Review
Endocrinology & Metabolism
Qiaoli Zhang, Rongcai Ye, Yuan-Yuan Zhang, Chen-Chen Fan, Jun Wang, Shuyu Wang, Suwen Chen, Xiaowei Liu
Summary: This review discusses the importance of brown adipose tissue (BAT) in metabolism and energy expenditure, as well as its potential therapeutic role in treating polycystic ovary syndrome (PCOS). Various studies have shown that BAT can regulate the features of PCOS and increasing BAT mass or activity has been effective in the treatment of PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Plant Sciences
Ying Xu, Jialing Tang, Qianyu Guo, Yidan Xu, Kaixuan Yan, Lihong Wu, Kang Xie, Anming Zhu, Xianglu Rong, Dewei Ye, Jiao Guo
Summary: Our study aimed to investigate the preventive effect of FTZ on letrozole-induced experimental PCOS and its associated insulin resistance in mice. The results showed that FTZ significantly attenuated letrozole-induced morphological changes in the ovary, reversed PCOS-related disruption of estrous status, and markedly alleviated PCOS-related insulin resistance by enhancing circulating level and transcriptional abundance of adiponectin in adipose tissue.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Oscar Osorio-Conles, Arturo Vega-Beyhart, Ainitze Ibarzabal, Jose Maria Balibrea, Josep Vidal, Ana de Hollanda
Summary: The metabolic syndrome is a cluster of dangerous heart attack risk factors. This study compares the dysfunction of obesity-associated white adipose tissue (WAT) between women with severe obesity with or without metabolic syndrome. The results show that women with metabolic syndrome exhibit greater adipocyte hypertrophy, increased fibrosis, and higher expression of macrophage and hypoxia markers in subcutaneous adipose tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Yuqin Zhang, Meili Cai, Diliqingna Dilimulati, Ziwei Lin, Hang Sun, Ran Cui, Hongxiang Fei, Xinxin Gao, Qiongjing Zeng, Xiaowen Shao, Manna Zhang, Shen Qu
Summary: This study found that a high level of visceral adipose tissue (VAT) mass is associated with an increased risk of hyperuricemia in patients with polycystic ovary syndrome (PCOS). Excessive VAT should be considered in the occurrence and development of PCOS with hyperuricemia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Pavel Hruska, Jan Kucera, Matej Pekar, Pavol Holeczy, Miloslav Mazur, Marek Buzga, Daniela Kuruczova, Peter Lenart, Jana Fialova Kucerova, David Potesil, Zbynek Zdrahal, Julie Bienertova-Vasku
Summary: The study compared the proteomic profiles of mature adipocytes from different adipose tissue depots, with findings showing that subcutaneous adipocytes are more active in vesicular transport, secretion, and lipid metabolism, while visceral adipocytes have higher protein expression related to mitochondrial energy metabolism and translational or biosynthetic activity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Susanne Schueler-Toprak, Olaf Ortmann, Christa Buechler, Oliver Treeck
Summary: This review article provides an update on the role of adipokines in polycystic ovary syndrome (PCOS) and endometriosis, as well as summarizes previous findings. The article also discusses the involvement of single nucleotide polymorphisms (SNPs) in genes coding for adipokines and their receptors, the secretome of adipocytes, and epigenetic alterations of adipokine genes. Furthermore, the article addresses the notable effects of brown adipose tissue (BAT) on PCOS.
Article
Endocrinology & Metabolism
Emma Oberg, Liselotte Blomberg, Torbjorn Akerstedt, Angelica Linden Hirschberg
Summary: This study compared sleep variables in women with PCOS and controls, and assessed the impact of behavioral modification intervention on sleep. The results showed that women with PCOS had shorter sleep duration and worse sleep efficiency, but their total sleep time at night was within the normal range. Behavioral modification intervention reduced daytime sleep duration and improved sleep behavior.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Bojana Micic, Ana Teofilovic, Ana Djordjevic, Natasa Velickovic, Djuro Macut, Danijela Vojnovic Milutinovic
Summary: Overfeeding during the postnatal period may predispose individuals to metabolic disturbances associated with PCOS, with visceral adipose tissue (VAT) maintaining its insulin sensitivity through increased AMPK activity, while subcutaneous adipose tissue (SAT) demonstrates worsened metabolic function, leading to systemic insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Menghua Zhu, Hongyu Li, Yue Yin, Min Ding, Cyriac Abby Philips, Fernando Gomes Romeiro, Xingshun Qi
Summary: Both excessive deficiency and accumulation of subcutaneous adipose tissues negatively influence the outcomes of cirrhotic patients.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Endocrinology & Metabolism
Lihua Yao, Qin Wang, Runjie Zhang, Xingyun Wang, Yiwen Liu, Fangfang Di, Liwen Song, Siliang Xu
Summary: This study identified differential metabolites in BAT transplantation that target key signaling pathways associated with PCOS, suggesting metabolome changes play a vital role in improving PCOS. Sphingosine, a differential metabolite, accelerated apoptosis in KGN cells, indicating its potential as a therapeutic target for PCOS treatment.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Surgery
Meili Cai, Jingyang Gao, Lei Du, Xiaoyun Cheng, Donglei Zhou, Jiangfan Zhu, Shen Qu, Manna Zhang
Summary: The study found that PCOS patients showed greater reduction in visceral adipose tissue (VAT) compared to other body regions, with a higher rate of VAT decrease in the PCOS group than in the control group, although this difference was not significant. Additionally, baseline HOMA-IR was identified as an independent risk factor for changes in VAT mass and volume at 3 months post-surgery in PCOS patients compared to control patients.
