Review
Environmental Sciences
Zheng-Yong Wen, Chuan-Jie Qin, Yun-Yun Lv, Yan-Ping Li, Yuan-Chao Zou, Sheng-Tao Guo, Qiong Shi
Summary: This article introduces the important roles of potassium channels in biological processes and the research progress in different species, with a focus on the role of TASK1 channel in fishes and its potential applications.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ling-Hui Chu, Chi-Chun Liao, Phui-Ly Liew, Chien-Wen Chen, Po-Hsuan Su, Kuo-Chang Wen, Hung-Cheng Lai, Rui-Lan Huang, Lin-Yu Chen
Summary: Adenomyosis is associated with dysmenorrhea and infertility. The mechanism of adenomyosis is still unclear. Studies have found genetic and epigenetic changes in the endometrium of patients with adenomyosis, which may lead to the invasion of endometrial tissues into the myometrium. Moreover, genes and protein expressions related to adenomyosis have been identified. Targeting KCNK9 with antibodies may be a potential therapy for symptoms related to adenomyosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Janina Sormann, Marcus Schewe, Peter Proks, Thibault Jouen-Tachoire, Shanlin Rao, Elena B. Riel, Katherine E. Agre, Amber Begtrup, John Dean, Maria Descartes, Jan Fischer, Alice Gardham, Carrie Lahner, Paul R. Mark, Srikanth Muppidi, Pavel N. Pichurin, Joseph Porrmann, Jens Schallner, Kirstin Smith, Volker Straub, Pradeep Vasudevan, Rebecca Willaert, Elisabeth P. Carpenter, Karin E. J. Rodstrom, Michael G. Hahn, Thomas Mueller, Thomas Baukrowitz, Matthew E. Hurles, Caroline F. Wright, Stephen J. Tucker
Summary: Sleep apnea, a common disorder with significant public health burden, has been associated with rare gain-of-function mutations in the KCNK3 gene, highlighting a new role for TASK-1 K+ channels and presenting possible therapeutic strategies.
Article
Urology & Nephrology
Rebecca A. Boyle, Jessica E. Baker, Vivek Charu, William E. Rainey, Vivek Bhalla
Summary: This case study presents a unique presentation of Conn's syndrome in a young man with resistant hypertension and severe hypokalemia, eventually diagnosed as primary aldosteronism. Genetic studies revealed a gain-of-function KCNJ5 mutation within an aldosterone-producing adenoma that was responsive to changes in extracellular potassium levels, highlighting the implications for the molecular mechanisms of potassium regulation of aldosterone.
CLINICAL KIDNEY JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Ryan J. McNally, Bushra Farukh, Philip J. Chowienczyk, Luca Faconti
Summary: The study found that diuretics increase plasma aldosterone in hypertensive patients, with all classes of diuretics having similar effects on PA. In individuals not treated with other antihypertensive medications, the change in plasma aldosterone is related to the change in systolic blood pressure but not to the change in potassium levels.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Clinical Neurology
Sophie F. Hill, Julie M. Ziobro, Paymaan Jafar-Nejad, Frank Rigo, Miriam H. Meisler
Summary: Voltage-gated sodium and potassium channels play a crucial role in regulating neuronal action potentials, and mutations in these channels can lead to seizure disorders. This study demonstrates that reducing the expression of Scn8a can compensate for loss-of-function mutations in Kcna1 and Kcnq2, providing a potential therapeutic approach for genetic epilepsies caused by mutations in potassium channel genes.
