Article
Endocrinology & Metabolism
Pavel Hruska, Jan Kucera, Matej Pekar, Pavol Holeczy, Miloslav Mazur, Marek Buzga, Daniela Kuruczova, Peter Lenart, Jana Fialova Kucerova, David Potesil, Zbynek Zdrahal, Julie Bienertova-Vasku
Summary: The study compared the proteomic profiles of mature adipocytes from different adipose tissue depots, with findings showing that subcutaneous adipocytes are more active in vesicular transport, secretion, and lipid metabolism, while visceral adipocytes have higher protein expression related to mitochondrial energy metabolism and translational or biosynthetic activity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Oscar Osorio-Conles, Arturo Vega-Beyhart, Ainitze Ibarzabal, Jose Maria Balibrea, Josep Vidal, Ana de Hollanda
Summary: The metabolic syndrome is a cluster of dangerous heart attack risk factors. This study compares the dysfunction of obesity-associated white adipose tissue (WAT) between women with severe obesity with or without metabolic syndrome. The results show that women with metabolic syndrome exhibit greater adipocyte hypertrophy, increased fibrosis, and higher expression of macrophage and hypoxia markers in subcutaneous adipose tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Menghua Zhu, Hongyu Li, Yue Yin, Min Ding, Cyriac Abby Philips, Fernando Gomes Romeiro, Xingshun Qi
Summary: Both excessive deficiency and accumulation of subcutaneous adipose tissues negatively influence the outcomes of cirrhotic patients.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Biochemistry & Molecular Biology
Gemma Arderiu, Guiomar Mendieta, Alex Gallinat, Carmen Lambert, Alberto Diez-Caballero, Carlos Ballesta, Lina Badimon
Summary: Obesity is linked to metabolic disorders and increased cardiovascular risk. The presence of type 2 diabetes mellitus (T2DM) affects the protein composition in adipose tissue and serum, leading to changes in systemic markers and dysregulation of metabolic pathways in visceral adipose tissue (VAT).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Xiang Zhang, Suki Ha, Harry Cheuk-Hay Lau, Jun Yu
Summary: Excess body weight, caused by sedentary lifestyle and unhealthy diet, is a global health problem affecting 2 billion people worldwide. Obesity, especially visceral adiposity, is closely associated with metabolic diseases such as type 2 diabetes, non-alcoholic fatty liver disease, cardiovascular disease, and certain types of cancer. Recent studies have revealed the involvement of genetic and epigenetic alterations, dysregulation of adipokines, changes in immunity, imbalance of white and brown adipose tissues, and gut microbial dysbiosis in mediating the pathogenic association between visceral adipose tissues and comorbidities. This review explores the epidemiology of excess body weight, mechanisms underlying chronic complications, utilization of visceral fat measurement for risk assessment, and current approaches for prevention and treatment.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Nutrition & Dietetics
Jun Han, Min Tang, Chaocheng Lu, Lei Shen, Jiaqi She, Guohao Wu
Summary: This study showed that subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) have different effects on the progression of cancer cachexia in gastric cancer patients. Patients with cachexia had significantly lower SAT index, while there was no significant difference in VAT index.
CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Henry S. Kahn
Summary: BMI does not provide information about the relative size of adipose tissue depots, while SAD is associated with visceral fat accumulation, which may contribute to the estimation of cardiometabolic risk. SADHtR is more strongly associated with intermediary predictors of cardiometabolic disease.
Article
Immunology
Lindsay T. Fourman, Takara L. Stanley, Mollie W. Ockene, Colin M. McClure, Mabel Toribio, Kathleen E. Corey, Raymond T. Chung, Martin Torriani, David E. Kleiner, Colleen M. Hadigan, Steven K. Grinspoon
Summary: In HIV-associated NAFLD, hepatic fibrosis is characterized by a distinct proteomic signature involving up-regulation of tissue repair and immune response pathways. Understanding these mechanisms and biomarkers is important for the management of NAFLD-related hepatic fibrosis in HIV patients.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Nutrition & Dietetics
Muhei Tanaka, Hiroshi Okada, Yoshitaka Hashimoto, Muneaki Kumagai, Hiromi Nishimura, Michiaki Fukui
Summary: This study found that intraperitoneal VAT (IVAT) and retroperitoneal VAT (RVAT) are differently associated with the prevalence of metabolic syndrome (MS) and its components. IVAT area index was independently associated with MS and its components, while RVAT area index was only associated with the blood pressure component.
