Article
Reproductive Biology
Nabil Mansour, Fouad Lamghari, Mostafa Nasef, Theneyan Mohamed Al Busaidi, Mohammad Shamim Hossein, Yeon Ik Jeong, Mina Kang, Huijeong Kim, Yura Bae, Bo Hyun Eum, Yeon Woo Jeong, Woo Suk Hwang
Summary: The study evaluated the number and maturity of recovered oocytes after two intervals of in-vivo maturation. It also examined the impact of developmental stage and number of cloned transferred blastocysts on pregnancy rate and early pregnancy loss in dromedary camels. The results showed that a fewer number of oocytes were recovered at 24-26 h compared to 18-20 h. Additionally, the transfer of two hatching cloned blastocysts per surrogate increased the pregnancy rate and decreased early pregnancy loss in dromedary camels.
Article
Public, Environmental & Occupational Health
Amy H. Farkas, Aaron Winn, Liliana E. Pezzin, Nicole Fergestrom, Prakash Laud, Joan M. Neuner
Summary: The study revealed that the use of side effect managing medications is common among women with breast cancer on AI therapy, with many patients having overlapping prescriptions, raising concern for potential harm from polypharmacy.
JOURNAL OF WOMENS HEALTH
(2021)
Review
Chemistry, Medicinal
Panagiotis Peitsidis, Panagiotis Tsikouras, Antonio Simone Lagana, Alexandros Laios, Ioannis Gkegkes, Christos Iavazzo
Summary: Endometriosis is a common gynecologic condition that affects women of reproductive age, causing symptoms such as pelvic pain, dysmenorrhea, dyspareunia, and infertility. Aromatase inhibitors have shown potential in managing these symptoms by suppressing estrogen synthesis. However, the quality of existing systematic reviews on the use of aromatase inhibitors in endometriosis treatment is low, and further research is needed to determine the optimal dosage and duration of therapy, as well as potential adverse effects.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Multidisciplinary Sciences
Gema Puspa Sari, Patrick Louis Lagman Hilario, Shunsuke Yuri, Arata Honda, Ayako Isotani
Summary: This study proposes a new method using a luteinizing hormone-releasing hormone agonist (LHRHa) to achieve simple production of pseudopregnant female mice. By administering LHRHa and pairing the female and male mice, a high success rate in generating genetically engineered mouse models was achieved.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Maria Sund, Miguel Garcia-Argibay, Hans Garmo, Johan Ahlgren, Anna-Karin Wennstig, Irma Fredriksson, Henrik Lindman, Antonis Valachis
Summary: This study found an increased risk for arrhythmia and acute ischemic heart disease in breast cancer patients treated with AIs for more than four years. This conclusion should be taken into consideration in the risk-benefit assessment of endocrine therapy.
Review
Medicine, General & Internal
Amit Akirov, Yaron Rudman
Summary: This study systematically reviewed the role of aromatase inhibitors in the treatment of male prolactinomas with dopamine-agonist-resistant or persistent hypogonadism. The results showed that aromatase inhibitors can reduce estrogen levels, improve sensitivity to dopamine agonists, and control prolactin levels, leading to the shrinking of tumors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Yufan Song, Mingmin Zhang
Summary: The study aimed to evaluate the effect of letrozole and clomiphene citrate on women with infertility and polycystic ovarian syndrome (PCOS). A total of 29 randomized controlled trials (RCTs) were included, involving 3,952 women and 7,633 ovulation induction cycles. The pooled analysis showed that letrozole had superior outcomes in terms of ovulation rate, clinical pregnancy rate, and live-birth rate compared to clomiphene citrate. Therefore, letrozole is recommended as an ovulation induction drug in women with infertility and PCOS.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Neurosciences
Alev Selek, Zehra Seda Unal Halbutogullari, Cigdem Inci Aydemir, Berrin Cetinarslan, Zeynep Canturk, Ilhan Tarkun, Gulay Erman, Cansu Subasi, Karaoz Erdal
Summary: This study investigates the potential of using an aromatase inhibitor as a substitute for testosterone in treating prolactinomas. The findings reveal that the aromatase inhibitor can inhibit cell proliferation and induce apoptosis in prolactinoma cells, as well as reduce prolactin and estrogen levels.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Veterinary Sciences
Samiullah Khan, Muhammad Ameen Jamal, Ibrar Muhammad Khan, Irfan Ullah, Abdul Jabbar, Nazir Muhammad Khan, Yong Liu
Summary: Goats not only provide meat and milk, but also other assistance to their owners. Superovulation techniques have not been widely implemented for goats, unlike in cattle. This review discusses the treatments and outcomes of inducing superovulation in various dairy goat breeds worldwide.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Chemistry, Medicinal
Ankita Sood, Damanpreet Kaur Lang, Rajwinder Kaur, Balraj Saini, Sandeep Arora
Summary: Treatment for breast cancer remains challenging, with aromatase inhibitors showing significantly improved efficacy and safety compared to other drugs.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
Review
Medicine, Research & Experimental
Manar A. Eissa, Eman Y. Gohar
Summary: The documented differences in cardiovascular and chronic kidney diseases risk between males and females are largely attributed to the role of estrogens. Estrogens exert cardiovascular and renal protective effects through the activation of estrogen receptors and interactions with the renin-angiotensin-aldosterone system. Aromatase, an enzyme involved in the conversion of androgens into estrogens, plays a crucial role in estrogen biosynthesis. The use of aromatase inhibitors to treat estrogen-related pathologies may be associated with cardiovascular events. The potential contribution of aromatase enzyme to cardio-renal protection is highlighted in this review.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, General & Internal
Ozlem Karabay Akgul, Hakan Guraslan
Summary: This study compared the clinical, metabolic, and hormonal characteristics of infertile women with PCOS who had or did not have follicle development after using letrozole for ovulation induction. Results showed that follicle development occurred in 85.2% of the women. There were no significant differences in clinical and metabolic values between ovulating and non-ovulating groups, but significant differences were observed in serum AMH value, total testosterone value, and FSH level. The study found that women with lower FSH, androgen, and AMH values had a higher rate of follicle development.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2023)
Article
Oncology
Farzin Khosrow-Khavar, Laurent Azoulay, Jean-Louis Montastruc, Francois Montastruc, Christel Renoux
Summary: This study compared the risk of Parkinson disease between aromatase inhibitors (AIs) and tamoxifen in women diagnosed with breast cancer, and found that AIs were not associated with an increased risk of PD compared to tamoxifen.
