Article
Otorhinolaryngology
Jennifer A. Silver, Mariya Bogatchenko, Marc Pusztaszeri, Veronique-Isabelle Forest, Michael P. Hier, Ji Wei Yang, Michael Tamilia, Richard J. Payne
Summary: The study found an association between BRAF V600E mutation and aggressive features in PTMC (<= 1 cm) and small PTC (1-1.5 cm). Determining the molecular status of these thyroid nodules for the presence of BRAF V600E can help guide patient management.
JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2021)
Article
Medicine, General & Internal
Yun-Suk Choi, Seong-Woon Choi, Jin-Wook Yi
Summary: This study identified TERT promoter mutations in PTC and found that they are associated with more aggressive behavior. Patients with TERT promoter mutations were older, had larger tumors, and exhibited other adverse clinical features, resulting in a poorer prognosis compared to those with wild-type TERT gene status.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Lorenza Mautone, Carlo Ferravante, Anna Tortora, Roberta Tarallo, Giorgio Giurato, Alessandro Weisz, Mario Vitale
Summary: Integrins, as cell-extracellular matrix adhesion molecules, play a key role in cancer metastasis. In papillary thyroid carcinoma patients, integrin expression is associated with histopathology, driver gene mutations, and disease aggressiveness, with ITGA3 subunit showing the highest correlation with disease progression.
Article
Multidisciplinary Sciences
Enock Adjei Agyekum, Yu-guo Wang, Fei-Ju Xu, Debora Akortia, Yong-zhen Ren, Kevoyne Hakeem Chambers, Xian Wang, Jenny Olalia Taupa, Xiao-qin Qian
Summary: This study aimed to predict the BRAF(V600E) mutation in patients with papillary thyroid carcinoma (PTC) using machine learning algorithms based on ultrasound elastography radiomic features. Among the six algorithms compared, support vector machine with radial basis function (SVM_RBF) showed the best diagnostic performance with high accuracy, AUC, sensitivity, specificity, positive predictive value, and negative predictive value.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Marina Muzza, Gabriele Pogliaghi, Carla Colombo, Erika Carbone, Valentina Cirello, Sonia Palazzo, Francesco Frattini, Davide Gentilini, Giacomo Gazzano, Luca Persani, Laura Fugazzola
Summary: Oxidative stress is found to play a role in the pathogenesis and progression of thyroid cancer. Thyroid tumors exhibit higher levels of oxidative stress compared to normal tissues. The degree of oxidative stress is inversely correlated with tumor differentiation and directly correlated with somatic mutations, tumor presentation, and aggressiveness.
Article
Biochemistry & Molecular Biology
Agnes Stephanie Harahap, Imam Subekti, Sonar Soni Panigoro, Mutiah Asmarinah, Fajar Lamhot Lisnawati, Retno Asti Werdhani, Hasrayati Agustina, Dina Khoirunnisa, Mutiah Mutmainnah, Fajar Lamhot Gultom, Abdillah Hasbi Assadyk, Maria Francisca Ham
Summary: This retrospective study aimed to assess the clinicopathology and pERK1/2 expression variations between BRAF-like and RAS-like papillary thyroid carcinoma (PTC) and establish predictive models for BRAFV600E and RAS-mutated PTCs. The results showed variations in biological behavior between BRAF-like and RAS-like PTCs, primarily determined by driver gene mutations and pERK1/2 expression levels.
Review
Biochemistry & Molecular Biology
Abdallah S. Attia, Mohammad Hussein, Peter P. Issa, Ahmad Elnahla, Ashraf Farhoud, Brandon M. Magazine, Mohanad R. Youssef, Mohamed Aboueisha, Mohamed Shama, Eman Toraih, Emad Kandil
Summary: The BRAF(V600E) mutation is associated with the clinicopathological progression of PTMC, leading to more aggressive tumors and higher recurrence risk. Patients with BRAF(V600E) mutations may require earlier interventions, while those with wild-type BRAF(V600E) PTMC can be managed conservatively.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Shubin Hong, Yubin Xie, Zhen Cheng, Jie Li, Weiman He, Zhuming Guo, Quan Zhang, Sui Peng, Minghui He, Shuang Yu, Lixia Xu, Rengyun Liu, Tianyi Xu, Yunjian Zhang, Yanbing Li, Jiguang Wang, Weiming Lv, Jun Yu, Haipeng Xiao
Summary: This study integrated transcriptomic sequencing, genomic analysis, and clinicopathologic information to discover and validate four molecular subtypes of papillary thyroid carcinoma (PTC). The different subtypes showed distinct immune infiltration, genetic alterations, and clinical characteristics. The study also revealed the molecular link between benign thyroid nodules and PTC subtypes and generated a gene expression signature for differential diagnosis. The findings provide opportunities for personalized treatment plans based on molecular subtyping.