Article
Cell Biology
Katarzyna J. Siemienowicz, Flavien Coukan, Stephen Franks, Mick T. Rae, W. Colin Duncan
Summary: The study suggests that aberrant adipogenesis during adolescence in patients with polycystic ovary syndrome (PCOS) affects the metabolic phenotype of adult PCOS, highlighting an opportunity for early clinical intervention to regulate adipogenesis.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Alaa Ibrahim Ali, Wassan Nori
Summary: This study aimed to investigate visfatin as a predictive marker for insulin resistance (IR) and hyperandrogenemia in non-obese women with polycystic ovary syndrome (PCOS). The results showed a significant correlation between visfatin and IR as well as hyperandrogenemia, suggesting the importance of visfatin in the pathophysiology of PCOS.
REPRODUCTIVE SCIENCES
(2022)
Article
Endocrinology & Metabolism
Rongcai Ye, Chunlong Yan, Huiqiao Zhou, Yuanyuan Huang, Meng Dong, Hanlin Zhang, Xiaoxiao Jiang, Shouli Yuan, Li Chen, Rui Jiang, Ziyu Cheng, Kexin Zheng, Qiaoli Zhang, Wanzhu Jin
Summary: PCOS is a common endocrine disease with no effective treatment currently available. Research suggests that cold treatment can activate endogenous BAT, improve fertility and ovarian conditions in PCOS rats, serving as a novel therapeutic strategy for PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Wenna Lucia Lima Santos, Clailson da Silva Pinheiro, Raisa de Oliveira Santos, Alda Cassia Alves da Silva, Juliana Soares Severo, Pedro Henrique Moraes Mendes, Luiza Carolinda de Sousa, Olga Maria Castro de Sousa, Brenda Lois Barros dos Santos, Kelly Beatriz Vieira de Oliveira, Antonio Klingem Freitas, Francisco Leonardo Torres-Leal, Armenio Aguiar dos Santos, Moises Tolentino Bent da Silva
Summary: PCOS affects body composition and nutritional parameters, and induces changes in oxidative stress in BAT. Physical exercise can prevent these alterations.
Article
Endocrinology & Metabolism
Marta Araujo-Castro, Gregori Casals, Felicia A. Hanzu, Eider Pascual-Corrales, Ana M. Garcia Cano, Val F. Lanza, Angel Luis del Rey Mejias, Marta Marchan, Hector F. Escobar-Morreale, Pablo Valderrabano
Summary: The study found that patients with nonfunctioning adrenal incidentalomas (NFAIs) have a decrease in androgen metabolite excretion and an increase in urinary free cortisol excretion. Patients with autonomous cortisol secretion (ACS) have a higher prevalence of hypertension, dyslipidemia, and diabetes, and lower excretion of androgen metabolites.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Marta Araujo-Castro, Ana M. Garcia Cano, Hector F. Escobar-Morreale, Pablo Valderrabano
Summary: This study aimed to develop a predictive model to stratify patients with non-functioning adrenal incidentalomas based on their risk of developing autonomous cortisol secretion (ACS) during follow-up. The baseline post-DST serum cortisol levels were found to be the most important factor for the development of ACS.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Marta Araujo-Castro, Eider Pascual-Corrales, Ana M. Garcia Cano, Marta Marchan, Gregori Casals, Felicia A. Hanzu, Miguel Angel Gomez-Bermejo, Hector F. Escobar Morreale, Pablo Valderrabano
Summary: This study compared body composition between patients with autonomous cortisol secretion (ACS), nonfunctioning adrenal incidentalomas (NFAIs), and control subjects. The results showed that ACS patients had lower bone and muscle mass and higher visceral fat mass. These differences may be related to the urinary excretion of steroid metabolites.