Article
Obstetrics & Gynecology
Jennifer J. Yland, Yu-Han Chiu, Paolo Rinaudo, John Hsu, Miguel A. Hernan, Sonia Hernandez-Diaz
Summary: For women with PCOS, letrozole was associated with higher risks of pregnancy, livebirth, and neonatal outcomes compared to clomiphene. In women with unexplained infertility, the two treatments resulted in comparable outcomes.
HUMAN REPRODUCTION
(2022)
Article
Nutrition & Dietetics
Maura Harrigan, Courtney McGowan, Annette Hood, Leah M. Ferrucci, ThaiHien Nguyen, Brenda Cartmel, Fang-Yong Li, Melinda L. Irwin, Tara Sanft
Summary: Dietary supplement use is common among breast cancer survivors, with a high prevalence of potential adverse interactions between prescribed endocrine therapy and dietary supplements.
Article
Obstetrics & Gynecology
Diana Monsivais, Jeffrey D. Bray, Emily Su, Mary Ellen Pavone, Matthew T. Dyson, Antonia Navarro, Toshiyuki Kakinuma, Serdar E. Bulun
FERTILITY AND STERILITY
(2012)
Article
Obstetrics & Gynecology
Mary Ellen Pavone, Serdar E. Bulun
FERTILITY AND STERILITY
(2012)
Article
Obstetrics & Gynecology
David Langoi, Mary Ellen Pavone, Bilgin Gurates, Daniel Chai, Asgerally Fazleabas, Serdar E. Bulun
FERTILITY AND STERILITY
(2013)
Article
Obstetrics & Gynecology
Mary Ellen Pavone, Matthew Dyson, Scott Reirstad, Elizabeth Pearson, Hiroshi Ishikawa, You Hong Cheng, Serdar E. Bulun
HUMAN REPRODUCTION
(2011)
Article
Obstetrics & Gynecology
Kara N. Goldman, Jennifer E. Hirshfeld-Cytron, Mary-Ellen Pavone, Andrew P. Thomas, Robert L. Vogelzang, Magdy P. Milad
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2012)
Article
Endocrinology & Metabolism
Xunqin Yin, Mary Ellen Pavone, Zhenxiao Lu, JianJun Wei, J. Julie Kim
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2012)
Article
Endocrinology & Metabolism
You-Hong Cheng, Hiroki Utsunomiya, Mary Ellen Pavone, Ping Yin, Serdar E. Bulun
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2011)
Article
Psychology, Clinical
Farnaz Jahangiri, Jennifer Hirshfeld-Cytron, Kara Goldman, Mary Ellen Pavone, Susan Gerber, Susan C. Klock
JOURNAL OF PSYCHOSOMATIC OBSTETRICS & GYNECOLOGY
(2011)
Article
Public, Environmental & Occupational Health
Shweta Nayak, Mary Ellen Pavone, Magdy Milad, Ralph Kazer
JOURNAL OF WOMENS HEALTH
(2011)
Editorial Material
Biochemistry & Molecular Biology
Min Xu, Mary Ellen Pavone, Teresa Woodruff
Article
Obstetrics & Gynecology
Mary Ellen Pavone, Jennifer E. Hirshfeld-Cytron, Ralph R. Kazer
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2011)
Article
Obstetrics & Gynecology
Serdar E. Bulun, Diana Monsavais, Mary Ellen Pavone, Matthew Dyson, Qing Xue, Erkut Attar, Hideki Tokunaga, Emily J. Su
SEMINARS IN REPRODUCTIVE MEDICINE
(2012)
Article
Oncology
J. J. Ma, D. Monsivais, M. T. Dyson, J. S. Coon, S. Malpani, M. Ono, H. Zhao, H. Xin, M. E. Pavone, J. J. Kim, D. Chakravarti, S. E. Bulun
Review
Obstetrics & Gynecology
Lia A. Bernardi, Mary Ellen Pavone