Article
Endocrinology & Metabolism
Yan Lin, Zhao-rong Wu, Yao-ping Shi, Min Ding, Xiao-yin Tang, Yi He, Bo Zhai, Ping Li
Summary: This study evaluates the efficiency, safety, and prognosis of ultrasound-guided percutaneous radiofrequency ablation (RFA) for unifocal papillary thyroid microcarcinomas (PTMCs) with BRAF V600E mutation. The results show that RFA is an effective and safe treatment option for unifocal PTMCs with BRAF V600E mutation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Irena Ivkovic, Zgjim Limani, Antonia Jakovcevic, Srecko Gajovic, Sven Seiwerth, Ana Danic Hadzibegovic, Drago Prgomet
Summary: By analyzing tissue samples from 146 patients with papillary thyroid cancer, we found that the BRAF V600E mutation and CPSF2 protein expression are associated with recurrence and disease-free survival. Patients with low CPSF2 protein expression and the BRAF V600E mutation were at higher risk for recurrence, while patients with high CPSF2 protein expression had longer disease-free survival. These findings provide important prognostic factors for papillary thyroid cancer.
Article
Oncology
Ga Hyun Kim, Hye Jin Heo, Ji Wan Kang, Eun-Kyung Kim, Seung Eun Baek, Keunyoung Kim, In Joo Kim, Sunghwan Suh, Byung-Joo Lee, Yun Hak Kim, Kyoungjune Pak
Summary: This study identified TEK and AXIN2 as potential factors involved in the multifocality of papillary thyroid carcinoma (PTC). In vitro experiments showed that inhibiting TEK and AXIN2 reduced the proliferation and migration of PTC cells. Additionally, serum TEK may serve as a diagnostic marker for multifocal PTC.
CANCER CELL INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Anello Marcello Poma, Elisabetta Macerola, Agnese Proietti, Paola Vignali, Rebecca Sparavelli, Liborio Torregrossa, Antonio Matrone, Alessio Basolo, Rossella Elisei, Ferruccio Santini, Clara Ugolini
Summary: This study evaluated the differences between papillary thyroid carcinoma (PTC) with different proportions of hobnail features and hobnail variant (HVPTC), finding that tumors with more than 30% hobnail areas are more likely to have distant metastasis and structural persistence, indicating the need for special attention.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Qizhi Tang, Weiyu Pan, Liangyue Peng
Summary: This study assessed the association between Hashimoto thyroiditis (HT) and clinical outcomes of papillary thyroid carcinoma (PTC). The results showed that PTC patients with HT had lower risks of lymph node metastasis, distant metastasis, extrathyroidal extension, recurrence, vascular invasion, and a better 20-year survival rate, while had higher risks of multifocality, perineural infiltration, and bilaterality. This suggests that PTC patients with HT may have favorable clinicopathologic characteristics.
Article
Oncology
Pratheesh Kumar Poyil, Abdul K. Siraj, Divya Padmaja, Sandeep Kumar Parvathareddy, Roxanne Diaz, Saravanan Thangavel, Rafia Begum, Wael Haqawi, Falah Hassan Al-Mohanna, Saif S. Al-Sobhi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Summary: This study investigated the expression and functional role of furin in Middle Eastern papillary thyroid carcinoma (PTC). Furin overexpression was observed in 44.6% of PTC cases and was associated with aggressive clinicopathological parameters and poor outcomes. Knockdown of FURIN suppressed tumor growth, migration, invasion, and epithelial-to-mesenchymal transition (EMT) in BRAF mutant cells, while overexpression of FURIN reversed these effects in BRAF wild-type cells. FURIN inhibition showed a synergistic antitumor effect with anti-MEK inhibitor treatment.
MOLECULAR ONCOLOGY
(2023)
Article
Oncology
Shiyang Liu, Bo Jiao, Shuyu Li, Lu Zhao, Weihong Zheng, Kun Wang, Jing Xu, Yao Tian, Chenguang Liu, Zhengwei Gui, Lin Zhang
Summary: This study found a significant association between oestrogen receptor alpha and BRAF(V600E) protein expression in papillary thyroid cancer. Higher ESR1 mRNA levels were linked to an increased percentage of BRAF(V600E) mutations, indicating poorer overall survival in patients with this mutation. Co-expression of BRAF(V600E) protein and oestrogen receptor alpha may serve as an indicator of cervical lymph node metastasis and poor overall survival in papillary thyroid cancer patients.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2021)