CLINICAL NUTRITION
(2021)
Article
Medicine, General & Internal
Maria Kalimeri, John J. Totman, Thomas Baum, Maximilian N. Diefenbach, Hans Hauner, Marcus R. Makowski, Karupppasamy Subburaj, David Cameron-Smith, Christiani Jeyakumar Henry, Dimitrios C. Karampinos, Daniela Junker
Summary: A study revealed that postmenopausal Asian women have higher visceral fat content compared to Caucasian women of the same age and BMI, with no significant correlation between BMI and visceral fat content in the Asian group. Further research is needed to understand the impact of this increased visceral fat on cardio-metabolic health, and there is a call to emphasize healthy lifestyle behaviors in non-obese postmenopausal women of Chinese ancestry.
Article
Engineering, Chemical
Chiara Giulia Fontanella, Ilaria Toniolo, Mirto Foletto, Luca Prevedello, Emanuele Luigi Carniel
Summary: This research focuses on the mechanical characterization of adipose tissues, specifically SAT and VAT, in patients with obesity. The results show that SAT has higher stiffness compared to VAT, and the stiffness is not significantly affected by gender, BMI, and age. This study provides a foundation for the development of more accurate computational models of human adipose tissue.
Article
Endocrinology & Metabolism
Peizhi Deng, Qingwei Yu, Haibo Tang, Yao Lu, Yingdong He
Summary: This study revealed a causal relationship between visceral adipose tissue and pre-eclampsia, and confirmed that visceral adipose tissue could accelerate age at menarche and contribute to the risk of incident pre-eclampsia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Gastroenterology & Hepatology
Nghiem B. Ha, Soo-Jin Cho, Yara Mohamad, Dorothea Kent, Grace Jun, Randi Wong, Vivek Swarnakar, Shezhang Lin, Jacquelyn J. Maher, Jennifer C. Lai
Summary: The study found that visceral adipose tissue inflammation is common in patients with cirrhosis undergoing liver transplantation, while subcutaneous adipose tissue inflammation is less common. Increased visceral adipose tissue was associated with inflammation, and the visceral-to-subcutaneous adipose tissue ratio (VSR) may serve as a prognostic marker for adverse outcomes in the liver transplant setting.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Nutrition & Dietetics
Tiziana Zotti, Antonia Giacco, Arianna Cuomo, Luigi Cerulo, Giuseppe Petito, Stefania Iervolino, Rosalba Senese, Federica Cioffi, Pasquale Vito, Gaetano Cardinale, Elena Silvestri, Assunta Lombardi, Maria Moreno, Antonia Lanni, Pieter de Lange
Summary: Combining exercise with fasting can increase the release of fatty acids from adipose tissues, providing fuel for surrounding organs. This study compared the effect of fasting and exercise on fatty acid composition in different adipose tissue depots, and found that exercise combined with fasting led to increased fatty acid mobilization from visceral adipose tissue.
Article
Nutrition & Dietetics
Chengzhe Tao, Yuna Huang, Xuzhao Huang, Zhi Li, Yun Fan, Yan Zhang, Tingya Wan, Liyu Lu, Qiaoqiao Xu, Wei Wu, Di Wu, Feng Zhang, Chuncheng Lu
Summary: This study found a positive association between blood Mn levels and visceral adipose tissue (VAT) mass as well as the risk of visceral obesity. The association was stronger in males, especially those with lower family income-to-poverty ratio.
