Review
Nutrition & Dietetics
Mohammed M. Hassanein, Hasniza Zaman Huri, Kauser Baig, Abduelmula R. Abduelkarem
Summary: Hormonal fluctuations, excessive clothing covering, sunscreen use, changes in body fat composition, a vitamin D-deficient diet, and a sedentary lifestyle can all predispose postmenopausal women to vitamin D deficiency. An effective supplementation plan requires a thorough understanding of underlying factors to achieve the desired therapeutic concentrations. This study conducted a systematic review to identify predictors that affect vitamin D status in postmenopausal women.
Article
Nutrition & Dietetics
Addolorata Corrado, Cinzia Rotondo, Daniela Cici, Stefano Berardi, Francesco Paolo Cantatore
Summary: This study demonstrated that supplementation with calcifediol is more effective and faster than cholecalciferol in increasing 25(OH)D serum levels and improving muscular function in post-menopausal women. Weekly administration of cholecalciferol showed the best results in this regard.
Article
Geriatrics & Gerontology
Yurun Cai, Amal A. Wanigatunga, Christine M. Mitchell, Jacek K. Urbanek, Edgar R. Miller, Stephen P. Juraschek, Erin D. Michos, Rita R. Kalyani, David L. Roth, Lawrence J. Appel, Jennifer A. Schrack
Summary: This study aimed to examine the effects of vitamin D supplementation on frailty using data from a randomized controlled trial. The results showed that high dose vitamin D supplementation did not prevent frailty, and there were no significant associations between vitamin D doses and frailty status.
Article
Obstetrics & Gynecology
Alayne D. Markland, Camille Vaughan, Alison Huang, Eunjung Kim, Vadim Y. Bubes, Vin Tangpricha, Julie Buring, I-Min Lee, Nancy Cook, JoAnn E. Manson, Francine Grodstein
Summary: This study found that vitamin D supplementation did not have a significant effect on the prevalence, incidence, or progression of urinary incontinence in older women.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Nutrition & Dietetics
Francois Parant, Justin Bouloy, Julie Haesebaert, Lamia Bendim'red, Karine Goldet, Philippe Vanhems, Laetitia Henaff, Thomas Gilbert, Charlotte Cuerq, Emilie Blond, Muriel Bost, Marc Bonnefoy
Summary: This study aimed to assess the relationships between vitamin D status and supplementation and the severity of COVID-19 in older adults. The study found that vitamin D supplementation taken during the 3 months preceding the infection onset may have a protective effect on the development of severe forms of COVID-19. Age, gender, and BMI were also found to be associated with the severity of COVID-19.
Article
Biochemistry & Molecular Biology
Rasmus Espersen, Banny Silva Barbosa Correia, Lars Rejnmark, Hanne Christine Bertram
Summary: This study investigated the diurnal changes in the blood metabolome and the effects of vitamin D-3 supplementation. The results showed diurnal effects on the majority of the quantified metabolites, with a change in the overall plasma metabolome around 12 AM. Vitamin D supplementation had a minor influence on the blood metabolome but significantly affected plasma acetone levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Angela Feiner Solis, Ana Avedillo Salas, Maria Jose Luesma Bartolome, Sonia Santander Ballestin
Summary: This systematic review examines the impact of vitamin D supplementation on the disease course of COVID-19. The results suggest that regardless of initial vitamin D serum levels, patients benefit from vitamin D supplementation, although the outcomes are inconsistent and larger clinical trials are needed for confirmation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Katie M. O'Brien, Quaker E. Harmon, Chandra L. Jackson, Mary Diaz-Santana, Jack A. Taylor, Clarice R. Weinberg, Dale P. Sandler
Summary: This study found that women with higher circulating 25-hydroxyvitamin D (25(OH)D) concentrations had a lower risk of breast cancer, especially among Hispanic/Latina women. The association was weaker among Black/African American women. There was no clear association between 24,25-dihydroxyvitamin D (24,25(OH)2D) and breast cancer risk.
Article
Nutrition & Dietetics
Elisabeth Lerchbaum, Verena Theiler-Schwetz, Martina Kollmann, Monika Woelfler, Stefan Pilz, Barbara Obermayer-Pietsch, Christian Trummer
Summary: Research suggests that vitamin D has significant effects on follicle-stimulating hormone (FSH) and luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio in women with polycystic ovary syndrome (PCOS), but has no significant impact on anti-Mullerian hormone (AMH) levels.
Article
Medicine, General & Internal
Besim Haluk Bacanakgil, Gulsah Ilhan, Karolin Ohanoglu
Summary: This study evaluated the effects of vitamin D supplementation on ovarian reserve markers and found that it significantly increased AMH level, AFC, 25(OH)D and calcium levels, while decreasing FSH level and alkaline phosphatase level.
Article
Nutrition & Dietetics
Yoonjung Park, Young-Mi Ah, Yun Mi Yu
Summary: This study conducted a meta-analysis of randomized controlled trials to investigate the effects of vitamin D supplementation on depressive symptom improvement in individuals aged ≥60 years with or without a diagnosis of depression or depressive symptoms. The results showed that vitamin D supplementation was not significantly associated with an improvement in depressive symptoms.
