Review
Biochemistry & Molecular Biology
Giovanni Fajardo, Michael Coronado, Melia Matthews, Daniel Bernstein
Summary: Alterations in mitochondrial function and morphology are critical adaptations to cardiovascular stress, working in concert in an attempt to restore organelle-level and cellular-level homeostasis. Processes that alter mitochondrial morphology include fission, fusion, mitophagy, and biogenesis, and these interact to maintain mitochondrial quality control. Both pathological stressors like ischemia and physiological stressors like aerobic exercise can induce morphologic adaptations in mitochondria, but with different outcomes for mitochondrial health. Understanding the mechanisms underlying alterations in mitochondrial quality control under diverse cardiovascular stressors can aid in developing pharmacologic interventions for restoring cellular homeostasis.
Review
Endocrinology & Metabolism
Chunlu Yan, Yao Shi, Lingqing Yuan, Donghui Lv, Bai Sun, Jiayu Wang, Xiyan Liu, Fangyu An
Summary: Mitochondria play a crucial role in providing cellular energy and maintaining the balance between osteogenesis and osteoclast activity. Mitochondrial dysfunction disrupts this balance and contributes to the pathogenesis of osteoporosis. Targeted therapy of mitochondria in osteoporosis can provide novel strategies for prevention and treatment of this disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Neurosciences
Frank J. Castora, Kimberly A. Kerns, Haley K. Pflanzer, Naomi L. Hitefield, Blake Gershon, Jason Shugoll, Morgan Shelton, Randolph A. Coleman
Summary: This study investigated the expression of nuclear-encoded mitochondrial genes in AD brains and found that altered expression of these genes can compromise mitochondrial function. A mathematical model was developed to identify potential therapeutic targets for AD.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Cardiac & Cardiovascular Systems
Xiaoqing Peng, Ruirui Hou, Yuanyuan Yang, Zhigang Luo, Yunxia Cao
Summary: This article discusses the role and current research status of mitochondrial quality control (mQC) in placental-originated preeclampsia (PE), and provides suggestions for future research, aiming to provide new ideas for the development of prevention and treatment strategies for PE.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Shiyi Kan, Caixia Pi, Li Zhang, Daimo Guo, Zhixing Niu, Yang Liu, Mengmeng Duan, Xiahua Pu, Mingru Bai, Chenchen Zhou, Demao Zhang, Jing Xie
Summary: This study investigates the role of FGF19 on chondrocytes, focusing on mitochondrial biogenesis and fusion. It is found that FGF19 enhances mitochondrial biogenesis and fusion through the activation of AMPKa-p38/MAPK signaling. These findings expand the understanding of FGF19 on chondrocyte metabolism.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Physiology
Heath G. Gasier, Hagir B. Suliman, Claude A. Piantadosi
Summary: The skeletal muscle HO-1/CO system is hypothesized to modulate components in the MQC cycle during metabolic stress.
EXERCISE AND SPORT SCIENCES REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Murali Vijayan, P. Hemachandra Reddy
Summary: The study aims to understand the protective effects of reduced VDAC1 on mitochondrial dynamics and biogenesis in transgenic TAU mice. The researchers found that a decrease in VDAC1 can significantly reduce mitochondrial fission proteins and increase mitochondrial fusion and biogenesis proteins. These findings may have significant implications for the development of reduced-VDAC1-based treatments for AD and tauopathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Noemi Esteras, Andrey Y. Abramov
Summary: Nrf2 plays a crucial role in regulating mitochondrial function and structure, promoting mitochondrial quality control and regulating basic aspects of function. These findings are important in combating mitochondrial dysfunction.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Endocrinology & Metabolism
John Noone, Donal J. O'Gorman, Helena C. Kenny
Summary: Mitochondrial dynamics is regulated by inner and outer mitochondrial membrane proteins, and OPA1 is a key regulator of inner membrane fusion, playing an important role in skeletal muscle and cardiac muscle physiology and pathophysiology.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Fasih Ahmad Rahman, Joe Quadrilatero
Summary: Remodeling of the mitochondrial network plays a critical role in maintaining cellular homeostasis and regulating skeletal muscle regeneration. The balance between biogenesis and mitophagy, as well as mitochondrial fission and fusion, are key processes in mitochondrial network remodeling.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Luciane C. Alberici, Helena C. F. Oliveira
Summary: Changes in plasma triglyceride metabolism and dietary fatty acid types are major contributors to metabolic and cardiovascular diseases. Mitochondrial adaptive responses play a crucial role in increasing energy expenditure and reducing oxidative stress in facing metabolic challenges.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Cell Biology
Tin Van Huynh, Lekha Rethi, Lekshmi Rethi, Chih-Hwa Chen, Yi-Jen Chen, Yu-Hsun Kao
Summary: Type 2 diabetes is a global burden with increasing numbers of affected individuals and treatment costs. Dysregulated mitochondrial dynamics play an essential role in the pathophysiology of insulin resistance, obesity, and type 2 diabetes. Mitochondrial dysfunction leads to various diseases, including cardiovascular diseases, metabolic disorders, and cancer.