Article
Endocrinology & Metabolism
Marta Araujo-Castro, Gregori Casals, Felicia A. Hanzu, Eider Pascual-Corrales, Ana M. Garcia Cano, Val F. Lanza, Angel Luis del Rey Mejias, Marta Marchan, Hector F. Escobar-Morreale, Pablo Valderrabano
Summary: The study found that patients with nonfunctioning adrenal incidentalomas (NFAIs) have a decrease in androgen metabolite excretion and an increase in urinary free cortisol excretion. Patients with autonomous cortisol secretion (ACS) have a higher prevalence of hypertension, dyslipidemia, and diabetes, and lower excretion of androgen metabolites.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Marta Araujo-Castro, Ana M. Garcia Cano, Hector F. Escobar-Morreale, Pablo Valderrabano
Summary: This study aimed to develop a predictive model to stratify patients with non-functioning adrenal incidentalomas based on their risk of developing autonomous cortisol secretion (ACS) during follow-up. The baseline post-DST serum cortisol levels were found to be the most important factor for the development of ACS.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Marta Araujo-Castro, Eider Pascual-Corrales, Ana M. Garcia Cano, Marta Marchan, Gregori Casals, Felicia A. Hanzu, Miguel Angel Gomez-Bermejo, Hector F. Escobar Morreale, Pablo Valderrabano
Summary: This study compared body composition between patients with autonomous cortisol secretion (ACS), nonfunctioning adrenal incidentalomas (NFAIs), and control subjects. The results showed that ACS patients had lower bone and muscle mass and higher visceral fat mass. These differences may be related to the urinary excretion of steroid metabolites.
ENDOCRINE PRACTICE
(2023)
Article
Cardiac & Cardiovascular Systems
Lia Nattero-Chavez, Maria Insenser, Alejandra Quintero Tobar, Elena Fernandez-Duran, Beatriz Dorado Avendano, Tom Fiers, Jean-Marc Kaufman, Manuel Luque-Ramirez, Hector F. Escobar-Morreale
Summary: This study aimed to investigate the relationship between sex and cardiovascular autonomic neuropathy in patients with type 1 diabetes. The results showed that women over 50 years old had twice the probability of developing cardiovascular autonomic neuropathy compared to younger women, and women had more severe cardiovascular autonomic neuropathy than men. Additionally, menopause was associated with an increased risk of cardiovascular autonomic neuropathy in women.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Endocrinology & Metabolism
Lia Nattero-Chavez, Ane Bayona Cebada, Elena Fernandez-Duran, Alejandra Quintero Tobar, Beatriz Dorado Avendano, Hector Escobar-Morreale, Manuel Luque-Ramirez
Summary: This study evaluated the effect of arterial stiffness on the circadian rhythm of blood pressure in patients with type 1 diabetes and cardiovascular autonomic neuropathy (CAN). It was found that the presence of arterial stiffness did not cause abnormalities in the circadian rhythm of blood pressure. A1c levels were identified as an important predictor of nighttime decrease in mean blood pressure.
