbances, and there may be a relationship between vitamin D levels and sleep quality. Treatment with 1,25(OH)(2)D-3 can improve sleep quality in tumor-bearing mice, suppress neuroinflammation, and enhance neurotrophic factors in the brain.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Malgorzata Grzesiak, Kinga Kaminska, Aleksandra Bodzioch, Ewa M. Drzewiecka, Anita Franczak, Katarzyna Knapczyk-Stwora
Summary: This study reveals the presence of vitamin D-3 metabolism in the uterus of pigs, with both endometrium and myometrium capable of synthesizing vitamin D-3, while only the endometrium is involved in its metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hong Chen, Mei-Zhen Zhu, Xi-Ting Wang, Min Ai, Shuang-Shuang Li, Ming-Yu Wan, Pei-Yao Wang, Wei-Wei Cai, Bao Hou, Fei Xu, Florian Lang, Li-Ying Qiu, Yue-Tao Zhou
Summary: 1,25(OH)(2)D-3 regulates glycolysis and migration of lung cancer cells by suppressing transcript levels and lactate production, as well as influencing cytoskeleton reconstruction, leading to inhibiting cell migration.
Article
Medical Laboratory Technology
Lisa E. Kilpatrick, Roger Bouillon, W. Clay Davis, Clark M. Henderson, Andrew N. Hoofnagle, Steven Pauwels, Dirk Vanderschueren, Etienne Waelkens, Hans Wildiers, James H. Yen, Karen W. Phinney
Summary: This study investigated the influence of different proteoforms of vitamin D-binding protein (VDBP) on quantification using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The results showed that VDBP proteoforms do not cause bias and a family of proteins can be accurately quantified using shared peptides. Assigning a reference value in a standard reference material can improve the accuracy of VDBP quantification in research and clinical samples.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Oncology
Rebecca A. Nelson, Andrew M. Blakely, Joseph C. Larson, Rowan T. Chlebowski, Yi-Jen Chen, Jane A. Cauley, Aladdin H. Shadyab, Lily L. Lai
Summary: This study followed 135,743 postmenopausal women for 17.7 years and found that postmenopausal women with pelvic cancer, especially those who received pelvic radiation, have a higher risk of pelvic fracture and overall mortality. This suggests that prevention of pelvic fractures should be emphasized in pelvic cancer survivors, in addition to cancer treatment.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Review
Andrology
Jolijn Van Cauwenberghe, Christophe De Block, Dirk Vanderschueren, Leen Antonio
Summary: Current available evidence suggests that traditional antidiabetic drugs have limited effects on testosterone levels, while GLP-1 receptor analogues show promising results for improving both testosterone levels and obesity in men with low testosterone levels. However, further studies are needed due to limited data and heterogeneous study groups.
Article
Geriatrics & Gerontology
Lauren S. Roe, Stephanie Harrison, Peggy M. Cawthon, Kyle D. Moored, Yujia Susanna Qiao, Kristine Ensrud, Katie L. Stone, Kelley Pettee Gabriel, Jane A. Cauley
Summary: Increasing the frequency of active bouts and reducing the duration of sedentary bouts may lower mortality risk among older men, regardless of total sedentary time.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Review
Economics
Nannan Li, Charlotte Beaudart, Jane A. Cauley, Steven W. Ing, Nancy E. Lane, Jean-Yves Reginster, Stuart Silverman, Andrea J. Singer, Mickael Hiligsmann
Summary: This study systematically reviewed economic evaluations of interventions for osteoporosis in men and found that anti-osteoporosis drugs and nutritional supplements are cost-effective for men with osteoporosis. In addition, screening strategies and post-fracture care programs also provide economic benefits for men. The cost-effectiveness and intervention thresholds were generally similar between men and women, with slightly higher incremental cost-effectiveness ratios in men.