Article
Cardiac & Cardiovascular Systems
Rasmus Dreier, Ulrik B. Andersen, Julie L. Forman, Majid Sheykhzade, Martin Egfjord, Jorgen L. Jeppesen
Summary: Increasing potassium intake raises plasma potassium and aldosterone levels, potentiating AngII-stimulated aldosterone secretion without affecting systemic cardiovascular hemodynamics in healthy normotensive men.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Microbiology
Mathieu Sicard, Alice Namias, Marco Perriat-Sanguinet, Eric Carron, Sandra Unal, Mine Altinli, Frederic Landmann, Mylene Weill
Summary: The study focuses on conditional sterility induced by Wolbachia endosymbionts in arthropods. It evaluated the penetrance variations of cytoplasmic incompatibility (CI) in Culex pipiens mosquitoes through the divergence of cid genes. The results show that while crosses with the same wPip group were mostly compatible, those involving different wPip groups exhibited partial or full incompatibility due to unique cid variants.
Article
Plant Sciences
Samar G. Thabet, Yasser S. Moursi, Ahmed Sallam, Mohamed A. Karam, Ahmad M. Alqudah
Summary: The study evaluated salt stress tolerance in 121 global spring barley accessions, identifying 80 significant SNPs associated with the traits studied, many of which encode potassium channels. Genes linked to salinity stress tolerance during seedling developmental phase were identified for the first time in this study.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Pablo Javier Azurmendi, Ayelen Rayen Toro, Alejandro Fabin Celfa, Dario Guevara, Martin Rogelio Solerno, Luis Alberto Di Ciano, Jorge Eduardo Toledo, Fernando Raill Ibarra, Elvira Emilia Arrizurieta, Elisabet Monica Oddo
Summary: The renal kallikrein-kinin system (RKKS) is involved in blood pressure control and sodium and water balance. The activity of kallikrein, an enzyme in this system, is higher in female spontaneously hypertensive rats (SHR) than in males, and ovariectomy decreases kallikrein activity and blood pressure. Pharmacological interventions of aldosterone receptor, epithelial sodium channels (ENaC), and rectifying outer medulla potassium channels (ROMK) influence the gene expression, renal tissue content, and urine release of kallikrein.
Article
Peripheral Vascular Disease
Christina A. Gancayco, Molly R. Gerding, David T. Breault, Mark P. Beenhakker, Paula O. Barrette, Nick A. Guagliardo
Summary: This study investigated the relationship between ion channel dysfunction in aldosterone-producing cells and autonomous aldosterone production. The results showed that channel dysfunction can lead to spontaneous calcium oscillatory activity and drive substantial autonomous aldosterone production.
Article
Cell Biology
Thibaud Parpaite, Lucie Brosse, Nina Sejourne, Amandine Laur, Yasmine Mechioukhi, Patrick Delmas, Bertrand Coste
Summary: This study combines recordings of mechanosensitive currents in mechanosensory neurons with single-cell RNA sequencing to explore the role of transcriptional profiles on mechanotransduction mechanisms. The research revealed that Piezo2 is enriched in rapidly adapting neurons expressing MS currents, while Tmem120a and Tmem150c are uniformly expressed in all mechanosensory neuron subtypes.
Article
Cardiac & Cardiovascular Systems
Yupeng Yan, Jin'e Wang, Liang Yu, Bing Cui, Hongrui Wang, Xiao Xiao, Yu Zhang, Jun Zheng, Jingjun Wang, Rutai Hui, Yibo Wang
Summary: The study revealed that ANKRD36 is involved in blood pressure regulation by interacting with YY1 and altering the expression of ENaC genes. Lower expression of ANKRD36 in hypertension may be a potential therapeutic target. The application of ENaC inhibitors for hypertension treatment could be expanded with close monitoring of serum K+ levels.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Karoline Alves Rossi, Camila Cruz Pereira Almenara, Rakel Passos Simoes, Lorraine Christiny Costa Sepulchro Mulher, Maiara Krause, Maria Tereza W. D. Carneiro, Alessandra Simao Padilha
Summary: This study aimed to investigate the pressoric and vascular effects of a 7-day exposure to CdCl2 in Wistar rats. The results showed that rats exposed to cadmium had elevated blood pressure and increased contractile response to phenylephrine. In addition, the vasodilation responses mediated by acetylcholine and sodium nitroprussiate were impaired in cadmium-exposed rats.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Clinical Neurology
Lin-ming Zhang, Ling Chen, Yi-fei Zhao, Wei-mei Duan, Lian-mei Zhong, Ming-wei Liu
Summary: Potassium channel genes linked to temporal lobe epilepsy (TLE) were identified using bioinformatic analysis. Protein-protein interaction and gene set enrichment analysis revealed their association with cation channel, respiratory chain, and oxidative phosphorylation. mRNA-transcription factor and ceRNA networks revealed their interactions with transcription factors and non-coding RNAs. Drug targeting analysis suggested the potential therapeutic relevance of these genes. Overall, this study provides important gene information for understanding and treating TLE.