DIABETES & VASCULAR DISEASE RESEARCH
(2023)
Article
Endocrinology & Metabolism
Lia Nattero-Chavez, Edurne Lecumberri Pascual, Esther De La Calle, Ane Bayona Cebada, Teresa Ruiz, Alejandra Quintero Tobar, Mar Lorenzo, Cristina Sanchez, Ana Izquierdo, Manuel Luque-Ramirez, Hector F. Escobar-Morreale
Summary: The efficacy of an advance closed-loop (AHCL) system in restoring awareness of hypoglycemia in patients with type 1 diabetes (T1D) was evaluated. The results showed that the AHCL system had significant effectiveness in improving hypoglycemic awareness and metabolic control.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Obstetrics & Gynecology
M. Insenser, A. Quintero, S. de Lope, F. Alvarez-Blasco, M. A. Martinez-Garcia, M. Luque-Ramirez, H. F. Escobar-Morreale
Summary: This research found that the expression of miR-142-3p and miR-598-3p, which are associated with polycystic ovary syndrome (PCOS), differs significantly between women with PCOS and those without. These circulating miRNAs, when combined with easily available measurements such as waist-to-hip ratio (WHR) and circulating LH-to-FSH (LH/FSH) ratios, can effectively distinguish between women with and without PCOS.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
Mercedes Millan-de-Meer, Manuel Luque-Ramirez, Lia Nattero-Chavez, Hector F. Escobar-Morreale
Summary: This study is a systematic review and meta-analysis on the consequences of PCOS during the late reproductive years and after menopause. The study found that women with PCOS in peri- and postmenopause presented increased levels of testosterone and androgens, as well as decreased levels of sex hormone-binding globulin. They also had higher measures of obesity, insulin resistance, and risk for diabetes and hypertension. Furthermore, they had lower levels of HDL cholesterol and higher levels of triglycerides. Although myocardial infarction and stroke were more prevalent in women with PCOS, the prevalence of cardiovascular disease, coronary artery disease, breast cancer, and age at menopause were similar between patients and controls. The study highlights the persistence of hyperandrogenism and the importance of addressing the comorbidity of weight excess in women with PCOS.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Endocrinology & Metabolism
Hector F. Escobar-Morreale, M. Angeles Martinez-Garcia, Maria Insenser, Nicolau Canellas, Xavier Correig, Manuel Luque-Ramirez
Summary: Using proton nuclear magnetic resonance spectroscopy metabolomics profiling, we found that androgen excess in women with PCOS induces masculinization of intermediate metabolism, which is also modulated by obesity.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Endocrinology & Metabolism
Hector F. Escobar-morreale, Maria Angeles Martinez-garcia, Maria Insenser, Nicolau Canellas, Xavier Correig, Manuel Luque-ramirez
Summary: This study used 1H-NMRS metabolomics profiling to explore the intermediate metabolism after a meal in women with polycystic ovary syndrome (PCOS) and men. The results showed that postprandial metabolomic profiles were mainly influenced by insulin effects, with obesity and PCOS also affecting postprandial metabolism.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Endocrinology & Metabolism
Gregori Casals, Roser Ferrer Costa, Eulalia Urgell Rull, Hector F. Escobar-Morreale, Jesus Argente, Gemma Sesmilo, Betina Biagetti
Summary: Accurate measurement of sex steroids is crucial for diagnosis and treatment of various conditions, but current chemiluminescent immunoassays have limitations. This review examines clinical assays for estradiol and testosterone measurements and their potential impact. It also provides recommendations for introducing mass spectrometry analysis into national health systems.
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2023)
Article
Endocrinology & Metabolism
Marta Araujo-Castro, Felicia A. Hanzu, Eider Pascual-Corrales, Ana Garcia M. Cano, Marta Marchan, Hector F. Escobar-Morreale, Pablo Valderrabano, Gregori Casals
Summary: This study aimed to analyze the reliability of the 1mg-dexamethasone suppression test (DST) as a marker for glucocorticoid excess and cardiometabolic risk in patients with adrenal incidentalomas (AIs). The urinary steroid profile (USP) was determined using gas chromatography coupled to mass spectrometry. The results showed a positive yet modest correlation between post-DST cortisol and total excretion of glucocorticoid metabolites, and the diagnostic accuracy of the DST for predicting ACS-related comorbidities improved when combined with other markers.
Article
Endocrinology & Metabolism
Noemi Brox-Torrecilla, Ana M. Garcia Cano, Pablo Valderrabano, Alejandra Quintero Tobar, Hector F. Escobar-Morreale, Marta Araujo-Castro
Summary: This study aimed to evaluate the prevalence and incidence of type 2 diabetes in patients with nonfunctioning adrenal incidentalomas (NFAI) or adrenal incidentalomas (AI) with autonomous cortisol secretion (ACS). The results showed no differences in the prevalence or incidence of type 2 diabetes between the groups, but patients with ACS had higher fasting plasma glucose and glycated hemoglobin levels. Diabetic patients also had higher urinary and salivary cortisol levels.