Article
Gastroenterology & Hepatology
Cai-Zhi Huang, Jie Zhang, Lin Zhang, Cui-Hua Yu, Yi Mo, Li-Ya Mo
Summary: Children with CHB have lower serum levels of 25(OH)D and VDBP than healthy controls. VDBP levels are negatively correlated with HBV replication, while low 25(OH)D levels are independently associated with hepatic fibrosis in children with CHB. There is no significant correlation between serum levels of 25(OH)D and VDBP.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Geriatrics & Gerontology
Jennifer A. Schrack, Yurun Cai, Jacek K. Urbanek, Amal A. Wanigatunga, Christine M. Mitchell, Edgar R. Miller III, Jack M. Guralnik, Stephen P. Juraschek, Erin D. Michos, David L. Roth, Lawrence J. Appel
Summary: This study aimed to assess whether vitamin D-3 supplementation could attenuate the decline in daily physical activity in low-functioning older adults. The results showed that supplementation with 1000 IU/day or higher of vitamin D-3 did not attenuate the decline in physical activity compared to 200 IU/day. Individuals with baseline serum 25(OH)D levels < 20 ng/mL experienced accelerated declines in physical activity.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Mirjana Babic Leko, Nikolina Pleic, Ivana Gunjaca, Tatijana Zemunik
Summary: Calciotropic hormones, PTH and calcitonin, play crucial roles in bone mineral metabolism and calcium-phosphate homeostasis. Environmental and genetic factors can influence their levels, with smoking, BMI, exercise, and micronutrients showing significant associations with PTH levels. Similarly, exposure to heavy metals like cadmium can also affect PTH levels. Research on the impact of environmental factors on calcitonin levels is limited, with smoking being the most clearly associated lifestyle factor with increased calcitonin levels. Additional studies are needed to better understand how environmental factors can affect PTH and calcitonin levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Raji Ramachandran Pillai, Nancy R. Premkumar, Shivanand Kattimani, Haritha Sagili, Anand Babu Wilson, Leena Sharon, Soundravally Rajendiran
Summary: The study showed that women with postpartum depressive symptoms had significantly lower serum levels of total, free, and bioavailable 25-hydroxyvitamin D compared to non-depressive women. These findings suggest a potential association between hypovitaminosis D and postpartum depression.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Malak El Sabeh, Paola Ghanem, Laila Al-Shaar, Maya Rahme, Rafic Baddoura, Georges Halaby, Ravinder J. Singh, Dirk Vanderschueren, Roger Bouillon, Ghada El-Hajj Fuleihan
Summary: This study investigates the impact of different vitamin D variables on bone and mineral metabolism and concludes that total 25(OH)D is more effective in predicting bone health in the elderly population compared to free and bioavailable 25(OH)D.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Laila Meija, Anna Piskurjova, Ksenija Nikolajeva, Olga Aizbalte, Roberta Rezgale, Aivars Lejnieks, Vinita Cauce
Summary: This cross-sectional study in Latvia evaluated the vitamin D levels and intake of pregnant women. The results showed that a minority of pregnant women had sufficient vitamin D, and diet did not significantly affect vitamin D levels. Therefore, a recommended daily intake of 63 mcg (2500 IU) of vitamin D during pregnancy is proposed to maintain optimal levels.
Review
Medicine, Research & Experimental
Kennedi Young, Megan R. Beggs, Chelsey Grimbly, R. Todd Alexander
Summary: Calcium and phosphate play crucial roles in physiological processes, while calcitriol acts as a positive regulator of mineralization and calcium and phosphate metabolism. The synthesis of calcitriol involves a multi-step process, primarily regulated by CYP27B1 and CYP24A1, with expression influenced by various hormones.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Endocrinology & Metabolism
Luigi di Filippo, Agnese Allora, Massimo Locatelli, Patrizia Rovere Querini, Stefano Frara, Giuseppe Banfi, Andrea Giustina
Summary: Hypocalcemia is a major feature of COVID-19, which is largely attributed to the prevalence of Vitamin D deficiency. This study confirmed a high prevalence of hypocalcemia in COVID-19 patients, especially in those with marked hypovitaminosis D not compensated by secondary hyperparathyroidism.
Article
Cardiac & Cardiovascular Systems
Congying Xia, Wenhua Lei, Yao Hu, Huazhen Yang, Xiaoxi Zeng, Mao Chen
Summary: This study found that increased serum phosphate levels were associated with a higher risk of incident aortic stenosis (AS), while serum calcium and vitamin D levels showed no association. This suggests that phosphate may be a potential interventional target for AS.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Endocrinology & Metabolism
Bess Dawson-Hughes, Jifan Wang, Kathryn Barger, Heike A. Bischoff-Ferrari, Christopher T. Sempos, Ramon A. Durazo-Arvizu, Lisa Ceglia
Summary: Supplementation with vitamin D may affect the risk of falling in older adults, and maintaining a 25(OH)D level between 20 and 40 ng/mL can help reduce the risk of falls.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Neurosciences
Eleonora Dzoljic, Marija Saric Matutinovic, Oliver Stojkovic, Jelena Velickovic, Neda Milinkovic, Vladimir Kostic, Svetlana Ignjatovic
Summary: The findings of this study confirm a significant relationship between hypovitaminosis D and Parkinson's disease. The study demonstrates a higher prevalence of vitamin D deficiency in Parkinson's disease patients and its potential to predict the onset and progression of the disease.
Article
Nutrition & Dietetics
Mehmet Emin Arayici, Yasemin Basbinar, Hulya Ellidokuz
Summary: This study used a meta-meta-analysis method to examine the effects of Vitamin D intake and serum 25-hydroxyvitamin-D levels on cancer incidence and mortality. The findings showed that higher Vitamin D intake and serum levels were associated with lower cancer risk and mortality. However, careful evaluation according to cancer types is important and recommended.
Article
Nutrition & Dietetics
Jelena Moisejenko-Golubovica, Valerija Groma, Simons Svirskis, Anna Ivanova
Summary: Ultraviolet radiation is a major contributor to skin malignancies, including basal cell carcinoma (BCC). Vitamin D plays a protective role in the development of BCC by antagonizing the Sonic Hedgehog (SHH) signaling. Serum vitamin D deficiency is associated with BCC, and vitamin D is related to DBP and SHH signaling pathway.
Review
Surgery
Zeinab Mokhtari, Elham Hosseini, Marsa Zaroudi, Deanna L. Gibson, Azita Hekmatdoost, Marjan Mansourian, Amin Salehi-Abargouei, Zahra Faghihimani, Gholamreza Askari
Summary: Vitamin D supplementation improves vitamin D status in bariatric patients, especially in those taking higher doses and with BMI greater than 50 kg/m(2), and it is also associated with prevention of increasing PTH serum concentration.
Article
Veterinary Sciences
Fatemeh Etemadi, Aboutorab Tabatabaei Naeini, Mahmoud Aminlari
Summary: This study assessed concentrations of vitamin D, PTH, and minerals in horse sera and their associations with lameness in horses. The results indicated that low levels of calcium and magnesium were associated with horse lameness, suggesting the important roles of these minerals in the normal function of the horse musculoskeletal system and prevention of lameness.
VETERINARY MEDICINE AND SCIENCE
(2023)