FRONTIERS IN NEUROLOGY
(2023)
Correction
Biochemistry & Molecular Biology
Jordan W. Smoller, Ole A. Andreassen, Howard J. Edenberg, Stephen V. Faraone, Stephen J. Glatt, Kenneth S. Kendler
MOLECULAR PSYCHIATRY
(2019)
Review
Biochemistry & Molecular Biology
Jordan W. Smoller, Ole A. Andreassen, Howard J. Edenberg, Stephen V. Faraone, Stephen J. Glatt, Kenneth S. Kendler
MOLECULAR PSYCHIATRY
(2019)
Article
Substance Abuse
Grace Chan, John R. Kramer, Marc A. Schuckit, Victor Hesselbrock, Kathleen K. Bucholz, Howard J. Edenberg, Laura Acion, Douglas Langbehn, Vivia McCutcheon, John I. Nurnberger, Michie Hesselbrock, Bernice Porjesz, Laura Bierut, Bethany C. Marenna, Angella Cookman, Samuel Kuperman
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
Article
Substance Abuse
Jessica L. Bourdon, Rebecca Tillman, Meredith W. Francis, Danielle M. Dick, Mallory Stephenson, Chella Kamarajan, Howard J. Edenberg, John Kramer, Samuel Kuperman, Kathleen K. Bucholz, Vivia V. McCutcheon
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2020)
Article
Multidisciplinary Sciences
Swapnalee Sarmah, Rajneesh Srivastava, Jeanette N. McClintick, Sarath C. Janga, Howard J. Edenberg, James A. Marrs
SCIENTIFIC REPORTS
(2020)
Article
Substance Abuse
Kriti S. Thapa, Andy B. Chen, Dongbing Lai, Xiaoling Xuei, Leah Wetherill, Jay A. Tischfield, Yunlong Liu, Howard J. Edenberg
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2020)
Article
Psychiatry
J. L. Meyers, D. B. Chorlian, T. B. Bigdeli, E. C. Johnson, F. Aliev, A. Agrawal, L. Almasy, A. Anokhin, H. J. Edenberg, T. Foroud, A. Goate, C. Kamarajan, S. Kinreich, J. Nurnberger, A. K. Pandey, G. Pandey, M. H. Plawecki, J. E. Salvatore, J. Zhang, A. Fanous, B. Porjesz
Summary: The study found that polygenic risk for schizophrenia is significantly associated with increased functional neural connectivity in young adults without a schizophrenia diagnosis, with differences observed based on sex and age. Similar associations were also seen in genetically related neuropsychiatric polygenic risk scores, suggesting a link between genetic risk and neural connectivity patterns in unaffected individuals.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Substance Abuse
Emma C. Johnson, Alexander S. Hatoum, Joseph D. Deak, Renato Polimanti, Robin M. Murray, Howard J. Edenberg, Joel Gelernter, Marta Di Forti, Arpana Agrawal
Summary: Genetic liability for cannabis use disorder is significantly associated with schizophrenia, even when considering additional risk factors such as cannabis ever-use, regular smoking, and nicotine dependence. There is mixed evidence regarding a causal relationship between cannabis use disorder and schizophrenia, with further research needed to clarify this association.