FRONTIERS IN NUTRITION
(2023)
Article
Ophthalmology
Sabbir T. Rahman, Mary Waterhouse, Briony Duarte Romero, Catherine Baxter, Dallas English, David A. Mackey, Peter R. Ebeling, Bruce K. Armstrong, Donald S. A. McLeod, Gunter Hartel, Rachel L. O'Connell, Jolieke C. van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Rachel E. Neale
Summary: Supplementing high-dose vitamin D may not significantly reduce the incidence of cataract surgery, regardless of age, sex, body mass index, serum vitamin D concentration, or ambient ultraviolet radiation.
Article
Gastroenterology & Hepatology
Hai Pham, Mary Waterhouse, Sabbir Rahman, Catherine Baxter, Briony Duarte Romero, Donald S. A. McLeod, Peter R. Ebeling, Dallas R. English, Gunter Hartel, Rachel L. O'Connell, Jolieke C. Van der Pols, Alison J. Venn, Penelope M. Webb, David C. Whiteman, Flavia Huygens, Rachel E. Neale
Summary: Observational studies suggest a link between vitamin D and gut microbiome composition, but randomized controlled trials of vitamin D supplementation have shown little evidence. This study analyzed data from the D-Health Trial and found that monthly doses of 60,000 IU of vitamin D-3 for 5 years did not alter the composition of the gut microbiome in older Australians.
Article
Biochemistry & Molecular Biology
Aislinn F. McCourt, Aifric M. O'Sullivan
Summary: Metabolomics can identify metabolite patterns associated with different nutrition phenotypes and determine changes in metabolism in response to nutrition interventions. This randomised, placebo-controlled trial (RCT) examined the influence of vitamin D status and the effect of vitamin D supplementation on metabolomic profiles in older adults.
Article
Endocrinology & Metabolism
Neda Rasouli, Irwin G. Brodsky, Ranee Chatterjee, Sun H. Kim, Richard E. Pratley, Myrlene A. Staten, Anastassios G. Pittas
Summary: Supplementation with vitamin D-3 for 24 months did not improve beta-cell function in people with prediabetes, but showed benefits in those with very low baseline vitamin D levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Lynette M. Smith, J. Christopher Gallagher
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
(2017)
Article
Endocrinology & Metabolism
Janice B. Schwartz, J. Christopher Gallagher, Rolf Jorde, Vivian Berg, Jennifer Walsh, Richard Eastell, Amy L. Evans, Simon Bowles, Kim E. Naylor, Kerry S. Jones, Inez Schoenmakers, Michael Holick, Eric Orwoll, Carrie Nielson, Martin Kaufmann, Glenville Jones, Roger Bouillon, Jennifer Lai, Davide Verotta, Daniel Bikle
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2018)
Article
Biochemistry & Molecular Biology
Vinod Yalamanchili, J. Christopher Gallagher
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2018)
Article
Obstetrics & Gynecology
Eric Surrey, Hugh S. Taylor, Linda Giudice, Bruce A. Lessey, Mauricio S. Abrao, David F. Archer, Michael P. Diamond, Neil P. Johnson, Nelson B. Watts, J. Chris Gallagher, James A. Simon, Bruce R. Carr, W. Paul Dmowski, Nicholas Leyland, Sukhbir S. Singh, Tomasz Rechberger, Sanjay K. Agarwal, W. Rachel Duan, Brittany Schwefel, James W. Thomas, Paul M. Peloso, Juki Ng, Ahmed M. Soliman, Kristof Chwalisz
OBSTETRICS AND GYNECOLOGY
(2018)
Article
Medicine, General & Internal
L. M. Smith, J. C. Gallagher, M. Kaufmann, G. Jones
JOURNAL OF INTERNAL MEDICINE
(2018)
Editorial Material
Endocrinology & Metabolism
J. Chris Gallagher
LANCET DIABETES & ENDOCRINOLOGY
(2018)
Article
Medicine, General & Internal
L. M. Smith, J. C. Gallagher
JOURNAL OF INTERNAL MEDICINE
(2019)
Article
Medicine, Research & Experimental
Timothy B. Plante, Kelly T. Gleason, Hailey N. Miller, Jeanne Charleston, Kristen McArthur, Cheryl Dennison Himmelfarb, Mariana Lazo, Daniel E. Ford, Edgar R. Miller, Lawrence J. Appel, Stephen P. Juraschek, Nicole Cronin, Scott McClure, Jennifer Miskimon, Christine M. Mitchell, Rita R. Kalyani, David L. Roth, Jennifer A. Schrack, Sarah L. Szanton, Jacek Urbanek, Jeremy Walston, Amal Wanigatunga, Sheriza N. Baksh, Amanda L. Blackford, Shumon Chattopadhyay, Lea T. Drye, John Dodge, Cathleen Ewing, Sana Haider, Stephanie C. Holland, Rosetta Jackson, Andrea Lears, Curtis Meinert, David Shade, Michael Smith, Alice L. Sternberg, James Tonascia, Mark L. Van Natta, Annette Wagoner, Erin D. Michos, J. Denise Bennett, Pamela Bowers, Josef Coresh, Patricia Crowley, Tammy Crunkleton, Briana Dick, Rebecca Evans, Mary Godwin, Lynne Hammann, Deborah Hawks, Karen Horning, Erika Hull, Brandi Mills, Melissa Minotti, Leann Raley, Amanda Reed, Rhonda Reeder, Cassie Reid, Melissa Shuda, Adria Spikes, Rhonda Stouffer, Kelly Weicht, Caroline Abbas, Bernellyn Carey, Syree Davis, Naomi DeRoche-Brown, Debra Gayles, Sherlina Holland, Ina Glenn-Smith, Duane Johnson, Mia Johnson, Eva Keyes, Danielle Santiago, Chanchai Sapun, Valerie Sneed, Lee Swartz, Letitia Thomas, Robert H. Christenson, Show-Hong Duh, Heather Rebuck, Clifford Rosen, Tom Cook, Pamela Duncan, Karen Hansen, Anne Kenny, Sue Shapses, Judy Hannah, Sergei Romashkan, Cindy D. Davis, Christopher T. Sempos, Jack M. Guralnik, J. C. Gallagher