ENDOCRINE PRACTICE
(2023)
Article
Cardiac & Cardiovascular Systems
Lia Nattero-Chavez, Maria Insenser, Alejandra Quintero Tobar, Elena Fernandez-Duran, Beatriz Dorado Avendano, Tom Fiers, Jean-Marc Kaufman, Manuel Luque-Ramirez, Hector F. Escobar-Morreale
Summary: This study aimed to investigate the relationship between sex and cardiovascular autonomic neuropathy in patients with type 1 diabetes. The results showed that women over 50 years old had twice the probability of developing cardiovascular autonomic neuropathy compared to younger women, and women had more severe cardiovascular autonomic neuropathy than men. Additionally, menopause was associated with an increased risk of cardiovascular autonomic neuropathy in women.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Endocrinology & Metabolism
Lia Nattero-Chavez, Ane Bayona Cebada, Elena Fernandez-Duran, Alejandra Quintero Tobar, Beatriz Dorado Avendano, Hector Escobar-Morreale, Manuel Luque-Ramirez
Summary: This study evaluated the effect of arterial stiffness on the circadian rhythm of blood pressure in patients with type 1 diabetes and cardiovascular autonomic neuropathy (CAN). It was found that the presence of arterial stiffness did not cause abnormalities in the circadian rhythm of blood pressure. A1c levels were identified as an important predictor of nighttime decrease in mean blood pressure.
DIABETES & VASCULAR DISEASE RESEARCH
(2023)
Article
Endocrinology & Metabolism
Lia Nattero-Chavez, Edurne Lecumberri Pascual, Esther De La Calle, Ane Bayona Cebada, Teresa Ruiz, Alejandra Quintero Tobar, Mar Lorenzo, Cristina Sanchez, Ana Izquierdo, Manuel Luque-Ramirez, Hector F. Escobar-Morreale
Summary: The efficacy of an advance closed-loop (AHCL) system in restoring awareness of hypoglycemia in patients with type 1 diabetes (T1D) was evaluated. The results showed that the AHCL system had significant effectiveness in improving hypoglycemic awareness and metabolic control.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Obstetrics & Gynecology
M. Insenser, A. Quintero, S. de Lope, F. Alvarez-Blasco, M. A. Martinez-Garcia, M. Luque-Ramirez, H. F. Escobar-Morreale
Summary: This research found that the expression of miR-142-3p and miR-598-3p, which are associated with polycystic ovary syndrome (PCOS), differs significantly between women with PCOS and those without. These circulating miRNAs, when combined with easily available measurements such as waist-to-hip ratio (WHR) and circulating LH-to-FSH (LH/FSH) ratios, can effectively distinguish between women with and without PCOS.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
Mercedes Millan-de-Meer, Manuel Luque-Ramirez, Lia Nattero-Chavez, Hector F. Escobar-Morreale
Summary: This study is a systematic review and meta-analysis on the consequences of PCOS during the late reproductive years and after menopause. The study found that women with PCOS in peri- and postmenopause presented increased levels of testosterone and androgens, as well as decreased levels of sex hormone-binding globulin. They also had higher measures of obesity, insulin resistance, and risk for diabetes and hypertension. Furthermore, they had lower levels of HDL cholesterol and higher levels of triglycerides. Although myocardial infarction and stroke were more prevalent in women with PCOS, the prevalence of cardiovascular disease, coronary artery disease, breast cancer, and age at menopause were similar between patients and controls. The study highlights the persistence of hyperandrogenism and the importance of addressing the comorbidity of weight excess in women with PCOS.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Endocrinology & Metabolism
Hector F. Escobar-Morreale, M. Angeles Martinez-Garcia, Maria Insenser, Nicolau Canellas, Xavier Correig, Manuel Luque-Ramirez
Summary: Using proton nuclear magnetic resonance spectroscopy metabolomics profiling, we found that androgen excess in women with PCOS induces masculinization of intermediate metabolism, which is also modulated by obesity.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Endocrinology & Metabolism
Hector F. Escobar-morreale, Maria Angeles Martinez-garcia, Maria Insenser, Nicolau Canellas, Xavier Correig, Manuel Luque-ramirez
Summary: This study used 1H-NMRS metabolomics profiling to explore the intermediate metabolism after a meal in women with polycystic ovary syndrome (PCOS) and men. The results showed that postprandial metabolomic profiles were mainly influenced by insulin effects, with obesity and PCOS also affecting postprandial metabolism.
BIOLOGY OF SEX DIFFERENCES
(2023)