Article
Biochemistry & Molecular Biology
Hsin-Jung Ho, Natsumi Aoki, Yi-Jou Wu, Ming-Chen Gao, Karin Sekine, Toshihiro Sakurai, Hitoshi Chiba, Hideaki Watanabe, Mitsugu Watanabe, Shu-Ping Hui
Summary: The presence of numerous mitochondria in kidney proximal tubular cells plays a crucial role in kidney diseases. The compound 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA), derived from Pacific oysters, has been found to protect renal tubular mitochondria from oxidative damage. DHMBA reduces reactive oxygen species (ROS) production, regulates mitochondrial homeostasis, and enhances mitochondrial respiration, thus potentially preventing the development of kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Grazyna Sygitowicz, Dariusz Sitkiewicz
Summary: The heart is a highly energy-dependent organ, and maintaining a well-functioning mitochondrial population is crucial for cardiac homeostasis. Mitochondrial dysfunction is associated with the development of various diseases, and the mitochondrial quality control system plays a key role in regulating mitochondrial structure and function.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Biochemistry & Molecular Biology
Hayoung Choi, Hongseok Yoo, Jin Young Lee, Junseon Park, Kyeongman Jeon
Summary: This study evaluated the association between mitochondrial DNA (mtDNA) and essential necroptosis mediators in sepsis patients. The results showed that plasma mtDNA copy number was significantly higher in non-survivors compared to survivors, and there was a strong correlation between mtDNA copy number and necroptosis mediators. These findings suggest that mtDNA may contribute to necroptosis and increase sepsis mortality.
Article
Anesthesiology
Chao-Yuan Huang, Fabian Guiza, Greet De Vlieger, Pieter Wouters, Jan Gunst, Michael Casaer, Ilse Vanhorebeek, Inge Derese, Greet Van den Berghe, Geert Meyfroidt
Summary: The purpose of this study was to develop and validate prediction models for AKI recovery in critically ill patients. The models showed poor performance in the general ICU population but had acceptable discrimination in cardiac surgery patients.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Cardiac & Cardiovascular Systems
Laura P. M. H. de Rooij, Lisa M. Becker, Laure Anne Teuwen, Bram Boeckx, Sander Jansen, Simon Feys, Stijn Verleden, Laurens Liesenborghs, Anna K. Stalder, Sasha Libbrecht, Tina Van Buyten, Gino Philips, Abhishek Subramanian, Sebastien J. Dumas, Elda Meta, Mila Borri, Liliana Sokol, Amelie Dendooven, Anh Co K. Truong, Jan Gunst, Pierre Van Mol, Jasmin D. Haslbauer, Katerina Rohlenova, Thomas Menter, Robbert Boudewijns, Vincent Geldhof, Stefan Vinckier, Jacob Amersfoort, Wim Wuyts, Dirk Van Raemdonck, Werner Jacobs, Laurens J. Ceulemans, Birgit Weynand, Bernard Thienpont, Martin Lammens, Mark Kuehnel, Guy Eelen, Mieke Dewerchin, Luc Schoonjans, Danny Jonigk, Jo van Dorpe, Alexandar Tzankov, Els Wauters, Massimiliano Mazzone, Johan Neyts, Joost Wauters, Diether Lambrechts, Peter Carmeliet
Summary: This study provides new insights into the abundance, expression patterns, and interactomes of endothelial cell (EC) subtypes in COVID-19 and idiopathic pulmonary fibrosis (IPF). The findings suggest the importance of ECs in the pathophysiology of both conditions and may contribute to future investigations into the progression and treatment of COVID-19 and IPF.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mathias Clarysse, Alison Accarie, Ricard Farre, Emilio Canovai, Diethard Monbaliu, Jan Gunst, Gert De Hertogh, Tim Vanuytsel, Jacques Pirenne, Laurens J. J. Ceulemans
Summary: Animal research on intestinal ischemia-reperfusion injury (IRI) is mainly done using rodent models. Previously, intraperitoneal injections with ketamine-xylazine mixtures were common, but now volatile anesthetics like isoflurane are more commonly used. However, the impact of the anesthetic method on intestinal IRI has not been studied. This study aims to analyze the different anesthetic methods and their influence on the extent of intestinal IRI in a rat model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Critical Care Medicine
Alexandre Pharaboz, Antoine Kimmoun, Jan Gunst, Kevin Duarte, Thomas Merkling, Etienne Gayat, Alexandre Mebazaa, Benjamin Glenn-Chousterman
Summary: The study aimed to determine the impact of pre-existing type II diabetes mellitus (T2DM) on 90-day mortality after admission to the intensive care unit (ICU). The results showed that in the unmatched cohort, patients with T2DM had a higher risk of death within 90 days compared to patients without diabetes. However, after propensity score matching, there was no significant difference in the 90-day mortality risk between T2DM patients and non-T2DM patients. These findings were consistent with the analysis performed on imputed datasets.