Article
Radiology, Nuclear Medicine & Medical Imaging
Martha Katherine Paniagua Huayllas, Gopi K. Sirineni, Lynette M. Smith, J. Christopher Gallagher, Ravinder J. Singh, Brian C. Netzel, Claudio E. Kater
AMERICAN JOURNAL OF ROENTGENOLOGY
(2020)
Article
Endocrinology & Metabolism
L. M. Smith, J. C. Gallagher
Summary: A study of 959 black and white women showed differences in the normal range of 24-h urine calcium excretion, leading to recommendations for updating the normal ranges used in clinical laboratories. The study aimed to define normal ranges for 24-h urine calcium for different age groups and races, and to investigate the relationship between urine calcium, calcium absorption, and vitamin D metabolites.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Martha K. P. Huayllas, Lynette M. Smith, J. Christopher Gallagher, Brian C. Netzel, Ravinder J. Singh, Claudio E. Kater
Summary: The study revealed increased activity in several steroid biosynthesis pathways in patients with adrenal incidentalomas, with higher steroid levels in bilateral cases compared to unilateral cases, and evidence of hypercortisolism in 30% of unilateral cases and 62% of bilateral cases.
CLINICAL ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ashwaq A. Awadh, Daniel E. Hilleman, Emily Knezevich, Mark A. Malesker, John C. Gallagher
Summary: This narrative review provides guidance for pharmacists on vitamin D supplementation, including criteria for deficiency and recommended intake levels. It emphasizes the importance of monitoring and appropriate prescription when using vitamin D for specific indications. However, current evidence remains insufficient to support the supplementation of vitamin D in various health conditions like cardiovascular disease, cancer, asthma, diabetes, and mental health issues.
JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
(2021)
Editorial Material
Endocrinology & Metabolism
J. Chris Gallagher
LANCET DIABETES & ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Martin Kaufmann, Karl-Peter Schlingmann, Linor Berezin, Arnaud Molin, Jesse Sheftel, Melanie Vig, John C. Gallagher, Akiko Nagata, Shadi Sedghi Masoud, Ryota Sakamoto, Kazuo Nagasawa, Motonari Uesugi, Marie Laure Kottler, Martin Konrad, Glenville Jones
Summary: In this study, using precision vitamin D metabolite profiling, researchers identified unique vitamin D metabolism profiles in some patients with idiopathic hypercalcemia (IH) and Williams-Beuren syndrome (WBS), suggesting hypersensitive expression of vitamin D-dependent genes as a potential mechanism of hypercalcemia in these patients. Normalization of serum calcium and vitamin D metabolites in an IH patient at follow-up indicates that symptomatic IH may be related to vitamin D nutritional status. This work highlights the importance of serum vitamin D metabolite profiling in differential diagnosis of vitamin D-related hypercalcemia and guiding appropriate treatment.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Kevin D. Cashman, Mairead E. Kiely, Rikke Andersen, Ida M. Gronborg, Inge Tetens, Laura Tripkovic, Susan A. Lanham-New, Christel Lamberg-Allardt, Folasade A. Adebayo, J. Christopher Gallagher, Lynette M. Smith, Jennifer M. Sacheck, Qiushi Huang, Kimmie Ng, Chen Yuan, Edward L. Giovannucci, Kumaravel Rajakumar, Charity G. Patterson, Inger Ohlund, Torbjorn Lind, Pia Karlsland Akeson, Christian Ritz
Summary: There is an urgent need to develop vitamin D dietary recommendations for dark-skinned populations at high latitudes, as they require higher vitamin D intake to maintain serum concentrations. The study found that the required vitamin D intake for dark-skinned individuals to maintain certain serum levels is substantially higher than that for White individuals.
EUROPEAN JOURNAL OF NUTRITION
(2022)