Article
Substance Abuse
Kaitlin E. Bountress, Frank Wendt, Daniel Bustamante, Arpana Agrawal, Bradley Webb, Nathan Gillespie, Howard Edenberg, Christina Sheerin, Emma Johnson, Renato Polimanti, Ananda Amstadter
Summary: The study found that PTSD may have a causal effect on AUD, but not on DPW. Additionally, neither DPW nor AUD exerted a causal effect on PTSD. These findings support the self-medication model and suggest groups to prioritize for prevention efforts.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Psychiatry
Jiayi Cox, Richard Sherva, Leah Wetherill, Tatiana Foroud, Howard J. Edenberg, Henry R. Kranzler, Joel Gelernter, Lindsay A. Farrer
Summary: The study found stimulant dependence to be heritable, with potential genetic factors and genes underlying the trait identified through a genome-wide association study. Four suggestive loci were identified, with genes related to other substance use disorders also being highlighted.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Psychology, Clinical
Jinni Su, Sally I-Chun Kuo, Fazil Aliev, Grace Chan, Howard J. Edenberg, Chella Kamarajan, Vivia V. McCutcheon, Jacquelyn L. Meyers, Marc Schuckit, Jay Tischfield, Danielle M. Dick
Summary: Genetic predispositions play an important role in alcohol use. Understanding how genetic risk influences alcohol outcomes through psychosocial mechanisms is critical for intervention efforts. This study found that sensation seeking and social support from family and friends mediate the relationship between genetic risk and alcohol use, highlighting the importance of intermediate phenotypes and gene-environment interactions in the pathways of risk.
JOURNAL OF ABNORMAL PSYCHOLOGY
(2021)
Article
Substance Abuse
Spencer B. Huggett, Emma C. Johnson, Alexander S. Hatoum, Dongbing Lai, Jenani Srijeyanthan, Jason A. Bubier, Elissa J. Chesler, Arpana Agrawal, Abraham A. Palmer, Howard J. Edenberg, Rohan H. C. Palmer
Summary: The study demonstrates that rodent gene expression studies can help identify genetic contributions to some substance use traits in humans, but with less specificity than expected. The results show that rodent gene-sets are enriched for specific traits in human GWAS, with enrichment increasing as trait heritability increases.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Neurosciences
Alexander S. Hatoum, Emma C. Johnson, Sarah M. C. Colbert, Renato Polimanti, Hang Zhou, Raymond K. Walters, Joel Gelernter, Howard J. Edenberg, Ryan Bogdan, Arpana Agrawal
Summary: Shared genetic liability partly explains susceptibility to alcohol, tobacco, cannabis, and opioid use disorders. The Addiction-Risk-Factor is associated with risk-taking, neuroticism, executive function, and non-substance psychopathology, retaining specific variance even after accounting for the genetics of substance use.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychology, Clinical
Jinni Su, Sally I-Chun Kuo, Angel Trevino, Peter B. Barr, Fazil Aliev, Kathleen Bucholz, Grace Chan, Howard J. Edenberg, Samuel Kuperman, Dongbing Lai, Jacquelyn L. Meyers, Gayathri Pandey, Bernice Porjesz, Danielle M. Dick
Summary: Higher parental educational attainment is associated with higher offspring educational attainment. This study examined the genetic and socioenvironmental pathways underlying this association using data from individuals of European ancestry. The results showed that the genetic scores of paternal and maternal educational attainment were associated with offspring educational attainment, and parental educational attainment, income, and parenting behaviors mediated this effect.
JOURNAL OF FAMILY PSYCHOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Tae-Hwi Schwantes-An, Matteo Vatta, Marco Abreu, Leah Wetherill, Howard J. Edenberg, Tatiana M. Foroud, Glenn M. Chertow, Sharon M. Moe
Summary: The study found no association between genes known to be associated with inherited cardiac conditions and SCD in patients undergoing hemodialysis, suggesting genetic causes may not be a major factor in SCD in this population.
CARDIORENAL MEDICINE
(2021)