JOURNAL OF CRITICAL CARE
(2023)
Article
Multidisciplinary Sciences
Lore Huwel, Joke Van Eessen, Jan Gunst, Manu L. N. G. Malbrain, Veerle Bosschem, Tom Vanacker, Sofie Verhaeghe, Dominique D. Benoit
Summary: This study aims to explore when healthcare professionals consider intensive care as appropriate care. Despite previous attempts to conceptualize appropriate care, there is a lack of understanding on its meaning and implementation. This is important as inappropriate care in the ICU is regularly reported by healthcare professionals, patients, and relatives.
Article
Endocrinology & Metabolism
Ilse Vanhorebeek, Jan Gunst, Michael P. Casaer, Inge Derese, Sarah Derde, Lies Pauwels, Johan Segers, Greet Hermans, Rik Gosselink, Greet van den Berghe
Summary: This study investigated the impact of critical illness on muscular expression of irisin, kynurenine aminotransferases, and amylase, and their association with clinical outcomes, as well as the effects of interventions that attenuate muscle wasting/weakness. The findings showed that critically ill patients had lower mRNA expression levels of FNDC5, KYAT1, and amylase compared to controls. Lower expression of FNDC5 was associated with higher ICU mortality and ICU-acquired weakness, while lower amylase expression was associated with longer ICU stay. Lower KYAT1 expression was associated with a lower risk of weakness. The study also found that neuromuscular electrical stimulation increased FNDC5 expression and that late parenteral nutrition patients had higher KYAT1 expression compared to early parenteral nutrition patients.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Review
Critical Care Medicine
Ilse Vanhorebeek, Michael Casaer, Jan Gunst
Summary: Critical illness poses a high risk of multiple organ failure due to insufficient activation of autophagy, which can remove damaged molecules and organelles. Animal studies have shown that activating autophagy protects against organ injuries, but artificial feeding may suppress autophagy activation. Safe and specific activation of autophagy holds potential in improving outcomes of critical illness.
CURRENT OPINION IN CRITICAL CARE
(2023)
Review
Critical Care Medicine
Jan Gunst, Sascha C. Verbruggen
Summary: Critically ill patients often experience insulin resistance and hyperglycemia, especially with early parenteral nutrition. Recent evidence suggests that maintaining glucose concentrations close to the antecedent average glucose level can reduce mortality risk. This review discusses the latest findings on glucose control in critical illness.
CURRENT OPINION IN CRITICAL CARE
(2023)
Article
Anesthesiology
Annika Reintam Blaser, Waleed Alhazzani, Emilie Belley-Cote, Morten Hylander Moller, Neill K. J. Adhikari, Lisa Burry, Craig M. Coopersmith, Zainab Al Duhailib, Tomoko Fujii, Anders Granholm, Jan Gunst, Naomi Hammond, Lu Ke, Francois Lamontagne, Cecilia Loudet, Matt Morgan, Marlies Ostermann, Matti Reinikainen, Ricardo Rosenfeld, Claudia Spies, Simon Oczkowski
Summary: According to this rapid practice guideline, intravenous vitamin C therapy is not recommended for adult patients with sepsis or septic shock. The effects of vitamin C on mortality at earlier timepoints are uncertain.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Review
Endocrinology & Metabolism
Lies Langouche, Arno Teblick, Jan Gunst, Greet Van den Berghe
Summary: Based on recent insights, the classical concept of an activated hypothalamus-pituitary-adrenocortical axis in response to critical illness is in need of revision. Peripheral adaptations play a more significant role in maintaining increased systemic cortisol availability and action in response to critical illness than centrally activated cortisol production and secretion. These adaptations include suppressed cortisol metabolism, alterations in expression of certain proteins, and negative feedback inhibition at the pituitary level. Prolonged critical illness may lead to central adrenal insufficiency.
Review
Critical Care Medicine
Jan Gunst, Michael. P. P. Casaer, Jean-Charles Preiser, Jean Reignier, Greet van den Berghe
Summary: Recent randomized controlled trials have shown that early full nutritional support does not benefit critically ill patients and may cause harm. The absence of benefit may not be due to low nutritional risk patients or low amino acid doses, as previously hypothesized. Mechanistic studies suggest that the lack of benefit is due to anabolic resistance and suppression of recovery-enhancing pathways induced by feeding. Large randomized controlled trials have not investigated the impact of different feeding strategies initiated after the acute phase in patients recovering from critical illness.