Article
Rheumatology
Walter Reinisch, Wayne Hellstrom, Radboud J. E. M. Dolhain, Suresh Sikka, Rene Westhovens, Rajiv Mehta, Timothy Ritter, Ursula Seidler, Oleksandr Golovchenko, Vladimir Simanenkov, Olena Garmish, Slawomir Jeka, Radka Moravcova, Vijay Rajendran, Franck-Olivier Le Brun, Sarah Arterburn, Timothy R. Watkins, Robin Besuyen, Dirk Vanderschueren
Summary: The phase 2 MANTA and MANTA-RAy studies aimed to determine the impact of the oral Janus kinase 1 inhibitor filgotinib on semen parameters and sex hormones in men with inflammatory diseases. Results showed that once daily filgotinib 200 mg for 13 weeks had no measurable impact on semen parameters or sex hormones.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Geriatrics & Gerontology
Sharon C. Welburn, Erin E. Fanning, Jane A. Cauley, Patrick J. Brown, Elsa S. Strotmeyer, Robert M. Boudreau, Todd M. Bear, Kyle D. Moored, Peggy M. Cawthon, Katie L. Stone, Nancy W. Glynn
Summary: This study found that both physical and mental fatigability are associated with increased fall risk in elderly men, with physical fatigability increasing the risk by 20% and mental fatigability increasing the risk of recurrent falling by 35% and 44% respectively.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Correction
Economics
Nannan Li, Charlotte Beaudart, Jane A. Cauley, Steven W. Ing, Nancy E. Lane, Jean-Yves Reginster, Stuart Silverman, Andrea J. Singer, Mickael Hiligsmann
Review
Medicine, General & Internal
Ross J. Marriott, Kevin Murray, Robert J. Adams, Leen Antonio, Christie M. Ballantyne, Douglas C. Bauer, Shalender Bhasin, Mary L. Biggs, Peggy M. Cawthon, David J. Couper, Adrian S. Dobs, Leon Flicker, David J. Handelsman, Graeme J. Hankey, Anke Hannemann, Robin Haring, Benjumin Hsu, Magnus Karlsson, Sean A. Martin, Alvin M. Matsumoto, Dan Mellstroem, Claes Ohlsson, Terence W. O'Neill, Eric S. Orwoll, Matteo Quartagno, Molly M. Shores, Antje Steveling, Asa Tivesten, Thomas G. Travison, Dirk Vanderschueren, Gary A. Wittert, Frederick C. W. Wu, Bu B. Yeap
Summary: The study found that various factors, including age, obesity, marital status, physical activity, smoking, hypertension, cardiovascular disease, cancer, and diabetes, are associated with variations in male testosterone, SHBG, and LH concentrations. Reduced testosterone and increased LH concentrations may indicate impaired testicular function in men older than 70 years.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Adrian Heald, Michael J. Cook, Leen Antonio, Jos Tournoy, Parisa Ghaffari, Fahmida Mannan, Helene Fachim, Dirk Vanderschueren, Ian Laing, Geoff Hackett, Felipe F. Casanueva, Ilpo T. Huhtaniemi, Mario Maggi, Giulia Rastrelli, Jolanta Slowikowska-Hilczer, Fred Wu, Terence W. O'Neill
Summary: This study found no association between androgen receptor CAG repeat number and mortality in European men. However, a post-hoc analysis showed a potential association in men with lower baseline testosterone concentrations, which requires further investigation.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Karel David, Gaetan Devos, Nick Narinx, Leen Antonio, Wout Devlies, Ludo Deboel, Dieter Schollaert, Anton Eisenhauer, Etienne Cavalier, Dirk Vanderschueren, Frank Claessens, Steven Joniau, Brigitte Decallonne
Summary: Prostate cancer patients treated with androgen deprivation therapy (ADT) have an increased risk of bone loss. This study suggests that 12 weeks of ADT in non-metastatic PCa patients results in early bone loss, and additional treatment with ARSI does not seem to worsen bone loss in the early phase. Future studies should investigate if these early biomarkers can predict fracture risk and be used in clinical practice for monitoring bone health in PCa patients undergoing ADT.
Article
Endocrinology & Metabolism
Lauren S. Roe, Stephanie Harrison, Peggy M. Cawthon, Kristine Ensrud, Kelley Pettee Gabriel, Deborah M. Kado, Jane A. Cauley
Summary: In addition to the volume of physical activity, frequent breaks from sedentary behavior and active bouts can reduce the risk of falls and fractures. A study found that there is a long-term relationship between the frequency of breaks from sedentary behavior and the occurrence of recurrent falls and fractures. The study also concluded that breaking up extended periods of sedentary time can reduce fall risk, regardless of the total sedentary time.
Article
Endocrinology & Metabolism
Lisa T. Langsetmo, John C. Schousboe, Brent A. Taylor, Jane A. Cauley, Howard M. Fink, Peggy M. Cawthon, Deborah E. Kado, Kristine Ensrud
Summary: Targeted fracture prevention strategies among late-life adults should consider both fracture risk and competing mortality risk. A machine learning method was used to evaluate risk factors and create models for hip fractures and competing mortality among adults aged 80 years and older. Random forest models were compared to Fine-Gray models with six variables. Top variables for predicting hip fractures were bone mineral density, while frailty was associated with competing mortality. Random forest models performed slightly better than Fine-Gray models for predicting mortality, but similarly for predicting hip fractures.
Meeting Abstract
Transplantation
Karel David, Nick Narinx, Jetty De Loor, Leen Antonio, Dirk Vanderschueren, Frank Claessens, Brigitte Decallonne, Pieter Evenepoel
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Neurosciences
Ashwini Kumar Nepal, Hubertus W. van Essen, Renate T. de Jongh, Natasja M. van Schoor, Rene H. J. Otten, Dirk Vanderschueren, Paul Lips, Nathalie Bravenboer
Summary: Axial loading in rodents provides a controlled setting for studying the effects of mechanical loading on bone outcomes. This review article summarizes the methodological aspects and modifying factors that can influence bone mass, structure, and density in response to axial loading. Results from rat and mouse studies indicate that peak load, frequency, and number of loading cycles are important parameters affecting bone outcomes. Consideration of methodological parameters and modifying factors is crucial for predicting loading-related bone outcomes.
JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS
(2023)
